242
IMPACT OF BODY MASS INDEX ON THE PROGRESSION OF
CHRONIC KIDNEY DISEASE
Khudoyberdieva G.
Scientific advisor: Abdullaev Sh.S.
TPMI, Department of Faculty internal diseases, occupational pathology, MFT, hospital
internal diseases, PID
Obesity has become a serious worldwide problem. More than 300 million adults are classified
as obese and the global number is predicted to reach 700 million by 2015. Increasing evidence
suggests that obesity is a risk factor for diabetes and chronic kidney diseases. As a marker of obesity,
high div mass index (BMI) has been reported to be related with diabetic nephropathy and end-stage
renal disease (Chen H.C. et al, 2011).
Aim.
To evaluate the influence of BMI on the progression of chronic kidney disease in patient
with and without diabetes.
Material and research methods.
We studied n=106 patients with chronic kidney disease
(diabetic: n=45, non-diabetic: n=61) followed up for 6.0 ± 1.2months. The rate of deterioration of
renal function was estimated by the slope of the curve of reciprocal glomerular filtration rate against
time. BMI was calculated as weight (kg) divided by height
2
(m
2
). According to the BMI, patients were
divided into the following groups: normal BMI (<25, n=29), overweight (25-29.9, n=43) and obese
(>30, n=34).
Results.
Obese patients required a higher number of antihypertensive agents compared to
overweight and normal weight patients. On the other hand, initial renal function, proteinuria, blood
pressure values under treatment and age were similar among normal, overweight and obese patients.
Furthermore, BMI did not differ significantly between males and females or between diabetics and
non-diabetics.
The rate of progression differed significantly between patients with normal BMI (-6.21± 0.12),
overweight (-8.42±0.87) and obese patients (-13.88±0.24 ml/min/6 months, p<0.01). Similarly, BMI
as a continuous variable correlated with the rate of deterioration of renal function (r=0.319, p<0.001).
This association was more prominent among diabetic patients (r=0.374, p<0.001) than among non-
diabetics (r=0.218, p<0.05), as well as among males (r=0.322, p<0.001) compared to females
(r=0.267, p<0.05).
Conclusions.
An increased BMI is associated with a faster decline of renal function in patients
with chronic kidney disease. This association is more prominent among diabetic patients compared to
non-diabetics and among males compared to females.
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