According to the research that was conducted by the World Health Organization, millions of animals are used for scientific and commercial testing. Research on living animals has been started in ancient times. Descriptions of the dissection of live animals have been found in ancient Greek writings from as early as circa 500 BC. Physician-scientists such as Aristotle, Herophilus, and Erasistratus performed the experiments to discover the functions of living organisms. Furthermore, some of the experimentation conducted on animals today is required by law.
This article is devoted to the preclinical study of the anti- atherosclerotic drug firutas on pathomorphological changes in animal organs during prolonged administration. Preclinical study of the general toxicology of the drug "Firutas" showed that it belongs to the IV class of low-toxic compounds. The drug "Firutas" does not have a cumulative and locally irritating effect. With repeated intramuscular administration to mice and rats, it does not affect the behavior and weight dynamics of animals, does not have a toxic effect on the composition of peripheral blood, kidney and liver function, as well as on the pathomorphology of animal organs and tissues. All the above data allow us to conclude that the drug does not have a toxic effect on the body of animals
The experiments were carried out on male white rats weighing 150-170 g. The first experimental group of animals was daily intragastrically injected with Mauric (2.8 mg / kg) for 30 days. The second experimental group of animals received heliotrin (5 mg / kg) according to the scheme. The control group of animals was injected with sterile saline. The spleen and mesenteric lymph nodes were examined using morphometric and electron microscopic methods.In the dynamics of chronic intoxication, a suppressive effect of xenobiotics (heliotrin and fosalon) on the T-dependent zones of the organs of immunogenesis was noted, which manifests itself as an increase in destructive processes with a decrease in the pool of proliferating cells.
Chronic intoxication leads to disturbances in the processes of immunogenesis in the body, one of the manifestations of which is structural and functional changes in the T- dependent zones of the peripheral organs of immunity.