The problem of free radical pathology, the most important characteristic of which is the accumulation of toxic products of lipid peroxidation, is of exceptional scientific and practical importance. Radical oxidative processes are a significant pathogenetic factor in many diseases and pathological conditions (1,2,4,7,11). One of the important aspects of studying the pathogenesis of various diseases is the study of the state of lipid peroxidation and the antioxidant system. Violation of the stationary state of free-radical oxidation is considered one of the universal, non-specific indicators of the presence of damage and is characteristic of a wide variety of diseases: atherosclerosis, stress, neuroses, diabetes mellitus, inflammatory processes, autoimmune diseases, etc. (3,5,6,8,9 ,10).
В настоящее время установлено, что одним из ведущих механизмов повреждения мембран является активация перекисного окисления липидов (ПОЛ) на фоне снижения уровня антиоксидантной защиты (АОС), а эффективным средством для их восстановления являются антиоксиданты.
Aim of the research was the study activity of sympaticoadrenal system (SAS) at elderly patients with ischemic heart disease (IHD) and combinant subclinical hypothyrosis (SH) the level of daily excretion of cateholamines (CA) and activity of mo- noaminoxyase (MAO) in combination with determine activity processes of peroxide oxidation of lipids (POL). Results of examination of 28 patients with IHD and 14 patients with IHD in combination with SH were analyzed. Patients with IHD in combination with SH had the decrease of activity of SAS, which manifested by decrease excretion of CA. The maximum decrease of activity of MAO in patients with IHD and concomitant SH was detected. Also processes of POL were augmented, it was verified by increased
level of malonic dialdehyde - final substance of peroxidation. On the base of received results, it could be supposed, that decrease activities of SAS and POL are interrelated inpatient with combined pathology
The goal of the research was to study the infringements of metabolizmes catecholami- nines and processes of peroxide oxidation of lipids (POL) at the patients with familial hypercholesterinemia. The subjects of the
study were 92 patients with familial hypercholesterinemia and 15 practically healthy individuals. The study condition sympaticadrenal system (SAS) (increase excretions of catecholaminines: adrenaline (A), noradrenaline (NA).dopamine (DA), DOPA), total cholesterol, cholesterol of low - density lipoproteins cholesterol of high - density lipoproteins, triglycerides, processes of peroxide oxidation of lipids and monoamoxydasa in plasma of blood . The study revealed that abnormalities activity of SAS
patients with familial hypercholesterinemia. low activity monoamoxydasa in plasma of blood and significantly higher level of POL, it was verified by increased level of malonic dialdehyde - final substance of peroxidation
In experiments on white rats it was established that administration of heliotrine during a month induced severe damage to the liver characterized by enhancement of lipid peroxidation, a decrease of enzyme activities - superoxide dismutase and catalase. Liquorice, immortelle flowers and mumie inhibited manifestation of heliotrine hepatitis and exerted antioxidant action. In combined use of natural compounds their antioxidant action increases.
An increased tendency towards high morbidity of liver diseases requires a detailed study of the pathogenesis of the liver and the search for effective hepatoprotectors that can eliminate pathobiochemical changes in hepatocytes: increased lipid peroxidation against the background of a decrease in the activity of antioxidant defense enzymes and a violation of the lipid composition of membranes.
Liver pathology leads to a violation of lipid metabolism, because it plays a leading role in this metabolism. The synthesis of bile is disrupted, hydrolytic enzymes are activated, the synthesis of phospholipids decreases, the digestion of lipids in the gastrointestinal tract and the absorption of fat breakdown products, as well as fat-soluble vitamins, including the antioxidant vitamin E are disrupted.
Clinico-laboratorial part of the work is based on a survey of 96 patients with chronic generalized periodontitis (CGP). 22 people of the patients have chronic generalized periodontitis mild (HGPM), patients with chronic generalized periodontitis average degree (HGPA) and chronic generalized severe periodontitis (HGSP) 42 and 32 people respectively, combined with hypothyroidism. For objectification of the clinical research of the periodontal tissues, we used indicators such as the periodontal index, papillary-marginalalveolar index and the index of Ketze. For aexact determination of the intensity of the inflammatory process
used Schiller-Pisarev trial. To measure the depth of periodontal pockets also held X-ray examinations. It was found that a significant activation of lipid peroxidation and reduced antioxidant defense observed in patients with severe CGP on the background of hypothyroidism. It is shown that thyroid dysfunction occurs pronounced activation of the immune system, manifested by increased levels of cytokines in the serum. The highest concentration of TNF, IL-1 and IL-4 were detected in patients with moderate CGP thyroid hypofunction.