Modern approaches in comprehensive treatment of ageal maculodystrophy

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Янгиева N., Мирбабаева F., Самцов L., & Рахимова A. (2020). Modern approaches in comprehensive treatment of ageal maculodystrophy. in Library, 20(1), 367–368. извлечено от https://inlibrary.uz/index.php/archive/article/view/14712
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Аннотация

Age-related  macular  degeneration  (AMD)  is  a  chronic  progressive disease characterized by damage to the Central photoactive zone of the retina. AMD is one of the most common eye diseases that threaten significant vision loss and disability in people over 60 years of age. Currently, several fundamental theories of the pathogenesis of senile macular degeneration have been identified: primary aging of the retinal pigment epithelium and Bruch's membrane, oxidative stress, which consists in damage to the eye tissues  due  to  an  imbalance  in  the  system  of  free  radical  formation  and  antioxidant protection, damage to the eye products, primary genetic defects, and pathological changes in the blood supply to the eyeball. AMD is a multifactorial disease, and the approach to its treatment should be comprehensive. In modem ophthalmology, bioregulatory therapy is a promising direction of pathogenetic influence. In this regard, the drug of the peptide structure "Retinalamin"is of particular interest. However, drug therapy can not always provide  compensation  for  impaired  metabolism,  and  its  results  are  unstable,  so physiotherapy becomes particularly relevant. Hyperbaric oxygenation (HBO) is one of the most effective and promising non-drug treatments for AMD.

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367

BED,

tumor block level and choosing the best way to decompress the bileexcreting

system, but MSCTA allows defining resectability of tumorous process.

Results of PAT treatment, complicated with MJ depend not only on the nature of

tumor formation, size of tumor and stage of the disease, but also on the treatment method.

MODERN APPROACHES IN COMPREHENSIVE TREATMENT OF AGEAL

MACULODYSTROPHY

Yangieva N.R., Mirbabaeva F.A., Samcnov L, Rakhimova A.

Tashkent State Dental Institute, Uzbekistan

Relevance.

Age-related macular degeneration (AMD) is a chronic progressive

disease characterized by damage to the Central photoactive zone of the retina. AMD is
one of the most common eye diseases that threaten significant vision loss and disability in
people over 60 years of age. Currently, several fundamental theories of the pathogenesis
of senile macular degeneration have been identified: primary aging of the retinal pigment
epithelium and Bruch's membrane, oxidative stress, which consists in damage to the eye
tissues due to an imbalance in the system of free radical formation and antioxidant
protection, damage to the eye products, primary genetic defects, and pathological changes
in the blood supply to the eyeball. AMD is a multifactorial disease, and the approach to
its treatment should be comprehensive. In modem ophthalmology, bioregulatory therapy
is a promising direction of pathogenetic influence. In this regard, the drug of the peptide
structure "Retinalamin"is of particular interest. However, drug therapy can not always
provide compensation for impaired metabolism, and its results are unstable, so
physiotherapy becomes particularly relevant. Hyperbaric oxygenation (HBO) is one of the
most effective and promising non-drug treatments for AMD.
The goal is to analyze the clinical and functional results of complex treatment, including
the peptide bioregulator "retinalamine "and Mildrotane in comparison with traditional
drug therapy, including the antioxidant"emoxypine".

Material and methods.

We conducted a study involving 33 patients (63 eyes) aged

61 to 82 years with dry atherosclerotic AMD. Among these patients, 9 people (17 eyes)
received complex treatment (a course of retinalamine p/b for 0.5

#

10 ml and Mildronate

I/V for 5.0

#

10), 24 people (46 eyes) received courses of emoxypine parabulbarno for 0.5

ml

#

10. Patients were examined 1, 3, 6 months after the treatment. Clinical and functional

studies included a standard ophthalmological examination with registration of the fundus
on a digital fundus camera.

Results.

Among patients receiving complex treatment in combination with

barotherapy, visual acuity improved in 70% of cases by an average of 0.1 - 0.2. a Decrease
in the number of Central relative cattle was observed in 60% of cases. Kchsm increased
in 76% of the eyes by an average of 2.0 Hz from the original. In the group receiving
traditional treatment, visual acuity improved by 50% of cases, on average by 0.05-0.15. A
decrease in the number of Central relative cattle was observed in 35% of cases. Kchsm
increased by 55% on average by 1.0-2.0 Hz from the original. In both groups, there was
an improvement in the fundus picture.

Conclusions.

Thus, complex treatment of AMD, including the peptide bioregulator


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368

"retinalamine" in combination with intravenous administration of mildranate, allows to
achieve the most effective results compared to traditional therapy. The conducted studies
indicate the effectiveness of this treatment and the feasibility of further research.

VALUE OF THE CLINICAL STATE EVALUATION SCALE IN

PATIENTS WITH CHRONIC HEART FAILURE

Oltiboeva

G.M., Kadyrova Sh.A.

Tashkent Medical

Academy,

Uzbekistan

Chronic heart failure (CHF) is a syndrome that develops as a result of various

diseases, especially diseases of the cardiovascular system, leading to decreased pumping
function of the heart, chronic hyperactivation and an imbalance of vasoconstrictor and
vasodilating neurohumoral systems with a complex of characteristic symptoms (shortness
of breath, fatigue and decreased physical activity, swelling, etc.), which are associated
with inadequate perfusion of organs and tissues at rest or during exercise, and often with
fluid retention in the div. Clinical examination of the patient allows you to dynamics to
evaluate the effectiveness of the treatment of heart failure.

Objective: To determine the points on the clinical condition assessment scale

(CSES) in patients with chronic heart failure (CHF) functional classes (FC) -I-IV

Material and methods: 45 patients with CHF were studied. Of these, 27 men, 18

women. The average age of patients is 63.4

±

3.2. Patients with hypertension (GB) were

13, coronary heart disease (CHD) -11, combined ischemic heart disease and hypertension
-15, combined ischemic heart disease, hypertension and diabetes mellitus-5. Chronic heart
failure

1

functional class (FC) was diagnosed in 11 patients,

II

FC-in 22,

III

FC-8, l-IV

FC-4 patients. All patients were evaluated complaints, medical history, an objective study.

Results of the study: All patients underwent scoring (CSES) with modifications

Mareeva V.Yu., 2000: symptoms like shortness of breath, weight gain over the last week,
wheezing in the lungs, interruptions in the heart, swelling of the cervical veins, enlarged
liver , the presence of pastiness, edema, the level of systolic blood pressure and their
severity.

Revealed by CSES in patients with FC

I

was -points equal to 3 points;

II

FC - 5

points; FC 111 - 8 points and FC IV - 10 points. All patients were also recorded
electrocardiographic

examination

(ECG)

and

echocardiography

examination

(echocardiography) and treated according to the standard. Evaluation of the effectiveness
of therapy was carried out according to the dynamics of the studied indicators and patient
complaints at the end of the study. Marked: improvement in 86.5% of cases, shortness of
breath significantly decreased in 38 (84.4%) patients, wheezing in the lungs disappeared
in 39 (86.6%) patients, edema decreased in 36

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