All articles - Dissertation

The urgency and relevance of the theme of the dissertation. Throughout the world, one of the topical directions in health care is an effective organization of the health care system, especially primary health care in rural areas, also further improvement of methodological approaches to evaluation of their activities.
For the years of Independence wide-spread program actions in the Health care system reforms have been performed in the Republic and their results arc the achievements accepted by the by the world. It’s of great importance to mention the development of primary medical sanitary aid in rural areas due to creation and effective activity of rural health units (RHU).
Further strengthening of the reform of the health care system, improving the efficiency of health care facilities, providing high quality of medical services to the public in accordance with modem requirements and standards, the introduction of advanced forms and methods of management and organization of work in health care arc taking place in the Republic. Decree of the President of the Republic of Uzbekistan dated by November 28, 2011 № PD-1652 «On measures to further strengthening of the reforms in the health system» testifies and defines the main directions of further strengthening of the reforms of the health system of the republic for 2012-2015.
Improvement of methodic approaches and medical organizational measures of accreditation of rural health units is one of the urgent tasks in the healthcare. From this point of view, the design of standards and indicators of RHU activity’s selfevaluation, improvement of the system of continuous professional development of personnel of medical facilities, design of a pilot package of standards and accreditation indicators of RHU, proposals to stimulate labor of doctors and patronage nurses of RHU located in areas rcmoting from urban infrastructure mountain and piedmont settlements, design of new staff standards of RHU based on the norms of the load on the medical staff of RHU, further improvement of the methodology of assessing the efficiency and quality of medical care is rendered by patronage nurses of RHU and RHU in general, arc important scientific and practical problems of the healthcare system.
The work to a certain degree contributes to solving the task determined in the Decree of the President of the Republic of Uzbekistan dated by September 19,2007, № PD-3923 «On further strengthening of the reforms and realization of state program of Health care development and their main directions and in PD-1652 dated by November, 2011 «About measures on further strengthening of the health care system reforming».
Purpose of the study is work out scientifically proved suggestions and recommendations for improvement methodic approaches and medical organizing measures of accreditation of rural health units.
Scientific novelty of the research.
Standards and indicators for accreditation of primary health care institution -RHU-activity have been worked out. Those include the following: effectiveness of arranging, management and financing of medical service; effectiveness of the process of organizing qualified and safe medical service (demography, morbidity, mortality, disablement), providing training, leadership, abilities, competence; material and technologic basis (resource providing, medical supplies, equipment); information resource basis (norms statements, clinical guidance, protocols).These enabled to do self-evaluation of RHU, assess real condition of medical service and quality of pilot institutions.
Academic program under the title «Basis of management and improvement of quality of medical service in the institution of health care system» was worked out. It includes 36 academic hours as well as adapted handout academic materials on quality management.
The system of efficiency of evaluation in activity and quality of medical service performed by patronage medical nurses of RHUcs was also developed. It is based on the following main indicators: prophylaxis of the diseases among local population, females of fertile age, pregnant women, newly-made mothers, children; evaluation and monitoring of physical development of children; vaccination of children; therapeutic work; quality of keeping medical papers. These all enabled to increase the efficiency of patronage medical nurses, improve the quality of dyspan-sarization of the population, correspondingly, decrease the number of patients treated in the departments of urgent medical service and the number of calls to ambulance service; to minimize the number of the patients referred to medical labor expertise.
The system of RHU activity evaluation in arranging qualified medical service to the population based on quantity data of having functional responsibilities of RHU medical workers, quality indicators (number of visits, late diagnostics of the problem having social significance), indicators of health condition and morbidity of RHU population, indicators characterizing material and technical basis and infrastructure of RHU has been worked out.
The system of effective coordination of RHU by central regional versatile polyclinics has been developed.
On the basis of the research on a doctoral thesis on « Improvement of methodic approaches and medical organizational measures of accreditation of primary health care institutions activity - RHU» provided the following conclusions:
1. In a modem public health system mechanisms for monitoring the quality and safety of medical care do not always work effectively, the reason for this is the lack of assessment methods and tools of quality management. Assessment of the level of quality and safety of care is carried out irregularly and is not standardized, which in turn dictates the need for accreditation of medical institutions.
2. In view of the lack of evidence-based approaches to the accreditation of health facilities in the country, including rural medical stations, on the basis of international experience standards and indicators for self-assessment activities of RHU for internal audit and evaluation of the real state of primary health care were developed and implemented . RHU self-esteem to assess the real state of the quality of care provided by the pilot institutions was done and makes it possible to monitor the quality of the activities of the FMC, get an objective assessment based on the facts. This in turn increases the awareness of medical personnel about problems that require improvement and search of appropriate potential for that.
3. Due to the lack of experience of health personnel in the field of accreditation for the development of resource provision and improvement of knowledge and skills of staff as well as training institutions in the pilot accreditation process, a system of continuous professional development (CPD) of medical personnel, methodology for improving the quality, accreditation and self-assessment tools for the institutions were worked out and applied . For the successful completion of the accreditation procedure and obtaining categories, staff of health facilities requires careful study and implementation of its activities in the standards and indicators of accreditation, the change of management system of the institutions.
4. Conducting of experts review activities (accreditation procedure) requires specific disciplinary skills, so the assessment team should include specialists in all the main areas to identify specific issues that need to be improved.
5. Accreditation of medical institutions including RHU is not conducted in the Republic. This necessitates the introduction of a pilot package of standards and accreditation of primary health care indicators, based on international experience. In this connection, a pilot project for the accreditation of rural health units has been developed and implemented. All RHU involved in an experiment to introduce the accreditation process successfully completed a pilot accreditation according to the tasks and developed programs with the relevant category of accreditation.
6. Implementation of the pilot project showed that the highest category of accreditation did not comply with any one of the pilot RHU. Consequently, the quality of provided primary health care to the rural population requires further development and improvement. Therefore the results of the study activities in RHU were considered in the development of resolutions of the Cabinet of Ministers of the Republic of Uzbekistan dated by March 5, 2014 № 50 «On measures to further optimization and improvement of the effectiveness of rural health units», and according to which:
- the network of RHU was optimized by eliminating of 243 shallow and ineffective RHU, which has reduced the 1215 units of personnel and released 5.5 billion sums on an annual basis;
- in the central district multidisciplinary clinics, within the total number of employees the post of vice head of the clinic - coordinator of the RHU was introduced.
- General practitioners working in remote urban infrastructure and located in the mountain foothill areas , were given a special allowance for special working conditions in the amount of 25% of the tariff rate which was included into the salary in the calculation of the legislation of their bonuses and allowances;
- the maximum size of bonuses for the continuous experience of patronage nurses in RHU was increased from 20 to 40 percent of the tariff rate. As a result, the average salary of nurses has increased for 17%;
- Entered into force on 1 March 2014 new staff regulations in RHU, which stipulate the reduction of existing load norms of patronage nurse in RHU in order to enable the visit for each attached family. Also, the position of senior nurse responsible for the organization of nursing, accounting, proper storage and consumption of drugs was introduced.
- a set of measures for the introduction of an improved system of training and improvement of professional skills of general practitioners and nurses in RHU was developed , approved and includes:
updating the material and technical base of the department of training of general practitioners in the medical schools and the regional branches of the Republican Center for training and specialization of medical workers;
introduction of distance learning and assessment of general practitioners on sites, with the creation of regional diverse medical centers, training classes equipped with a network computer equipment.
As a result of these measures the final reduction of the paramedical personnel number composed 5156 units, or 9% of the total with the release of budget funds in the amount of 19.2 billion, sums.
7. Great importance in ensuring the effective functions of SVP is given to patronage nurses. With this in mind, 96 RHUes in 5 regions of the republic rating of the effectiveness of patronage nurses was introduced and is believed to increase the responsibility of patronage nurses for the final results of its work to reduce the number of emergency hospitalization, medical emergencies and the number of patients referred to a medical labor examination, by improving the efficiency of preventive work.
8. In the absence of accreditation of medical institutions of the republic recommendations for the mechanism of rating activity of RHU in general as an intermediate step before the introduction of accreditation mechanisms were suggested.
9. The introduction of the practice of evidcnce-bascd health care accrediting RHU model will improve the quality of care, without major external contributions and resources.
10. The standards and indicators for the accreditation of quality management systems of medical care in primary health care can be offered for use in the system of material incentives for health care providers.
11. Science-based organizational model of accreditation of institutions of primary health care provides an opportunity to identify priority areas for the national level and, therefore, can be applied for the accreditation of other medical institutions of Uzbekistan.

Topicality and relevance of the dissertation topics. One of the major problems in modem biophysics is to study the relationship of structure and function of ion channels formed by proteins. On one hand, the ion channels arc nanoscopic pores which exhibit selectivity to ions, ability to selectively transport through the membranes different molecules or respond to them by changing their own properties. On the other hand, some organisms (including highly pathogenic ones) produce proteins that are capable to spontaneously integrate in the host cell membrane and form there ion channels de novo. Not only clinical symptoms of various infectious diseases, but also compositions of medium in which the cells and bacteria exist depend on these proteins. Therefore, nanopores formed by proteins attracted attention of researchers of all over the world, both in terms of basic principles of biophysical and physiological functioning of living cells, and from the practical aspect, as there arc ideas for their use as nano sequencers, components of nano-filter, biosensors and other nanodcvices. The data on what structural characteristics affect nanopore functioning and how selectivity depends on their structure and amino acid composition may help in designing nanoporcs with predetermined properties.
In international publications, scientists noted that knowledge about the structure of protein nanopores and its impact on their properties, can help both in the development of modem medicine and the development of nanodcvices used in modern devices. Most researchers believe that a-hemolysin (a-HL) is the most promising ion channel as a basis of these instruments, and therefore, a large number of papers devoted to the studies of the properties of this channel have been published. The ability of a-HL to form water-filled transmembrane pores in bilayer lipid membranes was first discovered over 35 years ago in Uzbekistan.
This dissertation research to a certain extent is the implementation of the tasks stipulated by the Joint Statement between Uzbekistan and Japan signed in February.
The aim of research work is to conduct structural and functional analysis of nanopores formed by different proteins.
Scientific novelty of the dissertation work includes the followings:
for the first time, using the method of asymmetric application of non-elcctro-lytes, it has been shown that the changes in the pore radius along the axis of the ion channels can be detected;
it was found that the radius of the VDAC ion channel changes upon transition from one to other conduction state;
it was found that the properties of ion channels depend not only on the sign of the charge of the charged groups distributed within a channel, but also by their location along the longitudinal axis of the channel;
a novel method for determining the stoichiometry of channels formed in situ has been proposed;
it is established that the maxi-anion channel does not belong to the family of VDAC proteins;
for the first time, it was demonstrated that blocking of ion channel by polyanions depends on their size and concentration of divalent cations;
it was found that the potential clamped on the membrane causes an elastic deformation of the a-HL pore.
CONCLUSIONS
1. Using the modified method of polymer probing, it was shown for the first time that:
a) the diameters of the two entrances of the a-HL channel arc close to each other and equal to 2.6-2.4 nm (cis/trans); the channel has two narrow portion: the main constriction has a diameter of 1.3 nm and is located approximately in the center of the channel, whereas the second one has a diameter of 1.8 nm and is located closer to the cis entrance of the pore;
b) the diameter of the cis entrance of VCC channel is 1.9 nm, and that of the trans entrance is 1,6 nm; there is a constriction inside the channel with a diameter of 1.2 nm;
c) the diameters of the cis and trans entrance of VDAC ion channel in its high-conductance state arc 2.0 nm and 4.0 nm, respectively. Upon transition to the low-conductance state, the diameters of both entrances decrease and become equal to 1.8 nm and 2.4 nm, respectively. The total decrease in channel volume is ~ 10 nm3, which is about 40% of the total pore volume.
2. Detailed comparison (under physiological conditions) of the biophysical properties of the maxi-anion channel and VDAC has shown that these two ion channels arc formed by different proteins.
3. For the first time, it was shown that introduction of additional negative charges to the structure of a-HL channel changes its selectivity from slightly anionic to highly cationic, whereas introduction of positive charges increases significantly the anionic selectivity. The extent of these changes depends on the radius of the channel at the point of addition of new charges (which mainly affects the selectivity of the ion) and the location of these charges along the longitudinal axis of the channel (which mostly alters the currcnt-to-voltage characteristic). These results demonstrate that the total charge of the pore wall is responsible for the cationanion selectivity of a-HL channel, and the position of the charges at the entrances is the main factor determining the shape of the current-voltage curves.
4. A new method of determining the stoichiometry of oligomeric ion channels has been developed based only on electrophysiological measurements. With this method, it was found that a-HL channel formed in the lipid bilayer membrane is a hcptamcr.
5. It has been established that a polyanion molecule enters into the pore due to electrostatic forces and physically blocks the passage of ions. Blocking probability of the a-HL channel by polyanions depends on the followings:
a) the presence and concentration of divalent cations, which, according to their effectiveness, can be ranked as follows: Zn2+ >Ca2+ >Mg2+;
b) the concentration, molecular weight and structure of the polyanion. Efficiency of effect of polyanions on the channel correlates with their effect on the membrane ^-potential;
c) the side of polyanion addition: addition of polyanions from the trans entrance is more efficient due to the asymmetric structure of a-HL channel.
6. For the first time, it was shown that the applied membrane potential causes an elastic deformation of the a-HL channel, which explains a residual asymmetry of the currcnt-to-voltagc characteristics at high salt concentrations as well as the voltage-dependence of channel block by a complex of 18-crown-6 with potassium cations.

Topicality and relevance of the theme of the dissertation. Taking into account the importance of normal growth as an important indicator of health status, the World Health Organization (WHO) worked out standards of children’s growth and development. The new Child Growth Standards provided the notion how children should grow, the performance of the monitoring of their growth and development with duly prophylactic actions.
Growth and development of children in a great degree depend on nutrition and clean environment. The problems of nutrition of the children arc conditioned by a complex of factors, among which the social welfare of the region, where a child lives, and formation of nutrition behaviour in the family arc the leading ones. For some regions of the world there is a problem of chronic malnutrition, which continues to be the reason of infant mortality, leads to the development of chronic nutrient deficiency in children, is a reason for the development of disorders, including intellectual ones, and increases the risk of morbidity with various infectious pathologies. Fast and excessive growth is linked with the higher prevalence of cardiac-vascular diseases and obesity. According to WHO, in 2010, about 115 million children had low body mass, 55 million - slow growth rate in relation to the body mass, and 171 million children under 5 years old had retardation of development. Besides that, in 2010, 43 million children of preschool age in developing and developed countries had excessive body weight or suffered from obesity 1. Prevalence of children’s obesity in the countries with low and average level of incomes is increasing for the last 10 years; according to WHO assessment in 2015, that coefficient reached 11%, approaching to the prevalence in the countries with the level of incomes above average one (12%)2'
In the world, great importance is given to scientific, organizational and methodological approaches to defining the features of physical development of children and improving nutrition, taking into account regional factors in medical prevention system. In this regard, special attention is given for the targeted scientific researches: assessment taking into account the regional peculiarities of physical development of children through the introduction of new standards of growth and development of children as recommended by the WHO; determining the frequency of different forms of eating disorders and their relationship with major diseases and immunological reactivity of children; improving the factor evaluation system affecting the health, physical and intellectual development of children.
Urgent tasks arc determining the level of growth and development of children in the regions of our republic, assessing the efficiency of the implemented programs in the republic to improve the nutrition and prevention of micronutrient deficiency through the application of the new standards of growth and development of children, as well as developing proposals and recommendations accordingly.
The dissertation is aimed at achieving the objectives set out in the Law of the Republic of Uzbekistan “On prevention of micronutrient deficiency among the population” of 7 June 2010, the Decrees of the President of the Republic of Uzbekistan PD-2133 “On the State program “The year of a healthy child” of 19 February 2014, and PD-2221 “On the State program to further strengthen the reproductive health of the population, the protection of maternal, child and adolescent health in Uzbekistan for the period of 2014-2018” of 1 August 2014.
The aim of the research is defining the peculiarities of physical development of children under 5 years old and assessing the efficiency of the programs for the improvement of their nutrition on the basis of modem organisational and methodological approaches.
Scientific novelty of the research was concluded in the following:
The indicators of physical development (length/height, weight, body weight index), regularities of their dynamic growth, and the forms of nutrition among the children under 5 years old were for the first time determined by means of monitoring on the basis of the new standards of growth and development recommended by the WHO.
The factors (underweight at birth, deviation of the principles of breast feeding, especially exclusively breast feeding within initial 6 months, irregular and irrational complementary feeding, morbidity, environment) causing disorders of nutrition, growth and development of children were determined. 
Hormonal adaptation in underweight newborn babies, and immunological reactivity in children with the main diseases (bronchial obstructive syndrome, pneumonia) and disorders of nutrition were determined.
The efficiency of the programs being carried out in Uzbekistan for the prevention of the deficiency of vital micronutrients (iron and vitamin A) providing the normal physical and intellectual development of children was evaluated according to certain indicators.
CONCLUSION
1. Irrespective of the sex in children under 5 years old of all the studied regions, anthropometric values of body mass and length/height in the majority of the cases were at the level of: median (0) - at the moment of birth, in the range from -ICO to +2CO from 0 to 6 months; in the range from -2CO to +1CO from 6 months to 5 years old; according to the body mass index in the range from -1 CO to +1CO in children of all ages, and they correspond to normal values in compliance with the WHO growth and development standards.
2. Underweight in relation to age was prevailing in the children under one year old among the forms of disorders of physical development and nutrition in all the regions. That form was more expressed in the regions, where the value of EBF in the initial 6 months and BF within 2 years covering was less (Tashkent and Khorezm regions). The similar tendency was observed in the following age stages. Disorder of physical development and nutrition in the children elder than 6 months was deteriorated due to ill-timed and inadequate introduction of food. In the dynamics of five-year monitoring till the end of 2012 - beginning of 2013, in all the regions there was a decrease of the frequency of all forms of disorders of nutrition irrespective of the age and sex of the children.
3. The leading position in the frequency of excessive weight and obesity was taken by Tashkent city and Fergana region. In Fergana region, excessive weight and obesity prevailed within the initial 12 months in boys. In the dynamics till the end of 2012, in all age stages Tashkent city took the leading position according to the frequency of excessive weight and obesity.
4. Premature and mature newborn underweight babies at the moment of birth had disorders of clinical and hormonal adaptation, and dishannonic physical development in the first 3-4 months (parameters of the growth curves were in the limits of -3CO) with further tendency for the achievement of age standard values of growth and development (to 6 months body mass index corresponded to the median), and it was the result of exclusive breast feeding.
5. Immune disorders in moderate protein-energetic deficiency of nutrition at the early stages of its development mostly reflect the defects of T-cellular part of immunity, which was characterized by low expression of CD3+ and CD4+ lymphocytes, testifying that in PEDN T-ccllular proliferative response to antigens was sufficiently weak. Decrease of the production of immunoglobulins linked with disorders of T-cellular regulation of the synthesis was also characteristic. These immunological disorders have an important prognostic importance in the definition of the resistance of an organism to diseases.
6. Ecologically dependent characteristics of immunological reactivity in the examined children with PEDN living in Sub-Aral area was deficit of phagocyte protection (p<0.01), and low amount of immunoglobulins IgG, IgA, IgM in blood (p<0.05).
7. Disorder of nutrition is important in the decrease of immune reactivity in children with pneumonia and bronchial obstruction syndrome. Severity of pneumonia and immune reactivity status in young children depend on the place of living. Thus, the children living in the Republic of Karakalpakstan in comparison with the children from Tashkent city had little amount of CD3+lymphocytes (p<0.01), CD8+lymphocytes (p<0.05) and immunoglobulins IgG, IgA (p<0.05) in the increase of cytotoxic potential of immune system cells (CD 16+ and CD20+, p<0.05).
8. The programs in the field of nutrition being implemented in Uzbekistan such as vitamin A supplementation to children from 6 to 59 months old, rational nutrition and consumption of fortified flour promoted prophylaxis and liquidation of disorders of nutrition, and allowed the improvement of the values of immunity and harmonic development of children under 5 years old irrespective of sex and place of living.

Topicality and relevance of the subject of dissertation. Nowadays in the fast developing field of laser technologies and nonlinear optics the research directed to the study of influence of multielectron effects and concentration of particles on resonant high-harmonic generation for the production of coherent radiation in vacuum ultraviolet and soft X-ray range is considered one of the most promising directions of laser physics. At the same time the main attention is paid to increase the efficiency of generated harmonics in conditions of resonance and quasi-synchronization of phases of interacting waves. These studies arc connected with the application of coherent radiation in the field of laser physics, nonlinear optics, femtosecond holography, generation of attosecond pulses, spectroscopy of ultrafast processes.
Fulfillment of conditions of resonant high-harmonic generation and quasimatching of phases of pump radiation with radiation of harmonics provides substantial increase of efficiency of conversion of energy of femtosecond pulses with intensity 1014-1015 W/cm2 used as pump radiation into radiation of harmonics. In connection with this the possibilities of utilization of artificial nanomaterials which have complicated structure as well as ones like cndohcdral fullerenes in practice of high-harmonic generation remain weakly studied.
The demand for the subject of the dissertation is shown by the development of the methodology of high-harmonic generation in plasma formations, the enhancement of the efficiency of nonlinear frequency conversion at resonant high-harmonic generation, the study of nanoparticles which arc produced during the process of laser ablation. Moreover, the creation of highly efficient nonlinear elements on the basis of the laser ablation method, while being of special importance for the solution of important problems of nonlinear optics, give the possibility to obtain the theoretical results on the analysis of concentration of laser plasma.
The influence of concentration of free electrons on the efficiency of high-harmonic generation, as well as the influence of concentration of particles on high-harmonic generation still remain almost completely unstudied. The solution of these problems will help to establish basic laws and peculiarities of resonant high-harmonic generation in real systems which arc of practical interest in creating highly efficient sources of coherent radiation in vacuum ultraviolet spectral range.
This thesis is devoted to solving in a certain degree the problems noted in the Decree of the President of the Republic of Uzbekistan DP-1442 “On the priorities of industrial development of Uzbekistan in 2011-2015” of 15 December, 2010 as well as in other normative legal documents accepted in this field.
The purpose of the research is determination of the influence of multielectron effects and concentration of particles on resonant high-harmonic generation.
The scientific novelty of the research consists of the following results:
it is shown that multi-electron effects lead to resonant high-harmonic generation as a result of nonelastic scattering of accelerated electron on the ion with excitation of ion’s electrons to resonant level;
a mechanism of resonant high-harmonic generation was suggested, which explains the results of experiments on resonant high-harmonic generation and allows to optimize the process of resonant high-harmonic generation on the base of computation of optimal pump and ablation pulses;
usage of nonionized plasma as promising medium was suggested for the observation of resonant high-harmonic generation based on transitions in singly ionized media;
on the base of theoretical calculations of plasmon absorption peaks of Cf)0-molecule’s casing in endohedral fullerenes Сбо+In and Сбо+Sb to corresponding ionic resonances of encapsulated semiconductors as well as shift of the maximum of resonant enhancement of a group of harmonics to the new plasmon absorption peaks possibility of uniform enhancement of a group of harmonics in laser plasma created by evaporation of mixture of cndohadral fullerenes has been demonstrated;
a method was developed for the theoretical determination of the concentration of atoms, ions and free electrons in plasma which is based on consideration of enhancement of a group of high harmonics during quasi-phase matching at hte rocess of laser ablation using long heating pulses;
mechanisms of restriction of efficiency of frequency conversion with growth of concentration of particles in laser plasma of carbon created using ablation pulses with duration of 8 picoseconds and 10 nanoseconds were revealed;
a technique of determination of dependence laws of degree of ionization at givn concentrations was suggested which leads to enhancement of single high harmonic in the plateau region up to more than 1000 times at the combination of quasi-phase matching and resonant conditions.
CONCLUSION
1. For the first time reliable information about spectra of resonant high-harmonic generation is provided on the base of exact potentials and parameters of pump pulses close to the experimental ones.
2. It is shown that the resonant high-harmonic generation is determined by population of resonant state by means of excitation of inner electrons of ion to resonant level as a result of inelastic scattering of the accelerated electron as well as by subsequent recombination of electrons from the excited level to the ground state with generation of resonant harmonic due to stimulated emission influenced by nonresonant harmonic of the same order.
3. For the first time theoretical simulation of high-harmonic generation in the plasma of Сбо fullerenes was performed using the time-dependent density functional method for the case of fully modelling the contribution of all carbon atoms into molecular field, at the same time the enhancement of harmonics was obtained in the range of surface plasmon resonance of Сьо fullerenes 10 times higher than outside this range.
4. It is shown that in laser plasma of endohcdral fullerenes In C6o and Sb C6o shift of maximum of resonant enhancement of a group of high harmonics relative to pure Сбо due to shift of plasmon absorption maxima of fullerene casing to atomic resonances of embedded atoms.
5. It is shown that the main factor restricting the possibilities of enhancement of high-harmonic generation by increasing concentration of laser plasma is the breach of conditions of phase matching with increase of concentration of free electrons.
6. It is shown that optimal relative to conversion efficiency plasma of indium can be obtained using ablation pulses with duration of 10 picoseconds and intensity of 2x109 W cm’2, while optimal plasma of chromium is created using ablation pulses with duration of 100 femtoseconds and intensity of 1011 W cm’2, that is linked to different ionization degrees of resonant levels of these elements.
8. For the first time a technique of control of efficiency of resonant high-harmonic generation was developed based on control of duration and intensity of ablation pulse in plasmas with spatially modulated optical density.

Topicality and demand of dissertation subject. A uterine myoma is among the most common benign tumours of the reproductive system organs and is observed in 15-20% of women. According to the World Health Organization (WHO), the last decade is characterized by an increase of the frequency of occurrences of uterine myomas, including among women of reproductive age.
In the years of independence, in the process of reformation of the system of health care, particular attention has been paid to the protection of maternal and child health at the state level. Full coverage of the population in our country through preventive examinations within the framework of the State programs aimed at improving the reproductive health of women, allows timely detection of the pathology of the reproductive system, including uterine myomas.
Despite the researches conducted in the world aimed at studying the aetiology and pathogenesis of myomas, today many questions require further solution. There arc various, including conflicting views on the role and participation of hormones in the development of myomas. Immune-histochemical studies have shown that the content of estrogenic and progesterone receptors arc higher in the myoma than in the healthy tissue of myometrium, but lower than in healthy uterine endometrium. Most of the researchers associate the development of myomas in young women with the influence of infections (intrauterine contraceptives, abortion, inflammation, sexually transmitted infections). In the last years, the leading role in the development of myomas is given to the immune system, in particular, the value of growth factors and a genetic predisposition to the occurrence of myomas arc being studied. Further study of the development of infertility in young women with myomas is required, which occurs in one third of cases. Inadequate study of the role and impact of these factors, the formation of myomas in women of reproductive age, high proliferative activity of nodes and the probability of their recurrence indicate the urgency of this problem. In connection with the emergence of high resolution ultrasound machines it became possible to diagnose myomas at the very beginning of their development, determine the blood flow of nodes and evaluate the level of their proliferative activity.
The issues of treatment of uterine myomas arc also among urgent areas of scientific researches. With the use of such medications as agonists GnRH (a-GnRH) and selective modulator progesterone receptors (SMPR) in practice, today the uterine myoma is treated mainly by the conservative method. The shortcoming of the conservative treatment is the low efficiency, the presence of contraindications to hormone therapy. Often, after the hormone therapy, myoma relapse is observed, especially in women of reproductive age. All this testifies the need for a differentiated individualized treatment. Early diagnosis of uterine myomas, the use of modem minimally invasive organ-preserving surgical techniques, improvement of the methods of prevention, rehabilitation and preservation of the reproductive function have important scientific and practical significance.
In a certain degree, this dissertation research serves to perform the tasks approved in the Resolution PD-1096 of the President Republic of Uzbekistan “On additional measures for the protection of health of mother and child, the formation of a healthy generation” of 13.04.2009 and the Resolution PD-2221 “On the State Program to further strengthen the reproductive health of the population, the protection of maternal, child and adolescent health in Uzbekistan for the period of 2014-2018” of 1.08.2014, as well as in other normative and legal documents adopted in this field.
The aim of the research is determining the indicators of regulatory immune mechanisms of development of different types of myomatous nodes depending on their proliferative activity and, improving the strategy of individual organpreserving treatment and prevention of the complications of uterine myomas in women of reproductive age.
Scientific novelty of the research was concluded in the following:
The nature of imbalance of pro-inflammatory and anti-inflammatory cytokines, and vascular endothelial growth factor (VEGF) depending on the proliferative activity of myomas was established.
Immunological markers were identified for the assessment of the risk degree of the proliferation of myomatous process, and in the postoperative period - the risk of node recurrence.
Dose-dependent cytotoxic and proapoptotic effect of transforming growth factor TGF-[32 was proved in the development of myoma;
The degree of blood supply of myomatous nodes at the dopplcrmctry examination of their blood flow is a marker to determine the type of nodes and monitor the effectiveness of the treatment.
Differential individualized treatment method of uterine myomas was worked out, depending on the type of myomatous nodes, a woman’s age, condition of the reproductive function and the presence of clinical symptoms of myomas. The effectiveness of an active strategy of treatment was shown, compared to the traditional observational strategy in young women with asymptomatic course of myomas.
A comprehensive organ-preserving treatment was worked out using a-GnRH and selective modulators of progesterone receptors to restore the reproductive function in the patients with uterine myomas.
CONCLUSION
1. The results of the studies showed that over the past 10 years there have been an increase in the morbidity of uterine myomas in women of reproductive age to 34.6%. In 65.2% cases, surgical treatment in women under 40 years old ended with the loss of the reproductive organ. Thus, hysterectomy was performed in 39.6% and total hysterectomy - in 25.6%. During the recent 5 years, the frequency of ME has increased — from 5 to 20% operations on the uterus.
2. The presence of clinical symptoms, the location of the nodes in the upper and lower thirds of the uterine body characterized by the best blood supply, recurrence and occurrence of new nodes, especially at the termination of supporting treatment arc characteristic of the proliferating uterine myomas. Asymptomatic nature and mostly subserous location of the nodes in the middle third is typical of simple myomas.
3. The dopplcrmctry definition of blood flow in myomatous nodes allows identifying the type of myomatous nodes (simple or proliferative) for the choice of the method of treatment. Ultrasound and dopplcrmctry markers of proliferating myomas are: the presence of multiple nodes, increased blood flow in and around the node, the average level of RI, primarily centripetal growth of nodes. Single, avascular nodes with high resistance index is characteristic of simple uterine myomas.
4. Pathomorphological studies conducted using light and electron scanning microscopy confirmed the presence of active centres of angiogenesis in the proliferative uterine myomas with the formation of multiple centres of neovascularization and formation of growth zones of myomatous nodes. The increase of the area of the vascular node was also discovered, which explains the clinical symptoms of proliferating myomas.
5. The increase in the levels of pro-inflammatory cytokines (IL-6 by 4-5 times, and TNF-a by 1.7 times) and the reduction of anti-inflammatory cytokines (IL-10 by 1.4-2.2 times) as compared with the control promote the growth and proliferation of myomas. In proliferating myomas, a high level of VEGF (by 2.5 times) indicate the activation of angiogenesis which allows using it as a marker of proliferating fast growing myomas. X-ray contrast studies of myomatous utcruses also revealed the increased vascular pattern mainly at proliferating uterine myomas.
6. Changes in the levels of growth factors (VEGF, TGF-02) demonstrate the role of the immune system in the pathogenesis of uterine myomas. Transforming growth factor TGF-02 has high dose-dependent cytotoxic effect on the cells of uterine myomas in vitro study. Low concentrations of TGF-02 stimulate the proliferation of the cells, and high concentrations block the proliferation and strengthen the apoptosis.
7. A comprehensive examination, including ultrasound scanning with dopplcrmctry, definition of VEGF, IL6, TNF-a allow identifying the type of myomatous nodes for the choice of the strategy of treatment. The sensitivity of the complex method of studies comprises 96%, specificity - 91%. There was an inverse correlation dependence of clinical and laboratory parameters of RI and VEGF (r = - 0.37-0.63). The statistical probability of a correct diagnosis of the proliferating myoma based on data of studies is 0.87.
8. Pregnancy with proliferative-active myomas often occurs with complications (by 6.6 times) than the simple type of node. The proliferative type of myomatous nodes is characterized by the growth and increase of the number of nodes during pregnancy and recurrence of myomas in the postnatal period. The probability of the risk of recurrence was 8.3%.
9. The efficiency of the organ-preserving treatment for uterine myomas depends on the duration of the disease, presence of symptoms, early treatment of myomas with the medicaments a-GnRH and esmiya. The treatment of myomas with a-GnRH is most effective for small-sized simple non-proliferative myomas. The probability of the risk of recurrence after the conservative treatment of the myomas amounted to 4.5%.
10. Prcopcrative treatment of myomas using the medicament esmiya for 3 months facilitated the performance of ME; laparoscopic ME had advantages over laparotomic enucleation of nodes in the form of reduced blood loss by 2.8 times and the time of the operation (2 times faster). The restoration of fertility occurred when ME was performed by laparoscopy in 3-6 months and by laparotomy in 12 months after the operation. The frequency of radical operations at the time of the study decreased by 2 times.
11. Comprehensive treatment including the rehabilitation treatment with proteolytic medications using medicinal electrophoresis increased the efficiency of modem organ-preserving treatment and promoted the prevention of the recurrence of uterine myomas. This made it possible to restore the reproductive function in 36.4% women within 12 months after ME.

The urgency and relevance of the theme of dissertation. In the world it is actual the application of modifiers on the basis of synthetic oligomers for improving the rheological properties and the regulation of structure formation of composite materials.
In the Republic of Uzbekistan, one of the most important problems in the field of chemical additives for building materials is to find new organic additive that increases endurance and durability of constructions and structures, subjected to impact of climatic conditions and aggressive environments.
In construction industry for regulating processes of structure formation and rheological features of concentrated suspensions arc used supcrplasticizers - organic chemical additives, allowing purposefully to change the mobility of raw mixtures and properties of ready made materials. The search of new effective additives that allow to modify the surface of interface phase and modify rheological properties of dispersions is an actual task.
The special properties of polyelectrolytc-supcrplasticizers refer the possibility of stabilizing dispersions and emulsions by adsorbing diphyletic macromolecules at the bound of interface, preventing the aggregation of particles; effect on the rheology of fluids and dispersions; ability to form physical gels; possibility to cause aggregation of particles in stable dispersion systems to facilitate the separation of liquid and solid phases; modification of surface properties on adsorption on them for providing wettability; solubilization of hydrophobic substances, by adsorption of supcrplasticizer on the surface of the solid phase particles precludes their adhesion by electrostatic forces and thereby reduces the viscosity of the suspension.
The dissertation to some extent may contribute to solve problems defined in accordance with the part of provisions by the President of the Republic of Uzbekistan № 1442 dated December 15, 2010 «About priorities of industrial development the Republic of Uzbekistan» and № 1072 dated March 12, 2009 «About program measures on realization of the most important projects on modernization, technical and technological reequipment of production», as well as other legal documents adopted in this area.
The aim of the research is the working out technology on obtaining organic super- and hypcrplasticizers based on local raw materials and the improvement of their means the technology production of cement compositions.
The scientific novelty of the research concludes the followings:
the technology of the new super- and hypcrplasticizers based on polycarboxylates and acetonoformaldchydes resin was worked out;
the structure and physic-chemical properties of synthesized organic chemical plasticizing additives based on polycarboxylates, polyols, acetonoformaldchydc resin was defined;
the influence of obtained plasticizing additives on the basis of polycarboxylates, polyols, cellulose derivatives and starch, acctonoformadchydc resin on physical-mechanical properties of cement systems was defined;
the physico-chemical properties of cement systems with the addition of su-plasticizer SDj-1 and hypcrplasticizer and supcrplasticizer on the base of accton-oformaldchydc resin was defined.
technology of application of obtained super- and hypcrplasticizcr of cement composition was worked out.
CONCLUSIONS
1. Obtained plasticizers based polyols and revealed that an increase in molecular weight polyol had a positive effect on the rheological and physico-mcchanical properties of the cement paste. It was determined that the plasticizer based on glycerol compared with other plasticizing additives which was obtained , showed the best results.
2. Obtained plasticizers which were synthesized from renewable sources (like starch, cellulose and derivatives thereof), had a positive effect. It was identified derived plasticizers were encouraged to use in the range of 0.1 - 0.5% by weight of cement.
3. Obtained supcrplasticizer SDj-1 in its chemical structure had functional groups that enhance the water solubility and adsorption on the particles of a macromolecule supcrplasticizer was proposed Portland cement and in the workplaces.
4. It was found that the isobutyl radical was effective for a polymcthylcnc radical modification, the optimum percentage of supcrplasticizer SDj-1. isobutyl and the radical - 95: 5, and the proposed modified supcrplasticizer was added to the cement paste - up to 1% by weight of cement.
5. It show that the resulting of hypcrplasticizcr had a high plasticizing effect when added mixes and can repeat the results with small quantities of superplasticizers. Hypcrplasticizers were 20 times more effective than supcrplasticizers.
6. It was proposed that supcrplasticizer of acctonoformaldchydc based resin having functional groups in its chemical structure, which improved the water solubility and adsorption on the particles of a macromolecule supcrplasticizer and Portland cement showed the results obtained by supcrplasticizer reduced the necessity to 15-20%, increased the strength of the cement stone.
7. It was determined that in addition to synthesized and super hypcrplasticizers of composites solutions based on gypsum and ccmcnt-limc binding was increased the mobility, placcbility, density and strength.
8. The technology of production and application of super- and hyperplasticisers based on local raw materials and implemented on the basis of LLC «Zcnatkor-TBB», LLC "Qulama qurilish", LLC "Jizzakh Binokor Savdo". By adding the received hyper and super plasticizers in cementitious systemsobserved to increase strength cement compositions in the early stages, and this in turn led to a reduction of the technological process of preparation of composite materials and energy costs

At present time in world scales a great importance is paid to the providing the increase of capacity of machines and equipments, which are being used for processing the agricultural production, lowering of power consumption, the safety of manufactured products.
Since achieving the Independence of the Republic with the purpose of providing the necessity of population in grain today in comparison with 1991 arc grown 10 times more grain ( in 2015 more 8 mln. tons), 5 times more bean (string bean, mash, green peas, local peas, soya ...). Due to that storage, primary processing, take off and processing separation on fractions, manufacture, increase of stores, export of food production and reinforcement foreign currency reserves of the country arc actual.
Being used in processing of grain equipment, their work routine and technologies do not fully suit to chemical, physical and mechanical properties, humidity of being grown grain in our republic. Especially for that reason a great importance has the study of physical-mcchanical properties of local sorts of grain in cutting regions, manufacture, testing and implementation of metal and power saving, compact, completing several technological processes of machines of new series, which are necessary for purification from different organic, mineral and large impurities and fractionation of grain on mass taking into account its essentials.
Working out on mathematical model and the calculation method of grain movement on machine cell for separation and fractionation on mass allow determining the kincmatical and constructive parameters of main working organs.
The formation of equation on grain movement by inclined, perforated shelves and lower inclined, shaken shelves for purification from light and large impurities and determination on its base constructive parameters inclined, perforated and lower shaken shelves arc the basic of grain movement mixture on the surface of shelves gravity flow by one layer, at that purification from cleaving organic and mineral impurities and grain shells arc provided. Mathematical modeling creates new directions for determination of modeling diameters of higher and lower shaken shelves, geometrical parameters of aspirational channels, the speed of air flow and absorption of light impurities from the staff of grain mixture from the surface of perforated shelves through aspirational channels, technological processes of separation to individual cubic content of large impurities and equable fetching of grain in feeding the roll of cell.
The given dissertation research in certain degree serves the completing tasks, defined in degrees of the President of the Republic of Uzbekistan №PD-1072 «On program measures of important projects realization on modernization, technical and technological upgrading of production for 2009-2014 years» from March 12, 2009y and №PD-1633 «On measures of further improvement of management organization and development of food production of the Republic for 2012-2015 years» from October 31, 2011 and also other normative-legal acts concerning the given activity.
The aim of the research is based on scientific evidence of kincmatical and constructive parameters of machines for separation and fractionation of grain crops, working out the constructive and technical documentations on the creation of machines.
Scientific novelty of the research includes the followings:
In cutting territories physical-mechanical properties of local sorts of grain were studied;
the interacted essentials parameters of processes for separation and fractionation of grain crops were defined;
the mathematical model and completed equation of grain motion on the surface of perforated shelves taking into account airflow was developed;
the speed of airflow and was chosen ventilator for purification of grain from light impurities in scparational cell was defined;
the mathematical model and completed equation of grain motion on the surface of lower shaken shelves for purification from large impurities in scparational cell taking into account airflow was developed;
the mathematical model and completed equation of grain motion on the surface of feeding roll of fractional cell taking into account the ressisstancc of air to the surface of grain on lateral cutting was developed;
kincmatical and technological parameters of combined separator taking into account physical-mechanical essentials of local sorts of grain were defined; the combined separator for purification from other impurities and fractionation of grain crops on mass with manufacture 7,5 t/h, properly sizes: -l=4500mm, h=2000mm, b=500mm was created.
CONCLUSION
1. New design of machines for separation and fractionation of grain crops, which combined cell separation and fractionation of grain, allowing to increase the performance of the machine and the quality of cleaning of the grain mixture from impurities and fractionation grain for the masses to exclude his injury, reduce material and energy consumption, as well as, to take a relatively small production area was worked out.
2. The mathematical model and method of calculation of the movement of the grain mixture in the chambers of the machine for separation and fractionation of the grain mass to determine the value of kinematic and geometric parameters of the main working bodies were worked out.
3. The design parameters of the inclined perforated shelves and lower shelves shaking on the basis of the equations of motion of the grain along the surfaces of inclined perforated shaking shelves and bottom shelves for cleaning grain from light impurities and large mixtures were revealed.
4. Rational parameters of inclined perforated and lower shaking shelves with a capacity of 7,5 t/h: the width of inclined shelves is 500 mm; the length of the inclined shelf is 400 mm; the angle of slope of the shelf is a - 23°; length of the lower sloping shelves - 430 mm, which allowed the movement of the grain mixture along the surfaces of the shelves by gravity with one layer, that provided separating of organic and mineral matter and shells of the grain.
5.It was established that on the basis of developed methods of mathematical modeling and experimental studies of dimensions, the perforations of perforated shelf for slant - 4 mm, lower shelf for shaking 7 mm, the width of the ducts of the aspiration channel 20 mm, height 1500 mm, air flow velocity of 7 m/s, which provided the absorption of light impurities, through the perforations and the suction channels, the separation of large impurities in a separate container and even loading the corn into the chamber of the supply roller.
6. Design parameters of the feeding roller depending on the process requirements and machine performance on the basis of mathematical modeling, which was a diameter of 350 mm, a width of 500 mm and speed 450 r/m, ensuring a smooth takeover of the grain and uniformly the same initial speed of its flight (l> = 6,28^/) were defined.
7. Differential equations, to determine the total height «h» and length of flight of a grain «L», depending on the initial speed of flight of grain from the feed roller , the angle of inclination of the guide tray , the drag coefficient of the air from the grain mass , and the characteristics of local varieties of grain.
8. It was found ,that when the angle of inclination of the guide tray a = 45° depending on weight of grain, the height of its flight ranges from 0,2 to 1 m, and the length of flight of a grain «L» ranges from 1,5 to 4 m. These options allow you to divide grain into several fractions according to the mass to reduce its moisture content from 2% to 3%, and fully clean grain from various impurities.
9. Physical -mechanical properties of local varieties of grain in regions of the country, which allow us scientifically substantiate the parameters of the new machines, created the separation and fractionation of the grain excluding the injury of local varieties of grain.
10. On the basis of the results of research, it was manufactured and introduced into the production a new design of machine for the separation and fractionation of crops with scientifically based options were developed. The implementation of which in manufacture have improved the performance of the machine.

The urgency and relevance of the topic of the dissertation. Currently, out of 13.5 billion hectares of land of the world, 1.4 billion hectares are intended for the cultivation of the agricultural products. High population growth and their demands require more efficient use of land.
In the agriculture of Uzbekistan, special attention is focused on the widespread introduction of modem agricultural technologies and improving the ameliorative conditions of irrigated lands. The chemicals - fertilizers, growth stimulants, pesticides, including defoliants and desiccants - arc important in the constant improvement of productivity and the improvement of soil fertility.
One of the conditions for successful and high-quality cleaning of cotton - raw during the pre-freezing period is the defoliation of cotton. Conducting quality defoliation makes it possible to carry out a complete cleaning of cotton in a short time. This creates conditions for the early sowing of grain, carrying out the autumn and winter activities and receiving an abundant harvest the following year.
Localization of the raw material bases of the production companies and the creation of the import-substituting products on their basis, the saturation of the domestic market needs with the consumer goods, as well as increasing the export potential are some of the most important reforms carried out in the Republic. In addressing this task, one of the most actual problems is the use of the products of hydrochloric acid digestion of the local dolomite, as raw material instead of imported «bischofite», by producing a solution of calcium chloride, magnesium and processing them with sodium chlorate in conversion method in a low-toxicity, high-performance new defoliants, accelerating the maturation and disclosure of cotton bolls, thus reducing the production costs of companies and thereby reduce the cost of the finished product.
This dissertation research to a certain extent serves to solve the tasks stipulated in the decree of the President of the Republic of Uzbekistan № 4707 on March 4, 2015 «About the measures for structural reforms, modernization and diversification of production in 2015-2019» and the regulations of the Cabinet of Ministers of the Republic of Uzbekistan № 3 of March 4, 2015 «On additional measures of reducing the production expenditures and decreasing the production costs in the industry», as well as in other legal documents adopted in this area.
The aim of the research is the development of technology for obtaining low-toxic and highly effective defoliant by the decomposition of dolomite mineral with hydrochloric acid, followed by conversion of the resulting product with sodium chlorate.
Scientific novelty of research is as follows:
for the first time, the possibility of obtaining a new calcium-magnesium chlorate defoliant using raw materials obtained on the basis of hydrochloric acid decomposition of the local dolomite instead of imported bishofit was determined;
the optimal technological parameters of the process of decomposition of dolomite with hydrochloric acid: concentration HC1 - 31,0%, the reaction time of 30-35 minutes, the temperature of the process 30-40°C were set and the total extraction of CaO and MgO is 99,42-99,60% were proven;
new data were first obtained on the interaction of components in complex water systems consisting of chloride and calcium chlorate, magnesium and sodium, as a result of which the solubility diagrams arc constructed polythcrmal and the possibility of obtaining a new calcium-magnesium chlorate defoliant was scientifically proven;
the optimum parameters of the conversion process of the solution of calcium and magnesium chloride with sodium chlorate, were determined;
the activation energy, order and the constant speed of the conversion process were determined, their temperature dependence was set , as a result of which the technology for production of a new type of calcium-magnesium chlorate defoliant was developed.
CONCLUSION
Based on the conducted study of the doctoral dissertation on the topic of «Development of technology for obtaining calcium-magnesium chlorate defoliant based on local raw materials,» the following conclusions arc presented:
1. The urgency and the need for defoliation of cotton with a view to a successful and high-quality harvest in pre-frosty period, as well as for carrying out the early autumn and winter activities were substantiated. The scientific and practical significance of the study in the priority areas of Science and Technology of the Republic was defined.
Chemical composition, physical-chemical and physical-mechanical properties of dolomite deposits «Shorsu» and «Pachkamar» were studied. The samples have the following chemical composition: CaO = 30-31,5% and MgO = 19,2-19,4%, CO2 = 45,0-45,5%, metal oxides of 1,42% and silicon oxide of 2,87%.
2. The research was conducted, aimed at studying the foam by reacting dolomite deposits «Shorsu» and «Pachkamar» with hydrochloric acid, depending on acid concentration, temperature, process time and stirrer speed. It was found that with increasing acid concentration increases the viscosity of the solution and in turn contributes to the multiplicity and stability of the foam. Increasing temperature leads to an intense foaming, but the decrease in viscosity of solutions decreases foam stability. High speed of the mixer leads to shorter «life» of the foam as well as to reduce the foam due to its destruction. Based on the studies and established relationships, it is proposed to conduct a process of decomposition of dolomite with hydrochloric acid in two steps (the first step is 35-40% rate of the total amount of acid, in the second stage the remaining 60-65% rate acid is fed). As a result, foam will be significantly reduced.
3. Hydrochloric acid decomposition of the dolomite was studied, depending on acid concentration, temperature and reaction time followed by separation of the insoluble residue by filtration, centrifugation and sedimentation. The basic kinetic parameters of the decomposition process were set and equations depending on speed constant of decomposition and its logarithm of temperature were withdrawn. The optimum parameters of decomposition were determined: concentration HC1 - 31.0%, the reaction time of 30-35 minutes, the process temperature of 30-40°C and for the continuous separation of insoluble residues of hydrochloric acid application apparatus of the centrifugal type.
A schematic block diagram of obtaining the solution of calcium and magnesium chloride by hydrochloric acid decomposition of dolomite was proposed. The material balance of producing one ton of calcium magnesium chloride solution was calculated. The cost price of 1 ton of calcium and magnesium chloride for raw materials is 625,284 soums, while the cost of 1 ton of imported bishofit imported from abroad - 1.512 million soums. The solution of calcium and magnesium chloride, proposed as a raw material, is 2.4 times cheaper compared to bishofit.
4. The physical-chemical solubility diagrams of water systems were studied: MgC12-CaC12-H20;[56,06%CaCl2+40,77%MgCI2+3,17%NaCl]-NaC103-H20, justifying the process of obtaining calcium-magnesium chlorate defoliant on the basis of the products of hydrochloric acid decomposition of dolomite and sodium chlorate in a wide temperature and concentration range . In the ternary system consisting of calcium and magnesium chloride, the formation of double salt 2MgCh CaC12-I2H2O was set. In a complex system involving calcium and magnesium chloride and sodium chlorate formation of a new set soluble solid sodium chloride was determined, which indicates the occurrence of exchange reaction between sodium chlorate, and calcium and magnesium chlorides to form chlorates solutions of calcium and magnesium. As the temperature increases the conversion of chlorides of calcium and magnesium with sodium chlorate in an aqueous medium flows better.
5. There have been carried out the process of the calcium and magnesium chlorides corresponding to chlorates for the «Shorsu» and «Pachkamar” deposits, depending on the temperature and duration of the process. The activation energy, speed constant and temperature coefficient of the conversion process were calculated. It was determined that the conversion is to be conducted at a temperature of 90°C and duration of 120 min with evaporation of the solution.
6. Based on the studies, the basic technological scheme of the new calcium-magnesium chlorate defoliant was suggested. The material balance of production of a new defoliant was calculated. The production power of the existing plant of HMD is 11800 tons/year. As a raw material, imported bishofit of 8850 tons in the sum of 4779 thousand USD or 13381.2 million UZS is used. As a result of the organization of the production on the basis of local raw materials, dolomite in the amount of 4012 tons worth 120.36 million UZS and hydrochloric acid in the amount of 8614 tons worth 6003,5 million UZS arc used. Thus, the organization of the production of new calcium-magnesium chlorate defoliant on the basis of the local raw materials will result in savings of 7257,33 million soums on raw materials. The defoliant “FanDef ’ was tested by producing in the industrial devices and the experimental sample in the amount of 1100 kg was produced.
7. Many years of agrochemical tests of proposed chlorate of calcium-magnesium defoliant on various upland cotton varieties in different soil and climatic conditions showed high activity and «softness» of its action on the plants as compared to the liquid magnesium chlorate defoliant. According to the results of the tests, «FanDef» contributed to an increase in cotton yield by an average of 2.1 1/ha.
If assumed that the annual cotton crop on average covers 1000 hectares, then 9000 kg. HMD in the amount of 21679,92 million soums or 9000 kg FanDef on 12386,565 UZS is needed for its process. Thus, the cost of processing the cotton crop using «FanDef» is less 9203,55 million soums compared to liquid magnesium chlorate defoliant.
8. It was determined by the studies, led by the Research Institute of Sanitation, Hygiene and Occupational Diseases of the Ministry of Health of the Republic of Uzbekistan to study the toxicology of calcium and magnesium chlorate defoliant that in terms of the parameters of acute toxicity the drug belongs to a hazard class of IV. The Institute developed «Guidelines for the protection of the environment and public health when using the defoliant FanDef in agriculture». The drug «FanDef» underwent extensive State Chemical Tests of the State Chemical Commission the Republic of Uzbekistan and recommended for use in agriculture as a defoliant of cotton.

Topicality and relevance of the theme of the dissertation. One of the urgent tasks of bioorganic chemistry, cell biology and pharmacology is the identification of novel compounds having antitumor property and other biological mechanisms. For many years in the republic’s scientific laboratories systematic research conducted on the isolation and synthesis of various classes of compounds and the study of their pharmacological activity, some of the compounds tested on various biological activities such as anti-arrhythmic, cholinesterase, estrogenic and anti-inflammatory, however their cytotoxic activity has not be studied.
Screening of cytotoxic activity of chemical compounds, pharmaceuticals, in vitro medical devices on different cell cultures is an integral part of pre-clinical studies according to international standards GLP (Good Laboratory Practice). Methods of in vitro studies allow significantly reducing the cost and reducing the time of the preliminary study of new chemical compounds.
Such problems as the differentiation, tumorigenesis, cell motility, proliferation, transfer of genetic information, regulation of gene expression and others settled in the world of science, mainly with the use of cell cultures. Cell cultures are also of great importance for the solution of applied problems of medicine and agriculture. In particular, the main problems of application should include the massive industrial production of vaccines and physiologically active compounds, the preparation of monoclonal antibodies by hybridoma technology, and the treatment of serious diseases using gene therapy and cell replacement therapy.
In connection with the above identification of compounds which inhibit the growth of tumor cells with low toxicity for normal cells and substances of proliferating the growth of normal cells, but not the cancerous for regenerative medicine, as well as preparation of hybridomas producing monoclonal antibodies to erythropoietin is relevant.
This research work to a certain degree corresponds to the tasks provided in the Resolution of the President of the Republic of Uzbekistan dated November 28, 2011 № PP-1652 "On measures to further deepen the reform of the health system" and the Cabinet of Ministers of March 29, 2012 № 91 "on measures to further strengthen the material-technical base and improvement of the organization of medical institutions," and other legal documents.
The aims of the research work arc finding the cytostatic compounds -inhibitors of growth of cancer cells with low toxicity for normal cells and compounds accelerating the growth of normal cells without the growth of cancerous cells, and obtaining of hybrid cells (hybridomas) producing monoclonal antibodies to recombinant erythropoietin.
Scientific novelty of the dissertation work is that the first time:
new pharmacological activity of a number of compounds and extracts is identified;
It proved that extracts - from the genus Convolvulus, Vinca major plant and Arundo donax, and endophyte fungi, parasites of the plants of genus Vinca have selective cytotoxic activity on tumor cell cultures;
revealed a selective inhibitor of growth of larynx cancer cells - N-bcnzyl convolvin - derivative of alkaloid convolvin, which isolated from active extract of plants of the genus Convolvulus, docs not inhibit the growth of breast cancer cells, cervical and normal cells;
identified selective inhibitors of growth of cancer cells - n-Cl-phcnylacetic acid, n-Cl-phenoxyacctic acid and iodmcthylat of phenylhydrazonc of norfluorokurarin;
It found that chlorinated alkaloids including derivatives of convolvin and vinkanin, exhibit high cytotoxic activity on cancer cell cultures at a level of the drug Cisplatin;
a method of producing cultures of mesenchymal cells;
It proved that ecdystcronc increases proliferation of normal skin cells -fibroblasts and kcratinocytes, and not increases proliferation of cells of larynx cancer, breast cancer and cervical cancer;
It found that used allofibroblasts together with ecdystcrone increases proliferation autocpidcrmocyts and cpithclialization tissue, which can be used in the treatment of burn wounds;
received hybridoma - producers of monoclonal antibodies to recombinant erythropoietin.
CONCLUSIONS
1. The cytotoxic activity of the genus Vinca plants extracts and fungi endophytes, parasitic on the genus Vinca plants, on the larynx cancer cells cultures - HEp-2, cervical cancer - HcLa, breast cancer - HBL-100 and normal cells fibroblasts, hepatocytes was studied. It established that the extracts of both plants and fungi possess cytotoxic activity. The extract from roots of Vinca major shows greater specificity for HeLa cells, and extract the fungi endophytes Alternaria sp parasitic on Vinca erecta leaves has greater specificity for HBL-100 cells and with low cytotoxicity for normal cells.
2. The cytotoxic activity of total alkaloids fractions from genus Convolvulus, Arundo and Buxus plants was studied. It has been established that alkaloids from aerial parts of Convolvulus krauseanus inhibit the growth of HEp-2 cells, and Arundo donax roots alkaloids inhibit HEp-2 and HcLa cells growth, with low toxicity to fibroblasts.
3. The cytotoxic activity of tropanc alkaloids from genus of Convolvulus and their derivatives was studied. It established that cytotoxic activity depends on the nature of a radical at nitrogen atom of tropanc residue. N-bcnzyl convolvin had the highest specificity, inhibits the growth of HEp-2 cells (IC50 = 12.3 mM/1) with low toxicity for fibroblasts cells (ICso= 32.8 mM/1).
4 The cytotoxic activity of Vinca erecta alkaloid - norfluorocurarin and its synthetic derivatives was studied. It established that iodmcthylate of phenylhydrazone of norfluorocurarin has the highest selectivity to inhibit the growth of HEp-2 cells, HcLa and HBL-100 (IC50 =19,1 mM/1 for all cancer cells) with low toxicity to fibroblasts (IC50 = 95.5 mM/1).
5. The cytotoxic activity of derivatives of phenyl and phcnoxyacctic acids was studied. The selective growth inhibitor of larynx cancer cells - n-Cl-phenoxyacctic acid (IC50 value of 5.2 - 52 mM/1), with low toxicity for normal cells (IC50 = 442 mM/1) was determined. n-Cl-acctylphcnylacctic acid inhibits the growth of cells Hcp-2, HcLa and HBL-100 (IC50 = 4.7 mM/1) and low toxic for normal cells (IC50 = 94 mM/1).
6. The cytotoxic and proliferative activities of phytostcroids were studied. It established that phytosteroidc - ecdystcrone inhibited the growth of cancer cells Hcp-2, HcLa and HBL-100 to 15% and induced of proliferation of normal fibroblastic cells to 80%.
7. The method of obtaining of tissue-engineering construction of skin composed of fibroblasts on basis of collagen substrate for healing of burning wounds optimized. It was shown that the use of ecdystcrone in conjunction with tissue-engineering construction gives 2 times faster epithclialization of burning wounds.
8. The hybridomas producing of monoclonal antibodies to recombinant erythropoietin obtained. The two most promising subclonc of hybrid-producing cells that were subsequently used to obtaining of preparative quantities of monoclonal antibodies to recombinant erythropoietin were selected.
9. The monoclonal antibodies to recombinant erythropoietin obtained from ascites fluid, purified and characterized. It established that the monoclonal antibody to the recombinant erythropoietin was cross reacted with plasma erythropoietin and recombinant, and belong to the class of IgG. The antibody titer in ascetic fluid was 1 x 107, in culture - 2 x 104. The high titer of 4 x 107 showed the total fraction of purified MAbs-EPO.
10. The method for isolation of erythropoietin from human placental blood using of synthesized immunosorbent with monoclonal antibody to human erythropoietin was developed.
11. The Guidelines “Estimation of cytotoxicity of drugs, medical devices, cosmetics, chemicals, pesticides and veterinary goods” (8H-R/18, 02.03.2016) developed and approved.

Topicality and demand of the subject of dissertation. Currently, the ecological conditions of the irrigated lands worldwide deteriorate due to land degradation, desertification and water logging, water and wind erosion, land salinization and soil pollution. «Annually, ca. 40 % of the irrigated areas around the world arc saline to a different degree, 7 million ha are subject to degradation and 25 million ha arc prone to desertification»1.
The activities to raise soil fertility, improve ameliorative soil conditions, rational use of available water resources and increase yields of cotton and other crops arc widely conducted in the irrigated areas of our country. The State programs substantiate the improvement of the ameliorative conditions of more than 1.7 million ha of irrigated land, which allows increasing the yield of cotton, wheat and other crops cultivated in the agricultural farms of Uzbekistan.
Implementation of the hydro-modular zoning is at present very important in the context of the Water Users' Associations and farms together with the improvement of the irrigation system of new cotton varieties. At the same time, there is an insufficient research on hydro-modular zoning of the automorphic, hydromorphic and semi-hydromorphic soils of the Republic of Karakalpakstan depending on the ameliorative and hydrogeological conditions of the regions and on the development of the optimal dates and irrigation norms of medium-fibrous cotton varieties “Chimbay-5018» and «Dustlik-2».
Among the pressing tasks of today is an optimization of the water and salinity balance and nutritional supply regime in the soil root zone taking into account the biological characteristics of these varieties, hydro-modular zoning and development of water use plans and projects of farms in the context of the Water Users' Associations on the basis of the regulatory documents.
This dissertation contributes to the implementation of the tasks defined in the Decree No. 245 of the Council of Ministers of the Republic of Karakalpakstan from November, 21st 2014, adopted in order to fulfill the Decree # PP-1958 of the President of the Republic of Uzbekistan from April, 19th, 2013 «On measures for further improvement of the ameliorative conditions of irrigated areas and the rational use of water resources in the period of 2013-2017», as well as the tasks defined by other regulatory and legal acts.
Purpose of the study is to provide scientific justification of the irrigation system of various cotton varieties, revision and practical implementation of the hydro-modular zoning in the areas of the Water Users’ Associations and farm households.
Scientific novelty of the research:
the agricultural areas of the farms and Water Users’ Associations were subdivided into the hydro-modular zones, irrigation regime of new cotton varieties is improved;
micro-hydro-modular zoning of the irrigated areas was developed for each reclamation zone depending on the cropping area, groundwater level fluctuations, speed of capillary rise;
mechanism of groundwater use by the plant roots was developed based on soil texture, morphological structure of the genetic horizons, sizes of macro and micro-aggregates, salinization degrees, irrigation and fertilizer application norms and biological properties of cotton varieties;
water balance and optimal irrigation dates and norms of cotton varieties «Chimbay-5018» and «Dustlik-2» in the hydro-modular zones were defined,
optimal irrigation regimes for automorphic, semi-hydromorphic and hydromorphic soils were developed based on soil conditions of the amelioration zone and hydro-modular areas;
osmotic pressure of the soil moisture and reduction of concentration of soil solution, increase of moisture during irrigation were identified.
CONCLUSIONS
1. It is recommended the following principles of zoning of the available agricultural land resources taking into account the natural and climatic, soil ameliorative and hydrogeological conditions of farms: automorphic groundwater levels arc at the depths of 3.0 m and deeper, and there is no impact of groundwater; semi-hydromorphic conditions, with groundwater levels of 2-3 m, where the influence of groundwater is weak; hydromorphic, with groundwater levels of 1-2 m and a strong influence.
When performing zoning of the ameliorative regions on automorphic soils, the groundwater rise by capillarity until the root system of cotton is virtually impossible. Equally, sandy, stony, fine-stone soils were not found in the automorphic soils of Karakalpakstan. In the areas of semi-hydromorphic, hydromorphic soils there is sufficient water supply from groundwater through the soil capillaries. Therefore, the principles of the hydro-modular zoning should take into account the texture, structure and composition of the soils up to the groundwater levels.
2. The zoning according to the ameliorative indicators and hydro-modular districts and accounting for the groundwater levels, soil salinity, texture properties, structure and composition of the soils, nine hydro-modular zones were established.
Sandy, heavy loamy and favorable soils arc especially highlighted on automorphic soils by their agrophysical conditions. Therefore, the separate zoning on the individual hydro-modular section was performed. Light and medium-textural soil conditions were subdivided into the separate hydro-modular zones. In the automorphic soils there is no effect of shallow groundwater and therefore the attention was not paid to the structure and composition of the soil profile.
Accounting for the influence on cotton roots, soil texture, and groundwater levels, zoning into the three separate hydro-modular areas was performed: sandy soils, loamy, light and medium textured soils, or heavy soils becoming lighter in the lower profiles; heavy-textured and favorable soils, heavy and multi-layered by structure.
3. The farmers of the Republic of Karakalpakstan sow cotton and grain crops on the area of 468832 ha. The ameliorative regions and hydro-ameliorative conditions have been examined and clarified in these areas. Analyses were performed in the areas of Tahtakupir, Korauzak, Chimbay, Kegeyli, Nukus, Kungirot, Kanlikul, Shumanay and Hudjayli. It was established that automorphic soils occupy 45921 ha, semi-hydromorphic 177503 ha, hydromorphic 108547 ha. These indicators in the Turtkul, Ellikkala, Bcruniy and Amudarya districts arc 5387, 35196, 85358 and 389246 ha, respectively.
4. The zoning of the ameliorative and hydro-modular districts should account for the moisture contribution from groundwater under cotton irrigation. In the semi-hydromorphic soils, light-loamy and homogeneous or favorable areas moisture contribution from groundwater was ranging from 38.7 to 45.1 % of plant water requirements (V-hydromodulc zone). The moisture contribution from groundwater on the heavy texture, layered soils was from 13.7 to 18.9 % of the total crop water use.
On the hydromorphic soils and in the VIII - hydro-modular zones, the moisture contribution from groundwater ranged from 61.2 to 66.9 %, in the IX -hydro-modular zone it was 24.5-28.4%; these indicators have been used to prepare and publish recommendations for all land users and farmers.
5. The changes in soil moisture before irrigation during the period of cotton growth have been observed on ameliorative regions and hydro-modular zones. They were subdivided based on the soil types, groundwater level, soil salinization. In the automorphic soils, groundwater levels of 3 m, soil moisture was 70-75-60 % Fc. In the areas prone to salinization and with the groundwater levels of 3 m and in hydromorphic soils, the soil moisture was 80-80-60 % Fc.
6. In the ameliorative regions and hydro-modular zones, to account for the water consumption during irrigation the depth of the soil layers has been clarified. It is 0-70 cm in the automorphic regions prior to cotton flowering, 0-100 cm during the period of flowering until appearance of bolls and 0-70 cm during the maturing period.
In the semi-hydromorphic soils of the V-VI - hydro-modular zones, these values were 0-50, 0-70, 0-50 cm, respectively. In the hydromorphic soils of the VIII, IX-hydro-modular zones they were 0-50, 0-50, 0-50 cm, respectively. All works were conducted in accordance with the research program. A report has been prepared, which can be considered as a normative document for irrigation.
7. Norms and number of seasonal irrigation works in the hydromorphic and semi-hydromorphic soils have been reduced and increased in the automorphic soils. In the hydro-modular zones, the irrigation norms for cotton have undergone changes depending on soil texture, composition and structure. On the basis of the results of experiments, an order of irrigation works, accounting coefficients and the layers of hydro-modular areas were clarified.
8. Good results have been obtained under irrigation using portable flumes PF-50, the use of this irrigation method allowed saving 23.7 % of water. Compared with the irrigation in furrows of 150-180 mJ of water to produce 0.1 ton of crop yield, the use of PF-50 allows using only 90-100 in3. Thus, wide use of PF-50 can help solving a number of economic and agro-ecological problems. Therefore, a number of agronomic recommendations have been prepared, and the wide application of this method has been advised.
9. The length of furrow with certain soil texture, infiltration rates and the slope on automorphic soils with the width of furrow 60 cm, the length of furrows should be 100-150 m. Water discharge into the furrows should be 0.3-0.6 1 s'1 and depth 12-16 cm. In semi-hydromorphic and hydromorphic soils, the length must be 80-100 m, while the water discharge should not exceed 0.3-0.6 1 s'1.
10. Seasonal water accumulation in the automorphic soils is relatively negligible and thus, it is necessary to apply irrigations in spring with 1200-1800 m3 depending on soil texture, it is necessary to ensure irrigation application before sowing in 0.5-1.0 ha of land.
In the semi-hydromorphic and hydromorphic soils, salt leaching in autumn depends on the water volumes. In case the total application rates arc low, the rate of salinity accumulation will be high. It was observed that leaching volumes were about 3500-5000 m3 to ensure the complete leaching of salts.
11. Examination of the order of irrigation of cotton varieties, the economic efficiency and profitability reached 42.5-47.7% from ha. The labor productivity and profitability of application of the PF-50 have been increased.
12. A system of norms of the water supply into the farms has been developed in accordance with the requirements. Under this system, water supply from the «Kcgeyli» channel for the «Suvchi» WCA and farms is 62.4 million m3. Comparison of these values with the old indicators shows that reduction of 25.7 % of water supply can be achieved while receiving higher yields by utilizing PF-50. The water consumption drops by 27.2 to 30.1 %. The development of the limit water supply plan for the use of water resources along with using it as a normative document has become the basis for a new design of irrigation sector: water supply, irrigation, management of irrigation systems.

The urgency and relevance of the theme of dissertation. As a result of increase in the processing industry in the world, environmental degradation and the effects of unreasonable use of natural resources, namely the growth needs of the industrial sectors in water resources, to humanity on the agenda raise the new tasks as universal problems. The objective of environmental protection is one of the large-scale, the most acute social problems of modern life and of its solution, the corresponding interests of all peoples, which fully determine the future of civilization.
In accord with the principle of sustainable development of the Republic of Uzbekistan an important primary task is the implementation of a harmonious correspondence sequentia macroeconomic planning with nature conservation policy, in close integration with the social and other sectors of policy. Environmental policy of the republic focused advisable goal to combination the transition from individual protected natural elements in general protected ecological systems along with the development of mechanisms based on the principle of guaranteeing the priority indicators of the human environment.
The main object of improving manufacturing processes and nature conservation acticity, is the modernization and reconstruction of industrial enterprises, reducing environmental impact, improving the efficiency of complex and rational use of natural resources through the implementation of environmentally friendly and resource-saving technologies, including energy recovery sources.
Using a large amount of water in the ore and metallurgical and chemical industries requires the implementation of a package of measures to reduce environmental pollution and introduction into production, from an environmental point of view, low-waste technologies. In the metallurgical, chemical and other industries for the treatment of industrial waste water, as well as the extraction of ions from certain metals, sorption ability, ion exchange sorbents and reagents have been widely used.
Due to the increasing needs of the republic in various assortments of ion exchange sorbents, their introduction is appropriate production based on local raw materials. The problem of the treatment of industrial waste water, as well as demineralization, can solve not only environmental issues, namely, to solve the effective implementation of material resources and raw materials of our country, through the production of import-substituting sorbents and reagents.
The presented dissertation is focused on ensuring the implementation of decisions of the President of the Republic of Uzbekistan PP-1442 dated December 15, 2010 «On the priorities of industrial development of Uzbekistan in 2011-2015» and PP-142 dated May 27, 2013 «On the program of action for environmental protection in Uzbekistan 2013-2017», as well as on the permission of the tasks set out in other normative and legal documents, corresponding to the activity.
The research objective is exposure of the possibility of using ion exchange sorbents in the processes of demineralization, wastewater treatment from metal ions in the chemical and metallurgical industries, the development of methods for the obtaining reagents from waste production and effective ion exchange sorbents based on furfural.
The scientific novelty of the thesis research lies in the following:
The scientific novelty of the research is as follows:
There have been obtained the anion exchanger - sorbents, forming with nonferrous metal ions weakly alkaline multifunctional, thermo-chemically stable complex by polycondensation of furfural benzoguanidin with diphenylguanidine;
It has been obtained that monofunctional carboxyl cation exchanger - sorbent with properties of selective sorption for ions of non-ferrous metals and uranium from industrial solutions by condensation of furfural with acrylic acid;
It has been determined that the dependence of the reaction rate constants, activation energies of the temperature, concentrations of initial materials, catalyst amount, and other factors based on kinetic studies of the process;
It has been found that the correlation dependences of the basic chemical, physical and chemical (sorption of ions of calcium, magnesium, copper, nickel, molybdenum and others., sorption capacity, monofunctionality, the degree of dissociation of the functional groups, and others.) on the chemical composition, physico-chemical and adsorption properties of the initial raw materials;
It has been developed that the technology of using local production of furfural and waste from Kungrat Soda Plant for ion exchange polymer sorbents with different functionality and calcium hydrosilicate with predetermined properties for cleaning and softening processes of industrial wastewater and extraction of nonferrous metal ions.
CONCLUSION
1. It has been recommended that approach for the preparation of weakly alkaline of polyfunctional anion sorbents with complex forming properties based on furfural benzoguanin and diphenylguanidine.
2. There has been the way for producing monofunktsional carboxylic cation exchanger - sorbents having selective sorption capacity to the non-ferrous metal ions and uranyl by polycondensation of furfural with acrylic acid.
3. Based on kinetic studies polycondensation reaction of PEPA, furfural and other monomers it has determined that rate constants, reaction activation energy. It has been shown that dependence of sorbents production technology on the reaction temperature, initial materials concentration, amount of catalyst and other factors.
4. It has been found that correlation dependences of the basic chemical, physical and chemical (sorption of ions of calcium, magnesium, copper, nickel, molybdenum and others., sorption capacity, monofunctionality, the degree of dissociation of the functional groups, and others.) on the chemical composition, physico-chemical and adsorption properties of the initial materials suitable for import substitution sorbents.
5. For the first time there has been used the technology of using waste Kungirat soda zavodi to produce calcium hydrosilicate different functionality with predetermined properties to process industrial wastewater treatment.
6. For the first time there has been developed the novel approach for effective purification of industrial wastewater. It has been found that the degree of purification of the wastewater reached up to 94-98% when used as a reagent of 200-600 mg/1 of calcium hydrosilicate and 100-200 mg/1 of aluminum sulphate coagulant. The basic technological scheme has been proposed.
7. It has been determined that the field of using the sorbents on the basis of chemical analyzes, physical-chemical and sorption properties. It has been recommended that their use for cleaning and softening industrial wastewater such as JSC « Kungrad Soda zavodi», JSC «Bektemir spirt-experimental zavodi» and JSC «Uzmetkombinat».

The actuality and relevancy of the subject. In the process of expansion of globalization and the rapid development of high-tech industry, the necessity to strengthen the economic growth and improve the quality of life of any country appears in its innovative activity. The kind of activity, in turn, is linked to the economic, scientific and technical potentials of the state, its innovative policy and resources, the spiritual state of the society. Accordingly, it is significant that a great attention is paid now to the trends of developing international tourism services market, in particular, in the sphere of its innovative development.
The President of Uzbekistan Islam Karimov emphasized at his speech of at the opening ceremony of the 99th session of the Executive Committee of the World Tourism Organization of the United Nations emphasized great significance of forming and supporting of the touristic brand “The Great Silk Road”, via strengthening the touristic status of Uzbekistan and developing the image of its attractiveness, as well as using the touristic resources of Fergana valley, Tashkent, Jizzakh regions39. In solving these tasks a specific role is assigned for the innovative development of tourism as one of the modem forms of service.
During the period of independence the touristic service is interpreted as one of the most perspective sphere of industry and attention to it has risen to the level of state policy. It should be emphasized that in 1993 there were only 4 private touristic firms in our country, however today there arc 800 touristic firms and hotels in private sector of touristic service, including 500 hotels with total volume of 30 thousand of places and approximately 300 tour operators and agents40. As a result of this work, according to the World Travel and Tourism Council index, in 2013 the Republic of Uzbekistan was mentioned among top five countries where tourism develops with the quickest rates.
Further development of tourism in our country aiming to increase its share in GDP (Gross Domestic Product) and provide the population with new employment opportunities asserts the existence of necessity in wide range analysis of tourism marketing services and development of perfect scientific researches which create the basis for promotion of prospective programs. The existence of these problems and the objective necessity of their solution prove the actuality of the subject of this research, devoted to the study of methodological and practical aspects of innovative development of national tourism service market.
Exploration of methodological foundation and practical aspects of improving the tourism service market a notable task of the world science and main attention is focused on following issues: determining out the directions of developing tourism services market and working out the innovative models of development of tourism in terms of national economy.
The dissertation research, in some extent, serves for achievement of strategic goals of innovative development of the tourism service market in the country, formulated in the speech of the President of the Republic of Uzbekistan Islam Karimov at the opening of the 99th session of the Executive Board of the United Nations World Tourism Organization42, as well as the tasks outlined in the Resolutions of the Cabinet Ministers № 53 dated March 10, 2015 "On some issues of tourism development in the Republic of Uzbekistan" and No 51 dated March 9, 2015 "On measures of developing of roadside and tourism infrastructure", as well as other legal acts relating to matters of innovative development of tourism service market.
The aim of the research consists of developing theoretical and methodological principles of improving national touristic service market.
Scientific novelty of the research consists of the following propositions:
proposals for the efficient use of regional tourist and recreational resources, increasing the types of improving the quality and export of touristic service have been developed;
organizational and economic mechanisms of formation of regional tourism and recreation cluster on the bases of effective use of the unique tourist potential of the region and the rapid development of international tourism arc worked out;
on the bases of ordering economic indicators, there has been developed a method for evaluating the effectiveness of tourism enterprises applying the model of dynamic standards;
there is elaborated medium-term forecast of innovative development of tourism indicators in terms of increasing invest attractiveness of the national tourism, strengthening of cooperation between the state and private business, as well as to increase the stream of tourists and formation of a positive image of Uzbekistan as a tourist destination;
CONCLUSION
The results of the research outlined in the doctor’s thesis on the theme "Improvement of methodological and practical bases of innovative development of the national touristic services market" allow to make the following conclusions:
1. In the process of research there were ascertained those groups economic and social factors having an immediate influence on the development of national tourism services market and its content was explored. The conceptual trend of classification of markets into different types and groups were determined.
2. For stable development of national tourism services market it is required to inquiry not only the sphere of tourism, but also the employment of methods of complex approach taking into consideration the activity of other relative branches of economy. Such method can be realized by adoption of a cluster model which unifies in its body the homogeneous branches, organizations, factories with a unique goal. As the result of research of the innovative development process of tourism services market the conceptual directions of forming of touristic-recreational model in conditions of Uzbekistan arc recommended.
3. In strategic decisions taken by the government there were outlined several important factors determining effectiveness of national tourism. These factors serve as methodological base for innovational development of tourism and realization of scientific researches aiming to define principles of optimal ways of forming touristic market. Accordingly, the optimal directions of innovative development of tourism services market were proposed.
4. Review of the modern state of the country’s economy convinces us of the existence of respective macroeconomic conditions for forming and successful realization of national innovative system in Uzbekistan. The main directions of forming national innovative system arc organized on the base of the Republic of Uzbekistan’s policy. In the correlation model the of elements of national innovative system proposed by author, the role of State consists of creating favorable institutional climate and infrastructure for private, organized, social and state structures, as well as developing complex technologies and fundamental knowledge of strategic importance for innovative activity. Proposed model of  correlating elements of national innovative system serves for elaborating the law and conception about future innovative activity of the Republic of Uzbekistan.
5. Formation of touristic clusters in the regions of Uzbekistan gives an impulse to the opening of new travel companies and complete activation of existing touristic-recreational resources and creation of new touristic production. Therefore the algorithm of model of forming and development of touristic-recreational cluster proposed may employ the potentials of the state and local organs, research institutions as well as employers.
6. Nowadays in many countries a total touristic brand of region is being formed, many countries help in advancement of national touristic production in the world market of tourism. As a consequence, it becomes necessary to run in cooperation with specialists and researchers a scientific project with an attractive title “Uzbekistan” on creation of a total touristic brand of the country for advancement of the national touristic products into the world market.
7. For more deep research in the tourism services market system there was suggested the method of application of the dynamic norms model in determination of system effectiveness of touristic firms management and its automatic computer program was elaborated.
The future development of researches in sphere of statistics of tourism in Uzbekistan is connected with the governmental support with application of the system of auxiliary calculations of tourism which is integrated into the national system of accounts of country. This model is necessary to be realized for specialized touristic sub regions, as well as for regions which have a big part of incomes in gross regional output derivable from tourism.
8. For determination of innovational development scale of tourism services market there was recommended to use the index “coefficient of intensity of tourism” by means of specific methods. These calculations are offered to use in practical statistics.
9. Elaborated by the author science-based innovative forecast is suggested along with facilitates to increase the investment attractiveness in the sphere of tourism in Uzbekistan, for consolidation of the State and private business collaboration. It serves to form an appropriate notion of touristic destinations of our country and effective activity of touristic firms.

Topicality and relevance of the dissertation theme. Water is the main limiting strategic resource in arid areas that determine the development of all sectors of the economy. Addressing issues of water supply has become an essential and complex contemporary scientific-technical problem, as «...coming to 2030 global deficiency of water resources in the planet will reach to 40 %...Global consumption of water in 2050 will increase up to 55 % »'. Population explosion and intensive development of economy intensifies shortage of water resources. Especially, that applies to areas with limited natural water resources where stable development depends on water transboardcrcd rivers.
In this regard, during the years of independence, the leadership of the Republic of Uzbekistan adopted a number of decisions to address the urgent problems of the country. «Water is considered as one of the main causes of climatic changes. Fighting against escalating risks and uncertainties of natural disasters is essential for elaboration of methodic and effective mechanisms of regulations»
With climatic global changes, development of advanced technic solutions for improving hydroccologic and meliorative-hydrologic conditions of irrigated lands in arid areas is required, including modernized technologies and methods of managing dynamics of moisture and salination conditions in aerated zones, subirrigation, water demineralization and soil melioration, principles of struggle against salination and erosion on the bases of complex experimental-theoretical analysis and forecasting main irrigation tendencies, that arc needed for practical usage by irrigational and agricultural organizations.
This dissertation research serves as fulfillment of tasks, listed in the Decree of the President of the Republic of Uzbekistan (№ UP - 3932 of 29.10. 2007) «On measures on radical improvement of land reclamation», the Decree of the President of the Republic of Uzbekistan from 19 april 2013 № PP - 1958 «On measures of further improvement of irrigated land and water management for the period 2013-2017, » Resolution of the Cabinet of Ministers R. Uz from 20 may 1999 № 259 «On holding irrigational-mcliorative works for the period of 1999-2000», from 21 july 2003 № 320 «On Improvement of Water Management», from 19 march 2013 № 82 "On Approval of the order of water use and consumption in the Republic of Uzbekistan" and other standardizcd-lcgal ducumcnts, accepted in this field.
Purpose of research is to develop waterproof hydroccologic technologies and meliorative-hydrologic methods.
The scientific novelty of research is as follows:
enhanced the principles of the creation of anti-filtering screen at a given depth of groundwater;
scientifically proved through sub-irrigation development of devices for controlling runoff and drainage schemes «Cascade»;
proposed water saving and soil-protective method, preventing irrigation erosion in flat gypsum soils;
for the first time recommended chemical meliorants, depressing soda salinization of soil with forming effective fertilizing- chili saltpetre;
developed metods of water demineralization;
suggested the technology of increasing efficiency of precipitation, irrigation and groundwater plants, which in-leads to the prevention of negative phenomena, improve productivity and increase the aeration zone energy (exergy);
CONCLUSION
1. Strategically-limiting nature of the region's water resources is justified by theoretical analysis of a representative period, the priority of water management characteristics of mathematical statistics, which confirms the correctness of the differentiation of natural water conditions and is the first experience of area-regional zoning in modem terminology. It is a type of application and geographical regionalization is to allocate natural water complexes (PVCs), considering historical administrative boundaries with a single natural base, which revealed new negative hydro-ecological and hydrological processes, to develop a set adaptive solutions for each upgraded PVHR.
2. Proven fundamental theory of metamorphism chemical composition of water to predict the state of irrigated lands of the arid zone. Updated formed ionsalt composition of water resources in the region. It is shown that metamorphism chemical types of groundwater well consistent with the types of soil salinity (at V.A.Kovda et al.).
3. The basic laws metamorphose waters in the region, which grow in the opposite direction (leaning toward hydro carbonate type) in the following order: surface water and groundwater PVHR upper- middle PVHR groundwater and sub - bottom PVHR groundwater. This was the theoretical basis for the projections of a new salinity (alkalinity) of soil at watcring-NII. It was found that the local areas may receive soda salinity in the above manner (3-5 years), t. E., To the geographic shift hydrocarbon groundwater in the southern and south-western directions, which is a form of modem desertification areas.
4. Substantiated the fundamental meaning of the "critical depth interval of occurrence of GW on the main reclamation - hydrological factors - groundwater salinity. Experimental and theoretical method developed principles for the determination of the NKR.
5. It was revealed that a qualitative change in the composition of the salts in the aeration zone by prolonged leaching irrigation regime on the background and the natural drainage leads to increased removal of non-toxic salts. This process is activated by leaching calcium sulfate (gypsum), which prevents the development of processes of alkalinity. In this connection it is necessary to change the ideology of drainage systems through the introduction of sub-irrigation technology in the range of 2 - 3 g /1 total mineralization GW.
This allowed for the first time the arid zones of the region to develop a modernized devices to regulate the drainage flow in order to introduce subirrigation through groundwater management by sticking to the depression of the curve in the range of the critical depth of the GW. We also propose the optimal formula for calculating the cascade devices. These facilities arc also recommended to arrange for sprinklers and river network.
6. An ecological and economical way of water demineralization, Ba-vanny on gas hydrate technology as one of the fundamental solutions to the water problem by preserving and protecting the resources of fresh surface water and groundwater in the arid zone by utilizing miner-ized water (2 - 3, 200 - 300 g /1).
7. Developed a method of soil desalinization chemical amcliorants it solves the dual problem of reclamation - soda salinization and suppresses the formation of nitrogen fertilizer blends (Chilean nitrate NaNO3).
8. In order to improve reclamation- hydrological conditions of local zones of aeration is provided a method of isolation of groundwater within the hydrogeological windows to prevent flooding (or draining) and salinization, which is due to thinning (or infiltration) mineralized GW in irrigated areas.
9. An analysis of experimental and theoretical studies Mclio-way radio has reduced the soil's physical and productive increase evaporation (transpiration), to improve the conditions of hydro-aeration zone, increase drought tolerance, overall biological activity, energy capacity, connectivity and productivity of soils.
10. Sound technologies subirrigation, demineralization and grind-orations contributes to accomplish the total water circulation technology in the scheme of complex use and protection (integrated management) of water.
11. Theoretical and field studies revealed patterns of irrigation erosion in flat gypsum soils. Designed upgraded method of combating comprising conjunction with the sowing of crops convolutions making up the bottom of the cutting grooves on the surface of the natural soil amcliorants (together or separately) - expanded vermiculite and firing (or) perlite and montmorillonite, bentonite and kaolin.
12. Identified patterns and results of this work should be considered identical subarid parts of the world.

Topicality and demand of the theme of dissertation. Last years soil salinity became one of the sharpest global problems of agriculture. Especially it concerns the countries with arid and semiarid climate. Thus in the world about 955 million hectare arc saline1 from which approximately one-third is considered saline with Na' ions.2 Salinization promotes fast degradation of agricultural lands. The cause of it is that many crops cannot normally grow in saline soils because the established microbioccnoses get broken and soil becomes practically lifeless.
One of the effective approaches for the solving of this problem is selection and introduction of salt-tolerant plant-microbial symbioses on problem lands. The most suitable for this arc legumes, particularly chickpea. However chickpea is very sensitive to soil salinization. Depending on concentration of salts in soil the quantity of seedlings considerably decreases, plants turn out undersized with poorly developed root system, immunity considerably declines, that as result leads to diseases and destruction of the plant. Soil salinization practically breaks symbiotic relations between legumes and rhizobia. Formation of nodules, atmospheric nitrogen fixation and nitrogenase activity as a result decreases. In particular many strains of nodule bacteria arc lost, that prevent the formation of effective symbioses.
Besides the big problem arc phytopathogcnic fungi causing chickpea root diseases. In separate years they result in to significant losses of crop and to decrease in its quality. It is known, that some microorganisms arc capable to inhibit the growth of phytopathogcnic fungi, for the account of such properties as production of hydrolytic enzymes, siderophores, HCN etc. One of the most effective microorganisms in this respect arc some representatives of genus Pseudomonas, which arc also promote decrease in various stresses at plants, thereby raising their tolerance to unfavorable biotic and abiotic environmental factors. However till now is not clear what role can play these bacteria in rhizobial-leguminous symbiose, and also their influence on a chickpea in the saline soils conditions is not studied enough. In this connection search of the effective salt-tolerant strains of nodule bacteria and pscudomonades, study of their effect on a chickpea in salinization conditions and creation on their basis of the effective competitive biopreparations for a chickpea growth and development improvement and also for its root diseases control in the saline soils conditions is an actual goal.
This dissertation research to some extent serves to carry out the tasks provided in the Resolution of the Cabinet of Ministers of the Republic of Uzbekistan Nol42 «On the Program of measures for protection of the environment of the Republic of Uzbekistan for 2013 - 2017» of May 27, 2013, as well as in other legal documents adopted in this area.
The aim of the research is creation of the effective biopreparation on the basis of growth-promoting rhizosphere microorganisms for improvement of chickpea productivity in the salinization conditions.
Scientific novelty of research consists in the following:
from nodules and rhizosphere of a chickpea cultivated on saline soils, isolated growth promoting bacterial strains, related to genuses Pseudomonas and Mesorhizobium which were identified accordingly as Pseudomonas chlororaphis-66 and Mesorhizobium ciceri-4 by means of method of 16S rRNA nucleotide content sequence definition;
received rifampicin-resistant strains of these bacteria thanks to which it was possible to define their colonizing abilities in chickpea root system;
for the first time established that Pseudononas chlororaphis-bb promotes active nodule formation in chickpea, and also raises its immunity, productivity and resistance to phytopathogcnic fungi;
studied various properties of strains M. ciceri-4 and P. chlororaphis-66, influencing chickpea growth and development, and also factors which arc responsible for biological control of phytopathogcnic fungi, causing chickpea root diseases;
for the first time established, that various chickpea breeds synthesize exudates of different nature (sugars, acids, amino acids) in different quantities and secrete them through the root system;
by fractionating of root exudates in the column with ion-exchange resin Dowex, 3 fractions: cationic (histidine, arginine, lysine, cysteine, serine, glycine, серин, глицин, asparaginic acid, leucine, isoleucine and alanine), anionic (gluconic, galactonic and mannuronic acids), neutral (glucose, galactose, arabinose, xylose and ribose) arc received;
defined that attractive ability of separate fractions (attraction region (cm): cationic-1.0; anionic-0.6; ncutral-0.8) is lower, than total (attraction region - 2.8 cm). The mixture of cationic and neutral fractions possesses higher attractive ability, than mixture of cationic and anionic and mixture of anionic and neutral fractions;
for the first time on the basis of selected strains Pseudomonas chlororaphis-66 and Mesorhizobium ciceri-4 is developed the new biopreparation «Pseudorhizobin».
1. Шурыгин В.В., Лян Ю.В., Жаббарова Д.П., Бурисв Т.Х., Эгамбсрдисва Д.Р., Давранов К. Банк ризосферных бактерий с антифунгальной активностью// УзМУ хабарлари, 2011. - №2. - С. 132-134.
2. Эгамбсрдисва Д., Жабборова Д., Шурыгин В., Эргашева У., Давранов К. Физиологическая характеристика ризосферных бактерий рода Pseudomonas, выделенных из засоленных почв Узбекистана// УзМУ хабарлари, 2011. - №2. - С. 128-131.
3. Egamberdieva D., Shurigin V., Davranov К. Colonisation of Pseudomonas chlororaphis TSAU13 and Pseudomonas extremorientalis TSAU20 in the rhizosphere of wheat under salt stress// Узбекский биологический журнал, 2011. - №4. - С. 26-29.
4. Шурыгин В.В., Нахалбасв Ж.Т., Давранов К. Влияние инокуляции семян нута бактериями Rhizobium и Pseudomonas на рост и развитие нута в условиях засоления// УзМУ хабарлари, 2012. - №4. - С. 35-40.
5. Лян Ю.В., Шурыгин В.В., Эгамбсрдисва Д.Р., Давранов К. Выделение и характеристика новых активных штаммов рода Pseudomonasll Доклады академии наук Республики Узбекистан, 2012. - №4. - С. 65-70.
6. Шурыгин В.В., Эгамбсрдисва Д.Р., Нахалбасв Ж.Т., Хаитов Б. Скрининг некоторых генотипов нута по устойчивости к засолению в засоленных, засушливых почвах Узбекистана// УзМУ хабарлари, 2012. - №4. -С. 38-39,44-45.
7. Лян Ю.В., Шурыгин В.В., Ражабов У.Р., Давранов К. Микробиопрспараты на основе ризосферных бактерий и их использование в сельскохозяйственной практике// УзМУ хабарлари, 2012. - №4. - С. 49-52.
8. Шурыгин В.В., Давранов К. Выделение и очистка бактерий семейства Rhizobiaceae, а также отбор штаммов, способных к образованию эффективных симбиозов с нутом// Узбекский биологический журнал, 2013. — №2.-С. 17-22.
9. Шурыгин В.В., Давранов К. Физиологическая характеристика и изучение свойств штамма Mesorhizobium ciceri-4, способствующего росту и развитию нута в условиях засоления// УзМУ хабарлари, 2013. - №4 (2). - С. 244-250.
10. Шурыгин В.В. Бактерии рода Pseudomonas, стимулирующие рост и развитие нута (скрининг)//УзМУ хабарлари, 2013. -№4 (2).-С. 184-186.
11. Шурыгин В.В., Эгамбсрдисва Д.Р., Давранов К.Д. Азотфиксирующая активность почв прикорневой зоны нута (Cicer arietinum L.), хлопчатника (Gossypium hirsutum L.) и пшеницы (Triticum aestivum Доклады академии наук Республики Узбекистан, 2014. - №4. - С. 69-72.
12. Шурыгин В.В., Эгамбсрдисва Д.Р., Давранов К.Д. Механизмы влияния Pseudomonas chlororaphis-frf> на рост и развитие нута в условиях засоления// Узбекский биологический журнал, 2014. - №3. - С. 16-21.
13. Шурыгин В.В., Эгамбсрдисва Д.Р., Давранов К.Д. Сравнение микробной активности в ризосфере нута (Cicer arietinum L.), хлопчатника (Gossypium hirsutum L.) и пшеницы (Triticum aestivum L.)// Узбекский биологический журнал, 2014. -№4. - С. 14-19.
14. Egambcrdieva D.R., Shurigin V.V., Gopalakrishnan S., Sharma R. Growth and symbiotic performance of chickpea (Cicer arietinum') cultivars under saline soil conditions// Journal of Biological and Chemical Research, 2014. - Vol. 31, No. 1. - P. 333-341. (№5. Global, IF=0,756)
15. Shurigin V.V. Technology of creation of complex microbiological «Pseudorhizobin» preparation improving chickpea growth and productivity in salinity conditions// International Journal of Advanced Biotechnology and Research, 2014. - Vol. 5, No. 2. - P. 262-270. (03.00.00. №9)
16. Shurigin V.V., Davranov K. Abdicv A. Screening of salt tolerant rhizobia for improving growth and nodulation of chickpea (Cicer arietinum) under arid soil conditions of Uzbekistan// Journal of Biological and Chemical Research, 2015. -Vol. 32, No. 2. - P. 534-540. (№5. Global, IF=0,876)
17. Egambcrdieva D., Jabborova D., Lyan Yu., Shurigin V., Davranov K. Colonisation of Pseudomonas chlororaphis TSAU13 and Pseudomonas extermorientalis TSAU20 in the rhizosphere of wheat under salt stress// Proceedings of the 2nd Asian PGPR Conference on Plant Growth-Promoting Rhizobactcria (PGPR) for sustainable agriculture. - Beijing (P.R. China), 2011. -P. 486.
18. Эгамбсрдисва Д.Р., Шурыгин В.В., Давранов К. Увеличение плодородия и продуктивности засоленных засушливых почв при использовании бактериальных удобрений// Аграрная наука - сельскому хозяйству: VII Международная научно-практическая конференция. - Барнаул (Россия), 2012. - Сборник статей, кн. 2. - С. 257-258.
19. Shurigin V.V. Improvement of growth and development of chickpea under arid saline soil conditions// «Охрана окружающей среды в Узбекистане: её состояние в настоящие дни и пути развития»: научно-практический семинар, посвященный Всемирному Дню охраны окружающей среды. -Ташкент, 2013.
20. Шурыгин В.В., Давранов К. Выращивание нута, с применением препарата «Псевдоризобин» - одно из решений проблемы деградации почвы пастбищ// Яйловлардан окилона фойдаланиш ва мухофаза килишнинг институционал масалалари: Республика илмий-амалий конференция. -Ташкент, 2013.-С. 174-178.
21. Shurigin V.V., Davranov К. The new bacterial preparation increasing potential of a chickpea in carbon sequestration and improving soil fertility// The soil resources of Uzbekistan: status, protection and the perspectives of their rational using: scientific-practical conference. - Tashkent, 2013. - P. 113-115.
22. Shurigin V.V., Davranov K. Biotechnological aspects of creation of complex symbiotic «Pseudorhizobin» preparation specific to a chickpea on the basis of aboriginal bacterial strains// Regional conference of young scientists on Recent trends in physical & biological sciences. - Bangalore (India), 2014. - P. 65.
23. Шурыгин В.В. Биоконтроль фитопатогенных грибов, вызывающих корневые болезни нута, при помощи PGPR, в условиях засоления почвы// Ломоносов-2014: Тез. докл. XXI Международной научной конференции студентов, аспирантов и молодых учёных. - Москва (Россия), 2014. -С. 229.
24. Egambcrdieva D., Jabborova D., Shurigin V. Microbial population in the rhizosphere soil of various crop plants as affected by salinity// 20th World congress of soil science. In commemoration of the 90th anniversary of the IUSS. - Jeju (Korea), 2014.-P. 342.
25. Шурыгин В.В. Корневые экссудаты нута (Cicer arietinum L.), как ключевой фактор его урожайности при применении биопрепаратов// Ломоносов-2015: Тез. докл. XXII Международной научной конференции студентов, аспирантов и молодых учёных. - Москва (Россия), 2015. - С. 360-361.
26. Shurigin V.V., Davranov К. «Pseudorhizobin» - the new biological preparation increasing chickpea yield in salinity conditions// Soils of Uzbekistan and resource saving technologies of improvement of their fertility: scientific-practical seminar. - Tashkent, 2015. - P. 10-13.
27. Egambcrdieva D., Shurigin V., Gopalakrishnan S., Shanna R. Microbial strategics for the improvement of legume production in hostile environments// In: Legumes under environmental stress: yield, improvement and adaptations. Editors: Azooz M.M., Ahmad P. - UK: John Wiley & Sons Ltd., 2015. - P. 133-144.
28. Давранов К.Д., Шурыгин В.В., Буриев Х.Ч., Уббиниязова Д. «Псевдоризобин» биологик прспаратини шўрланган тупрокларда нўхат экинига қўллаш самарадорлиги// Тавсиянома. Т.: Тош ДАУ таҳририят-нашриёт бўлими, 2015. - 23 с.
29. Shurigin V.V., Davranov K.D. The new bacterial strains for «Pseudorhizobin» biological preparation increasing chickpea fertility in soil salinity conditions// Атроф муҳитни ўзгариши шароитида ср рссурсларини муҳофаза қилиш ва улардан оқилона фойдаланиш масалалари: Республика илмий-амалий семинар маърузалари тўплами. - Тошкент, 2016. - С. 545-551.

Actuality and demand of the theme of dissertation. Due to the rapid development of scientific and technological progress in the world mathematical methods have become an important tool in the control of complex systems. In the control of many economic and technical processes it also needs to take into account conflict of different participants. In this regard, it has been created a new branch of mathematics, theory of dynamic games, which consists of two components - the theory of discrete and differential games. In today’s complex market relations in solving many economic and technical problems these theories find their important applications.
After our country gained its independence, in order to promote science and technology a number of reforms have been developed. The President of Uzbekistan decrees dated 7 August 2006 "On measures to improve the coordination and management of the development of science and technology", and of 15 July 2008 "On additional measures to stimulate innovative projects and technologies" and other legal acts of fundamental sciences and their application in various projects were highlighted. Differential games set as the theory of development of mathematical methods of control processes, combines the dynamism, control, fighting, awareness, and optimal number of other important qualities, and represent one of the most complicated mathematical models of real processes having great practical importance.
In the vast majority of works devoted to differential games of pursuit-evasion, it was considered systems in which control were chosen only from the class of bounded functions. Such geometry constraints imposed on the control expressed some constructive opportunities controlling device. The desire for greater adequacy of mathematical models to practical problems led to the necessity of studying differential games with integral constraints on the player controls. Such restrictions express, for example, limitations of energy control, a decrease of other substances, which are spent during the process. Especially in the study of mathematical models of technical processes constraints of this nature it is important in scientific and applied aspect.
The need for the study of control systems in the general statement of requires consideration of models when on the control it is imposed simultaneously both types of geometric and integral constraints, or their linear association. The relevance of the thesis is to develop the foundations of differential games in the direction of pursuit-evasion theory under various constraints on the player controls in the construction of adequate mathematical models to counteract the controlled processes, as well as the development of methods to solve such problems, allowing the development of the theory of mathematical methods of management and fundamental and applied aspects.
The aim of the research is to build a unique parallel prosecution strategy for integrated, linear and different types of restrictions on the controls of players and their application to solving problems of pursuit-evasion.
Scientific novelty consists of the following:
to meet the challenges of persecution, escape with simple movements of the players, when control of players imposed or geometry, or integral, or both geometric and integral constraints pursuer, built parallel prosecution strategy and set of new features, and lower estimates of convergence are obtained for the runaway problem;
It introduces a new concept called a linear constraint on the class of player controls, which contains as a special case and integral, and geometric constraints for the respective types of games built strategy of parallel proceedings;
we solve the problem of the Isaacs-Petrosyan's game with the "life line" when player movement described by linear differential equations, and in the management of players imposed geometric integrals-General or comprehensive restrictions in certain combinations;
method of resolving functions is applied to the solution of the problem of group pursuit with integral constraints on the player controls, and new sufficient conditions for the solvability;
sufficient conditions for the solvability of the group pursuit tasks to control example of Pontryagin, as well as the problem of "/-catch" in the case of integral constraints on the control.
CONCLUSIONS
1. The problems of pursuit-evasion is solved, when the points move without inertia and controls of the players satisfying integral, heterogeneous and complex constraints. For these cases constructed analogues of parallel strategies to ensure optimum convergence.
2. In first considered differential games with a new type of linear constraints on controls, reinforcing the traditional integrated and geometric constraints.
3. A complete solution the problem of pursuit-evasion, when the pursuer linear control imposed restriction, and control of the evader - purely geometric, the validity of the theorem on the alternative Krasovsky.
4. The solution of the problem of harassment in the case where the control of the pursuer and evader imposed linear constraints, appropriate strategies are built parallel to prosecution, as well to guarantee optimal convergence.
5. Investigate problems Isaacs-Petrosyan's game with the «life line», when the players of the same type of movement described by linear differential equations with several types of constraints on the player controls, obtained ratio expresses the change in the dynamics of the set meeting points.
6. Development of a method of resolving functions in relation to the problem of group pursuit with integral constraints on the player controls, obtain new sufficient conditions for the solvability of the pursuit problem in the production of Pontryagin.
The work is theoretical. The basis of the theory of differential games occupies a central place to build and ensure optimal strategies for the players. The scientific value of the results of research is to build such strategies under various constraints on the control and use. Note that the results in terms of content will form the basis of a new direction in the theory of controls.

The urgency and relevance of the theme of dissertation. The main focus in the development of medicinal products is to create drugs based on biologically active substances derived from local herbs.
The biological variety of flora of Uzbekistan serves as the potential source of valuable bioactive substances perspective for the use in medicine and agriculture. Among the wide spectrum of endemic plants the special attention is attracted by garden fennel flower - Nigella sativa L., related to family of buttercup - Ranunculaceae.
Seeds of garden fennel flower Nigella sativa have a variety of applications: as a highly effective diuretic, choleretic, mild laxative and immunostimulatory agent. In addition, some of the components provide excellent results in the treatment of various dermatological diseases associated with histamine neurohumoral and irregularities in the body. In dermatology used in atopic dermatitis, idiosyncracies, restore skin immunity, have a powerful antioxidant effec , eliminates stagnant processes of the skin.
Research of natural connections showing antimicrobial activity has both a theoretical value - for the study of molecular components and mechanisms of resistance of plants to pathogens and large practical value in agriculture and medicine. Major application antimicrobial proteins and peptides can find in medicine, as an alternative to the traditionally used antibiotics and antimicotics. It is known that as a result of wide use of antibiotics in medical practice in the last decades, for microorganisms the mechanisms of stability were produced. As a result there were strains steady to majority used presently to the antibiotics. Antimicrobial proteins and peptides in this plan are extraordinarily perspective, as they possess the wide spectrum of action, operate quickly and effectively, does not cause negative consequences.
Chemical composition of seed of garden fennel flower is studied well enough. Isolatee and characterizes lipids, carbohydrates, phenolic compounds, however the peptides contained in seed have not been studied, therefore the search of new high active antimicrobial proteins and peptides from garden fennel flower sowing and their all-round study is perspective direction and the problem of search and selection of new similar connections is very actual.
This dissertation research to some extent serves to carry out the tasks provided in the Resolution of the Cabinet of Ministers of the Republic of Uzbekistan №404 «On measures to support domestic manufacturers of drugs and medical products» of July 14, 2006, as well as in other legal documents adopted in this area.
The aim of research works is to develop methods for the isolation of individual cysteine-containing peptides from black cumin seeds, the establishment of their application in medicine and to pharmaceutical compositions on their basis.
Scientific novelty of the research work is as follows:
for the first time a systematic study of cationic peptides in seeds and seedlings of fennel flower garden Nigella sativa',
from the seeds of fennel flower garden recovered new lipid transfer protein Ns-LTPl with a molecular weight of 9602 Da containing 8 cysteine residues, to which the primary structure is installed and the data registered in the database BLAST;
isolated and characterized in detail 6 new peptides (Ns-Dl, Ns-D2, Ns-Wl, Ns-W2, Ns-Nl andNs-Gl).
it is shown that two new peptide homologous Ns-Dl and Ns-D2 with molecular weights of 5485 and 5498 Da, possess a strong inhibitory activity against phytopathogenic fungi;
defined that peptides Ns-Wl and Ns-W2 with molecular weights of 5143 and 5070 Da contain 8 cysteine residues and homologous y-purotionins cereals;
determined that Ns-Nl peptide with a molecular weight of 5696 Da in its composition contains 8 cysteine residues, is unique in the established N-terminal amino acid sequence;
defined peptide Ns-Gl with a molecular weight of 2794 , contains six cysteines in its structure and refers to a new class cysteinrich peptides, which have no analogues in molecular weight and the number of cysteine residues among the known antimicrobial peptides;
a comparative analysis of the spectrum of peptides in seeds and seedlings and found that seedlings blackie contains lipid transfer protein Ns-LTP2 with a molecular weight of 9086 Da, and 10 peptides related to defensins В-type, absent in the seeds.
CONCLUSION
1. A method for isolation of individual AMP from black cumin seed and seedling seed Nigella sativa, including acid extraction and complex chromatographic methods - affinity, size exclusion, high performance liquid chromatography.
2. From the seeds of black cumin isolated a new lipid transfer protein Ns-LTP1 with a molecular weight of 9602 Da, containing 8 cysteine residues, set the primary structure on which revealed that it belongs to a class of proteins lipid transfer. Ns-LTPl registered in the EMBL database with the identification number r86527. Determined biological activity against phytopathogen different groups; The effect of Ns-LTPl on the conductivity of the membrane clamp technique with planar bilayer phospholipid membranes. Based on these data suggested one of the possible mechanisms fungitoxicity LTP.
3. Select two homologous peptide Ns-Dl and Ns-D2, set their complete amino acid sequence and belonging to the class of defensins, shows homology to the peptides of the family Brassicaceae. Defensin Ns-D2 showed the highest antifungal and anti-microbial activity. At a concentration of 3.4 pg/ml defensin Ns-D2 destroying plasma membrane conidia B.sorokiniana.
4. Highlight the new peptide Ns-Nl with a molecular weight of 5696 Da, containing 8 cysteine residues. Based on the determination of the partial N-terminal amino acid sequence determined that the peptide has no homology to known peptides. Pending the EMBL database for the registration of a new homologous series family Ranunculaceae, containing this peptide.
5. Highlight peptides Ns-Wl and Ns-W2 with molecular weights of 5168 and 5070 Da homologous y-purotionins cereal. Installed partial N-terminal amino acid sequence.
6. First of black cumin seeds isolated peptide Ns-Gl, containing 6 cysteines its composition and consisting of two polypeptide chains joined by intra- and interchain disulfide bonds. The peptide is unique in its structure and has no structural analogues among known cationic peptides.
7. From seedling fennel flower garden allocated lipid transfer protein Ns-LTP2 with molecular weight 9086 Da and ten peptides related to defensins B-type, which is defined molecular weight and the number of cysteines.
8. The compounding ointment "Sedanil" based on black cumin seed oil and total peptides. Conducted preclinical pharmacological tests have shown high activity of wound-healing ointment proposed.
9. Projects of TFA to "Black cumin seed Nigella sativa", "Complex polypeptides" and "Pharmaceutical composition" and executed in accordance with the requirements.

The urgency and relevance of the topic of the dissertation. Under conditions of the continuing international financial crisis, the significance of efficient economic potential management in enterprises is growing. At the current moment, according to the experts of United Nations (Organization), factors which inhibit economic growth worldwide are «stagnant investment and diminishing productivity growth; continued disconnect between finance and real sector activities»35.
Thus, systematic reforms and deep structural economic reorganizations for stimulation of high growth rates in our country are targeted at the creation of «favourable conditions for the attraction of foreign direct investments, improvement of stock companies performance, promotion of their transparency and attractiveness for potential investors, introduction of up-to-date methods of corporate governance, empowerment of shareholders in strategic company management»36. Moreover, efficient corporate governance affects economic indicators of enterprises and their ability to attract capital, essential for potential economic growth. Thus, corporate governance is an important requirement, which identifies enterprises, including those with foreign investments, development.
Herewith «the main target for us should be continuous technological and technical renewal of production and continuous search of internal reserves, deep structural economic reorganizations, modernization and diversification of the manufacturing sector».
All that requires improvement of economic potential management mechanisms at foreign invested enterprises aimed at ensuring stable financial indicators and transparency in compliance with international financial reporting standards under the current macroeconomic policy. Therefore, it is reasonable to employ value principal for the management of economic potential at foreign invested enterprises. This principal is based on the just value concept. Under this concept, it is possible to disclose the essence and nature of enterprises, to form aims, methodology and strategy of their economic potential management, to solve existing problems systematically and fully.
The dissertation to a certain extent may contribute to implementing the tasks specified in the Decree by President of the Republic of Uzbekistan dated April 24, 2015 No UP-4720 «On measures aimed at introduction of the modern methods of corporate governance in the joint-stock companies» and the Resolution by President of the Republic of Uzbekistan dated December 21, 2015 No PP-2454 «On the additional measures aimed at attraction of the foreign investments into the joint-stock companies», as well as in other normative-legal acts related to this activity.
The aim of the research work is to improve the methodological bases of management of the economic potential of foreign-invested enterprises and the development of mechanisms of complex-balanced transparent management.
The scientific novelty of the research work is as follows:
there was justified the value principle for systematic presentation, investigation and management of economic potential at foreign invested enterprises depending on the potential of business property turnover, the potential of human resources and owners;
for the first time there was developed theoretical and methodological basis of complex-balanced model of transparent management of economic potential at foreign-invested enterprises and enhanced methods of its evaluation and empirical analysis;
there was developed a strategy of ensuring transparency of domestic foreign invested enterprises in compliance with International Financial Reporting Standards under the just value principle, depending on the real value and objective market price;
there were developed schematic mathematical multifactor models of complex-balanced value based management of economic potential at foreign invested enterprises;
there were defined implementation perspectives of the complex-balanced model for transparent value based economic potential management at foreign invested enterprises.
CONCLUSION
The conducted research on the topic «Improving the mechanisms of management of economic potential of foreign invested enterprises in Uzbekistan» led to the following conclusions:
1. The major prerequisites for improving of mechanisms of value management of foreign invested enterprises’ economic potential are micro and macroeconomic conditions, a favorable investment climate, sufficient resources and necessary reserves existing in Uzbekistan, and the potential of state programs of development of the corporate sector and its management system under the «Uzbek model» of development.
2. Foreign invested enterprise is a property mixture, which consists of properties of the owners, employees and economic turnover, and an object of socio-economic-information-legal relations provided with a corresponding operating mechanism, economic potential, legal structure, developed software. Based on these factors, foreign invested enterprise is a source of value, price and goodwill, entrepreneurship revenue and risk.
3. Foreign invested enterprises in Uzbekistan should be considered as an economic entity created under any legal and organizational structure, in which a part of authorized capital consists of investments in hard currency made either by individuals or by legal entities, either residents or non-residents of the country. The introduction of such a concept broadens investment sources and the volume of investments in hard currency into authorized capital of local foreign invested enterprises, it leads to an increased their economic potential.
4. Foreign invested enterprise’s economic potential is formed by the aggregated potential of the property (monetary and non-monetary) which is in business turnover, potential of the personnel (managers, clerks, workers) and potential of the owners (shareholders and stockholders), involved into the management process. Foreign invested enterprise’s economic potential can be measured by value of cumulative potential of economic opportunities of an enterprise, efficient usage of which is equivalent to their actual output.
5. It is topical to deal with an issue of value-based management of foreign invested enterprises’ economic potential, aimed at a continuous growth of their market value depending on speculative market prices of their shares. The solution of the issue allows timely detecting and avoiding «bubble» on real assets while making investment and managerial decisions.
6. Under the current conditions the value approach is the most pivotal for foreign invested enterprises’ economic potential management. On the basis of this approach it is possible to find out the essence and substance of a foreign invested enterprise and its economic potential, to define aims, methodology and strategies of economic potential management, to solve existing problems fully and systematically.
7. The common measurement of foreign invested enterprise’s economic potential and its components is value. It is purposeful to employ the integrated measure of just value of its assets, liabilities and equity, which depends on the real value and its market share price.
8. From a methodological point of view, the optimal management of foreign invested enterprises’ economic potential would be achieved by implementing a complex-balanced model of foreign invested enterprises’ economic potential valuebased management, which includes models of assets, liabilities and equity management, and a model of capital structure management.
9. It is necessary to estimate real value of a foreign invested enterprise through discounting free cash flows by its weighted average capital value; to create a proxy for market share price such as market capitalization. Just value of a foreign invested enterprise can be identified by calculating just value ratio via dividing its market capitalization by its real value. The range of values for just value ratio is from 0,414 to 2,414. The ratio will allow detecting a size of «bubble» on real assets, increasing foreign invested enterprise’s economic potential, ensuring clearness and solidity of administration (including investment) decisions, an optimal balance of interests of owners and managers.
10. In Uzbekistan during 2003-2015 share of foreign invested enterprises in GDP almost doubled. There was observed positive dynamics in the number of foreign invested enterprises, though a number of foreign invested enterprises in a form of joint-stock companies transformed into another legal forms of activity. Further enhancing processes in a structure of regional proportion of foreign-invested enterprises should be carried on. Moreover, it can be seen that global financial situation affects domestic foreign invested enterprises.
11. There should be implemented the empirical research of foreign invested enterprises’ economic potential value-based management to define problems, common tendencies and patterns of thier development. The selected factors of valuebased management of assets, liabilities and equity, and capital structure of the foreign invested enterprises can be used for the development of complex-balanced management of their economic potential. The reasons are strong statistical significance of these factors and the obtained values of determination coefficients of the models.
12. There can be observed dominance of the Pecking-order theory in foreign invested enterprises’ capital structure management process. In addition, it seems that the «new» pecking-order is followed in practice - retained earnings, additional authorized capital and only then attraction of external debt proceeds. It is evidence of strong potential for the development of financial market in Uzbekistan.
13. Reorganization of foreign invested limited liability enterprises with over 30% share of foreign investments into joint-stock companies should be stimulated. It will allow increasing their economic potential by introducing accounting and reporting in compliance with International Financial Reporting Standards and International Accounting Standards, and attracting additional investments up to 15 thousand USD.
14. Due to made amendments and additions to the law of «Stock companies and protection of shareholders’ rights» on 30 December 2015 (No LRU-396), complex-balanced model of value-based management should be used for identification of viability of medium- and long-term strategy of economic potential increase. This applies to foreign invested enterprises in the form of joint-stock companies, and control should be carried out by the companies themselves and by external controlling authorities.
15. It is found that the implementation of complex-balanced model in local foreign invested enterprise under the scenario of average real value growth of 33,2% would ensure achievement of real value of foreign invested enterprise of the European Union in a medium-term perspective. Under the scenario of average market capitalization growth at 20%, foreign invested enterprise s in Uzbekistan will reach targeted value of just value in 2017. Under scenario of average real value of 20,3%, local enterprises will reach the level of the European Union foreign invested enterprise s’ real value in 2025. If to set up average market capitalization growth at the rate of 15%, it is possible to reach the desired just value in 2019.

The topicality and significance of the subject of dissertation. Recently science has seen a rapid development of theory related fields, i.e. the mutual influence of two or more physical fields, in particular, a typical example of this direction of research is magneto-elasticity. Electromagnetic sensors arc in high demand at the present time in the world, according to forecasts only for the automotive market the proceeds of their sales in 2012 amounted to 812,2 million US dollars, next 2013 year they increased by 9,5%, and in subsequent two years this indicator grew by 6-7%, and the end of 2016 it is expected that the amount of revenue will reach 1,1 billion U.S. dollars1.
In Uzbekistan, held large-scale activities on the use of magneto-thin bodies in the technical designs and identify the influence of electromagnetic fields on the on deformation state of thin electro-conductive bodies. In this area, it is important to develop methods for determining the effects of electromagnetic fields on the deformation state of thin electro-conductive bodies of complex configuration, development of methods and algorithms for solving systems of differential equation in partial derivatives with initial-boundary conditions defining the magnctoelastic thin plates and shells of complex structural shapes, aimed at study the principles of creating magnctocumulativc generators for plasma confinement devices in fusion devices, magneto-hydrodynamic accelerators of contactless magnetic poles moving systems, high-quality and long-term use of measuring equipment, operating in the area of influence of electromagnetic fields.
In world practice, focuses on process modeling effects of electromagnetic fields on the deformation state of thin clcctro-conductivc bodies, development of mathematical models and numerical-analytical methods for solving partial differential equations derived from the initial and boundary conditions governing magnctoelastisity thin plates and shells of complex structural forms, using the method of R -functions formation of systems and structures of solutions satisfying the boundary conditions for the magnctoelastic plates and shells of complex configuration that is of particular interest from the scientific community. In this area, the implementation of targeted research arc priority tasks, including scientific research in the following areas: development of numerical and analytical methods and algorithms for solving systems of differential equations in partial derivatives with initial-boundary conditions, describing the influence of electromagnetic fields on the thin electro-conductive bodies (plates, shells) of complex configuration; development of complex software tools using the method of R-functions, magnctoelasticity thin bodies of complex shape, calculation algorithms of the class of problems of magnctoelasticity thin plates and shells of complex shape; conducting computational experiments to determine the degree of influence of electromagnetic fields on thin plates and shells with complex structural form, the development of algorithms for solving problems of statics and dynamics magnctoelasticity thin bodies.
In Uzbekistan, the modeling of the effects of electromagnetic fields on the state of deformation of thin clcctro-conductivc bodies, theory of magnetic elasticity for the interaction of the deformation field and the electromagnetic field in a solid clastic body is aimed at the study of the principles of creating magneto-cumulative generators, devices for plasma confinement in thermonuclear facility, magneto-hydrodynamic accelerators, contactless magnetic bearing of the moving systems, measuring equipment, working in the field of action of electromagnetic fields. In various industries technical and economic reliability from the practical application of magneto-elastic sensors is characterized by the error of their component errors of 2-3%.
The thesis is directly serve the implementation of the tasks set out in the following provisions of the President of the Republic of Uzbekistan: PP-1730 of 21 March 2012 «On measures for further implementation and development of modern information and communication technologies», the PP-1442 of 15 December 2010 «On the priorities of industrial development of Uzbekistan in 2011-2015 years», and in the decree of the Cabinet of Ministers of the Republic of Uzbekistan №64 of 7 March 2012 «On additional measures on decreasing production expenses and reduction of production cost in industry» and also in other standard legal documents accepted to the sphere.
The use of thin electro-conductive bodies in the elements of constructions of devices and machines under the influence of electromagnetic fields in modem electronic, medical and other measuring systems, as well as in communication devices, radio engineering and computer science establishes topicality of the research problems of mutual influence of electromagnetic fields and electro-conductive thin bodies having a complex configuration by R-function method (RFM).
The purpose of research is to develop algorithms and software tools of mathematical modeling of electromagnetic fields influence on the deformation state of the thin electro-conductive bodies of complex configuration using the R-functions and numerical-analytical methods.
Scientific novelty of dissertational research consists in the following:
a mathematical model describing the processes of influence of electromagnetic fields on the deformation state of thin electro-conductive bodies is built on the basis of the generalized variational Hamilton-Ostrogradsky principle with the terms of the linear theory of elasticity and Lorentz electromagnetic forces, the mathematical model of magnetic elasticity of thin plates and shells is constructed;
qualitative numerical-analytical methods and algorithms for solving systems of differential equations with initial-boundary conditions describing the effect of electromagnetic fields on clcctro-conductivc thin bodies (plates and shells) with a complex structural shape of the joint application of the variational Bubnov-Galcrkin method and the structural R-functions method is developed;
solutions structures and systems to practical boundary conditions at rigid-clamped, hinged-simply supported edge magnetoelastic plates and shells with complex configuration (with cuts) is formed;
complex software for calculation of magneto-elasticity of thin plates and shells is developed on conducted algorithms for solving problem classes of thin plates and shells magneto-elasticity with complex structural form;
the convergence of the computational algorithm concerning the number of coordinate functions of the solutions structure is shown, the practical applicability of the method and the reliability of the obtained numerical calculation results of magnetic elasticity of thin bodies by comparing with the exact solutions is proved;
the algorithms for carrying out computational experiments to study the static and dynamic effects of electromagnetic fields on the deformation state of the thin perfectly conducting bodies with complex structural form is developed.
CONCLUSION
On the basis of studies on the doctoral thesis « Mathematical modeling of processes of the electromagnetic fields’ effects on deformational condition of thin conductive bodies by the method of R-function» presented the following conclusions:
1. The fundamental geometric and physical relationships of the linear elasticity theory and linear electrodynamics arc defined taking into account properties of the structure and mechanical characteristics of the material for electro-conductive thin bodies under the influence of electromagnetic forces;
2. new mathematical models arc developed and a two-dimensional mathematical model of magnetic elasticity of thin shells and plates is built on the basis of generalized principle of Hamilton-Ostrogradsky using the Kirchhoff-Lyav hypothesis for thin bodies taking into account the linear Cauchy relations and Hooke's law of elasticity and relations of the linear theory of electrodynamics, in particular, Maxwell's equations, the influence of the electromagnetic field is determined by the volume of Lorentz pondcromotive forces but the surface and contour forces arc defined by Maxwell's electromagnetic tensor.
3. analytical and numerical methods and algorithms for solving systems of differential equations with initial-boundary conditions describing the effect of electromagnetic fields on the deformation state of the conductive thin bodies (plates and shells) complex shape with a joint application of the variational method of Bubnov-Galcrkin method and the structural R-functions method arc developed and the resolving equations (discrete model) arc obtained.
4. solution structure (sequence of coordinate functions) to the basic boundary value problem of magneto-clastic plates and shells with complex configuration area (a circle with two and four circular cutouts, polygon, rectangle with rounded comers, etc.) by the method of R-functions is formed and normalized equations for complex fields of the thin bodies, using card operations of algebraic the R-functions theory is constructed;
5. Vector-matrix equations for discrete models of magnetic elasticity of the subtle bodies, formed by the corresponding block of the matrix of damping, etc. when modeling thin-walled structures defined by systems of linear algebraic and ordinary differential equations with initial conditions and numerical methods for solving these systems of equations based on the use of quadrature sums, methods of Newmark and Gaussian elimination is developed;
6. software in the form of a complex of programs for calculation of magnetic elasticity of thin bodies by the method of R-functions on the computer, consisting of ten core modules is developed on the base of modular analysis of algorithms for solving problem classes of magnetic elasticity of thin plates and shells with complex shape;
7. numcrically-analytical methods arc developed and the validity of the obtained numerical calculation results of magnetic elasticity for thin plates of areas a classic shape (square, circle) by comparing exact and approximate solutions by the R-functions method is substantiated, moreover the plates having rigidly-clamped and hingcd-simply supported boundary conditions arc considered. The convergence of the computational algorithm of calculating the magnetic elasticity of thin shells and plates with complex structural form with regard to the number of coordinate functions of the structure of the solutions built by R-functions method and on the number of nodes (points) when calculating double integrals is studied. As the basic polynomial is selected by power polynomial, and good convergence is observed when the degree of the polynomial 3-4 (which corresponds to 10-15 coordinate functions).
8. computational experiments on the solution of problems of statics of magnetic elasticity for thin plates of complex configuration (with two circle and four circular cutouts, complex polygon shape, a ring) arc described on the basis of the developed algorithmic and software Toolkit (software package). The effect of static electromagnetic field on the deformation state of the plate with rigidly-clamped and hinged boundary conditions at a given magnetic field with different values and directions of the magnetic field is shown;
9. The dynamic effect of the electromagnetic field on the deformation state of the plate with rigidly-clamped and hinged boundary conditions on the basis of the developed algorithmic and software complex and computational experiments on problems of dynamics of magnetic elasticity of thin bodies for areas with a complex configuration by the R-functions method is studied. Plates of constant thickness, made of a material with finite electrical conductivity in an external electromagnetic field arc considered. This problem is solved in two stages: the first is the problem of electrostatics and determine the values of the magnetic field, the second solves the problem of magnetic elasticity using the values of the magnetic field. The dynamic effect of the electromagnetic field on the deformation state of the thin bodies of complex structural forms is defined.
10. The results obtained in the form of algorithmic and software tools arc implemented in the solution of specific problems of magnetic elasticity of thin shells and plates with complex configuration in the framework of the contract and economic efficiency in the amount of 127.8 million soums is obtained as a result of the implementation.

The relevance and demanding of the dissertation the theme. To date, the world practice the leading position occupied by the creation of high-performance process control systems with the involvement of intelligent technologies. One of the most urgent tasks of rapidly evolving modem information society is the management of real dynamic systems based on processing and analysis of huge data streams. In this direction, some progress has been made in the leading countries of the world such as USA, Germany, Japan, South Korea, etc., Where on the practical implementation of the work carried out intensively in the industrial and non-industrial field, allowing to increase the efficiency of production, i.e. the competitiveness of the products, due to modernization of management practices using modern information technologies, allowing for the particular technological objects. Now in these countries used intelligent production control systems account for about 40-45%' of the total production. This results in reduction of resource and energy consumption by 35%2.
In the Republic of Uzbekistan held large-scale activities on the effective organization of measures aimed at creating a high-performance process control systems and production. In this area, we carried out a series of research projects, including for the development of effective individual technological objects control systems in various industries, intellectualization control processes, improving methods of research of intelligent control systems, creation of intellectual assets control processes.
The world's attention is paid to the development of neuro-fuzzy models and algorithms of control systems in problems of intellectualization process facilities management, building a knowledge base, their use in improving the control system. In this area, the implementation of targeted research is a top priority, including research in the following areas: development of hybrid models of dynamic processes based on neural networks and fuzzy logic, which allows to consider features of dynamic objects; intellectualization control processes based on the joint application of modern methods of control theory and principles of intellectualization; development of tools and software intellectualization control process; the development of sophisticated, highly adaptive control algorithms; creating knowledge-based adaptive processing control signals control algorithms; development of software - tools intellectualization of automated monitoring and control of dynamic objects in conditions of uncertainty.
This dissertation research is to a certain extent the tasks provided for in the Decree of the President of the Republic of Uzbekistan № PP-1989 on June 27, 2013 "On measures for further development of the national information and communication systems", as well as in other legal instruments adopted this sphere.
The aim of the study is to develop design models and algorithms for dynamic objects intellectualization control processes in conditions of uncertainty.
Scientific novelty of the research is as follows:
the basic classes of solved problems, developed principles of intellectualization of dynamic objects control processes that operate in conditions of uncertainty;
it developed a new approach to building intellectualization systems control processes dynamic objects that operate in conditions of uncertainty and vagueness of work situations, based on the integration of modern control theory, methods and intelligent technologies;
developed a set of intellectualized hybrid models of dynamic objects of control systems having adaptive properties, and allows in contrast to the known types of models to take into account the dynamic characteristics of controlled processes;
developed algorithmic design principles modeling algorithms research of dynamic objects, providing an effective solution to problems of selection of the best models and cotrol decisions;
solver created intellectualized dynamic objects control problems, combining traditional methods of automatic control theory and principles of intelligent control, in terms of structural, situational and parametric uncertainties;
developed algorithms for determining the coordinates of an object of immeasurable, correction control system parameters, as well as dynamic objects control systems synthesis based on neuro-fuzzy adaptive and predictive model;
synthesis algorithms developed adaptive neuro-fuzzy combination of dynamic objects control system, based on an interactive method of adaptation, which is a combination of the identification algorithm and genetic algorithms, which can effectively solve the problem of industrial objects control under uncertainty.
CONCLUSION
On the basis of the survey on his doctoral dissertation on the theme "Design of models and intellectualization of dynamic objects control processes algorithms in conditions of uncertainty", presented the following conclusions.
1. Based on the systematization and analysis of methods and algorithms for solving dynamic objects intelligent control problems developed the theoretical basis for the creation of intelligent control systems of dynamic objects through a combination of methods of control theory and principles of intelligent technologies.
2. Propose a new approach to the creation of a system of intellectualization of dynamic objects control processes that operate in conditions of uncertainty, based on the integration of classical control theory and methods of intelligent control.
3. The complex of intellectualized hybrid models of dynamic objects of control systems having adaptive properties, and allows in contrast to the known types of models to take into account the dynamic characteristics of controlled processes.
4. On the basis of neural networks, fuzzy logic, genetic algorithms and techniques of classical control theory developed a methodology for the construction of hybrid models of technological processes, which is the mathematical basis of intellectualization of dynamic objects control processes, and allowing to form complex patterns formalized control processes.
5. The developed algorithmic design principles modeling algorithms research of dynamic objects, providing an effective solution to problems of selection of the best systems functioning models computationally based on a combination of the method of hierarchy analysis, evaluation procedures and methods fuzzy logic.
6. Created intellectualized solver dynamic objects control problems, combining traditional methods of automatic control theory and principles of intelligent control in terms of structural, situational and parametric uncertainties.
7. Algorithms of adaptive prediction, determination unmeasured coordinate system and the correction of control parameters of the system, as well as the synthesis of adaptive neuro-fuzzy combination of dynamic objects control system based on an interactive method of adaptation, which is a combination of identification algorithms and genetic algorithms.
8. The principle of hierarchical multilevel modeling and study of intelligent control systems, based on a hierarchical description of the study of intelligent control system.
9. Algorithms for synthesis adaptive neuro-fuzzy control system, including a procedure for determining the architecture, structure and development model of interaction of its elements, assessing the impact of neural network parameters on the quality of performance of the system, allowing to increase the effectiveness of control systems with incomplete a priori information regarding the model of the control object and disturbance.
10. A system of automated monitoring and control of technological parameters of electric power facilities and petrochemical complexes, allowing to choose the optimum modes of technological units, reduce energy costs and improve productivity by reducing the specific consumption of energy used, and also to prevent a variety of emergency situations.

The topicality and importance of the dissertation. Today, cotton is planted in more than 35 countries, including 25 countries, where cotton is gown because of water dificit, there is a decrease in the yield and quality of cotton fiber1. Creating a drought-resistant breeding material for breeding varieties with high yield and quality of fiber, resistant to external stress factors, the complex agronomic characters is crucial problem of our time.
In this regard, in our Republic measures to increase cotton productivity and improve fiber quality, rational use of existing water resources, as well as the removal of varieties resistant to water scarcity arc widely used. When fading out, the primary material of cotton, genetically resistant to various stress factors and diseases, in particular, to water scarcity, with wild and semi-wild specimens can be achieved by increasing genetic variability of agronomic traits cultivated species, improvement of the genetic basis of existing donors. High efficiency allows to use different hybridization methods, leading to the emergence of genetically enriched genotypes as a result of recombination of positive polygenes in a hybrid body. In this case, the allocation of transgressive forms of recombinants having a new genetic variation is important.
The first variety of genetically properties selection adaptability of new sources of gcrmoplasmc ssp.yucatanense samples were identified in our research, ssp.punctatum, ssp.morilli, ssp.richmondi, ssp.marie-galante, ssp.brasiliense, G.thurberi, G.raimondi under conditions of water scarcity and soil salinity. As a result of research investigation the production of breeding hybrids derived from the identified samples using US and local varieties has been implemented.
Implcmcntating the tasks mentioned in the Law of new publication in 2002. "On Selection Achievements", "On Seed", adopted in 1996, and the Resolution of the Cabinet of Ministers №328 dated September 19, 1996 "On the policy of the Government of the Republic of Uzbekistan in the field of seed" the present work is derated to, the achievement of the wide variability of agronomic traits, the use of wild and semi-wild specimens in the development of new forms and varieties and lines of cotton resistant to water shortages.
The purposeof research is to use as the primary material the wild and semi-wild species of cotton - ssp.yucatanense, ssp.punctatum, ssp.morilli, ssp.richmondi, ssp.marie-galante kind of G.hirsutum L., local and American cotton selection including plants Fb F2, F3 and Ғ!0 adapting them genetically and creation of varieties and lines that are resistant to water scarcity and soil salinization.
Novelty of the research work is the following:
for the first time in domestic and foreign genetic breeding practice resistant to water scarcity, productive, high quality and long fiber cotton varieties with Mexican relating to G.hirsutum L. mind ssp.yucatanense wild and semi-wild ssp.punctatum, spp.morilli, spp.richmondi, spp.maric-galante samples varieties Acala-1517-70 American selection, Dcltapinc-16, Paumastcr -266, 0226, Short-cat, selection-compositac and local varieties of the C-6524, C-9070, Namangan-77, Tashkent-1, F-149,F-108.
There were identified new donors that had resistance to water scarcity, to Vcrticillium wilt in combination with high fiber quality. 
For the first time demonstrate the benefits and impact of crossing this forms together with the cultural varieties and the creation on their basis of complex polymorphic hybrids with 4-8 parental forms, 2-4 of which arc species and varieties that arc created with the fiber quality, especially IV and higher type.
Necessity of carrying out hybridization was proved and subsequent selection in the conditions with hard irrigation mode (0-1-0) to obtain genetically resistant to water scarcity (0-1-0) lines with useful features complex.
The first time that genetic patterns of inheritance and variability in hybrids involving introgression for new lines and the possibility by increasing variation the range in them for the main economically valuable attributes in conditions of water scarcity. Installed a dominant character and ovcrdominance resistance to water scarcity, precocity, the mass of raw boxes 1, yield and technological quality of fiber created from the varieties and lines.
For the first time produced varieties which arc resistant to water scarcity, with high precocity that meet international standards, according to the exit and the fiber quality of the relevant goals and objectives, proved the feasibility of the necessity of their trials and cultivation in different agro-climatic zones.

The actuality and necessity of the theme of the dissertation. Today the spread of bacterial diseases of cattle is 16.2% and mixed bacterial diseases is 10,9 percent in the world. Therefore, it is important to use resource-saving, import-substituting and exportable medicinal agents in order to prevent livestock diseases and antidiseases effort.
It have been implementing large scale measures on decreasing of mixed bacterial diseases of cattle, especially, calves and lambs, their treatment, prevention and anti-diseases effort.
It is very important to raise the number of heads of cattle, to increase efficiency, to get healthy calves and lambs, to care properly, to prevent from different diseases in state, local and private farms in order to developing and increasing the efficiency of livestock, which is the main sector of agriculture.
Infectious diseases including pasteurellosis, salmonellosis and colibacillosis among young animals are still grand problem of cattle breeding. Shortage of biological and chemical drugs in the sphere of veterinary medicine complicates this problem more and is becoming the cause of large spreading of aforementioned infectious diseases.
Researches on pathomorphological diagnostics of mixed types of pasteurellosis, salmonellosis and colibacillosis among young cattle, their treatment and prevention measures’ issues arc not implemented enough by today. Especially, it is important to produce local drugs in order to diagnose, treat and prevent these mixed diseases of young animals on time.
In case of operative diagnosing of mixed types of pasteurellosis, salmonellosis and colibacillosis among young cattle, these diseases will be prevented and in result, the heads of cattle will be increased and the quality of dairy and meat products will be improved. At present, operative diagnosing of mixed bacterial diseases of calves and lambs, at the same time researches directed on decreasing energy, materials and resources in treatment and preventing of diseases and improvement of labour efficiency arc actual tasks.
This dissertation work will serve to the implementation of Uzbekistan Republic Presidential Rcsolution#PK-842 “On additional measures on motivation of increasing the number of cattle in private subsidiary, dekhkan and local farms as well as expanding the production of cattle husbandry products” from April 21, 2008 and assigned tasks of the new edition of the Law#397 of the Republic of Uzbekistan “On Veterinary” from December 29, 2015, at certain extent.
The purpose of the study is developing of measures on identifying mixed cases of common colibactcriosis, salmonellosis and pasteurellosis diseases among cattle, diagnosing, and treatment.
Scientific novelty of the research is as follows:
• mixed cases of different types of pathogen agents of diseases in farm animals, their spread, epizootic conditions as well as illnesses in natural conditions have been determined for the first time in our republic;
• clinical signs, pathologicoanatomic and pathohistological changes of each disease and results of bacteriological tests have been performed;
• it’s been developed timely diagnose and differential diagnostics for mixed bacterial diseases for calves and lambs;
• it’s been invented same time treatment method for colibactcriosis, salmonellosis and pasteurellosis diseases;
• results of mixed bacterial diseases (pasteurellosis and diplococcus) of calves and lambs have been developed.
CONCLUSIONS
1. It’s recorded that, the level of spreading of mixed bacterial diseases (colibacillosis, salmonellosis, pasteurellosis and diplococcus) of young animals are following: in calves - 21.4%, in lambs - up to 27.5 %, at livestock farms of Uzbekistan.
2. It’s notable that, mixed bacterial diseases among calves are following: colibacteriosis + salmonellosis - up to 30%, colibactcriosis + pasteurellosis - up to 25%, diplococcus +pasteurcllosis - up to 18%; these parameters arc following in lambs: colibactcriosis + salmonellosis - up to 35%, pasteurellosis + diplococcus - up to 25% pastcurcllosis+ colibactcriosis -up to 28,7%.
3. It’s desirable to pay attention to that fact, that, mixed types of bacterial diseases occurred in calves and lambs of the farms of Kashkadarya, Navoiy, Samarkand, Bukhara and Jizzakh regions and Republic of Karakalpakstan.
4. It’s recommended to pay attention to following pathomorphological changes in calves and lambs with pasteurellosis, salmonellosis and colibacillosis diseases: increase in the overall reactions of blood vessels, edema formation, hemorrhages in mucous membranes of the intestines and catarrhal-hemorrhagic inflammations, spotted hemorrhages in parenchyma of livers and kidneys, development of catarrhal haemorrhagic croupous necrotizing pneumonia foci in lungs.
5. It’s advisable to pay attention to the following pathomorphological changes in calves and lambs with pasteurellosis and colibacillosis diseases: hemorrhages in all parenchymatous organs, catarrhal fibrinous pneumonia in lungs and fullness of blood vessels, edemas, appearing of catarrhal-hcmorrhagicgastrocntcritis in stomach and intestines.
6. In case of infection of calves and lambs with mixed pasteurellosis and salmonellosis, pathologicoanatomical changes were very deep and complex, and in most cases, it can be observed symptoms of both diseases in the organs of animals, also it should be noticed, that, accumulation of abdominal fibrin exudate, necrosis of lobar pneumonia pleuropneumonia arc signs of pasteurellosis; catarrhal-hemorrhagic inflammations in stomach and intestines, blood congestion in liver, kidney, spleen and rennet, hemorrhages, dystrophic changes, appearing of parathyphoidlymph arc signs of salmonellosis; severity or mildness of pathological process depends on virulence of the pathogens.
7. In diagnosing of disease, firstly, it’s recommended to identify causes of the disease, epizootic data, and based on clinical signs and pathologicoanatomical as well as results of bacteriological tests.
8. It’s recommended to inject axillary 1 ml hyperimmune scrum fori kg of live weight in treatment of bacterial diseases (pasteurellosis, salmonellosis and colibacillosis) against pasteurellosis, salmonellosis and colibacillosis of in calves, sheep, lambs and piglets.
9. In prevention of micd bacterial diseases (pasteurellosis and diplococcus) of calves, sheep and lambs, it’s recommended to inject calves subcutaneous with GOA formolatcd vaccine against these diseases two times; 3 ml in the first time and 3 ml in the second time and by the difference of 14 days and same vaccine injection for lambs: 2 ml in the first time and 3 ml in the second time and by the difference of 14 days
10. In order to prevent mixed bacterial diseases, it’s strongly recommended to use multivalent radio vaccine against pasteurellosis, salmonellosis and colibacillosis diseases of calves and lambs and vaccine associated against pasteurellosis + diplococcus diseases of calves and lambs on timely basis. Both vaccines originated in VRI.
11. If mixed diseases will be diagnosed by complex method on timely basis, it will be possible to treat andprevent these diseases.

Topicality and demand of the subject of dissertation. The recurring problem of water deficit and population growth in recent years in the world require effective use of land resources, in particular, the desert, semi-desert and dry farming regions. The cultivation of oilseed crops in dry farming regions is more cost-effective in comparison to other crops; therefore, they arc grown on an area of more than 10 million hectares in the world1.
Nowadays in our country, large-scale measures arc conducted to provide country’s population with our own seed oil. Therefore, area under oilseed crops are constantly expanding in dryland farming regions and these crops arc currently cultivated on more than 150.0 thousand hectares. There arc more than 1041.3 thousand hectares of dryland farming areas in our country in total, and it is possible to expand areas under oil crops further in these regions2.
As it is known, oilseeds arc damaged by numerous pests during vegetation period. Some pests appear every year and cause considerable damage to crops. It is not possible to achieve high and quality yields without using control measures. Particularly noteworthy arc research results aimed at determining pest species composition of such oilseed crops as safflower, flax and sesame, their biology, negative effects on yields, economic thresholds of these pests, as well as the improvement of effective methods and means of their control.
Application of effective measures of the integrated pest management system in oilseed crops provides with high and quality yields of seeds, as well as this eliminates wrong application of chemical means of plant protection against pests, and prevents intoxication of humans and contamination of the environment.
Thus investigations on revision of pest species composition of oil crops widely grown on dryland regions, evaluation of biological features of the main pests and degrees of their negative effects on yields, and determining optimal times and methods for application of control measures, arc urgent problems of the day.
Investigations of this thesis to a certain extent serve in realization of tasks put by the Act of the Oliy Majlis of the Republic of Uzbekistan №117-11 dated 31 August 2000 «Protection of agricultural plants against pests, diseases and weeds», Decree of the President of the Republic of Uzbekistan No. PP-1047 of January 26, 2009 «On additional measures to increase food production and saturation of the domestic market» and Resolution of the Cabinet of Ministers No. 148 of March 28, 2004 «On measures to improve the structure and enhance service efficiency in plant protection», as well as the tasks defined by other regulatory and legal acts.
The aim of the research work is identifying pests of dry land oilseed crops, determining dominant and the most damaging species among them, evaluating efficacy of cultural, biological and chemical methods used for control of the major pests basing on their biological and ecological features.
Scientific novelty of the research work is expressed in the followings:
pest species infesting oil crops in the dry land regions have been identified for the first time in conditions of our country, and these pests were classified into 3 groups as the major, the minor and insignificant pest species;
biological characteristics of the major pests and levels of their negative effects on crops’ yields have been evaluated;
bcncficials (entomophages) that naturally occur on oil crops have been identified, and weed species that can be used by pests and bcncficials as sources of food have been determined;
cultural, biological, and chemical control methods against the major pests have been developed;
modem technology of application of insecticides for pest control in oil crops has been tested.
CONCLUSIONS
1. It has been determined that safflower crops in dry land regions arc damaged by 44 species of insect pests belonging to 15 families of 7 orders. From these pests small safflower weevil, bordered straw moth, safflower fly and locusts cause serious economic losses, infestation of the crops in some years exceeds 40%.
2. It has been found that plants on flax fields were infested with 14 species of insect pests belonging to 7 families of 4 orders. However, severities of infestations were low and pests have not caused any notable harm to this crop.
3. It was revealed that sesame plants have been infested with 12 species of insect pests from 7 families and 3 orders. Normally these insects have not infested plants in any serious level, but some year’s infestations with locusts could cause significant yield losses.
4. It has been found that occurrence of 5 species of beneficial insects were frequent in agricultural biocoenoses of dry land oil crops, particularly including such entomophages as lady bugs (Coccinella septempunctata) and laccwings (Chrysopa carnea, Ch. septempunctata, Ch. albolineata, and Ch. dubitans), belonging to Coleoptera and Neuroptera orders. Among them seven-spotted lady bug has been the most frequent.
5. Bugs of the small safflower weevil start leaving overwintering sites in conditions when average daily air temperature exceeds 13°C. Depending on regions of our country this time has corresponded to the periods from the second and third decades of April till first decade of May.
6. Existence of a couple ($, <$) of the small safflower weevil bugs per 1 m2 could reduce quantity of seeds on this area by 161.6, or yield by 5.3 grams. Degree of yield infestation with the pest in this case has been 6.9±0.55%. Existence of two couples ($, of the small safflower weevil bugs per 1 m2 has decreased number of seeds by 323.2, and yield by 10.7 grams, or 13.7±1.13%.
7. Comparing with a treatment with no fall-ploughing, numbers of small safflower weevil bugs per 1 m2 have been lesser by 1.97±0.02, 2.3±0.5, 1.67±0.4, respectively, on fall-ploughed lands where safflower plants were sown on March 16, April 2 and 15. This proves importance of the cultural practice as one of measures in pest controlling.
8. According to our data an economic threshold for small safflower weevil is 7581 individuals/ha, or 0.8-1 individual/m2. Spraying with chemicals should start at reaching pest density this threshold. Wc recommend using the following insecticides that have shown high efficacy against small safflower weevil: Cypcrmcthrin 25 EC -0.2 L/ha; Atilla 5 EC - 0.25 L/ha; Confidor 20 EC - 0.2 L/ha; Dccis 2.5 EC-0.2 to 0.4 L/ha, and Sumi-alfa 5 EC- 0.4 L/ha.
9. The first generation of bordered straw moth imagoes start leaving from overwintering sites in the second decade of April in the conditions of the Kashkadarya region, and in third decade of April in Samarkand and Jizzakh areas. Presence of one bordered straw moth larva per a plant reduces number of seeds by 86.9±2.9, and yield infestation equals to 61.9±0.85%. And presence of two larvae on one plant decreases number of seeds by 137.4±1.6, and yield infestation reaches 97.8±2.2%.
10. Laboratory efficacy of bracon application in parasite:pcst ratio 1:10 on the 2ndday after treatment has been 60%, 4,hday - 80%, and 5thday - 100%. Using a bracon in ratio 1:15 has resulted in efficacies equal to 53.3%; 73.3%; 86.7%, and on 7th day - 93.3%. In field conditions efficacy of bracon against larvae at applying in ratio 1:10 on 5th, 10th, and 15th days has been, respectively, 47.9%, 56.7%, and 64.2%. Using a braconin parasitc:pcst ratio 1:15 has resulted in the efficacy 43.3%, 42.9%, and 48.2%, respectively.
11. We recommend to start insecticide spraying against bordered straw moth when number of its larvae exceeds 15555 per 1 ha, or when 6 larvae have been found on 100 plants. Efficacies of tested against this pest insecticides have been as below: Avaunt 15 EC at rates 0.3 L/ha and 0.4 L/ha-89.6-95.4%; Atilla 5 EC, 0.5 L/ha -85.5-88.6%; and Dccis 2.5 EC, 0.7 L/ha-89.8-90.2%.
12. The first generation of safflower fly develops on weeds from Asteraceae family. The second generation of this pest appears on safflower plants at budding growth stage - early May (Kashkadarya region), or in the mid-May (Samarkand region) and at the end of May - carly-Junc (Jizzakh region).
13. Up to 40% of safflower baskets can be damaged by safflower fly. The diameter of baskets is less, the infestation is more severe: 83.3% of seeds were damaged in baskets with a diameter less than 21 mm, 37% of seeds have been damaged in baskets with a diameter 21-25 mm, and only 13.1% of seeds were infested in baskets with a diamctcr>25 mm.
14. The following insecticides arc recommended against safflower fly during formation of safflower baskets: Cypcrmcthrin 25 EC (0.3 L/ha), Atilla 5 EC (0.2 L/ha), and Dccis 2,5 EC (0.2 L/ha).
15. Locusts of Dociostaurus and Calliptamus genera were distributed widely in regions where safflower crops have been grown. Dominating species there has been a Moroccan locust (Dociostaurus maroccanus) and it has consisted of 80.0% to 90.2% of all locusts. The following insecticides arc recommended to use against locusts: Atilla, 0.15-0.25 L/ha, Cypcrmcthrin, 0.2-0.3 L/ha, Dccis, 0.3-0.4 L/ha, and Sumi-alfa, 0.2-0.4 L/ha. It is advisable to use ultra low volumes (5-10 L/ha) of working liquids for spraying vegetation in conditions of dry land regions.
16. Analysis of the trial results on chemical protection of safflower plants against small safflower weevil and safflower fly have resulted in the following economical efficacy: comparing with untreated check treatment spraying plants with Cypcrmcthrin 25 EC (0,2 L/ha) has provided with an additional yield equal to 300 kgs/ha, and profitability of this has been 174.6%; those were at using Atilla 5 EC (0.25 L/ha) 370 kgs and 189.3%; Confidor 20 EC (0.2 L/ha) - 310kgs/ha and 163.5%; Decis 2.5 EC (0.2 L/ha) - 380 kgs/ha and 178.8%, and (0,4 L/ha) -450kgs/ha and 194.0%, and Sumi-alfa 5 EC (0.4 L/ha) - 310 kgs/ha and 168.6%, respectively.
17. Analysis of the trial results on chemical protection of safflower plants against the bordered straw moth has provided with the following on-farm and economic efficacy: comparing with untreated check treatment spraying plants with Avaunt 15 EC (0.3 L/ha) has provided with an additional yield equal to 440 kgs/ha, and profitability of this has been 178.8%; those at using same product at 0.4 L/ha rate were 480 kgs/ha and 175.9%; Atilla 5 EC (0.5 L/ha) - 420 kgs/ha (203.4%), and Dccis 2.5 EC (0.7 L/ha) - 450 kgs/ha (185.8%).

Topicality and demand of the subject of dissertation. Currently, one of the important physical and technical problems in dynamically developing directions of electronic computing and information technology is developing temperature sensors with improved functional characteristics on the basis of modified semiconductors, in particular with nanoclusters used for diagnosing various parameters and processes in industry, nuclear reactors, scientific researches and other areas of the national economy.
The study of the interrelationship of electro-physical parameters of the active region of silicon thermistors containing nanocluster inclusions of different atoms with their operational parameters allows revealing their previously unknown new technical solutions. Improving the active region, increasing the sensitivity and solving the problem of reducing the spread of the parameters, as well as developing the technology of producing a new generation of temperature sensors on the basis of materials with nanoclusters, which provide temperature measurement at different control conditions, are an important direction of researches.
The use of temperature sensors belonging to the class of semiconductor devices based on materials with nanoclusters in devices and systems of control of parameters of industrial facilities requires researching the ways to improve their sensitivity and switch schemes. Therefore, the studies conducted on the diffusion processes of various nanoinclusions, as well as the effects on the features of thermistors of nanocluster inclusions aimed at optimizing the functional parameters of thermistors are urgent.
This research is aimed at developing a new method of diffusion that provides the formation of nanoinclusions, as well as the choice of parameters of the material of a base, and developing the ways of obtaining contacts with improved adhesion, which are directed to the manufacture of temperature sensors with stable parameters. The need for the improvement of the functional characteristics of such temperature sensors, development of cost-effective technologies for their manufacturing and creation of a route of this technology has great scientific and practical importance.
This dissertation in the certain degree serves to perform the tasks assigned for the improvement of the competitiveness of the electronic products mentioned in the Decree PD-1442 of the President of Uzbekistan “On the priorities of industrial development of the Republic of Uzbekistan in 2011 - 2015” of 15 December 2010, as well as in other regulatory documents adopted in this field.
The aim of the research is to develop methods for obtaining a new diffusion technology for highly sensitive temperature sensors with nickel nanoclusters and develop on their basis a set of temperature sensors and devices with stable parameters and are resistant to different types of effects for temperature control systems of objects.
Scientific novelty of the research is as follows:
A method of nickel diffusion with embedded nanoinclusions in silicon was worked out, which consists of three steps, That is in each stage the temperature ranges (300600; 600^-900; 900-И200 °C) within which the temperature is risen consistently at a speed of 5 degrees/min, is maintained for 10 minutes and then is cooled at a speed of 100 degrees/sec.
A technology was created for obtaining a highly-doped layer for ohmic contacts to silicon structure doped with nickel, which means that a metal layer of nickel is deposited on the surface of the silicon structure by chemical means and is subjected to thermal treatment at 650°C for 10 minutes.
For the first time, a temperature sensor with high sensitivity (7800 K.) and stability of output characteristics was developed on the basis of silicon nanoclusters and a technological route of its production was proposed.
It was experimentally shown that the introduction of the correction feedback with the help of the operational amplifier leads to the reduction of the transient time of the temperature sensor by one time;
It was experimentally shown that the specific resistance of silicon temperature sensors doped with nickel with a carrier concentration of more than 1016 cm'3 changes slightly when exposed to gamma radiation dose of 106
roentgens, i.e. remains stable at radiation influence, and in samples with a carrier concentration of less than 1014 cm'3 at doses (5-^10)-106 roentgens, conductivity type inversion (n —> p) occurs.
A method of optimal structural parametrical designing of a measuring transducer based on the temperature sensor was proposed by computer simulation that allows to choose the form, output contacts, protective layer and parameters of the measuring system, in accordance with the required parameters (sensitivity, linearity of static characteristics, speed, etc.).
By choosing the required boundary interval of temperature, the possibility of reducing the errors of temperature sensors was determined, which are characterized by thermal inertia and nonlinearity of static natures.
CONCLUSION
On the basis of the conducted researches on the theme of the doctoral dissertation “Development of a silicon-based temperature sensor with the nanoclusters of nickel atoms and its manufacturing technology”, the following conclusions are presented:
1. A new method of nickel diffusion in silicon was proposed, consisting in carrying out a diffusion in an increasing temperature mode at a speed of 5-^10 degrees/minute in the temperature intervals of 600-1250 °C, which provides obtaining nickel nanoclusters in bulk silicon.
2. In order to obtain an ohmic contact with improved adhesion to the silicon surface, on which a diffusion of nickel was performed, we propose to make the deposition of a thin layer (3 microns) of nickel metal with a chemical process followed by heat treatment at 650 degrees Celsius for 10 minutes.
3. For the first time the principles of creating a silicon-based temperature sensor with nickel nanoclusters having a high sensitivity (7800 K) and stability of output characteristics, and a technological route of its manufacturing were proposed.
4. It was proved that when exposed to gamma radiation with a dose of 106 roentgens, the specific resistivity of the silicon temperature sensors doped with nickel remains unchanged, and with the increase of the radiation dose up to 10x roentgens, the coefficient of the temperature sensitivity increases by 10%.
5. By means of computer modeling, depending on the desired factor (sensitivity, cost, accuracy, reliability, etc.), methods of structural parametric design of the measuring transducer allowing to select the proper form of the sensor, contact terminals, a protective layer of the sensor and parameters of the measuring system were proposed.
6. The relationship was established between the corrective (linearized measurement parameter) resistances and the sensitivity of the temperature sensor, which allowed revealing the area of maximal sensitivity of the sensor in the electronic circuit.
7. By selecting the corrective resistances and a temperature interval in the required vicinity, the possibility of reducing the errors of temperature sensors arom 10% up to 2%, was revealed, which is conditioned by the nonlinearity of their static characteristics and thermal inertia.

Topicality and demand of the theme of dissertation. In the world of cocoons arc produced in more than 35 countries and is prepared annually on average 640 000 tonnes of cocoons. Among the countries that produce cocoons, arc the leading people's Republic of China, Uzbekistan, Japan and Korea and these countries produced 92% of the cocoons. Reception cocoon raw materials on the basis of quality indicators and the application of the most efficient technologies of their processing, in the processes of deepening globalization and increasing competitiveness of products on the market cocoon of raw materials remains one of the most important tasks.
In the years of independence in Uzbekistan special attention was paid to the effective development of sericulture, and the development of high quality competitive on the world market of raw materials and silk products. In this aspect, the improved food base, improving the productivity and quality of fibre, the cultivation of resistant pests and diseases of silkworms and development on the basis of modem requirements of production and processing of cocoons achieved tangible results.
Increase productivity and improve the quality of the cocoons by reducing the share of defective cocoons is essential to increase the efficiency of the economy. In this aspect, targeted research, including implementation of the following areas arc considered to be one of the important tasks: biological properties of cocoons, physical and mechanical properties taking into account quality indicators, development of modem methods of determining the qualitative parameters; automation and control of technological processes through the creation of a highspeed device; receiving the cocoons on quality indicators and the organization of this process; organization of control on every stage of cultivation of cocoons and a detailed study of the impact on the quality factors, the development of new technologies; saving of raw materials and high-performance of achievements of science and technology, development of machines and devices the creation of new generation energy-saving controls and automation. The above analysis of scientific studies and trends indicate the relevance of the topic of this thesis.
This dissertation research was to a certain extent is the implementation of the tasks stipulated in the decree of the President of the Republic of Uzbekistan PP-512 «About measures for further reforming of silk industry of Uzbekistan» dated 15 November 2006, PP-1512 «On additional measures to stimulate the development of textile industry» on 28 March 2011, and other regulatory instruments adopted in this field.
The object of the study arc the processes of sericulture, new devices for these processes and live cocoons.
Scientific novelty of research consists in the following:
developed and justified statistical methods to determine quality parameters (volumetric stiffness, silkiness of the cocoons, maturity of pods, density and shell thickness) of cocoons on the basis of the rigidity of their shell;
developed a device for determining the volume of solids of complex shape, which is used to determine the amount of cocoons that arc required for the calculation of the correction factor in the calculation of silkiness samples of live cocoons in rented party;
developed a method and apparatus for determining the percentage of immature and cocoons with a large specific volume (capercaillie). Given this information, calculation of silkincss of the cocoons;
there arc three types of method and apparatus for the more accurate determination of actual mass of silk cocoons, as well as the maturity, thickness and density of the shell cocoons hardness of the shell of the delivered consignment of cocoons;
upgraded device for measuring specific volume of cocoons PTI-1M with fixing a constant sample mass of live cocoons (3kg) and automatic removal of the layer height cocoons measuring cylinder, designed to determine silkiness of the cocoons without cut. Developed a rapid method for the determination of silkincss of the cocoons.
CONCLUSION
On the basis of conducted research we can draw the following conclusions:
1. To determine the qualitative parameters of silk cocoons proposed the use of non-destructive statistical methods on the basis of the rigidity of their shell. As a result, receive signals, analyzing and processing using mathematical methods and computer software, it is possible to define such quality parameters as the volumetric stiffness of the sample cocoons, the cocoons silkincss of the cocoons, maturity of pods, thickness and density of the shell cocoons.
2. To determine the correction factor required in calculating silkiness samples of live cocoons in rented party developed a device for determining the volume of solids of complex shape, which allows to determine the average volume of cocoons. The relative error of the developed device is equal to 0,17%.
3. To improve the measurement accuracy of the developed method and device for determining the percentage of immature cocoons and cocoons with a large specific volume, given this information, calculation of silkiness live cocoons. The relative error of the developed device does not exceed 1%.
4. The developed device for determining silkiness, ripeness and thickness of the shell silk cocoons without cut, allow high precision to determine the actual quantity of silk mass of cocoons, ripeness and thickness of the shell cocoons of the delivered consignment due to their rigidity of the shell.
5. To reduce the percentage of immature cocoons, bringing severe economic damage to sericulture, it is proposed modernized version of the instrument PTI-1M with an automatic removal of the layer height of the cocoons of the measuring cylinder. The standard error of live cocoons, defined in relation to without cut device FTI-1M is 0,456 %.
6. Proposed and experimentally proven mathematical model to calculate the correction factor for the volume of live cocoons, which it is proposed to use in determining silkiness in party live cocoons.
7. Developed a rapid method for the determination of silkiness live cocoons without their without cut, providing increase of accuracy and efficiency when determining live cocoons of any breed. The standard error of silkiness specific Express method (PTI-1M) relative to without cut less than 2 times the standard error of a particular silkincss cocoons method, PTI-1 относительно of without cut.
8. The optimal weight of 3kg live cocoons with the use of the device PTI-1M, is designed to determine silkincss live cocoons without cut. It also takes into account the presence of cocoons-grouse and muscardini of the cocoons, as an amendment in the calculation of silkiness of live cocoons in the computer version.
9. A method was developed to determine silkiness live cocoons hardness of their shell device PTI-1M, and implements software. The increase of accuracy of definition of live cocoons is achieved by taking into account the thickness of their shells. The standard error of silkiness determined by the proposed method relative to without cut is 0.4%.
10. Proposed and implemented the definition of the volumetric stiffness of the sample live cocoons with the help of the device PTI-1, which evaluated the technical and economic value of the game, both living and dry cocoons. It is shown that the value of the volumetric stiffness defined by the proposed technology, agreed with the experiments performed with single cocoons and calculating the average volumetric hardness.
11. Experimentally investigated the influence of different vibration modes on the degree of tapped and quality of cocoons. Determined the most optimal amplitude, frequency and time of vibration, ensuring a relatively uniform density of packing of cocoons in a cylindrical tank.
12. The influence of the moisture content of the cocoons on the accuracy of determining silkincss when conducting without cut, when determining the correction factor K, as well as with industrial acceptance of the cocoons.
13. The experimentally determined degree of influence of percentage content of cocoons-grouse on the readings of PTI-1M in the direction of overstatement. The Express-method of determination of the percentage of cocoons with a large specific volume and is given the formula for amendment in determining the real silkincss live cocoons at the time of their collection points cocoon of raw materials.
14. Justified and recommended to use sorting of cocoons in terms of specific volume (SCWA) grantovogo to separate the cocoons from the Persian aparsc. He is replacing manual labor increases the rate of separation 4 times on coronaricnnc points in the season harvesting of live cocoons and increases the accuracy of determining silkincss live cocoons without their without cut device of PTI-1, by pre-culling of cocoons-grouse with large specific volume of the sample.
15. Based on the comparison of the results of silkiness live cocoons of a certain method without cut, apparatus PTI-IM, and the proposed new Express technique it is shown that the values of silkiness live cocoons defined in the last two cases close to the value of silkiness on without cut and absolute root mean square error of a certain silkiness live cocoons less than one .

The relevance and demanding of the dissertation the theme. Today, the world's countries with different level of provision of electric power, the average power consumption is 37% in the industry, including mining and metals industry accounted for 12 In connection with the depletion of easily recoverable reserves of mineral resources and the involvement in the exploitation reserves localized in more difficult geological conditions, energy consumption for mining industry is constantly growing. According to statistics, the annual consumption of electrical energy in the mining industry in the world is 913.2 TWh. By results of researches by 2030 the growth of electrical energy consumption will be average 1.8% per year. Particular attention is paid to the implementation of measures to ensure the needs and requirements of industry, energy saving and efficiency of the process, optimization of electric energy consumption.
Mining and metallurgical industry is one of the largest energy consumers in the Republic of Uzbekistan, in which special attention is focused on the organization of effective measures for the implementation of high-performance technologies. In this regard, notable progress has been made in creating high-performance process control systems, standardization of electric energy consumption, improvement of management systems of technological process on the based of intelligent systems.
Acquired issues of particular importance to reduce energy intensity of process ore beneficiation process and energy efficiency technologies for processing mineral resources in view of its inherent characteristics. In this area, the implementation of targeted research is a priority, while highly relevant research in the following areas: the development of a rational law of variable frequency drive, identifying energy-saving modes of operation of the induction motor with static and dynamic processes and the creation of its mathematical model, the development of the wear pattern of the pump unit, the development of a mathematical model of the process and electricity rationing electricity consumption, taking into account the definition of the significant factors influencing the process, to develop an algorithm of forecasting of electric energy consumption. Ongoing scientific research on research areas above indicated is the actuality of the dissertation topic.
This dissertation research is to a certain degree perform tasks provided for in the law of the Republic of Uzbekistan "On the rational use of energy" (1997), Decree of the of the President of the Republic of Uzbekistan PD No. 2343 on May 5, 2015 "On the program to reduce energy consumption measures, the introduction of energy saving technologies in the fields of economy and social sphere for 2015-2019 " and the Decree of the Cabinet of Ministers of the Republic of Uzbekistan No. 333 on November 28, 2012 "On additional measures to reduce manufacturing costs and reduce production costs in the industry", as well as in other regulatory documents adopted in this area.
The aim of the research is to develop technical solutions based on the variable speed drive with electricity rationing parameters that provide energy efficiency enrichment processes.
Scientific novelty of dissertational research consists in the following:
identified the most important factors affecting the wear of pump components, developed a mathematical model of wear as a function of the main factors influencing it in the course of operation;
developed energy- and resource-saving operation of variable frequency drive system, "asynchronous motor - pump pumping pulp";
depending on the efficiency of installed electric power consumption of the degree of loading of the balls of the mill second-stage grinding the orc;
developed a comprehensive method of valuation and modeling of energy consumption parameters for the evaluation of energy saving efficiency;
developed a model for predicting the electrical energy consumption of the basic technological parameters of the function.