Authors

  • M.J. Allayeva
  • Z.X. Amonova

DOI:

https://doi.org/10.71337/inlibrary.uz.science-research.58055

Keywords:

taurin rux gepatit oʻtkir zaharlanish gepatoprotektor antioksidant oksidlovchi stress asetaminofen.

Abstract

Mazkur maqola taurin va rux kombinatsiyasining inson organizmiga tiklovchi ta’siri haqida so’z boradi. Maqola davomida asosli fikr va mulohazalar keltirilgan.

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TAURIN VA RUX KOMBINATSIYASINING INSON ORGANIZMIGA TIKLOVCHI

TA’SIRI- DUNYO OLIMLARI NIGOHIDA

Allayeva M.J.

Toshkent tibbiyot akademiyasi farmakologiya kafedrasi mudiri.

professor, biologiya fanlari doktori.

Amonova Z.X.

Toshkent tibbiyot akademiyasi, Termiz filiali farmakologiya fani asistenti.

https://doi.org/10.5281/zenodo.14539552

Annotatsiya. Mazkur maqola taurin va rux kombinatsiyasining inson organizmiga

tiklovchi ta’siri haqida so’z boradi. Maqola davomida asosli fikr va mulohazalar keltirilgan.

Kalit soʻzlar: taurin, rux, gepatit, oʻtkir zaharlanish, gepatoprotektor, antioksidant,

oksidlovchi stress, asetaminofen.

THE RESTORATIVE EFFECT OF THE COMBINATION OF TAURINE AND ZINC

ON THE HUMAN BODY - FROM THE POINT OF VIEW OF WORLD SCIENTISTS

Abstract. This article discusses the restorative effect of the combination of taurine and zinc

on the human div. The article presents reasonable ideas and considerations.

Keywords: taurine, zinc, hepatitis, acute poisoning, hepatoprotector, antioxidant,

oxidative stress, acetaminophen.

ВОССТАНАВЛИВАЮЩЕЕ ДЕЙСТВИЕ СОЧЕТАНИЯ ТАУРИНА И ЦИНКА НА

ОРГАНИЗМ ЧЕЛОВЕКА – ГЛАЗАМИ МИРОВЫХ УЧЕНЫХ

Аннотация. В данной статье речь идет о восстановительном влиянии сочетания

таурина и цинка на организм человека. Аргументированные мнения и комментарии

представлены на протяжении всей статьи.

Ключевые слова: таурин, цинк, гепатит, острое отравление, гепатопротектор,

антиоксидант, окислительный стресс, ацетаминофен.

Taurin va rux kombinatsiyasi organizm uchun kuchli himoya va qo‘llab-quvvatlash

mexanizmini hosil qiladi. Ularning birgalikdagi ta’siri quyidagilarni o‘z ichiga oladi:

Yuqori antioksidant himoya – taurin va rux birgalikda hujayralarni kuchli antioksidant

himoya bilan ta’minlaydi va oksidlovchi stressni kamaytiradi [1,2]. Immunitetni kuchaytirish –

ularning birgalikda ta’siri immun hujayralar samaradorligini oshiradi va infeksiyalarga qarshi

himoya mexanizmlarini yaxshilaydi [3]. Energiya ishlab chiqarishni oshirish – taurin hujayra

energetikasini kuchaytirsa, rux fermentlar faoliyatini qo‘llab-quvvatlaydi, bu esa umumiy energiya

darajasini oshiradi [4]. Yurak va asab tizimini mustahkamlash – bu moddalar birgalikda yurakning

sog‘lom ishlashi va asab tizimi faoliyatini qo‘llab-quvvatlaydi [5]. Tadqiqotlar taurinning rux bilan


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birgalikda qo‘llanilganda yurak-qon tomir kasalliklari, immun tizimi muammolari va yuqori

oksidlovchi stress xavfini kamaytirishini ko‘rsatmoqda [6]. Ayniqsa, ular organizmning

infeksiyalarga qarshi chidamliligini oshiradi va qarish jarayonini sekinlashtiradi [7].

Taurin va rux (Zn) birgalikda gepatoprotektor sifatida qo‘llanilishiga oid tadqiqotlar,

ularning jigarni himoya qilishdagi samarali ta’sirini va birgalikdagi foydalari haqida qiziqarli

natijalar ko‘rsatdi. Ikkala modda ham jigarni toksik moddalar ta’siridan himoya qilish,

yallig‘lanishni kamaytirish va hujayralarning regeneratsiyasini qo‘llab-quvvatlashda muhim rol

o‘ynaydi.

Quyida taurin va ruxning gepatoprotektiv (jigarni himoya qilish) ta’siri bo‘yicha

o‘tkazilgan asosiy tadqiqotlarga qisqacha to‘xtalib o‘tamiz.

Tadqiqotlar ko‘rsatishicha, taurin va ruxning birgalikdagi qo‘llanilishi jigarni toksik

moddalar, masalan, paratsetamol (har xil dorilar, alkogol yoki kimyoviy moddalar bilan) tufayli

yuzaga keladigan zararli ta’sirlardan himoya qilishda samarali bo‘ladi [8,9]. Rux o‘zining

gepatoprotektiv (jigarni himoya qilish) xususiyatlari bilan tanilgan, shuningdek, taurinning

antioksidant va yallig‘lanishga qarshi ta’siri ushbu jarayonlarni kuchaytiradi [10].

Paratsetamol (asetaminofen) katta dozada qabul qilinganida jigar hujayralarini

shikastlaydi. Ba’zi tadqiqotlar shuni ko‘rsatdiki, taurin va ruxning birgalikda qo‘llanilishi jigarni

toksik ta’sirlardan himoya qiladi [11]. Rux jigar hujayralaridagi antioksidant tizimni kuchaytiradi,

taurin esa yallig‘lanishni kamaytirish va hujayralarni oksidlovchi stressdan himoya qilishda

yordam beradi. Birgalikda bu moddalar jigarni qayta tiklash jarayonini qo‘llab-quvvatlaydi [12].

Zux va taurin yordamida jigarning regeneratsiyasi: Taurin va ruxning qo‘llanilishi jigar

hujayralarining regeneratsiyasini tezlashtiradi [13]. Rux jigar hujayralarida metalloproteinazalarni

faollashtirib, jigarda yangilanish va to‘qima tiklanishini rag‘batlantiradi, taurin esa bu jarayonni

qo‘llab-quvvatlaydi va jigar to‘qimalarini himoya qiladi [14]. Bir qator tadqiqotlar taurin va ruxni

birgalikda qo‘llash jigar fibrozi va sirrozini oldini olishda foydali ekanligini ko‘rsatdi. Rux

antioksidant sifatida hujayralarni zararli moddalardan himoya qilsa, taurin yallig‘lanishni

kamaytiradi va jigar shikastlanishini sekinlashtiradi [15].

Ba’zi tadqiqotlar shuni ko‘rsatdiki, taurin va rux kombinatsiyasi surunkali jigar

yallig‘lanishini kamaytiradi. Bunda ruxning antioksidant ta’siri jigar hujayralarining

oksidlanishiga qarshi kurashishga yordam beradi, taurin esa yallig‘lanishni va hujayra

shikastlanishini kamaytiradi. Bu ikki moddaning birgalikda ta’siri jigarning shikastlanishini

sekinlashtiradi va regeneratsiyasini yaxshilaydi [16].

Taurin va rux, birgalikda, jigarni detoksikatsiya qilishda ham samarali hisoblanadi. Taurin

safro ishlab chiqarishni qo‘llab-quvvatlasa, rux jigarning toksik moddalarni zararsizlantirish

qobiliyatini kuchaytiradi. Shu bilan birga, taurin va ruxning kombinatsiyasi jigarni toksik


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moddalardan tezda tozalashga yordam beradi. Jigarni toksik moddalar bilan bog‘liq zararli

ta’sirlardan himoya qilish: Jigarni tozalash va zararsizlantirish jarayonida taurin va rux birgalikda

ishlaganda jigarning toksik moddalarga chidamliligi oshadi [17]. Tadqiqotlar shuni ko‘rsatadi-ki,

taurin va rux qo‘llanilganda, jigarning detoksikatsiya faoliyati yaxshilanadi va hujayralarning

regeneratsiyasi tezlashadi.

Taurin va ruxning birgalikda qo‘llanilishi jigar kasalliklarida samarali gepatoprotektor

sifatida ishlaydi. Ularning birgalikdagi ta’siri jigarni toksik moddalar va oksidlovchi stressdan

himoya qiladi, regeneratsiya jarayonlarini kuchaytiradi, va yallig‘lanishni kamaytiradi.

Tadqiqotlar taurin va ruxning kombinatsiyasining jigarni himoya qilish va uning sog‘lom

ishlashini ta’minlashda katta ahamiyatga ega ekanligini ko‘rsatmoqda. Bu moddalar, ayniqsa,

surunkali jigar kasalliklari, jigar fibrozasi va sirrozi bilan kasallangan bemorlarda samarali bo‘lishi

mumkin.

Taurin va rux bilan bog‘liq tadqiqotlar ko‘plab olimlar va tadqiqotchilar tomonidan amalga

oshirilgan. Bu moddalarning gepatoprotektiv (jigarni himoya qilish) ta’siri, antioksidant va

yallig‘lanishga qarshi faoliyatlari, shuningdek, ularning jigarni detoksikatsiya qilishdagi roli

haqida bir nechta muhim ilmiy ishlar mavjud. Quyida taurin va rux bilan ishlagan ba’zi taniqli

olimlar va ularning tadqiqotlari haqida ma’lumot beraman:

Bir nechta olimlar va tadqiqotchilar taurin va ruxning gepatoprotektiv xususiyatlari

bo‘yicha tadqiqotlar olib borgan. Ularning asosiy tadqiqotlari quyidagilardan iborat:

Yeh Y.H. va uning jamoasi taurin va ruxning antioksidant faolligini o‘rganib, ularning

jigarni oksidlovchi stressdan himoya qilishdagi samaradorligini ko‘rsatdilar [17]. Ularning

ishlarida taurin va ruxning birgalikdagi qo‘llanilishi jigar hujayralarida erkin radikallarni

kamaytirish va yallig‘lanishni pasaytirish bilan bog‘liq.

Heidari R va Kendler taurin va ruxning jigarni himoya qilishdagi rolini o‘rgangan. Uning

tadqiqotlari ko‘rsatadiki, ushbu moddalar, ayniqsa, parasetamol yoki alkogol bilan bog‘liq jigar

shikastlanishida samarali hisoblanadi [18, 19]. Ularning kombinatsiyasi jigar regeneratsiyasini va

detoksikatsiya jarayonlarini qo‘llab-quvvatlaydi.

Surai P.F. taurin va ruxning birgalikda erkin radikallarni neytrallashtirishdagi ta’sirini

o‘rgangan. Uning tadqiqotlari ruxning antioksidant faolligini va taurin bilan kombinatsiyasining

jigar hujayralarining oksidlanishiga qarshi qanday himoya qilishini ko‘rsatdi [20]. Bu tadqiqotlar

taurin va ruxning birgalikda jigarni himoya qilishda katta ahamiyatga ega ekanligini ta’kidlaydi.

Qaradakhi T va uning jamoasi taurin va ruxning yallig‘lanishga qarshi ta’sirini o‘rgangan.

Tadqiqotlar shuni ko‘rsatdi-ki, bu moddalar birgalikda jigar yallig‘lanishini kamaytiradi va jigar

hujayralarini shikastlanishdan himoya qiladi [21]. Uning ishlarida bu ikki moddani qo‘llash

surunkali jigar kasalliklarini davolashda samarali bo‘lishi mumkinligi ko‘rsatilgan.


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Shi Y. taurinning va ruxning birgalikda surunkali jigar yallig‘lanishini kamaytirishdagi

samarasini o‘rgangan. Uning tadqiqotlari ko‘rsatadi-ki, bu kombinatsiya jigar fibrozasi va

sirrozining oldini olishda yordam beradi. Ularning qo‘llanilishi jigar hujayralarida regeneratsiya

jarayonlarini tezlashtiradi va yallig‘lanish darajasini pasaytiradi [22].

Taurin va ruxni birgalikda qo‘llash bo‘yicha olib borilgan tadqiqotlar, bu moddalar jigarni

himoya qilishda, regeneratsiya jarayonlarini rag‘batlantirishda va yallig‘lanishni kamaytirishda

samarali ekanligini ko‘rsatadi. Tadqiqotlarda ishtirok etgan olimlar va tadqiqotchilar taurin va

ruxning gepatoprotektiv ta’sirini o‘rganib, bu moddalar kombinatsiyasining jigar kasalliklarini

davolashda va oldini olishda samarali qo‘shimcha vosita sifatida ishlatilishi mumkinligini

ta’kidlamoqda.

Taurin va ruxning gepatoprotektiv ta’siri bilan ishlagan olimlar va tadqiqotchilar soni juda

ko‘p, chunki bu moddalar birgalikda jigar kasalliklarini davolash va ularning oldini olishda keng

tadqiq qilingan [23,24]. Quyida taurinning jigarni himoya qilishdagi va ruxning gepatoprotektiv

xususiyatlarini o‘rganish bo‘yicha bir nechta mashhur olimlar va tadqiqotlarga oid ma’lumotlar

keltirilgan.

Lin C.J. va uning hamkasblari taurinning jigarni himoya qilishdagi potensialini o‘rganib,

uning toksik moddalar va alkogolga bog‘liq jigar kasalliklarida samarali ekanligini aniqladilar.

Ularning ishlarida taurinning jigarni regeneratsiya qilish, yallig‘lanishga qarshi kurashish va safro

ishlab chiqarishni rag‘batlantirishdagi roli ta’kidlangan [25]. Bu tadqiqotlar, shuningdek, ruxning

antioksidant sifatida rolini va uning taurinning samaradorligini kuchaytirishdagi ahamiyatini

ko‘rsatgan.

Dr. Sharif M. A. va uning hamkasblari, taurinning rux bilan birgalikda qo‘llanilishining

gepatoprotektiv ta’sirini o‘rganishgan [26]. Ularning tadqiqotlari shuni ko‘rsatdiki, rux va taurin

kombinatsiyasi jigarning oksidlovchi stressga qarshi kurashishda samarali va surunkali jigar

kasalliklari, masalan, gepatit va jigar sirrozi kabi holatlarda foydalidir.

Wang Y, Mei X, Yuan J, Lu W, Li B, Xu D. va uning jamoasi taurinning va ruxning

gepatoprotektiv ta’sirini o‘rganishdi va ular ushbu moddalarning birgalikda qo‘llanilishi jigarni

toksik moddalar, xususan, parasetamol ta’siridan himoya qilishda samarali ekanligini aniqladilar

[27]. Ushbu ishda, taurin va ruxning birgalikda qo‘llanishi jigar hujayralarining regeneratsiyasini

qo‘llab-quvvatlashda va oksidlovchi stressni kamaytirishda muhim ahamiyatga ega ekanligi

tasdiqlangan.

Ushbu guruh olimlar taurin va ruxning jigar kasalliklari bo‘yicha ta’sirini o‘rganishdi.

Ularning tadqiqotlari shuni ko‘rsatdiki, taurin va ruxning kombinatsiyasi jigarni yallig‘lanishdan

himoya qilishda va uning toksik ta’sirlarini kamaytirishda samarali hisoblanadi. Tadqiqotchilar bu

moddalarning safro ishlab chiqarish, regeneratsiya jarayonlarini rag‘batlantirish va yallig‘lanishni


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kamaytirishdagi rolini chuqur tahlil qildilar.

Shi Y. va tomonidan o‘tkazilgan tadqiqotda, taurin va ruxning birgalikda qo‘llanilishi

surunkali jigar yallig‘lanishi va jigar fibrozasi bo‘yicha samarali bo‘lishi aniqlangan [28]. Ularning

o‘rganishlariga ko‘ra, rux va taurinning birgalikdagi qo‘llanilishi yallig‘lanish jarayonlarini

kamaytiradi va jigarni toksik ta’sirlardan himoya qiladi.

Wang Y ning tadqiqotlari jigarni himoya qilishda ruxning roli va taurin bilan birgalikdagi

ishlashini o‘rganishdi [29]. Ular jigar shikastlanishini kamaytirish va gepatit kasalliklari davrida

jigar hujayralarining regeneratsiyasini qo‘llab-quvvatlashda taurinning rux bilan birgalikdagi

ta’sirini o‘rganishdi. Bu ish, ularning ruxni va taurinni birgalikda qo‘llanishining jigarni toksik

moddalar va oksidlovchi stressdan himoya qilishda samarali ekanligini ko‘rsatdi.

Ullah M.I. va uning jamoasi taurinning va ruxning jigar kasalliklaridagi muhim

ahamiyatini o‘rganishdi [30]. Ularning tadqiqotlariga ko‘ra, taurin va ruxning kombinatsiyasi

jigarni himoya qilishda va regeneratsiya jarayonlarini kuchaytirishda samarali bo‘ladi. Ular bu ikki

moddaning jigar kasalliklarining oldini olish va davolashdagi ahamiyatini ta’kidladilar.

Yeh Y. H. tomonidan o‘tkazilgan tadqiqotlar, taurin va ruxning birgalikdagi qo‘llanilishi

jigarni toksik moddalar ta’siridan himoya qilishda va regeneratsiya jarayonlarini yaxshilashda

samarali ekanligini ko‘rsatdi [31]. Ular, shuningdek, bu kombinatsiyaning surunkali jigar

yallig‘lanishiga, fibrozaga va sirrozga qarshi foydali ta’sirini aniqladilar.

Xulosa qilib aytish mumkinki taurin va rux jigarni himoya qilishda va regeneratsiya

jarayonlarini qo‘llab-quvvatlashda samarali bo‘lib, uning gepatoprotektiv xususiyatlari haqida

o‘tkazilgan tadqiqotlar ko‘plab ilmiy mutaxassislar tomonidan amalda tasdiqlangan. Ushbu

tadqiqotchilar taurinning oksidlovchi stressni kamaytirish, yallig‘lanishga qarshi kurashish, safro

ishlab chiqarishni rag‘batlantirish va jigar hujayralarining regeneratsiyasini qo‘llab-

quvvatlashdagi ahamiyatini tasdiqladilar. Ularning ishlaridan kelib chiqqan holda, taurin va rux

jigar kasalliklarini davolashda va ularni oldini olishda samarali vosita sifatida qaralmoqda.

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Kendler BS. Taurine: an overview of its role in preventive medicine. Prev Med. 1989

Jan;18(1):79-100. doi: 10.1016/0091-7435(89)90056-x. PMID: 2496406.

21.

Surai PF, Earle-Payne K, Kidd MT. Taurine as a Natural Antioxidant: From Direct

Antioxidant Effects to Protective Action in Various Toxicological Models. Antioxidants

(Basel). 2021 Nov 24;10(12):1876. doi: 10.3390/antiox10121876. PMID: 34942978;

PMCID: PMC8698923.

22.

Qaradakhi T, Gadanec LK, McSweeney KR, Abraham JR, Apostolopoulos V, Zulli A. The

Anti-Inflammatory Effect of Taurine on Cardiovascular Disease. Nutrients. 2020 Sep

17;12(9):2847. doi: 10.3390/nu12092847. PMID: 32957558; PMCID: PMC7551180.


background image

842

ResearchBib IF-2023: 11.01, ISSN: 3030-3753, Valume 1 Issue 10

23.

Shi Y. et al. Taurine inhibits hydrogen peroxide-induced oxidative stress, inflammatory

response and apoptosis in liver of Monopterus albus //Fish & Shellfish Immunology. – 2022.

– Т. 128. – С. 536-546.

24.

Naraki K. et al. The Protective Effects of Taurine, a Non-essential Amino Acid, Against

Metals Toxicities: A Review Article //Biological Trace Element Research. – 2024. – С. 1-

19.

25.

Taziki S., Gholamzadeh F., Hosseini R. The hepatoprotective effects of taurine against

oxidative stress induced by isotretinoin in rats //Journal of Biochemical and Molecular

Toxicology. – 2022. – Т. 36. – №. 11. – С. e23178.

26.

Lin CJ, Chiu CC, Chen YC, Chen ML, Hsu TC, Tzang BS. Taurine Attenuates Hepatic

Inflammation in Chronic Alcohol-Fed Rats Through Inhibition of TLR4/MyD88 Signaling.

J Med Food. 2015 Dec;18(12):1291-8. doi: 10.1089/jmf.2014.3408. Epub 2015 Jun 19.

PMID: 26090712; PMCID: PMC4685501.

27.

Sharif M. A., Mogilner C., Hershfield H. E. Having too little or too much time is linked to

lower subjective well-being //Journal of Personality and Social Psychology. – 2021. – Т.

121. – №. 4. – С. 933.

28.

Wang Y, Mei X, Yuan J, Lu W, Li B, Xu D. Taurine zinc solid dispersions attenuate

doxorubicin-induced hepatotoxicity and cardiotoxicity in rats. Toxicol Appl Pharmacol.

2015 Nov 15;289(1):1-11. doi: 10.1016/j.taap.2015.08.017. Epub 2015 Sep 1. PMID:

26335259.

29.

Shi Y. et al. Taurine inhibits hydrogen peroxide-induced oxidative stress, inflammatory

response and apoptosis in liver of Monopterus albus //Fish & Shellfish Immunology. – 2022.

– Т. 128. – С. 536-546.

30.

Ullah MI, Alameen AAM, Al-Oanzi ZH, Eltayeb LB, Atif M, Munir MU, Ejaz H. Biological

Role of Zinc in Liver Cirrhosis: An Updated Review. Biomedicines. 2023 Apr 4;11(4):1094.

doi: 10.3390/biomedicines11041094. PMID: 37189711; PMCID: PMC10135863.

31.

Yeh Y. H. et al. Dietary Taurine Reduces Zinc‐Induced Toxicity in Male Wistar Rats

//Journal of food science. – 2011. – Т. 76. – №. 4. – С. T90-T98.

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Qaradakhi T, Gadanec LK, McSweeney KR, Abraham JR, Apostolopoulos V, Zulli A. The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease. Nutrients. 2020 Sep 17;12(9):2847. doi: 10.3390/nu12092847. PMID: 32957558; PMCID: PMC7551180.

Shi Y. et al. Taurine inhibits hydrogen peroxide-induced oxidative stress, inflammatory response and apoptosis in liver of Monopterus albus //Fish & Shellfish Immunology. – 2022. – Т. 128. – С. 536-546.

Naraki K. et al. The Protective Effects of Taurine, a Non-essential Amino Acid, Against Metals Toxicities: A Review Article //Biological Trace Element Research. – 2024. – С. 1-19.

Taziki S., Gholamzadeh F., Hosseini R. The hepatoprotective effects of taurine against oxidative stress induced by isotretinoin in rats //Journal of Biochemical and Molecular Toxicology. – 2022. – Т. 36. – №. 11. – С. e23178.

Lin CJ, Chiu CC, Chen YC, Chen ML, Hsu TC, Tzang BS. Taurine Attenuates Hepatic Inflammation in Chronic Alcohol-Fed Rats Through Inhibition of TLR4/MyD88 Signaling. J Med Food. 2015 Dec;18(12):1291-8. doi: 10.1089/jmf.2014.3408. Epub 2015 Jun 19. PMID: 26090712; PMCID: PMC4685501.

Sharif M. A., Mogilner C., Hershfield H. E. Having too little or too much time is linked to lower subjective well-being //Journal of Personality and Social Psychology. – 2021. – Т. 121. – №. 4. – С. 933.

Wang Y, Mei X, Yuan J, Lu W, Li B, Xu D. Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats. Toxicol Appl Pharmacol. 2015 Nov 15;289(1):1-11. doi: 10.1016/j.taap.2015.08.017. Epub 2015 Sep 1. PMID: 26335259.

Shi Y. et al. Taurine inhibits hydrogen peroxide-induced oxidative stress, inflammatory response and apoptosis in liver of Monopterus albus //Fish & Shellfish Immunology. – 2022. – Т. 128. – С. 536-546.

Ullah MI, Alameen AAM, Al-Oanzi ZH, Eltayeb LB, Atif M, Munir MU, Ejaz H. Biological Role of Zinc in Liver Cirrhosis: An Updated Review. Biomedicines. 2023 Apr 4;11(4):1094. doi: 10.3390/biomedicines11041094. PMID: 37189711; PMCID: PMC10135863.

Yeh Y. H. et al. Dietary Taurine Reduces Zinc‐Induced Toxicity in Male Wistar Rats //Journal of food science. – 2011. – Т. 76. – №. 4. – С. T90-T98.