Features of local immunity of the oral cavity in patients with ontogenous inflammatory disease of the maxillo-facial region

It has now been proven that when peripheral nerves are damaged in the spinal cord,  cytokines  are  produced  (interleukin-1,  interleukin-6,  tumor  necrosis  factor alpha), which contribute to the persistence of pain. Blocking cytokines reduces pain. With the development of this area of research, new prospects are associated in the development of drugs for the treatment of chronic neuropathic pain. According to V.P. Zueva (1981), in almost 60% of patients with purulent-inflammatory diseases of the maxillofacial region, pathological changes in the immune system are detected. Mild and  moderate  severity  of  the  purulent  process  (usually  abscesses)  cause  moderate changes in the immune system. In severe phlegmon, inhibition of immunity occurs, especially pronounced in putrefactive necrotic forms, which necessitates studies of the immunobiological reactivity of the body. Thus, a dynamic assessment of the immune status  in  patients  with  purulent-inflammatory diseases  of  the maxillofacial and  the selection  of  adequate  methods  of  immunocorrection  seems  to  be  necessary.  In  our opinion,  the  study  of  the  characteristics  of  changes  in  the  nervous  system, psychoemotional  sphere  and  related  disorders  of  neuroendocrine  regulation  in patients with acute odontogenic periostitis of the jaw will help expand the range of pathogenetically  substantiated  methods  of  treatment,  increase  the  effectiveness  of therapy and prevention of complications.