Subject of research: 128 patients with acute, subacute, secondary-chronic and primary-chronic types of Rock fever.
Aim of research: early diagnosis of audio and vestibular disturbances on patients undergo Rock fever and against background of usage of ototoxic medicines by applying of modem complex tools of audio research and impcdanccmctry.
Tools of research: general clinical research, special inquiries: examination of otolaryngologic organs, acoumctcring, tone threshold audiomctcring, voice audiometery, impcdanccmctry, detection of audio sensitivity to ultrasound under methodology of В. M. Sagalovich, vestibulometery, clcctronistagmography, reenccphalography.
Results received and their novelty: different types of audio disturbances were first time discovered from patients with Rock fever infection during a complex inquiry of audio and vestibular organs status: in acute and subacute types of Rock fever there dominate the audio disturbances on sound conductivity, in chronic type - the mixed or advantageously ncurosensoric character. There was applied an impcdanccmetry to define a character and level of injury of audio organ.
A scheme of complex conservative therapy included the mounts that influence on hemodynamics; adjuvants; the mounts that influence on tissue interchange; antyhypoxantincs that improve microcirculation of internal car; enzyme mounts that eliminate cicatrical and soldering processes in medium ear.
Practical value of dissertation: a qualified method of diagnosis of different types audio disturbances was proposed to practical public health. The methods of early diagnosis allow asserting a necessity of usage of early complex inquiries of audio and vestibular analyzers to make a prevention and development of further abnormalities (hard hearing and surdity).
A level of introduction: received results were introduced to the work of Otolaryngologic department of Second Tashkent State Medical Institute and clinical infectious hospital of Scientific Research Institute of Epidemiology, Microbiology of Infection Diseases of Republic of Uzbekistan.
Fields of applying: otolaryngology, infection diseases.
Subject of the inquiry: 298 patients with finn deformations of the larynx and trachea
Aim of the inquiry: early rehabilitation of patients with firm deformations of the larynx and trachea path optimization and creating clinical and pathogenic methods of complex treatment.
Methods of the inquiry: clinical examination, special examination: LOR-examination, endoscopy of air ways, X-ray, CT, MRI of larynx, trachea and bronchus, bacterial examination of larynx and trachea wounds; morphological examination, biochemical methods of examination: lipid peroxidation, antioxidant enzymes, activity of hepatic monooxygenase system (MOS); biophysical methods of examination: исследование electric damage of erythrocytes’ membrane (EDEM), blood viscosity (BV) and blood shift velocity (BSV); cytological examination.
The results achieved and their novelty: In patients with firm deformations of the larynx and trachea, firstly basing on complex investigation clinical and structural-functional parameters revealed pathomorphological changes in neck tissues as chronic inflammation with productive component. Despite, revealed disrupt balance of process lipid peroxidation and antioxidant system, hydroxylic function of liver, decrease of electoral penetrability of erythrocytes’ membrane and aggravate of hemorheology. With this, level of expression of changes depends on clinic form and load disease, correlate with stage of wound healing and after restore of functions of the larynx and trachea gradually becoming normal. Presented classification of the firm deformations of the larynx and trachea, permitting complexly counting etiologic factor and morphological variant of the damage of laryngotracheal tract. In scheme of the pathogenic complex conservative therapy before and after reconstructive operations included medicine, influencing on Hemodynamic, with ability membranotrope action, systemic enzymotherapy, immunostimulators, and correction of the tissue metabolism by laser. Created private and modified methods of reconstructive laryngotracheoplasty in case of cicatricle stenosis of glottic and subglottic parts, bilateral paralyses of the larynx, cicatricle deformations of pharyngolarynx, combination deformations and defects of the larynx and trachea, permitting single stage restore laryngotracheal ways.
Practical value: The investigation of pathogenic mechanism of developing of the firm deformations of the larynx and trachea on data of changes of main functional and metabolic processes will permit not only activating and improving of pathogenic therapy, and forecasting variant of development and course of postoperative period after reconstructive operations.
Use of proposed methods of complex conservative and surgical treatment of the firm deformations of the larynx and trachea allowed to provide whole volume of restoring means in more short time and with less quantity of stage operations, preoperative preparing till 3 days, hospital stay till 14-20 days, surgical operations in 1.9 time.
Degree of embed and economical effectivity: The results of investigation intruded in treatment practice of the First and Second Tashkent Medical Institutes, LOR-clinics of Samarqand territorial children hospital, territorial hospital of Karshi. Materials of the investigation using in study process of LOR - cathedra First Tashkent Medical Institutes during lectures and practice tutorials with students, magistracies, and clinic ordinators. Determined main economic effect in use of proposed complex therapy in connection with reduce of term of treatment and hospital stay (on an average 10 days) and taking off or decreased disability on 67% patients.
Sphere of usage: otorhinolaryngology, surgery, reanimation
Причины нарушения слуха у ребенка могут быть врожденными или приобретенными, возможны и сочетания различных факторов. Устойчивые снижения слуха приводят к критическим нарушениям психоречевого развития, вплоть до полного отсутствия речи с нарушениями интеллекта. Распространенными причинами потери слуха являются генетические дефекты у новорожденных, ушные инфекции и серная пробка у детей. Генетической предрасположенностью вызваны около 40% случаев тугоухости у детей. Если в семье были слабослышащие люди, есть вероятность того, что заболевание передастся на уровне генов.Ослабленные болезнью малыши чаще других страдают от порока развития уха или слухового нерва. Поэтому здоровью детей, которые родились недоношенными или с маленьким весом, либо переболели желтухой в раннем возрасте, нужно уделить пристальное внимание.
Из публикуемого Всемирной организацией здравоохранения (ВОЗ) первого Всемирного доклада по проблемам слуха, следует, что к 2050 году почти 2,5 миллиарда человек во всем мире - т.е. каждый четвертый - будут страдать той или иной степенью потери слуха. Если в ближайшее время не будут приняты меры, то по меньшей мере около 700 миллионов человек из них будут нуждаться в услугах по охране здоровья уха и органов слуха и других реабилитационных услугах в этой области.
The aim of the study was a comparative assessment of the results of electrophysiological and electroacoustic methods for studying hearing in patients with Meniere's disease during an attack and between attacks. A total of 47 patients with a reliable or confirmed diagnosis of Meniere's disease were under observation, which constituted the main group. The results of the study showed that TEOAE was not recorded in the period between attacks in 89,4%, PIOAE - in 76%, while this indicator during an attack of BM was 100% and 89,4%.
Objects of research: 447 patients, from them 68 with chronic purulent middle otitis and 379 with dry meso- and cpitympanitis.
Purpose of research: to estimate efficiency and forecasting of results of various variants of tympanoplasty.
Methods of research: common clinical investigation, voice-frequency threshold and over threshold audiometry, research of hearing in low and expanded range of frequencies, speech audiometry, ultrasound research of hearing, rontgenography of mastoid, computer tomography, otomicroscopy.
Received results and their novelty: at chronic purulent middle otitis it is proved carrying out two stage tympanoplasty - as the first stage reconstructive-sanity operations - atticoantrotomy on to the “closed” type with mastoidoplasty, and as the second stage hear improving operations. The way of laying of a transplant is developed and introduced as the “romashki”, raising efficiency of engraftment and functional results. Efficiency is revealed at carrying out myringoplasty and tympanoplasty on a “dry” car. Developed forecasting criteria, based on the objective data for planned operations.
Practical value: developed the ways of reconstructive-plastic and hear improving operations, estimation of their efficiency and forecasting expected result at patients with chronic inflammatory diseases of middle car.
Degree of embed and economic effectivity: results and conclusions of research arc introduced into practice in ENT-dcpartmcnts and polyclinics, in educational process of Tashkent medical academy.
Field of application: otorhinolaryngology.
In the textual studies of the peoples of the world, attention to the study of national literary heritage based on primary sources is growing stronger than ever. The study of manuscript sources makes it possible to restore the texts of the works of a poet or writer in accordance with the original (at least close to it), regardless of the period in which they lived. Without restoring a reliable text, the poet's work cannot be analyzed in terms of theoretical problems of literary studies. In world textology, research is being conducted on such scientific problems as comparative analysis of manuscript sources, creating a scientific biography of the creator, and studying the history of the text of an artistic work. Among them, a great deal of experience, knowledge and material has been collected within the framework of studying the sources of Eastern manuscripts spread throughout the world's libraries, including the works of Alisher Navoi and Babur, great figures of Turkish literature. Extensive research is the basis for the creation of the theoretical foundations of textual studies. Uzbek textology has progressed on the basis of existing scientific experiences and has achieved certain results in the study of classic literary sources. Researching the literary heritage of authors who have left a bright mark in the history of national literature, studying manuscript and lithographic sources based on the latest scientific achievements is one of the primary tasks of source studies and textual studies. After all, "...studying and promoting Uzbek classic and modern literature at the international level, analyzing this multifaceted topic in integral connection with the most important processes taking place in the world's literary space today, creating the necessary scientific - drawing practical conclusions is of great importance..." 1 . Accordingly, it becomes clear that it is urgent to carry out a scientific monographic study of the sources of the lyric divan of Khorezm literary environment representative Mutrib Khonakharob (1853-1923), study the textual history of the poet's works, and develop the principles of preparing a scientific and critical text. The study of Mutrib's work began during the poet's lifetime. Tabibiy recognizes the achievements of the poet in poetry and music in the collections "Majmuat ush-shuaroyi payravi Feruzshahi" and "Majmuat mukhammasot ush-shuaroyi Feruzshahi". "Biographies of poets and writers of Khiva" by Hasanmurad Laffasi, "Poets and singers of Khorezm" by Bobojon Tarroh, "Tazkirayi Qayyumiy" by Polatjon Qayyumiy also provide valuable information about the poet's work. O. Sharafiddinov, M. Yunusov, N.M. Mallayev, Yu. Yusupov, M. Pirnazarov, A. Abdugafurov published articles. These articles cover the biography of the poet, the ideological scope and artistry of his works, thematic and genre features of his literary heritage. But in most of them, the poet's works were interpreted under the influence of communist ideology. M. Pirnazarov studied manuscript and lithographic sources of Mutrib's lyrical heritage, subject scope, genre features, and artistic skills. Although this research provided valuable information for its time, problems such as creating a scientific biography of the poet, researching the author's works in the field of theoretical problems of textual studies, and creating a scientific-critical text are still waiting to be solved. In studying the poet's literary heritage, the book "Mutrib Khonaharobi (Ref. Collection)" is noteworthy. However, besides the fact that the text of these poems is not complete, there are also errors in the reading of words. In this tutorial, the manuscripts numbered 906/VII, 903/IV, 2679/II of the Department of Muhammad Hasan Mutrib kept in the main and H. Sulayman funds of the Academy of Sciences of the Republic of Uzbekistan, as well as Turkish manuscripts in bayoz, complex and tazkira poems, information about the poems in manuscript bayoz kept in Khiva Ichonqala Muhammad Rahimkhan Feruz II Museum.
The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
This scientific article endeavors to delve into and draw comparisons between the linguistic and cultural elements of advertising texts in both Uzbek and English languages. This study thoroughly examines and analyzes diverse linguistic and cultural characteristics embedded within advertisements, with a particular emphasis on their influence on target audiences within distinct cultural contexts. Through meticulous examination and interpretation, this research sheds light on the intricate interplay between language, culture, and advertising strategies, ultimately offering valuable insights for enhancing cross-cultural advertising communication. By employing a systematic research approach, the study explores the multifaceted dimensions of advertising language in both Uzbek and English. It investigates how language choices, rhetorical devices, and persuasive techniques are adapted and employed differently across these two languages to effectively convey messages to their respective audiences. Additionally, the research delves into the cultural aspects manifested within these advertisements, such as values, symbols, and societal norms, which greatly impact the effectiveness and reception of the advertisements within their target cultures.
This scientific article endeavors to delve into and draw comparisons between the linguistic and cultural elements of advertising texts in both Uzbek and English languages. This study thoroughly examines and analyzes diverse linguistic and cultural characteristics embedded within advertisements, with a particular emphasis on their influence on target audiences within distinct cultural contexts. Through meticulous examination and interpretation, this research sheds light on the intricate interplay between language, culture, and advertising strategies, ultimately offering valuable insights for enhancing cross-cultural advertising communication. By employing a systematic research approach, the study explores the multifaceted dimensions of advertising language in both Uzbek and English. It investigates how language choices, rhetorical devices, and persuasive techniques are adapted and employed differently across these two languages to effectively convey messages to their respective audiences. Additionally, the research delves into the cultural aspects manifested within these advertisements, such as values, symbols, and societal norms, which greatly impact the effectiveness and reception of the advertisements within their target cultures.
Среди пациентов с ЛОР-патологией, обращающихся за медицинской помощью в клинику, 5,7-7% страдают ХГСО. По данным Всемирной организации здравоохранения (ВОЗ) 2013 года, более 5% населения мира (360 миллионов человек) страдают той или иной степенью тугоухости, потеря слуха в лучше слышащем ухе, превышающая 40 дБ у взрослых людей и 30 дБ у детей. Среди людей, имевшие нарушения слуха патологией ХГСО, страдают от 1 до 46% человек. Согласно прогнозам экспертов ВОЗ к 2020 году увеличивается число людей с нарушениями слуха на 30%.