Subject of the inquiry: the protective carcass of a cabin of universal wheel tractor-cultivator.
Aim of the inquiry: design procedure working out on durability and the substantiation of strength parameters of the carcass of cabin of tractor of a class 1.4.
Methods of inquiry: Researches were spent by methods of mathematical and experimental modeling of deflections of elements of the bearing carcass of the cabin of the tractor at overturning in quasi-static to statement
The results achieved and their novelty:
- the mathematical model of calculation of the carcass of the cabin of the tractor on durability is made;
- the design procedure of the protective carcass of the cabin of the tractor on durability taking into account process of distribution of a zone of plastic deformation on length and height of cross-section section of elements of the construction of the carcass;
- Dependences strength properties of rod elements of the construction of the carcass from the bend and curvature moment.
Practical value: the cabin design procedure on the durability is developed, allowing at a design stage and operational development of a design with high degree of reliability to receive demanded strengthening characteristics (the Patent for the computer program № DGU 01583). The multiple analysis of the construction of the cabin of tractor TTZ 80.20 is carried out and the new carcass of the cabin of the tractor (the Patent for utility model № 1'AP 00563) is offered.
Degree of embed and economic effectiveness: Results of work are transferred to special design engineering bureau “Tractor” for practical use at carrying out of developmental works on modernization and construction development of new carcass of cabins of tractors.
Sphere of usage: automobile construction and tractor construction.
The purpose of the study was to determine and evaluate the features of morphological changes in the liver parenchyma of 5-month-old white outbred rats under the influence of anti inflammatory drugs under conditions of polypharmacy.
The object of study for experimental studies was taken 250 white male rats weighing 200-250 g.
The scientific novelty of the research is as follows: polypharmacy of anti-inflammatory drugs negatively affects all parameters of liver structures. Under the influence of polypharmacy, there is a decrease in the absolute mass of the liver, volume and morphological parameters of the liver parenchyma. The decrease in morphometric parameters depends on the number of drugs in polypharmacy; under conditions of polypharmacy, the state of the hepatic capillaries and internal bile ducts, as well as biological membranes, was studied, as a result of which the structural structure of the liver, the development of destruction of the hepatic tissue were studied, and the morphofunctional foundations of this condition were shown.
Implementation of the research results. Based on the obtained scientific results, the morphofunctional characteristics of the liver of rats in the norm and under the influence of polypharmacy were determined:
Approved methodological recommendations: "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Conclusion No. 8n-r / 265 dated 14.03.2022 of the Ministry of Health of the Republic of Uzbekistan) and "Methodology for determining the morphometric parameters of the liver during polypharmacy of anti-inflammatory drugs" (Uzbekistan, Conclusion of the Ministry of Health of the Republic of Uzbekistan No. 8 n-z 180 of 2022), electronic program No. DGU 1038 "Program for studying the comparative characteristics of morphological changes caused by polypharmacy in the liver."
The scientific results obtained in the study of morphological and functional properties and morphometric changes in the structure of the liver under the influence of polypharmacy have been introduced into the practice of the Samarkand branch of the Republican Specialized Oncological and Radiological Scientific and Practical Medical Center of the Samarkand City Medical Association (Order of the Ministry of Health of the Republic of Uzbekistan dated March 14, 2022, 8n-r / 265-No. and conclusion No. 8 n-z 180 of 2022). The implementation of the obtained research data allows developing methods for early diagnosis, treatment and prediction of organopathology by morphological parameters, improving the quality of life and reducing the number of complications.
The structure and scope of the dissertation. The structure of the dissertation consists of an introduction, three chapters, a conclusion and a list of references. The volume of the dissertation was 103 pages.