In patients with radiculopathies of various origins, along with chronic pain syndrome, various prolapse of the pyramidal sphere of the peripheral nervous system is observed [1]. In groups of patients with radiculopathies, the motor sphere was investigated using the described methods of studying the neurological status Skoromets A. A, which revealed a statistically significant limitation of the motor sphere [2]. The performed electroneuromyography confirmed the lesion in the motor fibers in patients with chronic pain syndrome with radiculopathies of various origins [4].
The article presents the features of the clinical course of chronic brucellosis at the present stage, the issues of diagnostics and treatment, taking into account the results of our own observations of patients with damage of the nervous system and musculoskeletal system. There is characteristic of clinical and epidemiological, laboratory and instrumental diagnostics of chronic brucellosis, the issues of etiopathogenetic therapy are considered.
To study the state of systemic immunity and local immunity before and during chemotherapy in patients with gastric adenocarcinoma.
From 2017 to 2018 at the Tashkent city branch of the Republican specialized scientific and practical medical center of oncology and radiology 20 primary metastatic patients with gastric adenocarcinoma received chemotherapy. The sampling of biological material (peripheral blood, tumor tissue) was carried out twice (before treatment and during the first control examination, after 3 courses). The percentage of the degree of infiltration of tumor tissue by lymphocytes (CD45+CD14-TILs) was estimated by flow cytometry; T cells (CD3+CD19-TILs); B cells (CD3-CD19+TILs); NK cells (CD3-CD16+CD56+TILs); CD16 and CD8 effector cells and their cytotoxic potential (CTP) (CD16+Perforin+TILs; CD16CTPTILs), (CD8+Perforin+TILs; CD8CTPTILs); regulatory T cells - NKT cells (CD3+CD16+CD56+TILs), CD4 (CD4+CD25+CD127-TILs) and CD8 (CD8+CD11b-CD28-TILs) regulatory cells and these parameters of systemic results. The factor of a favorable prognosis for PFS in patients with metastatic gastric cancer in the peripheral blood was an increase in the number of CD8 + T-regulatory cells (5.1% - 12.1%, p = 0.019), and in tumor tissue - an increase in the perforin potential of effector CD16 cells (0.5% - 4.9%, p = 0.030) and their cytotoxic potential (13.2% - 55.7%, p = 0.011). When assessing the changes in the indices of local immunity during chemotherapy, it was noted a negative effect of an increase of T cells (22.0% - -9.7%, p = 0.012), NKT - cells (207.9% - -13.8%, p = 0.002) and CD4 + T-regulatory cells (190.7% - -25.2%, p = 0.002). In contrast, an increase in the level of effector CD16 cells during chemotherapy increases the likelihood of surviving PFS - 9 months (-69.5% - 9.1%, p = 0.013).
Indicators of local and systemic immunity serve as additional prognostic factors for gastric cancer.
Монография посвящена одной из актуапьной проблеме офтальмологии - лечению спазма аккомодации, а именно медикаментозной циклоплегии, с помощью которой имеется возможность полного выключения аккомодации. В монографии описываются различные методы лечения спазма аккомодации. Широкое традиционное использование различных концентраций атропина, гоматропина, а также комбинация этих препаратов с другими медикаментами, не полностью удовлетворяют офтальмологов, особенно при необходимости выключения спазма аккомодации у детей школьного возраста. Авторами обосновываются проведенные исследования, приводятся доказательства безопасности закапывания различных мидриатиков и последующие их положительные результаты. Теоретические аспекты данной проблемы подкреплены обширным собственным материалом авторов. Изучение результатов фармакологических методов подтверждает целесообразность рекомендуемой авторами самого надёжного, эффективного лечения - применение /% мидримакса, как монотерапии. Этот метод может рекомендоваться как способ выбора медикаментозного лечения аккомодационного стойкого спазма при неэффективности использования традиционных методов.
Information, that is, the different cultural traditions of each country, lifestyle and national mentality play a role. It is no coincidence that more and more attention has recently been paid to the problem of national mentality, and a lot of scientific research is being conducted in this direction. The text displayed in modern media culture helps to better understand the dynamic processes taking place in modern journalism as a special element of progress. The purpose of communication reflects not only technological goals, but also communication and cultural needs. It is in the media that they present themselves in the most striking way.
In this thesis, to study the expression and types of conflict in fiction by analyzing the expression of conflict in Mark Twain's "The Adventures of Hucklebberry Finn " andconflict is motivated by differences in the characteristics that brought the individual in an interaction. The differences
among them are related to the physical characteristics, intelligence, knowledge, customs, beliefs, and so forth. With it accompanies individual characteristics in social interaction, conflict is a normal situation in any society and any society is not one who has never experienced a conflict between its members or with other community groups, the conflict will only disappear with the loss of society itself
Cognitive linguists have paid much attention to the amazing universality of many conceptual metaphors. However, their theory does not take into account the equally striking variety of figurative conceptualization, both intercultural and within culture. This article is an attempt to give information for metaphorical theory, which allows us to consider universality and figurative change at the same time. The main purpose of the work is described with examples.
To evaluate and compare the long-term results of uranoplasty, we studied the state of soft palate function in 27 children with secondary and residual deformations of the palate after uranoplasty. A spectral analysis of sounds in children with secondary and residual deformations of the palate in the long term after uranoplasty shows that the degree of nasality practically does not change in dynamics and confirms the need for individual approaches to planning the stages of primary uranoplasty
It has been established that in recent years the pharmaceutical market has been actively growing in our country: the number of registered medicines (drugs) and dosage forms is increasing, programs are being developed to increase the availability of medicines to the population. At the same time, the problem of an irrational approach to treatment, which is typical not only for Uzbekistan, is well known. According to the WHO, more than 50% of all drugs are prescribed or distributed irrationally, 50% of patients take drugs incorrectly, a third of the world's population does not have access to life-saving drugs, and up to 10% of all hospitalizations are associated with adverse drug reactions, most of which could be would prevent. In the world, 12 million people die a year, 7 million of them could have been saved with adequate therapy. According to the WHO program: "all people, wherever they were, could receive the drugs they need at the lowest cost: so that these drugs are safe and effective, and they are prescribed and used rationally."
The impact of economic activity, as well as scientific and technological progress on the environment is characterized by production of large amount of pollutants, waste and other factors that lead to changes in natural landscapes, pollution of the atmosphere and natural water resources. Continuous increase and expansion in industrial production of chemicals inevitably entail rise of their environmental load. Exceeding thresholds ecosystems’ reliability under the influence of extreme anthropogenic factors can cause significant changes in conditions of existence and functioning of biogeocenoses.
Среди внелегочного туберкулеза мочеполовой туберкулез занимает щее место, последние годы отмечается рост нефротуберкулеза у лиц пожилого возраста (ерсесян А.А., 2005). [Исследование течения, диагностики и лечения нефротуберкулеза имеет большое значение.
На основании результатов проведенных исследований ряда авторов провести сравнительную оценку эффективности использования различных антисептических растворов в комплексе с оральными ирригаторамиу больных с переломами нижней челюсти.