Изучить сравнительную эффективность иммунодепрессантов и генно-инженерных биопрепаратов в лечении ювенильного идиопатического артрита у детей.
In the textual studies of the peoples of the world, attention to the study of national literary heritage based on primary sources is growing stronger than ever. The study of manuscript sources makes it possible to restore the texts of the works of a poet or writer in accordance with the original (at least close to it), regardless of the period in which they lived. Without restoring a reliable text, the poet's work cannot be analyzed in terms of theoretical problems of literary studies. In world textology, research is being conducted on such scientific problems as comparative analysis of manuscript sources, creating a scientific biography of the creator, and studying the history of the text of an artistic work. Among them, a great deal of experience, knowledge and material has been collected within the framework of studying the sources of Eastern manuscripts spread throughout the world's libraries, including the works of Alisher Navoi and Babur, great figures of Turkish literature. Extensive research is the basis for the creation of the theoretical foundations of textual studies. Uzbek textology has progressed on the basis of existing scientific experiences and has achieved certain results in the study of classic literary sources. Researching the literary heritage of authors who have left a bright mark in the history of national literature, studying manuscript and lithographic sources based on the latest scientific achievements is one of the primary tasks of source studies and textual studies. After all, "...studying and promoting Uzbek classic and modern literature at the international level, analyzing this multifaceted topic in integral connection with the most important processes taking place in the world's literary space today, creating the necessary scientific - drawing practical conclusions is of great importance..." 1 . Accordingly, it becomes clear that it is urgent to carry out a scientific monographic study of the sources of the lyric divan of Khorezm literary environment representative Mutrib Khonakharob (1853-1923), study the textual history of the poet's works, and develop the principles of preparing a scientific and critical text. The study of Mutrib's work began during the poet's lifetime. Tabibiy recognizes the achievements of the poet in poetry and music in the collections "Majmuat ush-shuaroyi payravi Feruzshahi" and "Majmuat mukhammasot ush-shuaroyi Feruzshahi". "Biographies of poets and writers of Khiva" by Hasanmurad Laffasi, "Poets and singers of Khorezm" by Bobojon Tarroh, "Tazkirayi Qayyumiy" by Polatjon Qayyumiy also provide valuable information about the poet's work. O. Sharafiddinov, M. Yunusov, N.M. Mallayev, Yu. Yusupov, M. Pirnazarov, A. Abdugafurov published articles. These articles cover the biography of the poet, the ideological scope and artistry of his works, thematic and genre features of his literary heritage. But in most of them, the poet's works were interpreted under the influence of communist ideology. M. Pirnazarov studied manuscript and lithographic sources of Mutrib's lyrical heritage, subject scope, genre features, and artistic skills. Although this research provided valuable information for its time, problems such as creating a scientific biography of the poet, researching the author's works in the field of theoretical problems of textual studies, and creating a scientific-critical text are still waiting to be solved. In studying the poet's literary heritage, the book "Mutrib Khonaharobi (Ref. Collection)" is noteworthy. However, besides the fact that the text of these poems is not complete, there are also errors in the reading of words. In this tutorial, the manuscripts numbered 906/VII, 903/IV, 2679/II of the Department of Muhammad Hasan Mutrib kept in the main and H. Sulayman funds of the Academy of Sciences of the Republic of Uzbekistan, as well as Turkish manuscripts in bayoz, complex and tazkira poems, information about the poems in manuscript bayoz kept in Khiva Ichonqala Muhammad Rahimkhan Feruz II Museum.
Ювенильный ревматоидный артрит (ЮРА) относится к числу наиболее тяжелых и социально значимых форм хронической патологии у детей. За последние 10–15 лет достигнуты определенные успехи в лечении этой патологии. Тем не менее, далеко не все проблемы решены. Статистика указывает на высокий процент детей с многолетним прогрессирующим течением заболевания, с функциональной недостаточностью, с признаками лекарственной болезни, вызванной противоревматическими средствами.
Ювенильный идиопатический артрит (ЮИА) – наиболее частое ревматическое многофакторное заболевание, развивающееся у детей в возрасте младше 16 лет. Известно, что именно первые годы болезни являются решающими в развитии и прогрессировании патологического процесса. Динамика клинико лабораторных проявлений ювенильного идиопатического артрита (ЮИА) – одна из обширно дебатируемых трудностей ревматологии, актуальность которой уясняют два главных фактора – тонкости течения заболевания у малышей с разными вариантами дебюта и эффективность всевозможных подходов основополагающей терапии.
The purpose of this article is to determine the orientation of schoolchildren in terms of grades in subjects and soft skills using machine learning methods. The article examined the difficulties of constructing a sigmoid function using multivariate linear regression, and also digitized grades obtained in selected subjects in the field of student education over 10 years and their various parameters, reasons and student capabilities. . Using these numbers, a training data set was created. As a result, a classification of subjects studied by schoolchildren over 10 years and their assessments was developed. Neural network architectures, modules, the most commonly used activation functions in machine learning algorithms, training methods and methods for constructing linear and logistic regression, disadvantages and opportunities are analyzed. Ways to simplify the gradient descent function for multivariate linear regression by vector calculation have been studied. Because there are many variables involved in this type of linear regression, vector calculations have proven to be more convenient. Methods for parallel calculation of gradient descent processes using vector calculations are also considered. In particular, the addition of training data table columns, transposition of coefficients - AT, vectorized representation of a linear function, hyperparameters for gradient descent (learning rate - , number of steps) were defined.
Определение основных характеристик диагностики и лечения заболеваний, таких как ЮИА.
Материалы и методы. Это ретроспективное исследование включало шестьдесят пациентов с ЮИА (60 девочек и 20 мальчиков) в возрасте от 2 до 16 лет (средний возраст детей 8,0±1,2 лет), в соответствии с критериями Международной Лиги Ассоциаций Ревматологов (МЛАР) [23] и было последовательно отобрано из отделения ревматологии, реабилитации и эндокринологии Ташкентской медицинской академии для исследования.