We examined 43 patients with breast cancer, who, as in the previous group, underwent percutaneous transhepatic cholecystostomy, however, the bile separated through the external drainage was preliminarily purified from toxic and ballast substances using the Lignov sorbent. Subsequently, the patients took it orally.
In the first group of patients, the concentration of IL-6 in the blood serum prior to the application of percutaneous transhepatic cholecystostomy was higher than normal, averaging 152.65±16.3 pg/ml. Immediately after the application of percutaneous transhepatic cholecystostomy in bile, this indicator averaged 68.58±7.24 pg / ml. At the end of the observation, the decrease in the level of IL-6 in the blood compared to the initial one was 64.4%, and in bile-54.3 (P<0.001). In the second group of patients, after the application of percutaneous transhepatic cholecystostomy, the concentration of IL-6 in the blood serum averaged 151.52±14.2 pg / ml, and in bile - 67.43±9.14 pg/ml. The initially high concentration of IL-6 in the blood and bile after bile absorption decreased by 75.7% (36.81±4.4 pg /ml) and 73.9% (17.57±2.2 pg/ml), respectively, from the initial level. The inclusion of bile absorption in the therapeutic complex significantly changed the concentration of IL-6 in blood serum (P<0.01) and bile.
The dynamics of parameters in blood serum and bile in patients of this group indicates a significant efficiency of bile absorption. Initially high indicators of endotoxicosis, such as SMP, TNF-α, IL-6 and bilirubin, were removed from the body by bile absorption, which made it possible to remove toxic substances from the body. The study of SMPs in blood serum and bile in patients of the main group revealed a more accelerated elimination of them with bile than in the control group. An increase in the concentration of SMP in bile was accompanied by a decrease in it in the blood serum.
Study of the effect of darmonal and phytin compounds on the exocrine function of the liver in acute experimental hepatitis. At the beginning of experimental hepatitis, these drugs were administered orally at a dose of 100 mg/kg. The results obtained led to an increase in the exocrine function of the liver under the influence.