Purpose of work w as the cliniko-functional assessment of efficiency of a preparation “CORTEXIN” in the complex treatment of a diabetic retinopathy at non proliferative and preproliferative stages. Under supervision there were 30 patients (60 eyes) aged from 40 till 81 years old, with a diabetic retinopathy at nonproliferative and preproliferative stages who were divided into 2 groups. The first group (main) - 15 people (30 eyes) in addition to traditional treatment took “CORTEXIN” preparation of 10 mg on 0,5ml parabulbarly 1 time within 10 days. The second group (control) — 15 people (30 eyes) underwent traditional therapy. There were 12 males (40%) and 18 females (60%). The efficacy of treatment was studied by methods of visiometry, ophthalmoscopy and perimetry. The examinations have been performed before and 1, 3 and 6 months after treatment. During the carried out treatment in the main group of patients the improvement of visual acuity, field of vision and condition of retina w ith keeping the stable effect till 6 months was fixed. And ali this allows authors to recommend “CORTEXIN” application in the complex treatment of diabetic retinopathy at nonproliferative and preproliferative stages.