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CHARACTERISTICS OF THE CLINICAL COURSE OF CHRONIC
CHOLECYSTITIS BASED ON COMORBIDITY IN THE GERONT-
SUPERGERONT POPULATION OF THE FERGANA VALLEY,
DIRECTIONS FOR PREVENTION
Botirov J.A.
Mamasoliev N.S.
Madazimov M.M.
Nishonova N.A.
Andijan State Medical Institute, Uzbekistan
https://doi.org/10.5281/zenodo.12741965
Relevance and necessity of the topic.
From the results of the research
conducted in Uzbekistan, it is known that 6 syndromes dominate the clinical
presentation of cholecystitis in the geront and supergeront population: pain
syndrome or feeling, dyspeptic syndrome, cholecystocardial syndrome, neurotic
syndrome, vegetodystonia syndrome and allergic syndrome. In young and
middle age, as well as from clinical studies, these indicators differ by relatively
low [1;2;3;4;5].
The aim of the research
is to study and determine the epidemiological,
clinical and preventive characteristics of cholecystitis in the young, middle-aged,
geront and supergeront populations of different regions of Uzbekistan.
Materials and research methods.
This study is considered a
simultaneous epidemiological investigation and it is based on the analysis of the
results obtained in a population of 2682 people. Residents of 6 regions of the
country - Andijan, Namangan, Fergana, Jizzakh, Syrdarya and Kashkadarya -
were involved in the study. Based on the tasks set in the work, 6 simultaneous
epidemiological studies were organized and carried out in the valley and oasis
regions of Uzbekistan.
A detailed description of the organization and conduct of the
epidemiological study was provided: the screening group was formed,
questionnaires were prepared, and the screening group was introduced to the
necessary equipment for the study. A procedure for working with the population
was created and a procedure for checking the population was developed.
Results and Discussions.
On the basis of comorbidity, the characteristics
of the clinical course of chronic cholecystitis in the geront and supergeront
population and the clinical course in the Fergana Valley were analyzed.
Chronic cholecystitis in the geront-supergeront conditions of the valley,
according to the table data, up to 44.1% is confirmed by the clinical course on
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the basis of comorbidity. Comorbidity is mostly caused by 11 diseases and they
are confirmed as follows: steatohepatitis (n=42/0), chronic viral hepatitis
(n=89/0), viral liver cirrhosis (n=9/0), acute ischemic heart disease (n =284/3),
glomerular diseases (n=118/2), gastroenterological diseases (n=251/3),
neurocirculatory asthenia (n=105/2), joint diseases (n=320/3), respiratory
diseases (n =83/1) and anemia (n=213/3).
Chronic cholecystitis detected in total comorbidity (n=1595/18) in the
geront population - 27.9% (stoneless type - 24.4% and stone type - 3.5%) and in
the supergeront population - 0.3% (Chronic cholecystitis without stones - 0.3%
and stony type – 0.00%) is determined by frequency distribution (RR=1.016;
95% Cl=0.480 – 2.148; χ2=0.002? S=0.001; P>0.05).
On the basis of other comorbidities, chronic cholecystitis in the geront and
supergeront population of the valley is confirmed with the following detection
frequencies: 1) in comorbidity of chronic viral hepatitis - 18.0% (non-stone type
- 16.9% and stone type - 1.1% and 0.00% 2) in viral liver cirrhosis comorbidity -
22.2% (Chronic cholecystitis without stones - 22.2% and Chronic cholecystitis
with stones - 0.00%) and from 0.00%; 3) on the basis of comorbidity with acute
ischemic heart disease - 24.7% (non-stone type - 20.0% and stone type - 4.7%)
and 0.00%; 4) in comorbidity of chronic ischemic heart disease - 33.8% (Chronic
cholecystitis with stones - 30.3% and Chronic cholecystitis with stones - 3.5%)
and 0.7% (Chronic cholecystitis without stones - 0.7% and Chronic cholecystitis
with stones – from 0.00%); 5) in the comorbidity of glomerular diseases - 41.7%
(non-stone type - 36.7% and stone type - 5.0%) and 0.8% (Chronic cholecystitis
without stones - 0.8% and Chronic cholecystitis with stones - 0, 00%); 6) in
comorbidity of gastroenterological diseases - 20.5% (Chronic cholecystitis
without stones - 17.3% and Chronic cholecystitis with stones - 3.1%) and 0.00%;
7) comorbidity with neurocirculatory asthenia - 21.5% (Chronic cholecystitis
without stones - 17.8% and Chronic cholecystitis with stones - 3.7%) and 0.00%;
8) in comorbidity with joint diseases - 22.0% (non-stone type - 18.6% and stone
type - 3.4% and 0.00%; 9) in comorbidity with respiratory diseases - 22.6% (in
non-stone type - 20 .2% and in stone type - from 2.4%) and in indicators from
0.00%.
Conclusion
. The leading comorbidity diseases in the geront-gerontological
population of the valley are anemia (increases the risk of severe-complicated
course of chronic cholecystitis by 44%), glomerular diseases (increases the
dangerous course of chronic cholecystitis by 41.7%) and chronic ischemic heart
diseases (Chronic increases the risk of cholecystitis by 33%).
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