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LDH ACTIVITY IN THE BLOOD SERUM OF CHILDREN WITH
COMPLICATED PNEUMONIA
Fayziev A.N.
Tashkent Pediatric Medical Institute. Tashkent, Uzbekistan
INTRODUCTION
Despite numerous studies in the field of pediatric pulmonology, the
problems of acute and complicated pneumonia in young children still remain
relevant. With this pathology, taking into account the phase of the disease, and its
clinical forms (complicated, uncomplicated), the study of isoform lactate
dehydrogenase (LDH) in the blood of children with complicated pneumonia is of
great scientific and practical interest.
PURPOSE OF THE RESEARCH
To study the features of LDH changes in the blood serum of children with
complicated pneumonia and the relationship of the revealed changes depending
on the clinical course.
MATERIALS AND METHODS
The studies were carried out on 56 sick children with complicated
pneumonia who were inpatient treatment at the Tashkent Pediatric Medical
Institute clinic and 12 practically healthy children aged 1 to 3 years. The most
frequent syndromes aggravating the course of the underlying disease were
cardio-respiratory syndrome (17 patients, 30.4%), obstructive syndrome
(15 children, 26.8%), cardiovascular syndrome (13 children, 23.2%),
neurotoxicosis (11 patients, 19.6%). In all cases, the diagnosis of
bronchopneumonia was based on X-ray data. Along with general clinical methods,
the percentage of LDH isoforms in the blood serum was determined by the
method of dis-electrophoresis in polyacrylamide gel.
RESULTS
Studies have shown that LDH1, LDH2, and LDH3 are high in practically
healthy young children, while the values of LDH4 and LDH5 are low. At the same
time, in sick children with complicated pneumonia in the acute period of the
disease, there is a tendency to a decrease in LDH1 and LDH2, while the content of
other isoforms significantly increases. This is especially clearly manifested in the
content of LDH4 and LDH5, the values of which are statistically significantly
higher by 31.4 and 95.8%, respectively. By the recovery period, a tendency to
restore the content of various LDH isoforms was revealed, however, despite this,
the values of LDH4 and LDH5 remain high. It should be said that LDH isoforms
have an organ topology and reflect the degree of damage to certain organs.
LDH is a tetramer consisting of H and M subunits; their ratio determines the
I Конгресс детских врачей Республики Узбекистан
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«Актуальные вопросы практической педиатрии»
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localization of the enzyme and the type of oxidative metabolism. The data
obtained indicate the predominance of the anaerobic pathway of glucose
oxidation in the div of sick children and the involvement of the liver in the
pathological process and increased catabolism of muscle proteins to a certain
extent. At the same time, it was of interest to study LDH isoforms in children with
complicated pneumonia depending on concomitant syndromes. Significant
changes in the isoenzyme spectrum of LDH were found in children with cardio-
respiratory syndrome and catfish. Moreover, its specific features have been
identified. Thus, in the presence of cardiovascular, cardio-respiratory, obstructive
syndromes, and neurotoxicosis, the LDH4 level statistically significantly increases
in 2.11; 2.49; 2.57, and 3.34 times. If the level of LDH5 in the presence of
cardiovascular, cardiorespiratory, and especially neurotoxicosis significantly
decreases by 1.37; 1.89, and 5.37 times, then in obstructive syndrome we
observed its increase by 2.42 times.
CONCLUSIONS
Thus, the studies carried out revealed that the complicated course of acute
pneumonia in young children is revealed by a change in serum LDH isoforms, the
severity of which depends on the aggravated complication. More pronounced
changes are characteristic of complications such as neurotoxicosis and cardio-
respiratory syndrome.
REFERENCES:
1.
Исмагулов
,
Ж
., &
Нурмухамедов
,
Х
. (2021).
Критерии безопасности
переливания коллоидных растворов у детей при пневмониях. Перспективы
развития медицины, 1(1), 101
-102.
2.
Бекназаров, А., Хайдаров, М., Маматкулов, И., & Ашурова, Г. (2021).
Преимущества общей анестезии севофлюраном у детей с детским
церебральным параличом в офтальмохирургии, in Library, 27(1), 41
-44.
извлечено от https://inlibrary.uz/index.php/archive/article
/view/18897
