Screening for toxocariasis of patients with allergic diseases

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Ахмедова, М., Ибрагимов, М., & Анваров, Ж. (2014). Screening for toxocariasis of patients with allergic diseases. Журнал проблемы биологии и медицины, (3 (79), 188. извлечено от https://inlibrary.uz/index.php/problems_biology/article/view/6318
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Аннотация

Toxocariasis is a disease of humans caused by larvae (immature worms) of either the dog roundworm (Toxocara canis) or the cat roundworm (Toxocara cati). Toxocariasis is often called visceral larva migrans. This zoonotic, helminthic infection is a major cause of blindness and may provoke rheumatic, neurologic or asthmatic symptoms. Humans normally become infected by ingestion of embryonated eggs from contaminated sources (soil, fresh or unwashed vegetables).

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Современные вопросы медицинской паразитологии и инфекционных заболеваний

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Проблемы биологии и медицины, 2014, №3 (79)

SCREENING FOR TOXOCARIASIS OF PATIENTS WITH ALLERGIC DISEASES

M.D. Akhmedova, M.B. Ibragimov, J.A. Anvarov

Tashkent medical academy

Toxocariasis is a disease of humans caused

by larvae (immature worms) of either the dog
roundworm (Toxocara canis) or the cat roundworm
(Toxocara cati). Toxocariasis is often called visceral
larva migrans. This zoonotic, helminthic infection is
a major cause of blindness and may provoke
rheumatic, neurologic or asthmatic symptoms.
Humans normally become infected by ingestion of
embryonated eggs from contaminated sources (soil,
fresh or unwashed vegetables).

Diagnosis of toxocariasis is difficult in view

of polymorphism and uncertainty of clinical
manifestations.

Clinical

manifestations

of

toxocariasis do not have their own specific features,
complicating the diagnosis of the disease. Patients
often focus doctor’s attention on previously
established diagnosis: bronchial asthma, atopic
dermatitis and other. Eosinophilia is often severe
and sometimes represents the only sign of infection,
except in ocular and neurological forms. Therefore,
a key role in diagnosis belongs to laboratory
methods of diagnostics.

The object. Optimization of diagnosis of

toxocariasis among high risk groups.

Materials and methods. 30 patients aged 21

to 55 years (men - 17, women - 13) were under our
supervision. 19 of them were in the in-patient
Department of the specialized allergological center,
11 patients were treated in outpatient clinics
allergological center and Republic infectious
diseases clinic. We have examined for toxocariasis
30 patients with chronic allergic diseases (bronchial
asthma, urticaria, atopic dermatitis), and patients
with high level of eosinophils of unknown etiology.

During the study all the patients were carefully
analyzed for the history of the illness, accent has
been

made

on

epidemiological

anamnesis.

Collecting epidemiological history we asked about
the presence of an animal in the house, especially
the dogs and the presence of pietism (geophagia).
Clinical and laboratory examination were carried
out.

Serological testing for toxocariasis was

performed at the laboratory of immunology of
parasites, by using ELISA test system "Toxocara-
strip".

Results. Positive results were received in 14

patients from 30 examined patients. The frequency
of major clinical manifestations of toxocariasis was
presented as follows: manifestations of allergic skin
rash - 7 (50,0%), astheno-vegetative syndrome - in
11 (78,5%), intoxication syndrome - in 10 (71.4%),
pulmonary syndrome in 5 (35.7%), enlargement of
lymph nodes - 4 (28,5%), alopecia in 1 (7,1%). In
peripheral blood eosinophilia were found in 13
(92,8%) patients.

Conclusion. Based on epidemiological

analysis it was established that the key risk factors
for infection with T. canis are existence of
geophagia and/or contact with a dog (79%). The
range of clinical variants of toxocariasis course
varies to a great extent. These data coincide with the
literature data. The most frequently toxocariasis was
diagnosed in patients with allergic skin rash
(50,0%), astheno-vegetative syndrome (78,5%),
intoxication syndrome (71,4%) and high titers of
antibodies to T. canis.

THE CORELATIONS BETWEEN IMMUNOGRAM PARAMETERS IN THE PATIENTS

WITH CHRONIC VIRAL HEPATITIS C

U.P. Nabieva, T.A. Agzamova

Institute of immunology of the Academy of Sciences of the Republic of Uzbekistan,

Tashkent pediatric medical institute

The wide prevalence of hepatitis С virus

among the population, prediction to chronic process,
frequent development of the liver cirrhosis and
hepatocellular carcinoma as well as variability of
immune responses make the problem of chronic
hepatitis C one of the most important aspects in the
area not only in the hepatology but also in the whole
field of the internal medicine. The prolonged
existence of the HCV in the human div is
explained by its ability to survive under the
conditions of strength and various immune

responses. Without providing of the complete virus
elimination the immune system has significant
effect on the development of HCV-infection.

The purpose of our investigation was to study

correlations between immunogram parameters in the
patients with chronic viral hepatitis C.

There were studied 35 patients with chronic

viral hepatitis C (CVHC), mean age was 39,33±5,23
years. Out of 35 in 9 patients viral genome was PCR
(-), in 26 patients – PCR(+). Immunological
investigation was performed with use of monoclonal

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