As a result of numerous clinical and experimental studies, a relationship has been established between changes in the oral cavity and pathology of internal organs. In modem dentistry, interest in research on concomitant pathologies is explained by the accumulation of new arguments, the emergence of new information in the system of the whole organism [3,5]. This analysis focuses on the prevalence of hepatitis infection and its various oral manifestations,consequences and clinical course. In this regard, the monitoring of outpatient records of patients with concomitant pathology, such as hepatitis А, В, C with inflammatory processes of the oral cavity and maxillofacial area after tooth extraction for emergency indications in the clinic of surgical dentistry of the clinic of the Tashkent State Dental Institute over the past 5 years was carried out.
При любом хирургическом вмешательстве в полости рта, неудовлетворительный уровень гигиены полости рта и воспалительные заболевания пародонта, значительно повышают риск общих инфекционных осложнений, вызванные патогенной пародонтальной микрофлорой
It is known that in chronic liver diseases, secondary immunodeficiency is formed, which is of great importance for the dental system and the entire body as a whole. Therefore, it becomes clear the importance of studying the state of the protective system of oral tissues in chronic viral liver pathology, which requires timely and constant correction. The aim of this study was to evaluate the activity of proinflammatory cytokines and cytolytic enzymes in patients with chronic viral hepatitis before tooth extraction. The level of cytokine IL-1 in patients with CVI before tooth extraction was on average 43.97±3.56 pg / ml, whereas in healthy people the studied indicator was on average 5.41 ± 0.42 pg / ml. The patients showed an increase in the level of IFN in the blood serum by an average of 6.2 times, the level of interleukin-18, belonging to the IL-1 family, was statistically significantly increased by 2.4 times in patients with CVI, compared with the control group. The features of CVH are dissociations between the levels of proinflammatory cytokines IL-1, IL-6, IL-18 and interferon. This indicates the disintegration of the inflammatory process occurring in the periodontal tissues and with the transition to a chronic course of the disease. Changes in the level of IL-1, IL-6, IL-18 and interferon in the blood serum of patients with CVI from normal parameters before tooth extraction is an indicator of the severity of the inflammatory process in the liver, as evidenced by changes in the dynamics of cytolytic enzymes.