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No. 3 (2020) Journal of hepato-gastroenterology research
No. 3 (2020) Journal of hepato-gastroenterology research
Journal:
Journal of hepato-gastroenterological research
Published:
2020-11-26
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Мақолалар
EVOLUTION OF APPROACHES TO THE THERAPY OF REFRACTED CELLIACIA IN CHILDREN OF THE UZBEK POPULATION
Examined 200 children with celiac disease aged 1-14 years. The diagnosis of the disease was verified based on the criteria of the European Association of Pediatric Gastroenterologists (1999). Celiac disease was revealed as a typical form in 81%, an atypical form was found in 19%, of which 21.5% had a refractory course of the disease. Depending on the drug therapy, 4 groups were identified: -1st-30 children who, in addition to traditional therapy, received ecdisten 0.01 g at 1 mg / kg / day; -2nd- 37 children who additionally received antioxidant zinc with 20 mg / day; - 3rd - 28 children who additionally received ecdisten 0.01 g at 1 mg / kg / day in combination with antioxicaps with zinc at 20 mg / day; -4-I- 47 children who received the generally accepted basic therapy. The course of treatment is 1 month. The studies were carried out after 3, 6 and 12 months. The results obtained indicate the restoration of the intestinal absorption function against the background of the modified treatment, more significant changes were obtained in patients who received the combined use of ecdisten with antioxicaps with zinc. This combination, against the background of basic therapy in the refractory course of the disease, has a beneficial effect on the clinical course, reduces the degree of structural and functional disorders, improves the outcome of the disease. To obtain a stable clinical remission, it is necessary to carry out repeated courses of modified therapy in a differentiated manner.
Zulfiya Abdujabarova
5-8
60
3
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PECULIARITIES OF CYTOKINE STATUS IN DIFFERENT FORMS OF CHRONIC PYELONEPHRITIS IN CHILDREN
Despite the successes of theoretical and practical nephrology, the incidence of CP in children, in recent years, is characterized by a high growth trend and represents a serious medical and social problem. Purpose of the study. To study the state of cytokine status in children with chronic pyelonephritis. Materials and research methods. The work is based on clinical studies of 177 patients with CP (of which 105 children with recurrent and 72 patients with latent form) aged 4 to 15 years. Results and discussions. In the study of serum concentrations of the studied cytokines in patients with exacerbation of the chronic process, a significant increase in pro-inflammatory TNF-α and INF-ᵧ was revealed. Exceeding the anti-inflammatory IL-4 control values by more than five times occurred against the background of an increase in the concentration of TNF-α and INF-ᵧ. Conclusions. Patients with LHP were characterized by significant differences in urinary levels only in TNF-α from those of the active phase of rHP (P <0.05), which is also characteristic of serum concentrations.
Nargiza Akhmedzhanova, Ismoil Akhmedzhanov, Norkul Ruzikulov , Ablokul Akhmatov
12-15
26
8
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COMPARATIVE ANALYSIS OF SOME LABORATORY INDICATORS OF ALCOHOLIC AND VIRAL HEPATITIS
The article provides information on the biochemical parameters of liver function in alcoholic and viral hepatitis, as well as on the markers of viral hepatitis. According to the World Health Organization, about 2 billion people worldwide consume alcohol. Therefore, it is important to distinguish alcoholic hepatitis from viral hepatitis.
Shogida Berdiyarova, Nargiza Yusupova
20-23
20
5
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CLINICAL AND INSTRUMENTAL MANIFESTATIONS OF THE CENTRAL NERVOUS SYSTEM DISORDER IN NEWBORNS WITH CONGENITAL HEART DISEASES
The aim of the study was to study the epidemiology of congenital heart defects in newborns and the clinical and instrumental features of central nervous system damaged in this category of patients. It was revealed that in the structure of congenital heart diseases the leading place is occupied by the defect of the interventricular septum, less often the defect of the interatrial septum and tetralogy of Fallot. In children with congenital heart defects, the hypoxic nature of damage to the central nervous system is much more common than hypoxic-hemorrhagic.
Vyacheslav Lim
28-31
33
7
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ULTRASONIC VERIFICATION OF PORTAL HYPERTENSION IN LIVER CIRROSIS
The work is based on the results of examination of patients with diffuse liver diseases by ultrasound Doppler. Unconditional and conditional types of ultrasound signs were identified, allowing to detect cirrhosis of the liver and the accompanying portal hypertension. The values of the main ultrasound parameters reflecting structural and hemodynamic changes in liver cirrhosis were analyzed in patients of all groups. The ultrasound method with vascular Doppler imaging made it possible to trace the dynamics of the increase in the manifestations of portal hypertension in patients with liver cirrhosis at different stages of the development of the pathological process. Ultrasound diagnostics of liver cirrhosis is difficult in patients with initial manifestations of portal hypertension and is extremely informative in the study of patients with developed portal hypertension syndrome.
Gulshod Mardieva , Parvina Obloberdieva
36-39
35
7
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RESULTS OF ENDOSCOPIC LIGATION OF VARICOSE VEINS OF THE ESOPHAGUS IN THE TREATMENT OF COMPLICATION OF PORTAL HYPERTENSION
The article analyzes the results of treatment of 294 patients with bleeding from varicose veins of the esophagus with portal hypertension using endoscopic ligation. The current views on the pathogenesis of portal hypertension syndrome and approaches to their treatment are described in detail. The effectiveness of endoscopic ligation at the height of bleeding with minimal use of Senkstaken-Blackmore obturator probes was shown. Recommendations for targeted and multicomponent correction of the hemostasis system and pressure reduction in the portal blood flow are described in detail. Prolonged endoscopic treatment is required, including repeated ligation sessions 1 and 3 months after the first stage, followed by regular dynamic monitoring every 6 months.
Shukhrat Urakov, Utkir Abidov , Avaz Haydarov
43-48
71
26
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OPTIMIZATION OF THERAPY FOR IRRITABLE BOWEL SYNDROME
60 children with irritable bowel syndrome were observed, divided into 2 groups: group I (30 children) received the prebiotic Dufalac and fermented milk mixtures, group II (30 children) – traditional therapy and adapted fresh mixtures. The effectiveness of Dufalac and fermented milk mixtures in irritable bowel syndrome, which occurs with constipation and intestinal dysbiosis, is shown.
Nurali Shavazi , Bakhora Zakirova, Kamola Azimova , Maksim Lim, Marina Ibragimova
54-58
51
5
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RESULTS OF STUDYING THE STATUS OF TRUE NUTRITION - IN THE EXAMPLE OF PATIENTS WITH CHRONIC LIVER DISEASE
Healthy eating is essential to human health and learning about proper nutrition is important in the origin and prevention of diseases. A total of 125 patients with chronic hepatic diseases (47 with chronic hepatitis and 78 with hepatic cirrhosis) were examined on the basis of a WHO questionnaire. The results revealed that patients consumed animal fat, meat products more frequently in their diets, and low consumption of dairy products and vitamin-rich wet fruits and vegetables, especially in patients with hepatic cirrhosis compared with patients with chronic hepatitis. These indications are of diagnostic importance and appropriate diet therapy recommendations will be developed.
Nodira Shamuratova
63-65
38
10
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FEATURES OF DAMAGE TO KIDNEY IN CHILDREN AT OBESITY
The review provides information on the morphology and function of the kidneys in children with obesity. The influence and relationship of numerous pathogenetic factors acting on the kidneys is discussed. The use of early biomarkers of kidney pathology in obesity with an assessment of the level of lipid, carbohydrate metabolism, insulin resistance, serum leptin and adiponectin is promising for the diagnosis of renal lesions in obesity in children.
Nargiza Goyibova
72-76
22
3
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OBSTRUCTIVE BRONCHITIS IN CHILDREN: RELATIONSHIP OF INTESTINAL MICROECOLOGY WITH CLINICAL CHARACTERISTICS
52 children with acute obstructive bronchitis were examined. The intestinal microflora was studied according to the generally accepted method. The relationship of intestinal microbiota indicators with the severity of clinical symptoms in acute obstructive bronchitis in children was revealed. Dysbiotic disorders of the intestinal microflora are interrelated with the severity of clinical manifestations, affecting the functional ability of the gastrointestinal tract, contribute to the sensitization of the body and increase bronchial obstruction.
Kamola Azizova, Nurali Shavazi , Bakhora Zakirova, Gulnoza Kardjavova
9-11
59
8
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PHARMACOEPIDEMIOLOGY OF HEPATOPROTECTORS, USED IN PATIENTS WITH LIVER CIRRHOSIS, RECEIVED TREATMENT IN SOME MEDICAL CENTRES OF KHOREZM REGION
Retrospectively, 239 cases history of patients with liver cirrhosis who received treatment in some medical centres of Khorezm region were studiedbypharmacoepidemiologicalmethods.For the study the questionnaire included 38 items of hepatoprotectors used in the practice of medicine in Uzbekistan.It is revealed that pharmacotherapy of patients with liver cirrhosis who received treatment in some medical centres of Khorezm region, the moderate severity of the pathological process and in compliance with the guidelines recognized by the world community of gastroenterologists. In the treatment of patients with cirrhosis of the liver doctors used gepatoprotektory separately and in combination.
Yulduz Bekchanova
16-19
20
7
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CARDIOVASCULAR SYSTEM IN CHILDREN AND ADOLESCENTS WITH OBESITY
60 adolescents with obesity were examined. It was revealed that the development of myocardial hypertrophy is influenced by body weight, blood pressure, vasoconstriction processes, as well as insulin resistance, hyperuricemia and atherogenic dyslipidemia. Some children have metabolic syndrome, which requires therapy for this condition to prevent early complications and disability in adolescents in the adult period.
Lilya Garifulina , Zilola Kholmuradova
24-27
27
6
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MODERN APPROACHES TO THE OCCASION OF GASTRIC AND 12-FINGER GASTRIC DISEASE
Gastric or peptic ulcer is one of the most important medical and social problems in our society today related to quality deterioration. According to modern concepts, peptic ulcer disease is a chronic recurrent polyetiological disease that occurs as a result of the interaction of exogenous and endogenous factors. However, the development of this disease is led by internal factors, namely: hereditary predisposition, the influence of the nervous and endocrine systems.
Dilrabo Mamatkulova, Nafisa Turayeva , Gulnoza Rustamova
32-35
27
5
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USE OF ENTEROFURIL IN YOUNG CHILDREN WITH DIARRHEA OF VARIOUS ETIOLOGY
Examined 18 children aged from 6 months to 3 years with diarrhea of various etiology. It was revealed that the cause of diarrhea in young children is various pathogenic bacteria, microbes and viruses; broad-spectrum antibiotics, individual allergic reaction to certain foods; disruption of the stomach, insufficient release of enzymes in the small intestine. It was found that the use of enterofuril caused a significantly faster therapeutic effect in comparison with other drugs.
Hikmatullo Turaev , Rano Nuralieva, Olim Siddikov
40-42
30
5
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MODIFIED METHOD OF INGUINAL HERNIA REPAIR
Inguinal hernias are among the most common hernias in the world. They are diagnosed more often among men, 10 or more times higher than among women. Objective of the study: to increase the efficiency of surgical treatment of inguinal hernias by improving the technology of strengthening both walls of the inguinal canal. Materials and research methods. The study is based on the results of surgical treatment of 47 patients who underwent hernioalloplasty for inguinal hernia in the surgical department of the clinic of the Samarkand State Medical Institute. Research results. Of the 47 performed hernioalloplasty in 14 (29.8%) cases (the main group), we used the modified method of hernioalloplasty of inguinal hernias. In these patients, after a conventional skin incision, the aponeurosis of the external oblique abdominal muscle was dissected. Highly isolated and removed the hernial sac. Then followed the isolation of the spermatic cord along its entire length. The transverse fascia was exposed at the inner opening of the inguinal canal. The mesh graft 10 × 15 cm was opened intraoperatively, considering individual characteristics. Conclusions. The presented technique of reconstruction of the inguinal canal, aimed at reducing trauma and reducing the time of intervention, can be used in wide practice.
Sherali Usarov , Salim Davlatov, Kosim Rakhmanov
49-53
26
9
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MEDICINAL POISONING IN CHILDREN AND METHODS OF THEIR PREVENTION
The aim of the study was to examine the causes of drug poisoning in children and to develop the prevention of drug poisoning in children. The main causes of drug poisoning were widespread advertising of medicines on television. Uncontrolled use of medicines listening to advertising on television, the use of medicines on the recommendation of pharmacy employees, taking medicines by parents in the presence of children, etc. Everything is dictated by the need for optimization of preventive work aimed at the prevention of drug poisoning in children. In children's departments of hospitals, primary health care, rural medical centers, kindergartens, nurseries, it is necessary to organize a permanent school for young mothers, where to consider the dangers of self-treatment of children, first aid in case of drug poisoning at home.
Nurali Shavazi , Mardonkul Rustamov , Maksim Lim, Muhiba Ataeva, Nurali Daniyarov
59-62
61
9
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OBESITY AND VITAMIN D DEFICIENCY IN CHILDREN AND ADOLESCENTS
This article is devoted to the relevance of the problem of vitamin D deficiency in children, its role in the development of obesity and other somatic pathology. The data on the prevalence of vitamin D deficiency in children and adolescents, risk factors and pathogenesis of the development of vitamin D deficiency in obesity in children are presented. Methods for correcting vitamin D deficiency in obesity and other metabolic disorders are also discussed.
Maksuda Ashurova
66-71
52
11
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OBESITY AS A RISK FACTOR FOR HEPATOBILIARY SYSTEM IN CHILDREN
This article is provides facts about changes in the liver during obesity in the framework of non-alcoholic fatty liver disease. The review contains pathogenesis and morphological characteristics of the development of this condition, features of the clinical picture, as well as methods of invasive and non-invasive diagnosis.
Dilafruz Turaeva , Lilya Garifulina
77-81
45
7
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