Zamonaviy yurak-qon tomir preparatlari orasida amlodipin preparatlari arterial gipertenziya (AH) va yurak-qon tomir kasalliklarini (CHD) davolash uchun muhim o'rin tutadi. Bunda asosiy afzallik Norvasc® (amlodipin besilat) ga tegishli. PIFAGOR III farmakoepidemiologik tadqiqotiga ko'ra, gipertenziya bilan og'rigan bemorlar tomonidan qabul qilingan antihipertenziv dorilar (AHP) tarkibidagi amlodipinning ulushi 15% ga etadi.
Tadqiqotning maqsadi kalamushlarda paratsetamol tomonidan qo'zg'atilgan o'tkir toksik dori-darmonli gepatit modelida Darmonal moddasi va fitin birikmalarining himoya ta'sir mexanizmini o'rganish edi. Tadqiqot materiali va usullari og'irligi 140-200 g bo'lgan har ikki jinsdagi kalamushlarda o'tkazildi.Dori vositasida jigar shikastlanishi 2 kun davomida 500 mg/kg dozada paratsetamolni oshqozonga kiritish orqali ko'paytirildi. Sinov birikmalari Darmonal, Fitin-C va mos yozuvlar Liv.52 preparati gepatitning ko'payishidan keyin 7 kun ichida 100 mg / kg dozada kiritildi. Tanlangan supramolekulyar komplekslarning samaradorligi va ta'sir mexanizmini paratsetamol keltirib chiqaradigan toksik dori-darmonli gepatit modelida aniqlash uchun biz quyidagilarni o'rgandik: qon zardobidagi umumiy oqsil va albumin miqdori bo'yicha jigarning oqsil sintez qilish funktsiyasi, ekskretor va umumiy va to'g'ridan-to'g'ri bilirubin miqdori bo'yicha jigarning toksik funktsiyasi, qon zardobidagi karbamid miqdori bo'yicha endogen intoksikatsiya, indikator fermentlari (alanin aminotransferaza (ALT) va qon zardobidagi aspartat aminotransferaza (AST)) faolligiga ko'ra sitolitik sindrom. Tadqiqot natijalari. Darmonal, Fitin-S va ularning birgalikda qo'llanilishi bilan Liv.52 etalon preparatining o'ziga xos faolligini paratsetamol va uglerodli tetrakloridli gepatit modelida o'rganish shuni ko'rsatdiki, dorilar og'iz orqali 100 mg / dozada yuborilganda. kg, aniq gepatoprotektiv ta'sirga ega.
Tadqiqotning maqsadi darmonal va jltin birikmalarining jigar to'qimalarida glikogen va sut kislotasi miqdoriga ta 'sirini о 'rganishdir.
Materiallar va usullar. Yangi fltin birikmalari o'rganildi: fitin-C, kobalt fitat va maxsus sharoitlarda yetishtirilgan bug'doy don hujayralaridan olingan patentiangan darmonal moddasi. Taqqoslash uchun, jigar kasalliklarini davolashda qo'llaniladigan o'simlik kelib chiqishi Liv-52 bioflavonoidi ham o'rganildi. Tadqiqot 120-150 g og'irlikdagi 60 ta oq kalamushlarda o'tkazildLToksik gepatit 4 kun davomida 0,8 ml/100 g dozada uglerod tetrakloridning 50% yog'li eritmasini teri ostiga yuborish orqali qo'zg'atildi. Natijalar shuni ko'rsatadiki, ekstraktni birgalikda qo'llash Liv-52 ni hayvonlarga bir vaqtda qo'llashdan sezilarli darajada ustundir, ayniqsapreparat fitin-C bilan birgalikda qo'llanganda bunday ta'sir ko'rsatilganda. Biofaol moddani fitinning murakkab birikmasi bilan birgalikda qo'llashda и dori-darmonlarni alohida qo'llashdan ko'ra jigarda glikogenning to'planishiga olib keldi, gepatotoksin - uglerod tetraklorid uglevod almashinuvini pasaytiradi va jigar to'qimalarida glikogenning ko'payishiga olib keladi. va sut kislotasining kamayishi.
Uglerod tetraxlorid qo'zg'atadigan toksik gepatitda kombinatsiyalangan davolash samaraliroq ekanligi, gepatoprotektiv ta'sir ko'rsatishi va jigar faoliyatiniyaxshilashi aniqlandi.
Analysis of the assortment of sedatives registered in the Republic of Uzbekistan showed that sedatives are represented on the pharmaceutical market of the country by such dosage forms as drops, solutions, tinctures, syrups, medicinal herbal raw materials, capsules and tablets. Considering that sedatives registered in the form of a substance, with the exception of the dry extract of Leoglycyrfl produced by “Uzkimyofarm”, there are practically no names of S.K. Islambekov in the Joint Stock Company. In this regard, we consider it expedient to create a new sedative medicinal product of herbal origin in the form of a substance and obtain dosage forms based on it.
Poultry farming is one of the most developed industries, and it is very important to operate the industry completely without waste. More than 20,000 chickens are slaughtered in poultry factories per month. Taking into account that on average 100 grams of feathers are extracted from one chicken, the main goal is to extract keratin protein by processing more than 2 tons of chicken feathers per month. During the research, my method of extracting protein from feathers will be discussed. In addition, determination of the amount of nitrogen in the protein isolated by a special method, determination of the total protein and amino acids are discussed. In the results section, it was found that 25% dry mass was extracted, it contained 17 different amino acids. It was concluded that chicken feather protein can be used for cosmetics based on theoretical comparisons with keratin protein. Hair is composed mainly of keratin protein and a small amount of lipid.
Thiocynate, salivary substance and salivary stream rate were estimated. Results - Stream rate, sodium, potassium, calcium, phosphate, protein, lactate dehygrogenase, MIP 1 alpha, Malonaldehyde, 8hydroxydeoxyguanosine, thiocynate were found to increment fundamentally while Amylase movement, nutrient E and C and mouth opening were diminished in reenactment conditions in logical inconsistency to ordinary and recuperation stage. The edge for MSG and capsaicin expanded around 1.5 weakening advance, while sodium chloride diminished around 2 weakening during microgravity when contrasted with ordinary conditions. Less than overwhelming torment of teeth, facial oedema, less than overwhelming agony mandibular point districts, torment in sublingual and submandibular opening conduit areas, strange look, loss of impression of torment and temperature, diminished the tongue and mandibular development in reenactment microgravity conditions. Conclisons-These outcomes propose that reversible impact of microgravity is oedema of face, change in taste, strange demeanor of face, teeth agony and xerostomia.
Ушбу мақолада СС14 интоксикацияси оқибатида експериментал гепатит билан експериментал ҳайвонлар (каламуш) фитин бирикмалар билан бирга ўсимлик дори дармон гепатопротектор хусусиятларини ўрганиш натижаларини тақдим этади. Олинган тадқиқот натижалари шуни кўрсатдики, дармонал фитин бирикмалари билан биргаликда умумий оқсил синтезини оширади ва қон зардобининг оқсил фракциялари таркибини нормаллаштиради. Ҳар икки ўрганилган дорилар гепатотроп таъсири юқори даражасига эга. Дармонал ва фитин-C комбинацияси энг самарали бўлди. Ушбу таъсирга кўра, улар Лив-52 гепатопротектор препаратидан устунлиги аниқланди.