All articles - Gastroenterology and Hepatology
Number of articles: 744
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FEATURES OF THE DIAGNOSIS OF OBSTRUCTIVE JAUNDICE, ACCOMPANIED BY CIRRHOSIS OF THE LIVERThis article presents the results of a study of 66 patients with obstructive jaundice caused by gallstone disease, concomitant with cirrhosis of the liver (LC). All patients were divided into 2 groups: the first group included 46 patients with obstructive jaundice with LC, and the second - only 20 patients with obstructive jaundice. Obstructive jaundice in 64% of patients was caused by cholelithiasis treated in this surgical clinic, of which 20.4% of them were identified as concomitant diseases with various stages of liver cirrhosis. Compared were the complaints of patients of both groups, the clinical course, the results of objective observation, laboratory research, the results of additional instrumental examination and their specificity.
Journal of hepato-gastroenterological research -
SEPTIC-PURULENT COMPLICATIONS OF URGENT ABDOMINAL SURGERY. A NEW LOOK IN PREVENTION AND TREATMENTThe authors demonstrate a clinical and experimental morphological rationale for an aprobation helium-neon laser beam to reduce and prevent after complications of surgery. In the clinic, the method was used in 235 patients (with gastric resection, cholecystectomy, small and large intestine operations). The effectiveness of the proposed method is revealed. A decrease in postoperative purulent complications was noted.
Journal of hepato-gastroenterological research -
SURGICAL TACTICS IN TREATMENT OF ELDERLY AND ADDITIONAL PATIENTS WITH GASTRODUODENAL ULTRA DUODENAL BLEEDINGThe authors proposed a tactic based on the prognosis of recurrent bleeding, which made it possible to carry out rational regrouping in the framework of urgent surgical interventions, which cannot be achieved using the traditional active-expectant approach. In the course of work, the introduction of individually-active surgical tactics based on the prognosis of recurrent bleeding in the treatment of patients over 60 years of age with UHDH, has reduced the number of recurrent bleeding from 32.1 to 17.7%, respectively, to reduce the number of emergency operations from 90 to 50% and, thus, as a result, reduce the incidence of postoperative complications (from 38.8 to 22.9%) and mortality (from 24.5 to 12.5%).
Journal of hepato-gastroenterological research -
HISTOLOGICAL STUDIES OF ECHINOCOCCAL MEMBRANES AND LOCAL REACTION OF TISSUE FROM THE HOST ORGANISM, DEPENDING ON THE PRESENCE OF PATHOGENIC MICROFLORA AND INFECTION IN ECHINOCOCCAL CYSTSPurpose: to study the parasite’s surrounding tissues by complex methods of investigation for the presence of some pathogenetic relationship between the degree of viability of the parasite, its morphological modification, localization. amino acid composition, microflora of echinococcal fluid and local tissue reaction. Methods: microbiological studies from echinococcal cysts obtained from 68 operated patients from the contents of the parasite. Macro and microscopic studies were performed on 158 different echinococcal vesicles and surrounding tissues. Used material from 46 animals, and from 112 operated patients. Results: our studies found that viable and dystrophically altered cchinococcal vesicles had a shaped capsule, which in some cases had its own morphological features: in 7 bubbles it was single-layered, in 30 - double-layered, in 8 it had three-layer structure. Conclusions: studies of the membranes of echinococcus showed that in the fibrous membrane of E. Hominis. depending on the morphological modifications and the
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FREQUENCY OF MEETING ANORECTAL MALFORMATION AT ANTENATAL DIAGNOSTICS IN CHILDREN OF SAMARKAND AND SAMARKAND REGION1 he prevalence ot anorectal malformations ranges from I: JJUO to I: 5000 cases ot live births. With the development of antenatal diagnosis, ultrasound criteria specific to anus atresia are currently being actively discussed. The most affordable and effective method that allows you to establish anorectal malformations during pregnancy is ultrasound of the fetus. According to the approved protocol, when a fetus reveals sonographic signs of malformation in a screening center, the pregnant woman attaches herself to the department of pregnancy pathology. Screening ultrasound examination of pregnant women was performed at gestational age 20-22 weeks. Thus, antenatal ultrasound performed during gestational periods of 20-22 weeks shows a rather high information content for identifying sonographic signs, especially without fistulous forms of AWP in the fetus with a sensitivity of 57.1%. specificity - 98.8% and overall accuracy - 96.5 %.
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The term" gastroesophageal reflux disease " (Gers) is a syndrome characterized by persistent rsgurgitation of kslib - induced inflammation zharaens in the distal part of the esophagus as a result of constant rsgurgitation of the meda eki duodenal Max-Solutions and coplab symptoms. In fact, the rsgurgurgitation of ovkat products to kizilungach-this is a natural physiologist zharaen bulib, as a result of normal clearance of this kizilunun, several se-kond should be uttered. Constant regurgitation in the lekin, gerk symptoms may come and appear as a result of factors that overlap like irregular and disproportionate ovkatla-nish. The same SA-babli, the Congress, which was held in October 1997 Year in Genval, Belgium, was recognized as kerk independent disease. -
EVOLUTION OF APPROACHES TO THE THERAPY OF REFRACTED CELLIACIA IN CHILDREN OF THE UZBEK POPULATIONExamined 200 children with celiac disease aged 1-14 years. The diagnosis of the disease was verified based on the criteria of the European Association of Pediatric Gastroenterologists (1999). Celiac disease was revealed as a typical form in 81%, an atypical form was found in 19%, of which 21.5% had a refractory course of the disease. Depending on the drug therapy, 4 groups were identified: -1st-30 children who, in addition to traditional therapy, received ecdisten 0.01 g at 1 mg / kg / day; -2nd- 37 children who additionally received antioxidant zinc with 20 mg / day; - 3rd - 28 children who additionally received ecdisten 0.01 g at 1 mg / kg / day in combination with antioxicaps with zinc at 20 mg / day; -4-I- 47 children who received the generally accepted basic therapy. The course of treatment is 1 month. The studies were carried out after 3, 6 and 12 months. The results obtained indicate the restoration of the intestinal absorption function against the background of the modified treatment, more significant changes were obtained in patients who received the combined use of ecdisten with antioxicaps with zinc. This combination, against the background of basic therapy in the refractory course of the disease, has a beneficial effect on the clinical course, reduces the degree of structural and functional disorders, improves the outcome of the disease. To obtain a stable clinical remission, it is necessary to carry out repeated courses of modified therapy in a differentiated manner.
Journal of hepato-gastroenterological research -
OBSTRUCTIVE BRONCHITIS IN CHILDREN: RELATIONSHIP OF INTESTINAL MICROECOLOGY WITH CLINICAL CHARACTERISTICS52 children with acute obstructive bronchitis were examined. The intestinal microflora was studied according to the generally accepted method. The relationship of intestinal microbiota indicators with the severity of clinical symptoms in acute obstructive bronchitis in children was revealed. Dysbiotic disorders of the intestinal microflora are interrelated with the severity of clinical manifestations, affecting the functional ability of the gastrointestinal tract, contribute to the sensitization of the body and increase bronchial obstruction.
Journal of hepato-gastroenterological research -
PECULIARITIES OF CYTOKINE STATUS IN DIFFERENT FORMS OF CHRONIC PYELONEPHRITIS IN CHILDRENDespite the successes of theoretical and practical nephrology, the incidence of CP in children, in recent years, is characterized by a high growth trend and represents a serious medical and social problem. Purpose of the study. To study the state of cytokine status in children with chronic pyelonephritis. Materials and research methods. The work is based on clinical studies of 177 patients with CP (of which 105 children with recurrent and 72 patients with latent form) aged 4 to 15 years. Results and discussions. In the study of serum concentrations of the studied cytokines in patients with exacerbation of the chronic process, a significant increase in pro-inflammatory TNF-α and INF-ᵧ was revealed. Exceeding the anti-inflammatory IL-4 control values by more than five times occurred against the background of an increase in the concentration of TNF-α and INF-ᵧ. Conclusions. Patients with LHP were characterized by significant differences in urinary levels only in TNF-α from those of the active phase of rHP (P <0.05), which is also characteristic of serum concentrations.
Journal of hepato-gastroenterological research -
PHARMACOEPIDEMIOLOGY OF HEPATOPROTECTORS, USED IN PATIENTS WITH LIVER CIRRHOSIS, RECEIVED TREATMENT IN SOME MEDICAL CENTRES OF KHOREZM REGIONRetrospectively, 239 cases history of patients with liver cirrhosis who received treatment in some medical centres of Khorezm region were studiedbypharmacoepidemiologicalmethods.For the study the questionnaire included 38 items of hepatoprotectors used in the practice of medicine in Uzbekistan.It is revealed that pharmacotherapy of patients with liver cirrhosis who received treatment in some medical centres of Khorezm region, the moderate severity of the pathological process and in compliance with the guidelines recognized by the world community of gastroenterologists. In the treatment of patients with cirrhosis of the liver doctors used gepatoprotektory separately and in combination.
Journal of hepato-gastroenterological research -
COMPARATIVE ANALYSIS OF SOME LABORATORY INDICATORS OF ALCOHOLIC AND VIRAL HEPATITISThe article provides information on the biochemical parameters of liver function in alcoholic and viral hepatitis, as well as on the markers of viral hepatitis. According to the World Health Organization, about 2 billion people worldwide consume alcohol. Therefore, it is important to distinguish alcoholic hepatitis from viral hepatitis.
Journal of hepato-gastroenterological research -
CARDIOVASCULAR SYSTEM IN CHILDREN AND ADOLESCENTS WITH OBESITY60 adolescents with obesity were examined. It was revealed that the development of myocardial hypertrophy is influenced by body weight, blood pressure, vasoconstriction processes, as well as insulin resistance, hyperuricemia and atherogenic dyslipidemia. Some children have metabolic syndrome, which requires therapy for this condition to prevent early complications and disability in adolescents in the adult period.
Journal of hepato-gastroenterological research -
CLINICAL AND INSTRUMENTAL MANIFESTATIONS OF THE CENTRAL NERVOUS SYSTEM DISORDER IN NEWBORNS WITH CONGENITAL HEART DISEASESThe aim of the study was to study the epidemiology of congenital heart defects in newborns and the clinical and instrumental features of central nervous system damaged in this category of patients. It was revealed that in the structure of congenital heart diseases the leading place is occupied by the defect of the interventricular septum, less often the defect of the interatrial septum and tetralogy of Fallot. In children with congenital heart defects, the hypoxic nature of damage to the central nervous system is much more common than hypoxic-hemorrhagic.
Journal of hepato-gastroenterological research -
MODERN APPROACHES TO THE OCCASION OF GASTRIC AND 12-FINGER GASTRIC DISEASEGastric or peptic ulcer is one of the most important medical and social problems in our society today related to quality deterioration. According to modern concepts, peptic ulcer disease is a chronic recurrent polyetiological disease that occurs as a result of the interaction of exogenous and endogenous factors. However, the development of this disease is led by internal factors, namely: hereditary predisposition, the influence of the nervous and endocrine systems.
Journal of hepato-gastroenterological research -
ULTRASONIC VERIFICATION OF PORTAL HYPERTENSION IN LIVER CIRROSISThe work is based on the results of examination of patients with diffuse liver diseases by ultrasound Doppler. Unconditional and conditional types of ultrasound signs were identified, allowing to detect cirrhosis of the liver and the accompanying portal hypertension. The values of the main ultrasound parameters reflecting structural and hemodynamic changes in liver cirrhosis were analyzed in patients of all groups. The ultrasound method with vascular Doppler imaging made it possible to trace the dynamics of the increase in the manifestations of portal hypertension in patients with liver cirrhosis at different stages of the development of the pathological process. Ultrasound diagnostics of liver cirrhosis is difficult in patients with initial manifestations of portal hypertension and is extremely informative in the study of patients with developed portal hypertension syndrome.
Journal of hepato-gastroenterological research -
USE OF ENTEROFURIL IN YOUNG CHILDREN WITH DIARRHEA OF VARIOUS ETIOLOGYExamined 18 children aged from 6 months to 3 years with diarrhea of various etiology. It was revealed that the cause of diarrhea in young children is various pathogenic bacteria, microbes and viruses; broad-spectrum antibiotics, individual allergic reaction to certain foods; disruption of the stomach, insufficient release of enzymes in the small intestine. It was found that the use of enterofuril caused a significantly faster therapeutic effect in comparison with other drugs.
Journal of hepato-gastroenterological research -
RESULTS OF ENDOSCOPIC LIGATION OF VARICOSE VEINS OF THE ESOPHAGUS IN THE TREATMENT OF COMPLICATION OF PORTAL HYPERTENSIONThe article analyzes the results of treatment of 294 patients with bleeding from varicose veins of the esophagus with portal hypertension using endoscopic ligation. The current views on the pathogenesis of portal hypertension syndrome and approaches to their treatment are described in detail. The effectiveness of endoscopic ligation at the height of bleeding with minimal use of Senkstaken-Blackmore obturator probes was shown. Recommendations for targeted and multicomponent correction of the hemostasis system and pressure reduction in the portal blood flow are described in detail. Prolonged endoscopic treatment is required, including repeated ligation sessions 1 and 3 months after the first stage, followed by regular dynamic monitoring every 6 months.
Journal of hepato-gastroenterological research -
Inguinal hernias are among the most common hernias in the world. They are diagnosed more often among men, 10 or more times higher than among women. Objective of the study: to increase the efficiency of surgical treatment of inguinal hernias by improving the technology of strengthening both walls of the inguinal canal. Materials and research methods. The study is based on the results of surgical treatment of 47 patients who underwent hernioalloplasty for inguinal hernia in the surgical department of the clinic of the Samarkand State Medical Institute. Research results. Of the 47 performed hernioalloplasty in 14 (29.8%) cases (the main group), we used the modified method of hernioalloplasty of inguinal hernias. In these patients, after a conventional skin incision, the aponeurosis of the external oblique abdominal muscle was dissected. Highly isolated and removed the hernial sac. Then followed the isolation of the spermatic cord along its entire length. The transverse fascia was exposed at the inner opening of the inguinal canal. The mesh graft 10 × 15 cm was opened intraoperatively, considering individual characteristics. Conclusions. The presented technique of reconstruction of the inguinal canal, aimed at reducing trauma and reducing the time of intervention, can be used in wide practice. -
60 children with irritable bowel syndrome were observed, divided into 2 groups: group I (30 children) received the prebiotic Dufalac and fermented milk mixtures, group II (30 children) – traditional therapy and adapted fresh mixtures. The effectiveness of Dufalac and fermented milk mixtures in irritable bowel syndrome, which occurs with constipation and intestinal dysbiosis, is shown. -
MEDICINAL POISONING IN CHILDREN AND METHODS OF THEIR PREVENTIONThe aim of the study was to examine the causes of drug poisoning in children and to develop the prevention of drug poisoning in children. The main causes of drug poisoning were widespread advertising of medicines on television. Uncontrolled use of medicines listening to advertising on television, the use of medicines on the recommendation of pharmacy employees, taking medicines by parents in the presence of children, etc. Everything is dictated by the need for optimization of preventive work aimed at the prevention of drug poisoning in children. In children's departments of hospitals, primary health care, rural medical centers, kindergartens, nurseries, it is necessary to organize a permanent school for young mothers, where to consider the dangers of self-treatment of children, first aid in case of drug poisoning at home.
Journal of hepato-gastroenterological research -
RESULTS OF STUDYING THE STATUS OF TRUE NUTRITION - IN THE EXAMPLE OF PATIENTS WITH CHRONIC LIVER DISEASEHealthy eating is essential to human health and learning about proper nutrition is important in the origin and prevention of diseases. A total of 125 patients with chronic hepatic diseases (47 with chronic hepatitis and 78 with hepatic cirrhosis) were examined on the basis of a WHO questionnaire. The results revealed that patients consumed animal fat, meat products more frequently in their diets, and low consumption of dairy products and vitamin-rich wet fruits and vegetables, especially in patients with hepatic cirrhosis compared with patients with chronic hepatitis. These indications are of diagnostic importance and appropriate diet therapy recommendations will be developed.
Journal of hepato-gastroenterological research -
OBESITY AND VITAMIN D DEFICIENCY IN CHILDREN AND ADOLESCENTSThis article is devoted to the relevance of the problem of vitamin D deficiency in children, its role in the development of obesity and other somatic pathology. The data on the prevalence of vitamin D deficiency in children and adolescents, risk factors and pathogenesis of the development of vitamin D deficiency in obesity in children are presented. Methods for correcting vitamin D deficiency in obesity and other metabolic disorders are also discussed.
Journal of hepato-gastroenterological research -
The review provides information on the morphology and function of the kidneys in children with obesity. The influence and relationship of numerous pathogenetic factors acting on the kidneys is discussed. The use of early biomarkers of kidney pathology in obesity with an assessment of the level of lipid, carbohydrate metabolism, insulin resistance, serum leptin and adiponectin is promising for the diagnosis of renal lesions in obesity in children. -
OBESITY AS A RISK FACTOR FOR HEPATOBILIARY SYSTEM IN CHILDRENThis article is provides facts about changes in the liver during obesity in the framework of non-alcoholic fatty liver disease. The review contains pathogenesis and morphological characteristics of the development of this condition, features of the clinical picture, as well as methods of invasive and non-invasive diagnosis.
Journal of hepato-gastroenterological research -
THE SITUATION AND MODERN APPROACH IN THE STUDY OF COLON AND RECTUM TUMOR DISEASES IN ANDIJAN REGIONIn the last decade, the incidence of colon cancer has been increasing in the very kup countries of the world, including Uzbekistan. 50 new colorectal cancers out of 100000 axles are observed each year, and 5% of axles are diagnosed with cancer of the Tigris Colon for the rest of their lives [1,2, 3, 4]. All over the world, about 600 thousand people a year are diagnosed with colorectal cancer, and more than half of them die within the same year [5, 6]. Tugri found that 5% of all bad - quality usma diseases of bowel cancer-6%, 40-45% of the digestive system bad-quality usma diseases [7, 8, 9]. Every year more than 600 thousand colorectal cancer diagnoses are diagnosed around the world, of which 60% come from developed countries, while 40% come from colonized countries [3, 9, 10, 11, 39]. Tugri is an adult over 55 years of age and mostly 70-75 years old tugri is associated with risk factors for colon cancer [3, 4, 12], and of which 80-85% of the kuy i is associated with 1ii-IV Bosque, and more than half of them die within a year [13, 14]. ICT of the disease world
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