In conditions of age-related decrease in sex hormones and a number of pathological conditions and diseases in postmenopausal women, there is a deficiency of D hormone. In our country, the geographic location of which is below northern latitude and sufficient ultraviolet radiation, an insufficient content of vitamin D is seen in postmenopausal women. There are a lot of risk factors leading to vitamin D deficiency - the presence of smog and dust in cities, insufficient consumption of vitamin-fortified foods, the presence of problems with the gastrointestinal tract and excretory system and a number of others. One of the important factors that reduce vitamin storage is overweight and obesity, especially in combination with old age, when all absorption processes are reduced. The aim of our research was to study risk factors in women with vitamin D deficiency with subsequent correction of the deficiency state. We examined the level of total 25 (OH) D in the blood serum in 46 postmenopausal women, and identified risk factors. Vitamin D deficiency was detected in 86.96% of women, and its deficiency was registered in 10.87%. At the same time, a pronounced vitamin deficiency was not registered in any patient. Overweight was registered in 32.6%, obesity of varying degrees in 26.1%. Given the indicators, recommendations were given for correcting vitamin D deficiency. All postmenopausal women, especially those with risk factors for deficiency, are recommended to determine the basic level of vitamin D. In case of deficiency, drug correction is recommended to reduce the risk of cardiovascular and oncological diseases.
The study of vitamin D - dependent risk factors for the formation of essential arterial hypertension
(EAH) based on the assessment of serum levels of calcidiol (25 (OH) D), calcium and vasoconstrictor factor endothelin-1-21 in 132 students aged 13 to 16 years (average age 14.64 ± 0.19 years) with normal, high normal blood pressure and essential arterial hypertension (EAH) established the priority effect of vitamin D supply on the level of diastolic blood pressure in the group of children with labile arterial hypertension and in the group of children with stable on the parameters of systolic blood pressure. In the mechanism of EAH formation in children, an interdependence between vitamin D deficiency and the severity of endothelial dysfunction by the level of endothelin -1-21 was revealed. The following vitamin D were determined by diagnostic efficiency - dependent risk factors for the formation of EAH in children in decreasing importance: endothein-1-21> 0.41fmol / ml; vitamin D <20ng / ml; Ca <2.22 mmol / L.
Percentage of human population that suffer from chronic inflammatory parodontal diseases amounts to 70-98% [1]. This group of diseases is considered to be one of the most common reasons of teeth loss among people over 40 years of age. There are more than 50 somatic pathologies known to date, that get compounded by damage of parodontal tissues with 100% probability [2]. There is a tendency for «rejuvenation» of parodontal inflammatory diseases, that results in increasing prevalence among the age group of 18-24 [3]. Another tendency is that aggressiveness and severity of diagnosed pathologies increases considerably [4]. Statistically significant prevalence of vitamin D (21-29 ng/ml or 52,5-72,5 nmol/l) and deficiency (11-20 ng/ml or 27,5-50 nmol/l) [5], laboratory data in an array of research enable us to claim a substantial reverse dependence of parodontal inflammatory diseases’ intensity on vitamin D levels.
52 patients with rickets and 10 healthy children were examined. Among patients with rickets, 35 children were born in women with a complicated course of pregnancy (threat of termination, toxicosis of the first and second half). In 12 children, mothers had chronic liver and kidney diseases before giving birth.
The level of 25(OH) vitamin D (25-oxycalciferol) and 24.25 (OH)2 vitamin D (24.25-dioxycalciferol) was determined. The content of calcium-regulating hormones in the blood serum was determined by radioimmunological analysis. To assess the severity of the rickets process, the activity of alkaline phosphatase in the blood serum was determined using a standard kit.
The aim of our study was to determine the effect of specific prevention on the metabolism and course of the clinical form of rickets in young children.
The article presents the results of our own research on the study of the period of postnatal adaptation in newborns with a vitamin D deficiency. It was revealed that early postnatal adaptation in most newborns with vitamin D deficiency occurs with disorders manifested by the pathological course of neonatal jaundice, maladjustment of the cardiovascular system, significant loss of the initial body weight and its long recovery
The article provides a review of the literature on the role of vitamin D in the development and course of various diseases of
the cardiovascular system. An analysis of the literature showed that the studies performed are often experimental in nature, while clinical
trial data are scarce and contradictory. In children, data on the role of vitamin D in the occurrence and progression of cardiovascular
diseases are sporadic, which indicates the need for further scientific research in this direction.
Ҳозирги кунда Соғликни Саклаш Вазирлигининг асосий вазифаларидан бири ахоли саломатлигини асраш ва касалликлар олдини олишдир. Ҳозирги кунда рахитни даволашда витамин Д таркибли дори воситаларининг энг самаралисини танлаш жудаям муҳимдир. Рахит гўдак ешидаги болаларда энг кўп учрайдиган касалликлар гуруҳига киради. Рахит бола организмининг умумий касаллиги бўлиб, у биринчи навбатда кальций ва фосфор моддаларининг алмашинувининг бузилишига боғлик жараен, бемор болада касалликка қарши курашиш холатлари пасайган бўлади. Эрта рахит белгиларини кеч даволаш еки даволамаслик оқибатида бемор бола организми ривожланишдан орқада қолишга сабаб бўлади.
To evaluate changes in the oral cavity caused by osteoporosis in conditions of estrogen deficiency and the effect of hormone replacement therapy with calcium and vitamin D preparations
Tanada B 9 vitamini yetishmasligi ko‘plab jiddiy kasalliklarning rivojlanish xavfiga tahdid solishi mumkin, shuning uchun uning yetishmovchiligini vaqtida aniqlash va to‘ldirish juda muhimdir. Vitamin yetishmovchiligi belgilari quyidagilarni o‘z ichiga olis hi mumkin. Haddan tashqari rangparlik, shuningdek zaiflik bilan namoyon bo‘ladigan gemoglobin darajasining pasayishi, oshqozonda xlorid kislota yetarli darajada ishlab chiqarilmasligi tufayli paydo bo‘ladigan ishtahani pasayishi, tez-tez kayfiyat o‘zgarishi, depressiv holatlar, tirnoqlarning haddan tashqari mo‘rtligi, sochlar holatining yomonlashishi, shuningdek ularning yo‘qolishi va boshqalar.
Subject of the inquiry: diets for nutrition in the families and kindergardens, biological active addition to the food, animals, children.
Aim of the inquiry: elaboration of effective methods of rationalization of diet for nutrition of studying-educational institutions with usage of biological active additions for food.
Methods of inquiry: hygienic, medical- biological, toxicological, biochemical, chemical and statistical.
The results achieved and their novelty: According to the results of hygienic and toxicological explorations of biological active addition “ Biovit” was selected as the most successful, which made compensation of the deficit of vitamin C, A, B6, B12; folium acid, calcium, magnesium; irreplaceable aminoacids in daily diet of children, who attends kindergardens. It was estimated the increase of biological value of nutritional diet, increase of nitrogen’s balance, secretion of nitrogen, assimilation of the protein and improvement of biochemical index of nitrogenical components of the urine and sufficiency in vitamin C among children. The methodological approach was established to the basis of using biological active additions and estimation their effect in kindergardens.
Practical value: The results of research, which was appvouba by Sanitary rules and norms Republik of Uzbekistan, 2 methodical recommendations, method of avaluation of nutrition’s condition was elaborated and approved for practical health care according to research works;
Degree of embed and economic effectivity: the introduction on the Republic level has public cultural, general prophylactic, social and ecological hygienic role in the safety of the health of population.
Sphere of usage: in prophylactic medicine and hygienic practice, in study of medical Universities.