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FEATURES OF INTESTINAL MICROBIOCENOSIS IN CHILDREN WITH DIABETES
Abdusattorov Sh, 516-group, I - faculty of pediatrics
Scientific adviser: Karataeva L.A.
Department :
anatomy, pathological anatomy
Relevance.
Unfortunately, simple and absolutely reliable studies for the diagnosis of disorders
of the digestive organs, caused precisely by autonomous diabetic neuropathy, currently do not exist.
The study of the features of intestinal microbiocenosis in children with diabetes is a very urgent task
of modern medical science.
Purpose:
on the basis of literature data to study the features of intestinal microbiocenosis in
children with diabetes
Research Methods:
Intestinal microbiocenosis undergoes significant changes in the first days
and weeks of life. Moreover, there is a strong opinion that these changes are observed only during the
first month of a child’s life. So, A. M. Zaprudnov and L. N. Mazankova distinguish 3 phases of
microbial colonization of the intestine in the first month after birth: stage 1 (aseptic) lasts 10-20 hours
from the moment of birth; Stage 2 - lasts the first 2-4 days, at this stage, the primary colonization of
the intestinal tract of the newborn by various microorganisms occurs, especially cocci; Stage 3 - lasts
1-1.5 months - this is the period when the intestinal microflora becomes what it will be characteristic
of this div. In the human intestine contains about 500 species of microorganisms. It is customary to
distinguish between constant (indigenous, obligate, main) microflora, which prevails in number of
colony forming units (CFU), but is limited in species composition, and transient (optional,
conditionally pathogenic) microflora, which differs in the diversity of the microbial world, but inferior
to the first in terms of population density. The indigenous microflora of the small intestine is quite
simple and few: in the ileum, the total number of bacteria is 106 colony forming units (CFU) / ml,
and in the remaining parts of the small intestine less than 104 CFU / ml. Whereas streptococci,
lactobacilli and veylonella dominate in the duodenum and jejunum, then in the ileal colon Escherichia
coli and anaerobic bacteria. The colon is characterized by a high degree of contamination, which is
determined by the associations of anaerobic and optional anaerobic microorganisms: bifidobacteria
(108 - 109 CFU / g of feces); lactobacilli (106 - 108 CFU / g of feces); Escherichia (106 - 108 CFU /
g potassium); enterococci (105 - 106 CFU / g of feces); peptostreptococcus (105 - 106 CFU / g of
feces).
Results:
The evolutionary symbiosis of the intestinal microflora is in a state of biological
equilibrium with the cells of the human div and is subject to frequent disturbances under the
influence of unfavorable factors of the external and internal environment.
Conclusions:
Thus, based on literature data, we can say that in addition to the above mentioned
obligant (main) microorganisms, the intestines are populated with optional (conditionally pathogenic)
microflora. It includes: bacteroids, peptococci, streptococci, clostridia, mold fungi and others
(staphylococci, aerobic bacilli, candida, proteus, cytobacter, serrations, fusobacteria, eubacteria,
catenobacteria).
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