Cervical vertebral augmentation has emerged as a promising technique for the treatment of vertebral fractures and instability. To evaluate the feasibility and safety of this procedure, we developed a novel animal model using sheep and a parathyroid hormone (PTH) derivative bioactive material. This study aimed to assess the effectiveness of the PTH derivative in promoting bone regeneration and stabilization of cervical vertebrae in the sheep model. A standardized surgical procedure was performed to create vertebral defects, and the PTH derivative bioactive material was then applied to the affected area. Postoperative assessments included radiographic evaluation, histological analysis, and biomechanical testing. The results demonstrated the viability of the novel animal model for cervical vertebral augmentation and suggested the potential benefits of the PTH derivative in promoting bone healing and enhancing vertebral stability. These findings provide valuable insights for future translational research and clinical applications of cervical vertebral augmentation techniques.
To evaluate changes in the oral cavity caused by osteoporosis in conditions of estrogen deficiency and the effect of hormone replacement therapy with calcium and vitamin D preparations
During periods of puberty, social adaptation, clinical realization of these disorders can occur, leading to reproductive disorders. Over the past decade, thanks to the introduction of new diagnostic and functional tests into healthcare practice, data have appeared that made it possible to formulate modern ideas about the features of the endocrine status of girls during maturation and to identify a number of successive changes during its physiological course; this created the basis for an adequate assessment of the pathology of this period.
The study was carried out in 2018-2020 in the cardio rheumatology department of the 4th Children's City Hospital in Tashkent. We observed 254 children aged 7 to 15 years with acute rheumatic fever, who received corticosteroids. According to our results, despite the positive efficacy of hormone therapy in acute rheumatic fever, side effects are observed with a very high frequency (73%). It is recommended to prescribe hormonal therapy with caution and only in case of severecomplications of the disease, since the termination of the use of hormones can lead to a syndrome of cancellation or exacerbation of the process.
The functioning of the female reproductive system depends on the proper development and regulation of the hypothalamic-pituitary-ovarian axis. It is based on the secretion of GnRH, which stimulates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). There have been many studies investigating the factors that regulate the secretion of gonadotropins. In recent years, the significance and role of kisspeptin and its receptor has aroused interest. This review will provide data from foreign studies and literature on the role of kisspeptin in the regulation of the female reproductive system.
In conditions of age-related decrease in sex hormones and a number of pathological conditions and diseases in postmenopausal women, there is a deficiency of D hormone. In our country, the geographic location of which is below northern latitude and sufficient ultraviolet radiation, an insufficient content of vitamin D is seen in postmenopausal women. There are a lot of risk factors leading to vitamin D deficiency - the presence of smog and dust in cities, insufficient consumption of vitamin-fortified foods, the presence of problems with the gastrointestinal tract and excretory system and a number of others. One of the important factors that reduce vitamin storage is overweight and obesity, especially in combination with old age, when all absorption processes are reduced. The aim of our research was to study risk factors in women with vitamin D deficiency with subsequent correction of the deficiency state. We examined the level of total 25 (OH) D in the blood serum in 46 postmenopausal women, and identified risk factors. Vitamin D deficiency was detected in 86.96% of women, and its deficiency was registered in 10.87%. At the same time, a pronounced vitamin deficiency was not registered in any patient. Overweight was registered in 32.6%, obesity of varying degrees in 26.1%. Given the indicators, recommendations were given for correcting vitamin D deficiency. All postmenopausal women, especially those with risk factors for deficiency, are recommended to determine the basic level of vitamin D. In case of deficiency, drug correction is recommended to reduce the risk of cardiovascular and oncological diseases.