The article provides a review of the literature on the study of a new class of drug ARNI (angiotensin receptor neprilysin inhibitor) LCZ696 - thе combines a molecule of valsartan and an inhibitor of neprilysin sacubitrile in a molar ratio of 1: 1. The results of experimental and clinical studies on the use of ARNI in cardiovascular pathology are presented. The nephrological aspects of ARNI use in patients with chronic heart failure are also shown.
More than a century ago, a link was discovered between oral infections, tooth extraction and cardiovascular diseases (infectious endocarditis), and by the middle of the 20th century, the practice of routine prescribing antibiotics for the prevention of endocarditis before invasive dental procedures appeared Since 1950, the theory of infection development associated with infection of the alveolar bone system, The etiological role was also expanded to several other anatomical areas not related to the oral cavity.
The paper analyzes the features of transport injury in children, depending on the mechanism of injury. Children who were injured inside a car in an accident: "child passengers" and "children behind the wheel", were characterized by a relatively high frequency of injuries to the head, nasal bones and lower extremities. Also in this group of patients, damage to the bone, nervous and cardiovascular systems is noted, and in terms of quantity, damage to one or two systems is usually observed.
According to the structure of the severity of injuries, the first or second degree of severity usually prevails. In children who were injured outside the passenger compartment: "children pedestrians" hit by a car, the injury was characterized by a low incidence of head trauma and a high incidence of damage to the nasal bones and lower extremities. It should also be noted in these cases, mainly damage to the bone, respiratory and cardiovascular systems is observed, and in terms of quantity, damage to two or three systems is usually observed. According to the structure of the severity of injuries, the second and third degrees of severity usually prevail.
The article covers the etiology, pathogenesis, classification, diagnosis, clinical picture and treatment of coronary heart disease, provides a literature review. Cardiovascular disease (CVD) represents the leading cause of death among women as well as men. The number of deaths due to CVD in women are greater than in men. There are significant gender-related differences concerning CVD.
Rapid ramp up of immune responses against SARS-CoV-2 during pandemic enables adequate prevention and treatment for COVID-19. Estimating levels of SARS-CoV-2 spike protein antibodies post vaccination is crucial for designing mass-vaccination strategies. The aim of this study was to evaluate effectiveness of Sputnik V first dose in Pakistan. A cross-sectional study of 1000 participants was conducted for examining Gam-COVID-Vac or Sputnik V first dose effects at 21st days post administration at Islamabad Diagnostic Center, Islamabad, Pakistan. From 1000 real-time PCR negative (SARS-CoV-2 RNA) individuals, samples were collected and analyzed for antibodies to the SARS-CoV-2 spike protein using Electro-chemiluminescence immunoassay (ECLIA) (Elecsys # 09289267190 Roche, USA). 85% of the participants showed strong positive results with SARS-CoV-2 spike protein antibodies >1.5 AU/ml. The individuals with antibody titer >250 AU/ml were 34.9%. While participants with >100 AU/ml of antibodies were 12.7%. However 9.5% showed antibody titer of >25 AU/ml. 27% of participants had antibody titers of >1.5-2.5 AU/ml. While antibody titers of <1.5 AU/ml were observed among 15.9% of participants. Majority of the individuals represented significantly strong antibody titers against SARS-CoV-2 even before second booster dose of Ad5 based Sputnik V vaccine. Continuous monitoring of antibody levels among COVID-19 vaccinated populations are deemed to assess humoral immunity status against SARS-CoV-2 infections.
The article is dedicated to the actual and significant problem. Such as analysis of objective side of components of crime, in particular the basic of the illegal actions of the victim, providing in article 98,106 of Criminal code of Republic of Uzbekistan.
The problem of diarrhea in children of different ages remains one of the topical areas of modern medicine. The study of the characteristics of the microflora in diarrhea is associated with the development of therapeutic and preventive measures for this condition. The intestinal microflora performs important functions in the child's body, including the exchange of energy substrates and the formation of intestinal immunity. At the same time, the intestinal microflora changes during the first years of life. In addition to age-related changes, gut flora changes with nutritional status, birth path, antibiotic exposure, genetic factors, and episodes of diarrhea.
The article is devoted to the problem of using modern information
technologies in the formation of financial statements according to international standards.
The application of the principles of IFRS in the preparation of financial statements makes it possible to present information characterizing the property status and financial results of an organization in a language understandable to users around the world, and as a result, in the least time consuming way to gain the trust of investors, including foreign ones.
The ability to understand individuals on a deeper level and word related pressure of rustic and metropolitan police concentrated on 120 police constables who were haphazardly chosen from 22 police headquarters of Dharwadtaluk. The ability to understand individuals at their core poll created by Dulewicz and Higgs, 2001, word related pressure scale by Srivastav and Sing, 1984, financial status scale by Agarwal et al., 2005 and self organized survey to gather assistant data were utilized for information assortment.
Results uncovered that 50% had normal degree of the capacity to understand anyone at their core while 4.2 percent had high and 45.8 percent were in low levels. Larger part (56.67%) of ladies had normal degree of profound while 41.67 percent had low and just 1.67 were in undeniable level where as greater part (half) of men had low degree of word related pressure showing that expansion in family size diminished the pressure. The capacity to appreciate individuals on a profound level and word related pressure were adversely related showing higher the capacity to understand people on a profound level lesser was the word related pressure.