The intricate interplay between viral infections and cardiovascular complications has become a focal point of research attention. This period of extensive investigation has uncovered substantial connections between various viruses and cardiovascular diseases, including cytomegalovirus (CMV), coxsackievirus, influenza, human immunodeficiency virus (HIV), Epstein-Barr virus (EBV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as coxsackievirus A and B, enteroviruses, adenovirus, and parvovirus B19. These viruses exert diverse influences on cardiovascular health through multiple pathways, contributing to endothelial dysfunction, causing direct damage to cardiac tissue, and triggering inflammatory responses. The intricate interplay between viral infections and cardiovascular health emphasizes the importance of considering viral pathogens in the context of cardiovascular disease development, clinical management practices, and future research initiatives. This systematic review thoroughly examines the cardiovascular impacts resulting from various viral infections, shedding light on their underlying mechanisms and associated clinical implications. These valuable insights can inform clinical management strategies, preventive measures, and further investigations into the complex connection between viral infections and cardiovascular diseases, highlighting the necessity for ongoing research and vigilance in understanding and managing these pathogen-induced cardiac manifestations.
The One Health paradigm, emphasizes the interconnectedness of human, animal, and environmental health. Recognizing that disruptions in one domain affect others, the study underscores the importance of collaborative efforts across disciplines to address complex health issues. Herein we have highligted the challenges posed by diseases such as Bovine TB, Brucellosis, Q fever, Leptospirosis, rabies, Crimean-Congo Hemorrhagic Fever, and others. The narrative extends to global warming, environmental impacts, and the intricate relationships between climate change, agriculture, and health in low-income countries. 60% of infectious diseases are zoonotic, emphasizing the need for a One Health strategy. One Health initiative in various countries, including the Netherlands, the U.S., Kenya, Thailand, Australia, Norway, and Canada has remained successful. The study delves into the challenges faced by low-income countries, in implementing the One Health approach amidst climate-induced events, floods, and disease outbreaks. Furthermore, it highlights the significance of health education, surveillance, and prevention strategies for mitigating the impact of zoonotic diseases on public health, animal health, and the environment in low-income nations. The complex interplay of environmental changes, agricultural dynamics, and socio-economic factors underscores the need for a comprehensive and transdisciplinary approach to address zoonotic challenges effectively.
Conceptual Field tests were attempted on sandy soils with three trimming frameworks at India for a very long time during 2011-2013. The trials were executed in split plot plan by relegating h2o dissolvable phosphorus composts in primary plot and suggest ed portion of phosphorus in sub-plot with three replications. The most extreme practical yield of rice, child corn and Chickpea were recorded with the utilization of . The most extreme efficient yield of progressive harvests - wheat, mustard and groundnut were recorded with the application of treatment. Practically comparable patterns were seen as far as side-reaction yield, supplement take-up and leftover soil richness status. Every one of the degrees of in compound manures were discovered to be similarly successful for grain yield, straw yield, supplement take-up, and leftover soil richness.
Background: CT-guided fine-needle aspiration cytology is an established, indeed effective and precise method for diagnosing of pulmonary lesions. Though this procedure has the possibility to lead lung complications. Therefore, this study aimed to learn about the pathological spectrum of pulmonary lesions, examine the pattern of FNAC diagnosis of lung lesions, and analyse and compare the data with published figures.
Material & method: This study was carried out at the Pathology Department of Tairunnessa Memorial Medical College and Hospital, as well as the Popular Diagnostic Center in Gazipur, Bangladesh, where all cases were FNAC and cytologically diagnosed. From September 2000 to April 2022, a total of 171 cases were evaluated. All of the patients had nodular or mass lesions in their lungs and were diagnosed with a CT-guided FNAC by following a standard procedure.
Result: Out of 171 cases about 119 (69.59%) were male and 52 (30.40 %) female. It was noticed that approximately 117 (68.42%) were malignant cases. Of these, most common malignancy was adenocarcinoma (43.27%). There were about 31.67 % benign lung lesions cases. Among them, 17.54%, 8.87%, 3.5%, and 1.67% cases had pulmonary inflammatory lesions, tuberculosis, aspergillosis and abscess, respectively.
Conclusion: CT guided FNAC can diagnose pulmonary lesion fairly and accurately as well as may leading to less morbidity & mortality as treatment can be started early.
College students facing mental health challenges often experience difficulties in their academic pursuits and overall well-being. This research paper explores a novel approach to support and empower these students by integrating cognitive remediation therapy (CRT) and social-emotional learning (SEL). Cognitive remediation therapy targets cognitive deficits that may impede learning and academic performance, while social-emotional learning fosters emotional intelligence, self-awareness, and interpersonal skills. By combining these interventions, colleges can create a comprehensive support framework that addresses both cognitive and emotional aspects of students' lives. This study examines the benefits, challenges, and outcomes of implementing CRT and SEL within a college setting. Through interviews, surveys, and case studies, we capture insights from students, faculty, and mental health professionals, shedding light on how this integrated approach positively influences academic success, mental health, and overall well-being. The findings provide valuable guidance for educational institutions seeking to create inclusive environments that facilitate the success of college students facing mental health issues.
Cataclysmic events cause genuine impacts on monetary, social and sociological regions in Turkey. Seismic tremors are one of the significant cataclysmic events in Turkey. They influence social and financial life and instruction adversely. The more readiness and mindfulness are given against cataclysmic events, the more secure society will be. This investigation was completed to decide the perspectives on college understudies about seismic tremor mindfulness mentalities and to look at them as far as different factors. The exploration was led as a screening plan from quantitative examination models. In the examination, a scale was applied as an information assortment apparatus. The examination gathering of the exploration comprises of 619 college understudies learning at undergrad level in different resources at Düzce University in the scholarly year 2018-2019. "Tremor Awareness Scale", created by the analyst, was applied to these understudies. As per the consequences of the examination, there was a huge contrast in the impacts of seismic tremor sub-factor of the scale as far as sex of the understudies. There was no huge distinction between grade levels and quake mindfulness levels of college understudies in all sub-elements of the scale. In the impacts of seismic tremor sub factor, a huge contrast is found in quake consciousness of the understudies as far as their homes. No critical contrast was found in the other sub-components of the scale as per the home. There was no critical distinction in the quake attention to the college understudies in any sub variables of the tremor mindfulness levels as indicated by the quantity of floors of the understudies' homes. Because of the examination, it was proposed to coordinate trainings and meetings on cataclysmic events, particularly seismic tremors.
In modern abdominal surgery, one of the current areas for research continues to be the improvement of various options for plastic surgery of postoperative hernias. More than 2,100,000 operations for ventral hernia are performed annually in the world, and 42% of them are postoperative hernias. In recent years, there has been a clear trend toward the expanded use of various types of biological meshes in hernioplasty. “A pooled analysis of seven PCSTAR studies for incisional hernias using retromuscular mesh showed a hernia recurrence rate of 5.7%”[1]. The use of standard surgical interventions such as alloplasty in the onlay position does not solve the problem of early postoperative complications: seroma discharge, mesh migration, adhesive disease, high frequency of hernia recurrence, etc. At the same time, hernia repair with local tissue creates the problem of increased intra-abdominal pressure and late complications in the form of recurrent hernias. “An increase in postoperative intra-abdominal pressure leads to multiple organ failure, then abdominal compartment syndrome, and even death.” [2]. Currently, there is no consensus on the surgical approach for giant postoperative abdominal wall hernias, and therefore the need to continue to develop new technologies and improve There is no doubt about the tactics. In world practice, at present, the most relevant studies continue to be studies aimed at studying the morphological and functional aspects of recurrent postoperative ventral hernias; electron microscopy reveals ultrastructural destructive changes in skin cells, aponeurosis and muscles, which indicates morphofunctional insufficiency of abdominal wall tissues; issues of cell engineering are discussed new innovative materials, experimental studies are being carried out on animals testing the biotechnical properties, texture and elasticity of new polymers, research is being conducted on open approaches with division of the posterior component with the release of the transverse abdominis muscle and a retrograde mesh, robotic operations have begun. Modern aspects of the development of domestic healthcare include many measures aimed at improving the results of treatment of patients with postoperative ventral hernias and associated pathological conditions through the introduction of modern principles of intensive care and surgical tactics. The development strategy of New Uzbekistan for 2022-2026 in seven priority areas includes tasks to improve the quality of provision of qualified medical services to the population[3]. The implementation of these tasks, including by optimizing tactical and technical approaches to the choice of hernioplasty method, as well as the development of methods for the prevention of purulent-inflammatory complications in the field of alloplastic material, is one of the current areas of abdominal surgery and medicine in general, due to the high medical and social the significance of this pathology.
This dissertation research to a certain extent serves to fulfill the tasks approved by the Decree of the President of the Republic of Uzbekistan “On comprehensive measures to radically improve the healthcare system of the Republic of Uzbekistan” No. UP-5590 dated December 17, 2018, the Resolutions of the President of the Republic of Uzbekistan “On measures to transform the surgical service, improving the quality and expanding the scale of surgical operations in the regions" for No. PP-5254 dated October 4, 2021 and "On additional measures to ensure public health by further increasing the efficiency of medical prevention work" for No. PP-4891 dated November 12, 2020, and as well as other regulatory documents adopted in this area. Compliance of the research with the priority directions of development of science and technology of the republic. The dissertation research was carried out in accordance with the priority direction of development of science and technology of the VI Republic “Medicine and Pharmacology”. Review of foreign scientific research on the topic of the dissertation.[4] Research work aimed at improving the quality of therapeutic and preventive care for patients with ventral hernias, carried out by many leading scientific centers and higher educational institutions in the world, including the Department of Surgical and Perioperative Sciences, Umeå University, Umeå (Sweden), Department of Surgery, Kingston General Hospital, 76 Stuart Street, Kingston (Sweden). nada), Department of Surgery, Helsinki University Hospital, Helsinki ( Finland), Service de chirurgie digestive et oncologique, CHU d'Amiens (France), Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Tulsa (USA), Department of Surgery, Howard University College of Medicine, Washington (USA) , Yong Loo Lin School of Medicine, National University of Singapore (Singapore), Department of Surgery, Michigan Medicine, Ann Arbor, MI, USA; University of Calgary, Calgary (Canada), Division of Plastic Surgery, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania Health System, Philadelphia (USA), Brigham and Women's/Faulkner Hospital, Harvard Medical School, Boston (USA) , Department of Surgical Sciences, Uppsala University Hospital, Uppsala (Sweden), Department of Surgery, University of Texas Health Sciences Center at Houston, Houston (USA), Department of Surgery, Erasmus University Medical Center Rotterdam, Rotterdam (Netherlands), Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka (Japan), National Medical Research Center for Surgery named after A.V. Vishnevsky" (Russia), Republican Scientific Center for Emergency Medical Care (Uzbekistan), Tashkent Medical Academy (Uzbekistan), Republican Specialized Scientific and Practical Medical Center for Surgery named after Academician V. Vakhidov (Uzbekistan).
As a result of studies conducted around the world to increase the effectiveness of alloplasty for postoperative ventral hernias and reduce the risk of complications in the postoperative period, a number of scientific results were obtained, including: it was determined that patients who underwent reconstruction of the abdominal wall have an increased risk of postoperative respiratory failure, understanding the epidemiology of this complication can improve prevention (the Division of Plastic and Reconstructive Surgery, Department of Surgery, Oregon Health & Science University, USA); It has been proven that the larger the hernia, the higher the risk of early surgical complications, including such as respiratory decompensation, since hernias often increase in size over time, delaying surgery can lead to an increase in the size of the hernia and, therefore, a greater risk of complications (CentreforDigestiveDiseases, KarolinskaUniversityHospital, Stockholm, Sweden); it has been shown that the ratio of the hernia volume to the volume of the abdominal cavity <20% is an independent factor in tension-free closure, which justifies the interest in preoperative volumetry to adapt the tactics of surgical care (Servicedechirurgiegénérale, digestiveetendocrinienne, CHU LyonSud, HospicescivilsdeLyon, France); It has been determined that in patients undergoing elective laparoscopic hernia repair, predictors of mortality are older age and certain concomitant diseases: congestive heart failure, pulmonary circulatory disorders, coagulopathy, liver disease, metastatic cancer, neurological disorders and paralysis (Department of Surgery, College of Medicine, University of Oklahoma, Tulsa , USA); Older age, ascites, preoperative renal and pulmonary insufficiency have been found to be independent predictors of 30-day mortality, and in the presence of these risk factors, conservative treatment should be seriously considered (Department of Surgery, University of Kentucky College of Medicine, Lexington, USA); The American College of Surgeons (ACS) Universal Surgical Risk Calculator has been shown to accurately predict thirty-day outcomes, including major complications: venous thromboembolism, medical morbidity, surgical site infection, unplanned reoperation, mortality, and length of hospital stay (Department of Plastic Surgery, Brown University and Rhode Island Hospital, Providence, USA). At the present time in the world, the most relevant research in surgery continues to be the development of new methods of hernioplasty for large and giant ventral hernias, each of which has its own pros and cons depending on the complexity of implementation, the risk of postoperative complications and relapse, large randomized clinical trials are being conducted, comparing existing methods of traditional hernioplasty with laparoscopic access and robotic surgery, which has become increasingly widespread in the last 10 years, a search is being made for new synthetic and biological materials developed for the production and use of composite meshes that have the necessary strength and the ability to prevent fatal local complications in a contaminated environment. However, despite technical advances in this field, no modern hernia repair method or prosthesis meets all the requirements. One of the key problems is that existing synthetic endoprostheses do not have sufficient elasticity, resistance to infection, high mechanical strength and integrity over a long period of time. Further research into these clinical aspects will undoubtedly improve the current understanding of the capabilities of biocompatible endoprostheses and will make it possible to develop an optimal method for their placement during allohernioplasty. The degree of knowledge of the problem. The current period of development of abdominal surgery is characterized by an emphasis on the problems of the effectiveness of introducing new installation methods and techniques for attaching bioprostheses, options for various suture materials to determine the most promising directions for the development of these technologies [5]. Researchers led by BittnerR.[6] (2019) state that a giant postoperative abdominal wall hernia, the maximum diameter of which exceeds 12 cm or the ratio of the volume of the hernial sac to the abdominal cavity more than 20%, is difficult to treat, with a high recurrence rate and a large number of complications. One of the most challenging problems is that after the hernia contents return to the abdominal cavity, postoperative intra-abdominal pressure will increase, leading to multiple organ failure, then abdominal compartment syndrome (ACS), and even death. There is currently no agreement on the surgical approach for these giant incisional abdominal wall hernias. To prevent recurrences, some articles recommend placing the hernia mesh in the sublayer position and or linings (KirkpatrickAW.)[7]. According to CornetteB.[8], to prevent recurrence, it is recommended to place the hernia mesh in a sublayer or underlay position, and to achieve better mesh expansion, a component separation technique (CST) may be a suitable solution, but with a significant risk of complications and recurrence. JensenKK, et al. believe that truly successful giant hernia repair requires effective bridging or augmentation that will prevent recurrence with an acceptable risk of complications[9]. Another pressing issue in abdominal surgery is that patients with incisional hernias are extremely difficult to treat due to a number of factors including obesity, previous hernia repair, previous mesh placement, domain loss, and other variables.
The approach to patients with incisional hernias has changed significantly over the past 20 years due to both advances in mesh technology and surgical approaches. Key factors for successful outcome include modification of risk factors preoperatively, such as smoking cessation and weight loss, selection of mesh appropriate for the type of hernia and planned mesh location, and wide mesh coverage beyond the hernia defect. New techniques such as transabdominal muscle release and component separation with retrograde mesh placement and robotic approaches to abdominal wall hernia are increasingly being used in these patients[10]. Recent years have seen an increase in the number of biological meshes available for abdominal wall hernia repair. Biological meshes typically consist of materials obtained from humans, pigs, or cattle. The rationale for using biological meshes is that they can act as a scaffold for the growth of natural tissues. In addition, there are absorbable synthetic meshes that have properties similar to those of biological meshes, but with theoretically less risk because they are not derived from animal or human material. The choice of mesh for a ventral hernia depends on many factors, which include both the properties of the mesh and its location, for example, whether it should be placed intraperitoneally, preperitoneally, or retrorectus. BaierKF[11](2021) believes that the guiding principle should be to avoid placing uncoated polypropylene mesh in an intraperitoneal location where it may be in direct contact with internal organs. In addition, the type of hernia defect is another risk factor, such as whether the wound is clean or dirty, and whether the repair is performed with a bridge or abutment. Lightweight or biologic meshes to bridge the defect should be avoided due to increased recurrence rates. Holihan JL [12] (2016), Hodgkinson JD [13] (2018) believe that the principle of anatomical restoration to achieve a reliable, tension-free repair with reinforced mesh reduces the incidence of early postoperative complications and late recurrence of hernia compared with bridging mesh. The analysis of the literature concerning the theoretical aspects and clinical experience of using technologies for improving modern synthetic and biological prostheses that can provide a better plastic effect, as well as methods for preventing recurrence of ventral hernias, indicates that this is one of the priority areas in modern abdominal surgery. An unresolved issue remains the choice of the optimal endoprosthesis, which is highly effective and meets international standards for such properties as biological inertness and mechanical strength, as well as the method of positioning the mesh in relation to the layers of the abdominal wall. Considering that many of the allohernioplasty methods used today are not without drawbacks, the current direction is the development of new methods of repair for giant ventral hernias and methods for the prevention of postoperative complications in conditions of a contaminated wound, with justification of their effectiveness in a clinical experimental study. The connection between the dissertation research and the research plans of the research institution where the dissertation was completed. The dissertation research was carried out within the framework of the research work plan of the State Institution “RSNPMCH named after. acad. V. Vakhidov" under the project AL-422105574 "Development of new biocompatible mesh implants made of composite materials for reconstructive surgery of abdominal and diaphragmatic hernias" (2022-2024).
The purpose of the study is to improve the results of surgical treatment of large and giant postoperative ventral hernias by introducing new laser technologies and improving the tactical and technical aspects of surgical treatment. Objectives of the study: to study the structure of immediate complications after various types of prosthetic plastic surgery; to clarify the influence of obesity factors, primary or repeat hernioplasty on the incidence of immediate and long-term complications; to evaluate the role of the immediate complicated course of the postoperative period in the incidence of long-term complications of hernioplasty; to improve the technical aspects of alloplasty for large and giant postoperative ventral hernias (POVH); to improve the technique of photodynamic therapy (PDT) of the wound surface after prosthetic plastic surgery; to study in an experiment the effectiveness of using the proposed technique of alloplasty and PDT; evaluate the morphological features of the condition of tissues during prosthetic plastic surgery using the proposed method; in a comparative aspect, evaluate the clinical effectiveness of the proposed alloplasty options in the immediate and long-term periods. The object of the study was the results of allohernioplasty in 448 patients with extensive (large) and giant POVH, who were operated on at the surgical department of the 1st clinic of the Samarkand State Medical Institute in the period from 2012 to 2021, as well as experimental animals on which the effectiveness was assessed developed a technique for prosthetic repair of postoperative ventral hernias and applied the technique of photodynamic therapy.
The subject of the study is to analyze the effectiveness of the developed alloplasty of postoperative ventral hernias and intraoperative photodynamic therapy in abdominal surgery in experiments and in the clinic. Research methods. To achieve the goal of the study and solve the assigned problems, general clinical, instrumental, biotechnological, experimental, histomorphological, microbiological and statistical research methods were used. The scientific novelty of the study is as follows: it was established that the need for extensive tissue mobilization and, as a consequence, the intersection of lymphatic capillaries during implantation of the prosthesis in the onlay position, as well as the lack of sufficient resorption function of the hernial sac in the inlay position causes a high risk of the formation of clinically significant seromas; It was determined that with prosthetic hernioplasty, along with the volume of the defect, the type of plastic surgery and the degree of obesity, the most significant predictor of the risk of developing immediate complications is the factor of re-intervention in case of recurrent hernia with the presence of a “dormant infection” hidden in the remaining ligature granulomas or scar tissue; the structure and clinical features of the course of long-term complications of hernioplasty for giant and extensive hernias were clarified, taking into account the results of the immediate postoperative period, as well as the option of fixing the prosthesis, primary or repeated hernioplasty and the degree of obesity; the method of surgery for large hernias of the anterior abdominal wall has been improved, characterized by a combination of factors such as the formation of tension-free prosthetic repair, preservation of local resorptive function to prevent the development of fluid accumulations and reducing the risk of infection; the method of preventing the development or progression of wound infection during alloplasty of ventral hernias has been improved, aimed at enhancing the antibacterial effect and stimulating reparative activity through the photosensitizing and photodynamic effect of low-energy laser radiation; It was determined in an experimental model of prosthetic plastic surgery that the proposed method of fixing the prosthesis in combination with the use of the effect of photodynamic therapy through laser radiation helps to enhance reparative processes with a reduced risk of wound complications; It has been proven that all methods of antiseptic exposure and laser stimulation of the wound surface after prosthetic plastic surgery enhance preventive measures against the development of local infection, but are ineffective in the case of an already developed purulent-inflammatory process against the background of the use of alloplastic material. The practical results of the study are as follows: it has been determined that the implantation of synthetic materials for giant and extensive hernias is accompanied by a significant number of wound complications caused by both the surgical technique itself and the reaction of surrounding tissues to a foreign body, requiring improvement of tactical and technical approaches when performing hernioplasty; it was clarified that scar-degenerative changes in the tissues of the aponeurosis in giant and extensive hernias are a predisposing factor to the occurrence of post-prosthetic hernias, especially when implanting the prosthesis in the “inlay” position and, accordingly, require increasing the efficiency of their fixation and engraftment, as well as reducing the risk of developing local complications; it was determined based on the data of an experimental study that the proposed method of alloplasty for large ventral hernias makes it possible to achieve adequate reconstruction of the anterior abdominal wall, reduce the incidence of infection in the wound, and also use a smaller size of prosthetic material; it was determined that the proposed method of tension-free repair of large hernias of the anterior abdominal wall with strengthening of the aponeurosis with a mesh implant allows maintaining physiology, reducing the number of complications, shortening treatment time and reducing the risk of hernia recurrence; It has been determined that the proposed method for preventing the development or progression of wound infection during alloplasty of ventral hernias can reduce the frequency of suppuration, shorten the treatment time and the likelihood of relapse; It has been proven that the use of the proposed tactical and technical aspects of prosthetic repair for postoperative ventral hernias can reduce the incidence of specific complications, reduce rehabilitation time and the risk of hernia recurrence. Reliability of the research results. The reliability of the results is justified by the use of objective criteria for assessing the condition of patients, modern methods of diagnosis and treatment, the correct application of methodological approaches and sets of statistical analysis, methods for solving the problems discussed in the dissertation are based on modern scientific and practical concepts and approaches to the diagnosis and surgical treatment of patients with giant postoperative hernias. Scientific and practical significance of the research results. The results obtained make a significant contribution to the expansion of irradiation of existing ideas about the structure and clinical features of complications of hernioplasty for giant and extensive ventral hernias by identifying the morphological features of the development of a purulent-inflammatory process against the background of the use of alloplastic material, studying predictors of the risk of developing immediate complications, mechanisms for enhancing reparative processes through the use of an improved method of fixing the prosthesis in together using the effect of photodynamic therapy through laser radiation, which made it possible to enhance the antibacterial effect and improve the wound healing process. The practical significance of the study is that, based on the results obtained, the tactical and technical aspects of prosthetic hernioplasty have been optimized, the features of methods of antiseptic exposure and laser stimulation of the wound surface after prosthetic repair have been revealed, enhancing preventive measures for the development of local infection, and the method of surgery for large anterior abdominal hernias has been improved walls, characterized by a combination of factors such as the formation of tension-free prosthetic plasty, preservation of local resorptive function to prevent the development of fluid accumulations, thereby reducing the risk of developing postoperative complications, reducing the frequency of unsatisfactory results, length of hospitalization and the likelihood of relapse. Implementation of research results. According to the results of a scientific study to optimize the tactical and technical aspects of surgical treatment of large and giant postoperative ventral hernias: the “method for plastic surgery of giant hernias of the anterior abdominal wall” has been improved (invention patent No. IAP 2022 0148 dated April 18, 2022). The proposed method of tension-free repair of large hernias of the anterior abdominal wall with strengthening of the aponeurosis with a mesh implant made it possible to reduce the number of complications, shorten the treatment time and reduce the risk of hernia recurrence; the “method for preventing the progression of infection during alloplasty of infected hernias” has been improved (certificate of the Ministry of Health No. 08-32071 dated October 17, 2022). The proposed method made it possible to reduce the frequency of wound purulent-inflammatory complications and shorten the period of rehabilitation of patients after allohernioplasty; methodological recommendations “Tactical and technical aspects of prosthetic repair for large and giant postoperative ventral hernias” have been developed (certificate of the Ministry of Health No. 08-32071 dated October 17, 2022) . The developed recommendations made it possible to optimize the tactical and technical aspects of allohernioplasty in patients with large and giant postoperative ventral hernias; The scientific results obtained were introduced into the practical activities of healthcare, in particular, in the departments of surgery of the Khorezm and Andijan regional multidisciplinary medical centers, the clinic of the Samarkand State Medical University (certificate of the Ministry of Health No. 08-32071 dated October 17, 2022). Improving the tactical and technical aspects of prosthetic repair for postoperative ventral hernias has made it possible to reduce the incidence of specific immediate complications from 40.9% to 15.6%, to reduce rehabilitation time from 8.6±2.7 to 7.1±1.5 days, and also reduce the likelihood of long-term complications from 11.7% to 3.1%. Approbation of research results. The results of this study were discussed at 8 scientific and practical conferences, including 5 international and 3 republican ones. Publication of research results. 26 scientific works have been published on the topic of the dissertation, including 9 journal articles, 4 of which in republican and 5 in foreign journals recommended by the Higher Attestation Commission of the Republic of Uzbekistan for publication of the main scientific results of doctoral dissertations. Structure and scope of the dissertation. The dissertation consists of an introduction, seven chapters, a conclusion, conclusions, practical recommendations and a list of cited literature. The volume of work is 200 pages.
The purpose of this study was to investigate the relationship between sensation seeking, boredom proneness, and gaming addiction among college students. The study aimed to examine whether individuals with higher levels of sensation seeking and boredom proneness are more susceptible to developing gaming addiction. The research involved a sample of college students who completed self-report measures assessing their sensation seeking tendencies, boredom proneness, and gaming addiction symptoms. The findings indicated a positive correlation between sensation seeking and gaming addiction, as well as a positive correlation between boredom proneness and gaming addiction. These results suggest that certain personality traits and psychological factors may contribute to the development of gaming addiction among college students.
There is a dire requirement for youngsters to be prepared and taught in the field of business particularly college understudies. This review inspected the connection between business training and enterprising society among college understudies in Ghana. An example of 203 understudies was haphazardly chosen from the three schools in College of Cape Coast Ghana. Relationship coefficient was the parametric measurable instruments used to test the relationship in the review. Enterprising society was estimated utilizing innovative mentality, business startup intentions and pioneering direction. Four measurement were utilized under pioneering direction; proactiveness, determination, ingenuity and hazard taking inclination. A huge relationship was seen between business instruction and enterprising society. This concentrate along these lines contends that business instruction will furnish the understudies with the abilities with which to act naturally dependent.
The fast and accurate reversed-phase HPLC method was predicated on qualitative and quantitative estimation of the total concentrations of the essential thiols in the plasma of adults volunteers compared with epileptic patients, which is l-cysteine (Cys) total homocysteine (tHys), cysteinyl glycine (Cys-Gly), glutathione (GSH) and cysteamine (Cstm), respectively. The plasma samples of (50) epileptic patients were classified into three groups; the non-anti-epileptic drug consisted of 20 patients (12 male, eight female) who were mainly diagnosed with idiopathic generalized epilepsy. The mean age was 34 ± 13 (range 19–48) years. The second group consisted of 30 patients receiving two types of anti-epileptic drugs, 18 patients (12 male and six female) receiving Carbamazepine, and 12 patients (7 males and five female) receiving phenytoin. The mean age of the patients was 32 ± 11 Compared with 31 healthy volunteers (20 male and 11 female). The mean age of the controls was 31 ± 9 (range 26–49 years). The mean duration of treatment of patients receiving the anti-epileptic drug was six months). All measurement was done using pre-column derivatization with bromobimane, and the derivative of each standard mixture were baseline separated on C18-DB (50 x 4.6 mm ID) column, 3μm particle size. The regression coefficients for the separated and standard deviation SD within-run ranged from 0.09 to 8.40 μmol/L, and between-run ranged from 0.15to 9.16 μmol/L; the analytical procedure gave good linearity in the range between 1.25 to 20 µmole/ l, the detection limit was 0.1 µmole /L for all the thiol groups. Analytical recovery was 96.9–107.4 %; the mean concentration of plasma cysteine and total homocysteine was slightly higher in males than females; it was 221± 75 for adult males and 190± 44 μmol/L for adult females, while t-homocysteine was (10.55 ±2.45 vs. 9.79 ± 1.88 μmol/L, the results observed that the value of cysteine and homocysteine were significantly higher in epileptic patients using Carbamazepine and phenytoin than in healthy volunteers. Mean values for glutathione were lower, while cysteinyl glycine showed no significant difference in healthy and epileptic patients and no sex- and age-dependent.
Carbon Nanospheres (CNS) are synthesized by pyrolyzing Maize cob-hair using the CVD method for two hours, at 10000C in presence of Ni, Fe, or Co nanometals as the catalyst. The morphology of carbon nanomaterial was characterized by the HRSEM images. The XRD pattern and the Raman spectrum confirmed the graphitic nature of the carbon. Surface area measurement of CNM was done by the Methylene Blue test method. The impact of catalyst was noted on the surface area of the carbon nanosphere; the maximum being 95.018 m2/g when Fe nanoparticle was used as catalyst, 83.141 m2/g when Ni was used, and a minimum of 21.379 m2/g in presence of Co. These carbon nanospheres were used for Arsenic adsorption from water. Adsorption of Arsenic was assessed by Chand Pasha et al’s method. It was found that after 12 hrs of exposure, CNS with 95 m2/g surface area could adsorb 32% arsenic; CNS (of 23.8m2/g surface area adsorbed 31% whereas CNS (surface area of 21.379m2/g. could adsorb only 16% arsenic. The arsenic adsorption capacity was found to be affected by the available surface area.
A 70-year-old female visited our hospital last summer with a history of painless, progressive diminition of vision in the left eye for the the past 1 years. She complained of developing sudden pain in the left eye for the past three days. There was no other significant history. The significant findings on her left eye examination was a visual acuity of perception of light with accurate projection of rays, corneal edema, hypermature cataract seen through a hazy media, deep anterior chamber and floating white lens particles looking like minute snow flakes filling the aqueous and forming a pseudohypyon(figure 1).
This study aimed to evaluate the reliability of a trapezium plate for open reduction and internal fixation (ORIF) of mandibular subcondylar fractures with the simultaneous use of an endoscope. We selected and retrospectively studied 18 patients (12 males and 6 females) with unilateral mandibular subcondylar fractures who visited the Wonju Severance Christian Hospital. The mean age of the patients was 43.43 ± 15.76 years. Patients underwent ORIF with trapezium miniplate application through an intraoral incision under general anesthesia. The clinical and radiographic findings of the fractured side were compared with those of the non-operated side at 6 months followup. All occlusions became stable, and transient functional disturbances disappeared within 6 months of periodic follow-up. Functional mandibular movement recovered within the normal range, with an average mouth opening of 41.5 mm, protrusion of 7.5 mm, and lateral excursion of 7 mm at 6 months. Radiographic controls and statistical analysis confirmed a decent anatomical reduction in all 18 cases. In conclusion, the use of a trapezium miniplate with endoscope-assisted ORIF in mandibular subcondylar fractures can be useful for fixation and functional recovery.
This article investigates the phenomenon of teachers being bullied by college students in a higher education setting. Bullying can have severe negative consequences for both teachers and the learning environment. The aim of this study is to explore the understanding of bullying behaviors among college students and examine their behaviors towards teachers. By utilizing surveys, interviews, and observations, this research sheds light on the underlying causes, dynamics, and impacts of student-to-teacher bullying. The findings provide insights for educational institutions and policymakers to develop proactive strategies to prevent and address this issue effectively.
This article highlights about introducing students to the basics of science, the general principles of human activity, the formation of general, digital and material culture, the acquisition of specific skills, as well as finding innovative solutions to practical problems based on digital technologies in vocational education institutions and the experience of world-renowned, world-renowned, and successfully implemented curricula will play an important role in its implementation. In particular, the Cambridge International General Certificate of Secondary Education curricula are among them.
This article examines the effectiveness of integrating technology into English language classrooms for secondary-level students in Nukus. Through a synthesis of research findings, practical insights, and case studies, it explores the benefits, challenges, and best practices associated with using technology to enhance language learning in this context. The study emphasizes the importance of technology in fostering engagement, personalization, and authentic language experiences, while also addressing issues such as access, digital literacy, and teacher training. By illuminating the transformative potential of technology-enhanced language instruction, this article aims to inform educators, policymakers, and stakeholders about the opportunities and considerations inherent in leveraging technology to promote English language proficiency among secondary-level students in Uzbekistan.
The advent of inexorable human, and industrial activities as well as the input of nature has impacted the environment by releasing Heavy Metals into the aquatic system. Hence, the physical removal of hazardous HM remains a demand of the day. This review envisages the use of agro-waste with the incorporation of nanotechnology for the removal of HM from aquatic systems. The focus is on plant parts, plant metabolites, and plant-cellulose-derived Carbon Nanofibers (CNF) as materials used for the removal of Heavy Metals. Owing to their high surface area, high mechanical strength, greater chemical reactivity due to the presence of dangling bonds, non-toxicity, high porosity,channel-like morphology, and lower costas the precursor, energy-efficient production; makes CNF an effective adsorbent of Heavy Metals.CNF synthesized from agro-waste and plant-metabolite to adsorb Heavy Metals; as well as acts as a filtration base has been touched upon with the hope of bridging the gap between ever-increasing demand and available clean water. A brief introduction to the CNF, its structure, properties as well as common methods of synthesis of CNF is given. Moreover, Physico-Chemical and Biological methods that are being used is also touched upon. The article suggests the need for innovative, low-cost, and environmentally friendly surface modification techniques and the use of agro-waste-derived CNF for the removal of HM from water.
This research delves into the intricate relationship between sensation seeking, boredom proneness, and gaming addiction among college students. As the popularity of video gaming continues to surge, concerns about addiction have grown. By examining the interplay between these psychological traits and gaming habits, this study seeks to unveil the underlying mechanisms that contribute to gaming addiction. Through a comprehensive analysis of survey data and psychological assessments, our findings shed light on the complexities of gaming behavior and provide insights for educators, psychologists, and policymakers in addressing this modern challenge.
Impressive endeavors of the showing local area have been coordinated to catch understudies' consideration during college classes. It is notable that when understudies enter College they are amazingly acquainted with all the informatics instruments, uncommonly, tracking down data on the Internet and doing interesting power point introductions. Albeit this is a decent apparatus for the primary fast information and correspondence, a more profound review is constantly required. Considering understudies' low affectability to innovative issues because of their youthfulness, acquainting techniques with catch their focus and inspiration to learn is a critical variable for the advancement of crucial capabilities. After numerous long periods of showing a course earthenware production, polymers and composite materials in the Incorporated Expert in Mechanical Designing of the Workforce of Designing of the College of Porto, Portugal, the creators try to ceaselessly acquaint project based learning approaches with work on their understudies' grades and skills.
This research dealt with the relationship between the investment decision making and accounting disclosure, considering that accounting disclosure is the essence of accounting theory, so that the interest of scientific and professional bodies and those interested in accounting and disclosure increased after the emergence of joint-stock companies, and this development was linked with the financial statements, which are the outputs of the results of the activity of these companies, and the contents they contain. Data, information, and measurement bases that can be used by users of this information. Investment plays an important role in stimulating and activating any economy and its progress, as the importance of this investment is evident in the economy in general, as well as in the Iraqi economy in particular. The research aimed mainly to determine the impact of accounting disclosure on investment decision-making. To achieve the research goal, the researcher tested the research hypotheses, as the first hypothesis stated (there is no significant relationship between accounting disclosure and investment decisions). While the second hypothesis stated (there is a significant relationship Significant significance between accounting disclosure and investment decisions. The questionnaire technique was used as a tool to collect data from members of the study sample and distribute it to a sample of investors in companies listed on the Iraq Stock Exchange. Using appropriate statistical methods, a set of conclusions were reached, the most important of which are: There is a significant relationship at the level of significance (0.05) between. Accounting disclosure and investment decisions for a sample of investors in companies listed on the Iraqi Stock Exchange. The most important recommendations reached by the researcher are: that the banks in the study sample reconsider their administrative financial policies and benefit from the analyzes and results shown by the research, especially those related to determining accounting disclosure and investment decisions.
This study aims to know the spatial variation in the distribution of police stations in the administrative units of Baquba district. In addition to its reliance on the descriptive and analytical approach in addition to the cartographic representation using geographic information systems, the study also proved the validity of the hypothesis that states that there is a spatial disparity of the police stations in the study area, and it developed several points that could reach the optimal distribution of police stations in Baquba district.