Chronic recurrent aphthous stomatitis (stomatitis chronica aphtosa recidiva) is a chronic inflammatory disease of the oral mucosa of an infectious-allergic nature, characterized by periodic remissions and frequent exacerbations. Morphological elements on the oral mucosa are the so-called "ulcerative formations", that is, apht characterized by periodic remissions and partial exacerbations with a rash of aphtha. According to the latest publications of domestic and foreign authors, HRAS is usually considered as a polyetiological disease that plays a role in the formation and the nature of the course of the pathological process. The factor causing chronic aphthous stomatitis is staphylococcal infection, adenovirus, allergies, immune disorders, as well as diseases of organs and systems. First of all, it is a local effect aimed at reducing pain that makes it difficult to eat up to forced starvation, as well as at the speedy regeneration of the defect. Secondly, it is the regulation of the body's immunocompetent systems and a decrease in the level of bacterial allergies. In addition, the identification and treatment of background diseases with the involvement of specialists of different profiles (Lukinykh L.M., 2004; Savkina G.D., 2005; Drobotko JI.H., 2008).
Tajribalar og'irligi 150-170 g bo'lgan oq oq kalamushlarda o'tkazildi.Hayvonlarning birinchi tajriba guruhiga har kuni intraagastral ravishda Maurik (2,8 mg / kg) 30 kun davomida yuborildi. Hayvonlarning ikkinchi tajriba guruhi sxema bo'yicha geliotrin (5 mg / kg) oldi. Hayvonlarning nazorat guruhiga steril fiziologik eritma yuborildi. Dalak va mezenterial limfa tugunlari morfometrik va elektron mikroskopik usullar yordamida tekshirildi. Surunkali intoksikatsiya dinamikasida ksenobiotiklarning (geliotrin va fozalon) immunogenez organlarining T ga bog'liq zonalariga ta'sirchan ta'sirchanligi qayd etildi, bu proliferatsiya havzasining pasayishi bilan vayron qiluvchi jarayonlarning ko'payishi sifatida namoyon bo'ladi. hujayralar.
Xulosa: surunkali intoksikatsiya tanadagi immunogenez jarayonlarining buzilishiga olib keladi, ularning namoyon bo'lishlaridan biri immunitetning periferik organlarining T ga bog'liq zonalaridagi tarkibiy va funktsional o'zgarishlardir.