Судороги являются одним из наиболее частых проявлений нарушении функции мозга у детей младшего возраста. Они встречаются у каждого двадцатого ребенка в возрасте до 4-х лет. При этом в подавляющем большинстве случаев первичную диагностику и оказание экстренной терапии проводит врач – педиатр, а узкие специалисты (невропатолог, инфекционист) подключаются, при необходимости, последующих этапах ведения больного. Учитывая, что при оказании неотложной помощи детям с судорогами, а также для предупреждения пароксизмов при лихорадочных состояниях используются антипиретики, считаем целесообразным обсудить вопросы их рационального применения. Актуальность этого подчеркивается также тем, что неконтролируемое применение антипиретиков, неадекватный их выбор и режим дозирования могут приводить к развитию серьезных побочных и нежелательных реакций. Следует также отметить, превентивное назначение антипиретиков при повышении температуры тела у детей с судорогами в анамнезе рекомендуется практически всеми исследователями.
Clinically, neurotrophic disorders manifest themselves most often in acute brain diseases (strokes, injuries, meningoencephalitis, etc.), accompanied by the involvement of the hypothalamus - pituitary gland, brain stem, sympathetic and vagus nerves [3]. At the same time, the greatest functional and morphological disorders are observed in the gastrointestinal tract (ulcers, erosion, hemorrhages), lungs (edema, pneumonia) and pancreas (transient hyperglycemia) [1, p. 529] and liver (4, p. 170] Despite the fact that the main theater of action is expressed in a local catastrophe of the brain and neurological disorders, most researchers and practitioners do not pay due attention to the essential role of the "main laboratory" of the body - the morphofunctional state of the liver [7, p. 876].
Any pathological mechanisms are triggered by various etiological factors or biological events, therefore a large number of neurological diseases, especially of ischemic origin, with different evolution (acute, chronic) are degenerative and are reflected in the state of other vital organs [1 ,6]. The main task of eliminating cerebral ischemic catastrophes is to block ongoing pathogenetic processes in the shortest possible time, in order to maximally limit the penumbra zone in order to avoid massive death of brain cells [5, 11].
The effect of a decoction of liquorice root and an infusion of Helichrysum flowers on the processes of lipid peroxidation in chronic toxic hepatitis was studied. It has been established that a decoction of liquorice root and an infusion of Sandy immortelle flower in chronic poisoning with heliotrin has an antioxidant effect. In terms of hepatoprotective action, herbal preparations are not inferior to the well-known hepatoprotector silibor.
The effect of a decoction of liquorice root and an infusion of Helichrysum flowers on the processes of lipid peroxidation in chronic toxic hepatitis was studied. It has been established that a decoction of liquorice root and an infusion of Sandy immortelle flower in chronic poisoning with heliotrin has an antioxidant effect. In terms of hepatoprotective action, herbal preparations are not inferior to the well-known hepatoprotector carsil.
The influence of darmonal on the functional condition of liver lias been studied in toxic hepatitis. It was determined that darmonal increased content of protiens and improved detoxication function of liver by decreasing activity of cytolitic enzymes ALT and AST, decreasing cholestatic markers - APh and GGT. Darmonal showing hepatoprotective action improves function of liver and do not resign to other hepatoprotector - silibor.
This article is devoted to the preclinical study of the anti- atherosclerotic drug firutas on pathomorphological changes in animal organs during prolonged administration. Preclinical study of the general toxicology of the drug "Firutas" showed that it belongs to the IV class of low-toxic compounds. The drug "Firutas" does not have a cumulative and locally irritating effect. With repeated intramuscular administration to mice and rats, it does not affect the behavior and weight dynamics of animals, does not have a toxic effect on the composition of peripheral blood, kidney and liver function, as well as on the pathomorphology of animal organs and tissues. All the above data allow us to conclude that the drug does not have a toxic effect on the body of animals
The influence of stimusol (extract radix Glycyrrhiza+mumie) on lipid peroxidation processes and
synthesis of gall m the liver at chronic toxic hepatitis were researched. It was determined that stimusol during
chronic poisoning with heliotrine made antioxidant and choleretic action. Normalize of gall contains. It didn't
give up to famous, silibor by hepatoprotector action
In experiments on white rats it was established that administration of heliotrine during a month induced severe damage to the liver characterized by enhancement of lipid peroxidation, a decrease of enzyme activities - superoxide dismutase and catalase. Liquorice, immortelle flowers and mumie inhibited manifestation of heliotrine hepatitis and exerted antioxidant action. In combined use of natural compounds their antioxidant action increases.