It has been established that under conditions of chronic inflammation of the lungs with bronchiectasis in children, destructive changes predominate in the structures of innate and acquired immunity of the airways, indicating their inability to effectively perform a protective function.
During embryonic histogenesis of human lungs, early morpho- functional differentiation of apudocytes is observed. In the lungs of young children with an inflammatory pathology of this organ, endocrine structures are detected with great constancy, and their number is large. The longer the disease lasts, the more apudocytes and NETs are found in the bronchi and respiratory tract. In large bronchi there are more endocrine structures than in small ones. Inflammatory lung diseases in early postnatal ontogenesis are a predisposing factor for apudocyte hyperplasia.
The morphological features of the formation of the immune structures of the jejunum in newborns and during milk feeding were studied in 12 young rabbits. It has been established that in newborn animals the afferent immune structures of the jejunal mucosa are represented byaccumulations of lymphoid tissue without a definite shape, they are indistinctly limited from the surrounding connective tissue of the lamina propria. Structural and functional zones characteristic of lymph nodules cannot be detected. On the 10th day after birth, against the background of milk feeding, efferent immune structures are determined in the stroma of the villi and crypts, since the number of diffusely located lymphocytes and lymphoblasts increases sharply, lymphocytes are also found between epithelial cells. The noted morphological signs show an earlier development of the afferent link of immunogenesis in the jejunum of rabbits.
This article examines the role of statistics in meeting the needs of society for reliable and reliable statistical information about the innovative processes taking place in the Republic of Uzbekistan and their impact on the socio-economic development of the country. The article examines the transition of the economy of Uzbekistan to an innovative path of development and a strategy in this direction for the long term. The author examines a system of relevant indicators to reflect innovation.
The results on the development of highly reactive compositions of raw mixtures and low-power technology for obtaining sulfo-iron clinkers of low-temperature firing with integrated use as components of natural and man-made waste, study of the properties of cements based on them are presented.
In connection with the increase in the incidence of respiratory organs, interest has revived in the study of fundamental issues related to the diversity of lung cells. The aim of the study was to determine the features of the structural organization of the APUD-systcm of human lungs at different stages of embryonic development, as well as in inflammatory and tumor processes in them. The lungs of human fetuses and newborns, as well as children who died from respiratory diseases and in cancer patients were studied by histological methods. After fixation in Bouin's fluid, paraffin sections were stained using general histological methods: hematoxylin and cosin, according to the Van Gicson and Weigert method. To identify argyrophilic neuroendocrine cells, the sections were impregnated with silver nitrate according to the Grimclius method. Neuroendocrine cells (apudocytes) of the lungs arc determined at the tubular and alveolar stages of organ histogenesis. Branching of the bronchial tree is predetermined by closed apudocytes and neuroepithelial bodies. After birth, their number decreases. With maladaptive remodeling of the lungs caused by inflammation and especially by the tumor process, proliferation of apudocytes of a predominantly closed type occurs, and neuroepithelial bodies are also formed.