Bioavailability of fluoride from 3 different toothpastes in vivo

The aim of the present 3-leg crossover study was to assess the oral bioavailability of fluoride delivered with two NaF toothpastes (one longer marketed 1350 ppm and one recently introduced 1450ppm F), and a MFP toothpaste (1450 ppm F). Ten adult volunteers brushed their teeth for 1 min, followed by rinsing with 10 ml de-ionised purified water for 10 s. Samples of about 2mL of whole mixed unstimulated saliva were collected 1,5,10, 20, 30, 60,180 min after brushing. Individual salivary fluoride-time plots were established and the area under the curve (AUG) calculated. Стах and AUC of MFP were significantly (p<0.05) lower than that of the NaF formulations, but not difference was shown between both NaF formulations (p>0.05).The newly introduced NaF toothpaste had a sufficient bioavailability of fluoride comparable to that of standard NaF toothpaste. The MFP toothpaste showed a lower availability of ionisable fluoride.