Here are the results of the microscopic study of the shape and size of particles of 5 samples of amlodipine besylate substance of world manufacturers, registered and used in the pharmaceutical industry of Uzbekistan. Such characteristics as the size and shape of particles, as well as the crystalline state with the simultaneous photos have been evaluated. Factors of the shape of particles of the substance of the studied samples were calculated.
Czech Red-pied × Ayrshire × Red Holstein crossbreds, got an eating routine with either creation blend with rapeseed, rapeseed cakes and rapeseed oil (Energol; E-bunch; last feed combination with 62 g of unrefined fat per kg of dry matter, DM) or control creation blend (C-bunch; rough fat substance in all out feed blend 37 g/kg DM). Milk tests were taken on the fourteenth, 30th, 60th and 90th day of lactation, and fundamental milk constituents and unsaturated fat substance in milk not really set in stone. E-and C-bunches didn't vary in either milk yield or yield of milk fat, milk protein and lactose (P > 0.05). Lactose, calcium, milk protein and casein content expanded straightly (P < 0.05) with the expanding day of lactation both in E-milk and in C-milk. Casein content in E-milk was lower (P < 0.05) than in C-milk however all out lipid content didn't vary (P > 0.05) from that in C-milk. Dietary rapeseed diminished (P < 0.05) palmitic corrosive substance in milk by 20 rate units and simultaneously expanded (P < 0.05) oleic corrosive substance by 10 rate units in correlation with control milk; the proportion of all out C16/complete C18 unsaturated fats was thusly twice lower (P < 0.01) in E-milk. To the extent polyunsaturated unsaturated fats (PUFA) are concerned, the substance of linoleic corrosive (LA), α-linolenic corrosive (LNA) and eicosapentaenoic + docosahexaenoic corrosive were higher (P < 0.05) in E-milk; nonetheless, the PUFAn-6/PUFAn-3 proportion was not diverse among E-and C-milk. It was presumed that 1 liter of E-milk could give 20% of both LA and LNA every day prerequisite.
Drug Treatment Courts (DTCs) have emerged as an alternative approach to traditional criminal justice responses for individuals with substance use disorders. This quantitative study examines the post-sentencing and reoffense outcomes of a Drug Treatment Court in a Western Canadian city. The study analyzes data from a sample of individuals who participated in the DTC program, comparing their post-sentencing outcomes to a matched comparison group of individuals who went through the regular criminal justice process. Outcome measures include recidivism rates, substance use patterns, treatment completion rates, and social reintegration outcomes. The findings provide insights into the effectiveness of the Drug Treatment Court in reducing recidivism, improving treatment outcomes, and facilitating successful community reintegration among individuals with substance use disorders. The implications of these findings for policy, practice, and future research are discussed.
Among modern cardiovascular drugs, amlodipine preparations occupy a significant place for the treatment of both arterial hypertension (AH) and coronary heart disease (CHD). The main merit in this belongs to Norvasc® (amlodipine besylate). According to the PIFAGOR III pharmacoepidemiological study, the proportion of amlodipine in the structure of antihypertensive drugs (AHP) taken by patients with hypertension reaches 15%.
The study aimed to investigate the protective mechanisms of substance Darmonal and phytin compounds in the experimental model of acute toxic drug-induced hepatitis caused by paracetamol in rats.
The material and methods The research was carried out on white outbred rats of both sexes weighing 140-200 g. Drug-in¬duced liver damage was reproduced by introduction of paracetamol into the stomach in dose 500 mg/kg for 2 days. The test compounds Darmonal, Fitin-C and reference drug Liv.52 were administered for 7 days after hepatitis reproduction in doses 100 mg/kg. The effectiveness and mechanism of action for selected supramolecular complexes in the model of toxic drug-induced hepatitis was made by paracetamol. It was researched that liver protein-synthesizing function was due to the content of total protein and albumin in the blood serum, the excretory and toxic function of the liver by the content of total and direct bilirubin as well as the endogenous intoxication were according to the content of urea in the blood serum, but cytolytic syndrome occurred because of the activity of indicator enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in blood serum).
Research results. The study of specific activity of Darmonal in combination with Fitin-C and the reference drug Liv.52 on the model of paracetamol and carbon tetrachloride hepatitis showed that the drugs, being administered in dose 100 mg/kg, had a pronounced hepatoprotective effect.
The aim of study was to research the effect of darmonal and phytin compounds on the amount of glycogen and lactic acid in the liver tissues.
Materials and methods. The new compounds of phytin-C were studied: phytin-C, cobalt phytate and patent substance of darmonal obtained from wheat grain cells grown under special conditions. For comparison, the bioflavonoid of plant origin Liv-52, being used in treatment of liver diseases, was also studied. The study was carried out on 60 white rats weighing 120-150 g. The toxic hepatitis was caused by subcutaneous administration of 50% carbon tetrachlormetan oil solution in dose 0.8 ml/100 g for 4 days.
Results. The results showed that the combined introduction of extract significantly enlarged the outcome at joint use drug Liv-52 in animals, and, especially such effect was noticeable with addition phytin-C. The use bioactive substance in combination with complex phytin compound was more effective for accumulation of glycogen in the liver than using the drugs separately, hepatotoxin - carbon tetrachlormetan reduced carbohydrate metabolism and led to increase glycogen in liver tissues as well as the decreased lactic acid. It was determined that the combined treatment was more effective at toxic hepatitis induced by carbon tetrachlormetan, it had the hepatoprotective effect and improved liver function.
The product is a white or yellow powder in appearance, odorless or tasteless. The substance has high thermal and salt resistance, does not contain toxins. If the reagent is introduced into the aqueous phase of the solution, it acts as a thickener and helps to reduce the filtration rate. The moisture content of the substance is less than 10 percent. The material complies with international standards for this substance.
Analysis of the assortment of sedatives registered in the Republic of Uzbekistan showed that sedatives are represented on the pharmaceutical market of the country by such dosage forms as drops, solutions, tinctures, syrups, medicinal herbal raw materials, capsules and tablets. Considering that sedatives registered in the form of a substance, with the exception of the dry extract of Leoglycyrfl produced by “Uzkimyofarm”, there are practically no names of S.K. Islambekov in the Joint Stock Company. In this regard, we consider it expedient to create a new sedative medicinal product of herbal origin in the form of a substance and obtain dosage forms based on it.
The understudies of current age additionally anticipate such a marvel in language adapting in order to fit them in a promising situation subsequent to acquiring a degree. The change in every one of the fields in the new many years focuses on the execution of a creative language educating at the tertiary level. The current practices in learning English have turned into an issue during the students' grounds enrollment as the present learning is estimated by what they can compose on the substance. The current schedule, instructing and the assessment system of it centers primarily around expanding understudies' substance information with less spotlight on upgrading relational abilities. Subsequently, the review is an endeavor to expand the students' relational abilities to make them more employable; and the specialist made a utilitarian utilization of intuitive showing procedure in the language homeroom for a couple of months.
The understudies of current age additionally anticipate such a marvel in language adapting in order to fit them in a promising situation subsequent to acquiring a degree. The change in every one of the fields in the new many years focuses on the execution of a creative language educating at the tertiary level. The current practices in learning English have turned into an issue during the students' grounds enrollment as the present learning is estimated by what they can compose on the substance. The current schedule, instructing and the assessment system of it centers primarily around expanding understudies' substance information with less spotlight on upgrading relational abilities. Subsequently, the review is an endeavor to expand the students' relational abilities to make them more employable; and the specialist made a utilitarian utilization of intuitive showing procedure in the language homeroom for a couple of months.
The target of the review was to explore the effect of privatization on quality in optional training as far as guardians' discernment identifying with their fulfillment with nature of instructors, understudies' accomplishment, actual offices, subject substance, co-curricular exercises, assessment framework and guardians' gathering. An example of 119 guardians principally fathers (moms in the event that fathers kicked the bucket) of understudies concentrating in private auxiliary and government optional schools were chosen haphazardly. Out of which 55 guardians were from private auxiliary schools and 64 were from government schools. The fulfillment scale for guardians comprising of 28 things on seven elements of optional schooling like nature of instructors, understudies' accomplishment, actual offices, subject substance, co-curricular exercises, assessment framework and guardians' gathering was created by the agent.
This hypothetical article is dedicated to the production of Blended Learning Model [BLM] which targets giving a mastering climate to advancing enterprising abilities among ladies. Item Development measure has been utilized for creating BLM. Self-instructional systems are likewise applied to plan the learning circumstance in the BLM. Vis-à-vis and online method of learning are viably mixed in the BLM which incorporates 70% learning through on the web and just 30% occurs in up close and personal mode. There is a logical course arrangement that has been set up in various parts of the BLM, for example, the points and goals, responsibilities of student, substance and setting, learning results and human cooperations, collaborations with content, situations based learning for establishing relevant learning climate, and so forth Self-administered learning exercises have been produced with the end goal of compelling learning. Most extreme instructing learning exercises were helped out through a PC intervened online stage and some of them were given through the vis-à-vis method of learning. The advancement cycle of BLM has been portrayed in nitty gritty in present paper.
The World Health Organization has identified vaccination denial as one of the top 10 global health threats. Immunisation refusal in Uzbekistan is 1%," said Dilorom Tursunova, deputy head of the Health Ministry's Main Sanitary and Epidemiological Supervision Directorate. Vaccinatios are a simple solution to provide the body immunity for individuals without the individuals ever having to contract the disease and suffer the symptoms. The healthy human body naturally recognizes foreign substance, like pathogen to protect against future encounters. The body uses antibodies as one of its main defense mechanism.
Aim of the research was the study activity of sympaticoadrenal system (SAS) at elderly patients with ischemic heart disease (IHD) and combinant subclinical hypothyrosis (SH) the level of daily excretion of cateholamines (CA) and activity of mo- noaminoxyase (MAO) in combination with determine activity processes of peroxide oxidation of lipids (POL). Results of examination of 28 patients with IHD and 14 patients with IHD in combination with SH were analyzed. Patients with IHD in combination with SH had the decrease of activity of SAS, which manifested by decrease excretion of CA. The maximum decrease of activity of MAO in patients with IHD and concomitant SH was detected. Also processes of POL were augmented, it was verified by increased
level of malonic dialdehyde - final substance of peroxidation. On the base of received results, it could be supposed, that decrease activities of SAS and POL are interrelated inpatient with combined pathology
The work of reflection on learning and the important role the brain plays establishes a referential analysis with the goal of investigating and knowing everything related to the human being's knowledge and the activities he performs during the process of acquiring knowledge. These highlights how important it is to know this organ and how the content can be changed. Additionally, brain plasticity, which is the adaptation of changes or modifications that occur during the learning process, is emphasized. Significant learning is procured through great instructive practices and the utilization of dynamic philosophies, where a proper climate is laid out, in which inspiration assumes a significant part and procedures are as per the substance to be dealt with, which is preposterous without the cerebrum in question. The work is synthesized through analytical research and the use of the inductive method by analyzing the problem from the general to the specific, defining the elements that interfere with learning and the brain's imprint, the relationship with society in the cognition of contents, and the skills necessary for the development in various areas of knowledge. In addition, bibliographic resources are used to relate to the topic being discussed. The work's objective is to examine how the teaching-learning process affects the brain.
This paper reports Partner in Nursing examination of the impact of abuse stone powder and limeon the geotechnical properties of soil material. The compaction and changes inside the substance properties of the dirt with hydrogen particle fixation investigate once blended in with differed extents of abuse stone powder and limewere explored. Consequently, the viability of double-dealing Abuse Stone Powder and lime for fundamental research center tests as well as grain size examination, hydrogen particle focus investigate and ordinary Delegate compaction tests for balancing out fine-grained soil material was explored inside the lab. the portion of lime and WSPused on the examples changed from zero to Martinmas,which treatment of the examples with lime and WSPcontent show that the best wetness and most dry thickness upsides of the examples were altered. The outcomes show expanding inside the hydrogen particle fixation cost of soil material with expanding amount of abuse stone powder and lime. what's more, in this way the best wetness content improved with expanding lime and WSPcontent for every one of the examples. also the highest level of dry thickness debilitated with expanding lime, though the greatest amount of dry thickness upgraded with increasingWSP content. The way of behaving of the geotechnical properties of the dirt material once blended in with abuse stone powder and lime demonstrates that these materials square measure a nice modifier for this dirt.
Currently, many studies are being carried out to study the effectiveness of ointment ophthalmic preparations. Ophthalmic ointments are unique in that they have a multicomponent mechanism of action. On the one hand, due to the ointment base, the effect of the medicinal substance itself is prolonged, and on the other hand, due to the structural features of the mucous membrane of the conjunctival cavity, these medicinal substances are very quickly absorbed. In the treatment of pathology of the ocular surface, including meibomyitis, barley and chalazion, preference is given to local therapy and ointment forms. The study was aimed at studying the effectiveness of antibacterial ophthalmic ointment of domestic production Tobrex - in the treatment of acute and chronic diseases of the eyelids and conjunctiva.
Anticipating the trademark conduct of liquids as they stream across a Bluff body is significant in a few ventures including measure, food, substance and oil and gas enterprises. The Bluff body is utilized to incite the stream in other to reproduce the impacts of such stream across stream meters and other obtrusive estimation tests that may upset the progression of liquid in a line. In this work, a straightforward Bluff body which imitates the meeting side of a commonplace endeavor meter is utilized. ANSYS CFD Familiar is utilized to recreate the stream while Trick was utilized to produce the calculation of the Bluff body. The Semi-Verifiable Technique for Pressing factor Connected Condition (Straightforward) is utilized to mimic the stream across the Bluff body. The standard k-epsilon model is utilized for the disturbance demonstrating in the investigation. 25 mm Upstream of the Bluff body, it is seen that the pressing factor expanded as the speed increments, notwithstanding, downstream, it is seen that simply behind the Bluff body's wedge, the pressing factor stayed steady for the three flowrates reenacted.