The aim of study was to research the effect of darmonal and phytin compounds on the amount of glycogen and lactic acid in the liver tissues.
Materials and methods. The new compounds of phytin-C were studied: phytin-C, cobalt phytate and patent substance of darmonal obtained from wheat grain cells grown under special conditions. For comparison, the bioflavonoid of plant origin Liv-52, being used in treatment of liver diseases, was also studied. The study was carried out on 60 white rats weighing 120-150 g. The toxic hepatitis was caused by subcutaneous administration of 50% carbon tetrachlormetan oil solution in dose 0.8 ml/100 g for 4 days.
Results. The results showed that the combined introduction of extract significantly enlarged the outcome at joint use drug Liv-52 in animals, and, especially such effect was noticeable with addition phytin-C. The use bioactive substance in combination with complex phytin compound was more effective for accumulation of glycogen in the liver than using the drugs separately, hepatotoxin - carbon tetrachlormetan reduced carbohydrate metabolism and led to increase glycogen in liver tissues as well as the decreased lactic acid. It was determined that the combined treatment was more effective at toxic hepatitis induced by carbon tetrachlormetan, it had the hepatoprotective effect and improved liver function.
As a result of numerous clinical and experimental studies, a relationship has been established between changes in the oral cavity and pathology of internal organs. In modem dentistry, interest in research on concomitant pathologies is explained by the accumulation of new arguments, the emergence of new information in the system of the whole organism [3,5]. This analysis focuses on the prevalence of hepatitis infection and its various oral manifestations,consequences and clinical course. In this regard, the monitoring of outpatient records of patients with concomitant pathology, such as hepatitis А, В, C with inflammatory processes of the oral cavity and maxillofacial area after tooth extraction for emergency indications in the clinic of surgical dentistry of the clinic of the Tashkent State Dental Institute over the past 5 years was carried out.
HCV infection remains one of the leading problems in the diagnosis and treatment of chronic liver disease, given the scale of hepatitis C virus infection worldwide, the significant number of unexamined but at-risk patients, and the incidence of cirrhosis and liver cancer. Anemia is the most common hematological adverse event, which in turn significantly reduces the quality of life of patients during antiviral therapy, their adherence to treatment, and increases the risk of developing cardiovascular, renal and cerebral disorders.
With liver diseases, lipid metabolism is disturbed, fatty degeneration of the liver occurs. The studied drugs were studied in experimental studies. Experimental hepatitis was reproduced in outbred white rats of a mixed population by the administration of a hepatotropic poison of carbon tetrachloride. The effect of cobalt phytate and magnesium phytate preparations was studied with the most commonly used bioflavanoid silibor. Cobalt phytate, magnesium phytate and silibor preparations have a pronounced hepatoprotective effect, cobalt phytate and magnesium phytate are superior to silibor in this respect. The effect of the studied drugs is more pronounced in the treatment and prophylactic group.
This article presents the results of a study of the hepatoprotective properties of the herbal drug darmonal in combination with phytin compounds in experimental animals (rats) with experimental hepatitis caused by SS14 intoxication. The obtained research results showed that darmonal in combination with phytin compounds increases the synthesis of total protein and normalizes the composition of protein fractions of blood serum. Both studied drugs have a high level of hepatotropic effect. The combination of darmonal and fitin-C was the most effective. According to this effect, they were superior to the hepatoprotective drug LIV-52.
The influence of darmonal on the functional condition of liver lias been studied in toxic hepatitis. It was determined that darmonal increased content of protiens and improved detoxication function of liver by decreasing activity of cytolitic enzymes ALT and AST, decreasing cholestatic markers - APh and GGT. Darmonal showing hepatoprotective action improves function of liver and do not resign to other hepatoprotector - silibor.
In experimental toxic hepatitis caused by the hepatotropic poison carbon tetrachloride, a decrease in bile synthesis, bile-releasing function of the liver was revealed. There was a decrease in the composition of bilirubin, cholesterol and bile acids in the bile. In the treatment of experimental hepatitis with cobalt and silibor fiat, cholestasis decreased, the chemical composition of bile improved, as the content of bilirubin, cholesterol and total bile acids increased.
In experimental toxic hepatitis caused by the hepatotropic poison carbon tetrachloride, a decrease in bile synthesis, bile-releasing function of the liver was revealed. There was a decrease in the composition of bilirubin, cholesterol and bile acids in the bile. In the treatment of experimental hepatitis with cobalt and silibor fiat, cholestasis decreased, the chemical composition of bile improved, as the content of bilirubin, cholesterol and total bile acids increased.
Study of the effect of darmonal and phytin compounds on the exocrine function of the liver in acute experimental hepatitis. At the beginning of experimental hepatitis, these drugs were administered orally at a dose of 100 mg/kg. The results obtained led to an increase in the exocrine function of the liver under the influence.
It is known that in chronic liver diseases, secondary immunodeficiency is formed, which is of great importance for the dental system and the entire body as a whole. Therefore, it becomes clear the importance of studying the state of the protective system of oral tissues in chronic viral liver pathology, which requires timely and constant correction. The aim of this study was to evaluate the activity of proinflammatory cytokines and cytolytic enzymes in patients with chronic viral hepatitis before tooth extraction. The level of cytokine IL-1 in patients with CVI before tooth extraction was on average 43.97±3.56 pg / ml, whereas in healthy people the studied indicator was on average 5.41 ± 0.42 pg / ml. The patients showed an increase in the level of IFN in the blood serum by an average of 6.2 times, the level of interleukin-18, belonging to the IL-1 family, was statistically significantly increased by 2.4 times in patients with CVI, compared with the control group. The features of CVH are dissociations between the levels of proinflammatory cytokines IL-1, IL-6, IL-18 and interferon. This indicates the disintegration of the inflammatory process occurring in the periodontal tissues and with the transition to a chronic course of the disease. Changes in the level of IL-1, IL-6, IL-18 and interferon in the blood serum of patients with CVI from normal parameters before tooth extraction is an indicator of the severity of the inflammatory process in the liver, as evidenced by changes in the dynamics of cytolytic enzymes.
The influence of stimusol (extract radix Glycyrrhiza+mumie) on lipid peroxidation processes and
synthesis of gall m the liver at chronic toxic hepatitis were researched. It was determined that stimusol during
chronic poisoning with heliotrine made antioxidant and choleretic action. Normalize of gall contains. It didn't
give up to famous, silibor by hepatoprotector action
It is known that in chronic liver diseases, secondary immunodeficiency is formed, which is of great importance for the dental system and the entire body as a whole. Therefore, it becomes clear the importance of studying the state of the protective system of oral tissues in chronic viral liver pathology, which requires timely and constant correction. The aim of this study was to evaluate the activity of proinflammatory cytokines and cytolytic enzymes in patients with chronic viral hepatitis before tooth extraction. The level of cytokine IL-1 in patients with CVI before tooth extraction was on average 43.97±3.56 pg / ml, whereas in healthy people the studied indicator was on average 5.41 ± 0.42 pg / ml. The patients showed an increase in the level of IFN in the blood serum by an average of 6.2 times, the level of interleukin-18, belonging to the IL-1 family, was statistically significantly increased by 2.4 times in patients with CVI, compared with the control group. The features of CVH are dissociations between the levels of proinflammatory cytokines IL-1, IL-6, IL-18 and interferon. This indicates the disintegration of the inflammatory process occurring in the periodontal tissues and with the transition to a chronic course of the disease. Changes in the level of IL-1, IL-6, IL-18 and interferon in the blood serum of patients with CVI from normal parameters before tooth extraction is an indicator of the severity of the inflammatory process in the liver, as evidenced by changes in the dynamics of cytolytic enzymes.
The hepatoprotective activity of Ferula asafoetida resin gum in comparison with legalon was investigated in paracetamol hepatitis experimentally. It has been established that the gum of Ferula asafoetida resin prevents the development of cholestatistic and cytolytic syndromes, hyperbilirubinemia, hypoproteinemia. In terms of its pharmacological activity, the gum of Ferula asafoetida resin is not inferior to legalon. Obtained results recommend further studies of the pharmacological properties of the gum resin of Ferula asafoetida and the development of its officinal drug form
In experiments on white rats it was established that administration of heliotrine during a month induced severe damage to the liver characterized by enhancement of lipid peroxidation, a decrease of enzyme activities - superoxide dismutase and catalase. Liquorice, immortelle flowers and mumie inhibited manifestation of heliotrine hepatitis and exerted antioxidant action. In combined use of natural compounds their antioxidant action increases.