367
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DEVELOPMENT OF BIODEGRADABLE BANDAGES FROM PINUS SYLVESTRIS
BARK: PHYTOCHEMICAL ANALYSIS AND BIOLOGICAL ACTIVITY
Chapaksin I.V.
Chapaksina B.N.
Seytenova A.K.
Kostanay Higher Medical College, Kostanay, Kazakhstan
e-mail: chapaksinevan44@gmail.com, tel.: +77059159900
https://doi.org/10.5281/zenodo.17337797
Relevance.
Modern medicine has an urgent need for environmentally friendly, biocompatible,
and effective wound dressing materials. The bark of Scots pine (Pinus sylvestris) is a promising
renewable source of biologically active compounds with proven antimicrobial and wound-healing
properties, which determines the relevance of its study.
Objective of the study:
To substantiate the possibility of using Pinus sylvestris bark for the
development of environmentally friendly wound dressing materials with enhanced antiseptic
properties.
Materials and Methods:
A phytochemical analysis of the bark was carried out using IR
spectrophotometry and thin-layer chromatography. A technology for processing the bark into fibrous
material was developed, including the stages of cleaning, fiberization, and stabilization. The
antimicrobial activity and resistance to biodegradation were evaluated under incubation conditions
with fungal cultures
Aspergillus niger
and
Penicillium chrysogenum
. The physico-mechanical
properties of the obtained samples (tensile strength, moisture absorption, air permeability) were also
studied.
Results:
It was found that pine bark is rich in flavonoids (quercetin, kaempferol), phenolic acids
(caffeic, ferulic), and terpenoids (α-pinene), which account for its strong antioxidant and antiseptic
activity. The developed bandages demonstrated superior characteristics compared to synthetic and
gauze analogues: tensile strength — 45 N, moisture absorption — 180%, air permeability — 2.5
cm³/cm²/s. A biodegradation resistance experiment showed that impregnation with yarrow extract
significantly increased the material’s resistance to fungal destruction (affected area of only 15%
versus 40% in the untreated sample and 70% in the synthetic sample on day 14).
Conclusions:
The results of the study confirm the potential of Scots pine bark for the
production of biodegradable, biocompatible wound dressing materials with prolonged antiseptic
activity. Further research will focus on optimizing the technology and conducting preclinical trials.
