Early diagnosis of Myeloproliferative diseases (MPD) is one of the serious problems of oncohematological practice. MPD efers to multifactorial diseases, the development of which is influenced by both environmental factors and genetic predisposition. The study studied the association of the carriage of the genotype for the polymorphic marker encoding glycoprotein-P and the development of MPD. The homozygous T / T genotype of the rs1045642 polymorphism of the MDR1 gene is a significant determinant of the increased risk of developing MPD in Uzbekistan (P<0.05). Conclusion. Genotype association the rs1045642 polymorphism of the MDR1 gene is associated with the risk of developing MPD.
С 90-х годов прошлого века повышение качества медицинской помощи стало на повестке дня систем здравоохранения многих стран. Значительный прогресс в системах здравоохранения развитых стран (Канада, страны Европейского Союза, США, Япония и др.) достигнутый в течение последних десятилетий, обусловлено внедрением новых подходов к управлению в сфере здравоохранения, основанных на концепции непрерывного повышения качества
The objectives of this study were to describe Uzbek women’s experiences of the severity and frequency of
premenstrual symptoms, and whether these symptoms were affected by a range of sociodemographic and lifestyle variables including education level and age. The result showed that the relationship between duration and severity was not statistically different among symptoms, and not dependent on any sociodemographic variables (age, educational level) While studying of clinical picture spectrum it was found that he most prevalent symptoms of premenstrual syndrome are physical. Physical symptoms are the most prevalent premenstrual symptoms experienced by Uzbek women, and this is also concur with results of other studies conducted in different parts of the world. A significant number of women report moderately severe premenstrual symptoms and these vary with age, educational level and parity