The aim of research was to determine the role of middle-sized molecules with renal partial functions in children with chronic secondary pyelonephritis (CSPN). The investigation was carried out in 2 groups of pa-tients the main group included 25 patients with the main or concomitant diagnosis of exacerbation of chronic pyelonephritis aged 4 to 14 years and a control group consisting of 30 healthy subjects. It was found that in the active phase of CSPN a suppression of renal partial functions and increased of middle-sized molecules, C-reactive protein and decreased of albumin in blood plasma. Examination 25 patients with (CSPN) showed that their blood plasma level of middle-sized molecules reflects the severity of their clinical state and corre-lates with the level of glomerular filtration and urea concentration. The diagnostic value of the method for determining middle-sized molecules, albumin in blood plasma of patients with renal diseases allows its wide use to be recommended in the clinical practice
N Akhmedzhanova, Kh Mamatkulov, K Dilmuradova, I Akhmedzhanov
The effect of gastric hydrolysis of proteins on the formation of protein-polysaccharide complexes was studied. The study was conducted in vitro, gastric juice, starch, casein, albumin solutions, as well as casein and albumin hydrolysates were used in the work. It is concluded that the use of a mixture of starch and casein or albumin contributes to a significant decrease in light transmission, which is the inverse of the increase in turbidity of the solution. Simultaneously, an increase in turbidity may be a consequence of the formation of starch-casein or starch-albumin complexes. Simultaneously, the use of a mixture of starch and casein hydrolysate or albumin hydrolysate contributes to higher light transmission or lower turbidity of the solution, which may be a consequence of the low formation of starch complexes and protein hydrolysates. The obtained results also demonstrate that the hydrolysis of proteins by pepsin of the stomach contributes to a decrease in the number of protein-polysaccharide complexes.
Theaim of this work was an attempt to evaluate the effect of сomplex treatment on some endogenous in-toxication indicators in chronic pyelonephritis developed on the background of dismetabolic nephropathy (DMN) (DCHP). Patents and methods. A survey of 130 children DCHP, aged 4 to 15 years. Patients were di-vided into 3 groups depending on treatment method. Results. Comparative assessment of the results of the study of endogenous intoxication conducted after treatment in children with DСHP, depending on the method of treatment, demonstrated the effectiveness of "renal tyubazh" compared to other methods of therapy. Conclu-
sion. The use of complex treatment of "renal tyubazh" when DCHP is the most appropriate method of therapy. This method leads to the restoration of the TCA (total concentration of albumin) and ECA (effective concentra-tion of albumin) in the blood, TCA and SMP (medium molecular peptides) in the urine
Specific antigenemia and biochemical changes in children with alimentary toxicosis (AT) induced by Salmonella, Escherichia and Proteus spp. were studied. Expressed antigenemia was observed against the background of intoxication was observed, it depended on severity and stage of the disease, followed by decrease of total protein and albumin, insignificant increase of Al AT and AsAT activity, that can be considered as additional criterion for evaluation of the severity of pathologic process and intoxication syndrome. Invert correlation was found between antigenemia and activity of Al At and AsAT. It confinns pathogenetic significance of specific toxins in manifestations of intoxication syndrome in children with AT.
A Valiev, I Mukhamedov, Z Khalilova, A Abdushukurov, O Khudoerova
Dysmetabolic nephropathy (DM) and matured on its phone secondary pyelonephritis in children are highly actual in Pediatrics and children nephrology. The aim of the work: To identify diagnostic informative complex of indication Endogenous intoxication (EI). It were examined 55 children in age from 4 till 14 years, 30 absolute healthy and 25 with Chronic Pyelonephritis on the phone of Dysmetabolic Nephropathy with oxalate-calcium crystallluria in the stage exacerbation disease. It was established reliable decreasing of indications kidney function, and increasing oxaluria, and also reducing general albumin and increasing the level of medium molecul, M-RP. Assessment results of research in functional state of kidneys and the medi-um level of molecul in blood plasm in children with Chronic Pyelonephritis showed diagnostical significance to identify MM, as diagnostic method of EI.
N Akhmedzhanova, F Khamidova, R Muradova, R Nuralieva
"I have never found albumin, except in those cases when there were convulsions or complaints that are harbingers of an attack" (Lewer C.W. Cases of puerperal convulsions with remarks. Hospital Record 1843; 2:495-517).
D Abdullaev, S Gayibov, M Abdullayeva, D Abdullayeva
The complex model of filter for extracorporeal removal systems consists of derived cotton cellulose and polypropylene. This new model of filter has good barrier possibility (binding of the particles of the absorbent) and additional detoxicant properties. This additional characteristics of the complex model of filter (CMF) includes reduction of the level in blood plasma some of toxic substations such as bilirubin - on 22% (p<0,05); the average molecules of the plasma - on 25,4% (p<0,05); the factor of the necrosis to tumors alpha - on 18,5% (p<0,05) from basic level before filtration. There were no reliable changes of the glucose, total protein, albumin, electrolytes concentrations in plasma after filtering through CMF. Premises and basis for realization of the additional detoxification characteristic of the CMF include its biological compatibility and high soiption possibility of derived cellulose. Polypropylene can perfects the barrier properties of CMF. The combination of derived cellulose with polypropylene in complex model of filter -CMF can be offered for the further tests as filter for extracorporeal removal systems.