It has now been established that with viral hepatitis, incl. and with Chronic viral hepatitis С (CHC), a universal mechanism of hepatocyte death develops through the increased production of reactive oxygen species, causing excessive lipid peroxidation of membrane structures (Glushkov S.I., 2016; Aripov O.A., 2018.). In this case, the main function of protection is when lipid peroxidation (LPO) is activated, the antioxidant defense system (AOD) of cells is performed, the deficiency of which becomes one of the factors for the activation of pro-oxidant systems. An important point in the effectiveness of AOP is the balance of SOD and catalase. A decrease in the activity of one of the AOP enzymes can lead to excessive accumulation of reactive oxygen species and membrane damage. An imbalance in the activity of the LPO and AOP systems is the basis for the onset of cellular destruction [Bueverov A.O. 2012].
Заболевания органов дыхания занимают доминирующее место среди заболеваний по обращаемости в медицинские учреждения. Длительный кашель более 3-х недель наблюдается достаточно часто, обычно при бронхитах у детей в раннем и в дошкольном периоде.
Urinary incontinence in middle-aged women is a complication of severe vaginal delivery, large fetuses or multiple pregnancies, urinary incontinence, intermittent injuries and operations on the pelvic organs, obesity, diabetes, smoking. Urinary incontinence is divided into three types depending on its cause: these are stress urinary incontinence, urgent urinary incontinence, and the inability to manage full urine. Of these, a lot of women suffer from this type of stress urinary incontinence and it begins mainly after forty-five years, it happens when women sneeze or cough, laugh a lot, so women complain of involuntary urination. In turn, it is one of the first signs of the disease and also plays an important role in diagnosis. Urinary incontinence causes discomfort and stress in women, their tightness when smoking and joining in a team
The review article provides up-to-date information about the etiology, pathogenesis, classification, clinical picture and diagnosis of the disease. The issues of drug treatment of reactive arthritis are covered.
The monograph presents modern aspects of syndialysis arterial hypotension: solved and unresolved problems of predicting, preventing and diagnosing this complication during dialysis. The characteristics of clinical and pathogenetic features, diagnosis, treatment, prognosis and prevention of syndialysis arterial hypotension are given. The data of the dynamics of clinical, functional and laboratory studies of syndialytic arterial hypotension in patients on dialysis are presented. An algorithm for verifying the status of hydration and preventing syndialysis hypotension is presented. The monograph is intended for nephrologists, doctors of related specialties, masters and students of medical institutes.
Urticaria is an allergic disease characterized by the appearance of blisters on the skin and mucous membranes. The disease can be caused by external factors (temperature, mechanical, chemical) or internal (diseases of internal organs, disorders of the nervous system). [1, 2]. Allergies can be caused by toxins, bacteria, and undigested food. In the diagnosis of the disease, anamnestic data, dermography and various skin allergological tests are used. There are acute (up to 6 weeks) and chronic (more than 6 weeks) urticaria. The latter is characterized by daily or frequent symptoms (blistering, itching, angioedema for 6 weeks or more [3, 4]. During life, 0.5-1% of the entire population of people suffers from chronic urticaria. At the same time, if acute urticaria is usually associated with the action of exogenous factors and allergens (food, medicines, insect bites, etc).
Применить модель KFRE для оценки риска прогрессирования почечной недостаточности у пациентов с ХБП. Для прогнозирования течения ХБП по модели KFRE (3 переменными) необходимо включить следующие па-раметры: возраст, пол, расчетная СКФ (рСКФ) по формуле CKD-EPI с модификацией от 2011 года. Модель позволяет прогнозировать у больных с ХБП III-IV стадией риск прогрессирования в тер-минальную ХБП, в течение последующих 5 лет.
Glaucoma is one of the most significant ophthalmic diseases, which, with late detection and lack of timely treatment, adjusted depending on the patient's condition, leads to blindness. Of particular value in the organization of monitoring is personalized accounting in the form of registers to optimize the provision of specialized medical care, including to persons suffering from socially significant diseases, which is primary glaucoma. The aim of this study is to improve the organization of medical care for primary glaucoma by creating an electronic program for medical examinations. To improve the quality of medical care for primary glaucoma, we have developed an electronic program "Card of medical examination of a patient with primary glaucoma", which is designed to record and analyze the main clinical and statistical indicators, and monitor this disease. The map clearly shows the dynamics of the patient's management process: when the diagnosis was made, what treatment was carried out, the transition from stage to stage, in what time frame he was observed, the results of research, when he applied to the primary link of health care, and when to the specialized link of health care, etc. The map makes it possible to conduct an expert assessment of the timing of the detection of the disease, the adequacy and timeliness of the treatment and diagnostic process and medical examinations, the competence of doctors. The automated electronic program "Map of clinical examination of a patient with primary glaucoma" contains such a statistical tool as an integrated query constructor for extracting any information about patients, in which the user can set conditions for any database fields in any combination and get the resulting table with fields that can be configured for visualization.
In children, glomerulonephritis is a disease characterized by rapid progression and complication caused by an irreversible process of the renal glomeruli. Currently, methods of molecular diagnostics have begun to actively develop, which not only complement traditional research methods, but also provide insight from the point of view of molecular pathophysiology. It is expected that a key role in the diagnosis of kidney disease is played by the identification of genes and their changes in the course of the disease, which predict the course of the disease. Changes in chromosomal polymorphic genes of matrix metalloproteinase and its tissue inhibitors, as well as how this change manifests itself in chronic glomerulonephritis, were determined in the prognosis of the disease.