468
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
STUDY OF THE ALLERGIC AND CUMULATIVE EFFECTS OF A HERBAL TEA
MADE FROM A CICHORIUM INTYBUS PLANT
R.D. Ramazanova
Z.T. Fayziyeva
Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan
e-mail: dilfuza1012@icloud.com
https://doi.org/10.5281/zenodo.17342491
Relevance:
One of the priority tasks in the field of pharmaceuticals is to provide the population
of our republic with effective and safe medicinal products and biologically active supplements (BAS)
derived from local plants.
Objective:
To study the allergic and cumulative effects of the herbal tea made from the
(
Cichorium intybus
) plant.
Materials and Methods:
Experiments to study the allergic effects of the herbal tea made from
the common desert plant (
Cichorium intybus
) were conducted on 36 white rats of both sexes,
weighing 165–170 g, using the method of V. A. Ado. To induce hypersensitivity in the rats, a 0.5–1
ml/kg subcutaneous injection of chicken egg white solution diluted in physiological saline (1:5 ratio)
was administered three times at two-day intervals. Simultaneously, 0.1 ml of vaseline oil was injected.
On the 21st day of sensitization, a 1 ml/kg dose of chicken egg white protein was injected
intraperitoneally.
The control group received an equivalent volume of distilled water. The test animals were given the
herbal tea in the form of an infusion at doses of 10 and 20 ml/kg for 10 days. The cumulative
properties of the herbal tea made from the common desert plant (
Cichorium intybus
) were studied on
24 rats of both sexes, weighing 150–160 g. The herbal tea was administered orally: 10 ml/kg for the
first 4 days, 15 ml/kg for the next 4 days, 20 ml/kg from days 9 to 12, and 25 ml/kg for the final 5
days.The control group received an equivalent volume of distilled water.The condition of the animals
was monitored visually, with attention given to their general condition, appetite, and response to
external stimuli. At the end of the experiment, the animals were euthanized by decapitation, and their
internal organs were examined macroscopically.
Experimental Results:
The results of studying the allergic effect were as follows: in the control
group of animals that received the appropriate volume of distilled water, signs of anaphylaxis were
observed. These included increased and shallow breathing, decreased skeletal muscle tone, impaired
coordination of movements, and signs of restlessness. In the experimental groups, where animals
received the herbal tea made from the common desert plant (
Cichorium intybus
) at doses of 10 and
20 ml/kg, these changes were significantly reduced compared to the control group and were not
clearly observed.Thus, the studied herbal tea does not exhibit allergenic effects. According to the
results of the cumulative effect study, no significant differences in div weight were observed
between the experimental and control groups of animals. The mucous membranes and skin of all
animals remained unchanged. All animals had a satisfactory appetite and consumed the same amount
of food and water. Respiratory function remained normal across all groups, and no cases of diarrhea
were observed in any of the animals. At the end of the experiment, macroscopic examination of the
internal organs showed a normal appearance. No visual changes were detected in the internal organs
of rats from either the experimental or control groups.Thus, the herbal tea does not exhibit cumulative
effects.
469
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
Conclusion.
The herbal tea prepared from
Cichorium intybus
does not exhibit allergic or
cumulative effects in experimental animals at the studied doses.
