This article discusses the system of technical regulation in our country in the field of building materials production and its efficiency, coordinate state policy in the sphere of state (international) standards, increasing the competitiveness of enterprises through the introduction of international standards, planning processes, introduction of modern international standards, key challenges, prospects of implementation of national and international standards.
The article considers and solves the problem of determining the average operation period of belt conveyor rollers used for transporting overburdened rocks in the conditions of the Angren open pit. The main objective of the study is to determine the operation period of the conveyor belt rollers by considering statistical and dynamic loads on individual pieces of rock. A graph of the dependence of the service life of the belt conveyor rollers on the belt speed was obtained. Recommendations for increasing the service life of belt conveyor rollers are presented.
In this work, for the first time, the possibility of using the analogy method in solving scientific and pedagogical problems in the light of personnel training is analyzed. It is shown that the use of analogy is useful for quick assimilation of educational material and in solving physical problems. In particular, the possibility of using the concepts and methods of geometric optics in the design of electrical devices by analogy with the corresponding optical instruments is shown.
In this work the experience of teaching course in general physics, taking into account the structure and properties of nanomaterials are presented. The experience of teaching course in general physics, taking into account the properties of nanomaterials, showed increased interest of students in the chosen specialty. These features pose methodological problem that must be solved in the process of publishing educational literature.
The article analyzes the issues of significant attention to the modernization of the irrigation system of Ferghana valley over the years of independence, providing the field with modern equipment, protecting water resources, reclamation of irrigated lands, reconstruction, repair of hydraulic structures and increasing capital investments from year to year.
The service sector is closely linked to the history of mankind, and this scientific article is the evolutionary model of the service sector, which shows that the development of the service sector in this scientific model is becoming digital services, which is related to human daily life. Therefore, this scientific article provides a scientific definition of the terms service and digital services.
To study the state of systemic immunity and local immunity before and during chemotherapy in patients with gastric adenocarcinoma.
From 2017 to 2018 at the Tashkent city branch of the Republican specialized scientific and practical medical center of oncology and radiology 20 primary metastatic patients with gastric adenocarcinoma received chemotherapy. The sampling of biological material (peripheral blood, tumor tissue) was carried out twice (before treatment and during the first control examination, after 3 courses). The percentage of the degree of infiltration of tumor tissue by lymphocytes (CD45+CD14-TILs) was estimated by flow cytometry; T cells (CD3+CD19-TILs); B cells (CD3-CD19+TILs); NK cells (CD3-CD16+CD56+TILs); CD16 and CD8 effector cells and their cytotoxic potential (CTP) (CD16+Perforin+TILs; CD16CTPTILs), (CD8+Perforin+TILs; CD8CTPTILs); regulatory T cells - NKT cells (CD3+CD16+CD56+TILs), CD4 (CD4+CD25+CD127-TILs) and CD8 (CD8+CD11b-CD28-TILs) regulatory cells and these parameters of systemic results. The factor of a favorable prognosis for PFS in patients with metastatic gastric cancer in the peripheral blood was an increase in the number of CD8 + T-regulatory cells (5.1% - 12.1%, p = 0.019), and in tumor tissue - an increase in the perforin potential of effector CD16 cells (0.5% - 4.9%, p = 0.030) and their cytotoxic potential (13.2% - 55.7%, p = 0.011). When assessing the changes in the indices of local immunity during chemotherapy, it was noted a negative effect of an increase of T cells (22.0% - -9.7%, p = 0.012), NKT - cells (207.9% - -13.8%, p = 0.002) and CD4 + T-regulatory cells (190.7% - -25.2%, p = 0.002). In contrast, an increase in the level of effector CD16 cells during chemotherapy increases the likelihood of surviving PFS - 9 months (-69.5% - 9.1%, p = 0.013).
Indicators of local and systemic immunity serve as additional prognostic factors for gastric cancer.