Характерной чертой пищеварительного процесса в период новорожденности является низкий уровень желудочной секреции, что обусловливает более высокую функциональную нагрузку на тонкий кишечник. С целью выяснения адаптационных возможностей пищеварительной системы в этот период изучали влияние искусственного вскармливания заменителем молока на белок переваривающую функцию желудка и тонкого кишечника в модельных опытах на новорожденных крысятах
Subjects of the research: 1066 patients with peritonitis.
Purpose of the research: improvement of the results of treatment of the patients with peritonitis by determination of the prognostic significance of clinical-metabolic parameters in the estimation of severity of patients condition, flow and outcome of the disease.
Methods used in the research: clinical, microbiological, biochemical methods of investigation, mathematical statistics and mathematical modeling.
Results obtained and their novelty
1. The prognostic significance of clinical-anamnestic, microbiological, laboratorial- instrumental and metabolic data has been determined on the basis of the correlational interrelation between metabolic parameters and bacterial contamination in patients with peritonitis
2. When the actions of NIDE (UIDI) RC and GI are studied in clinical conditions it is shown, that their combined application during the operation and postoperative periods considerably decreases the culture growth in peritoneal exudates and improves metabolic parameters.
3. On the basis of the method of mathematical modeling, programs arc proposed to estimate the severity of patient s condition and predictability of flow, the outcome of disease in the patients with peritonitis.
Practical significance
1. The special features of the disturbance of metabolic parameters dependent on the bacterial contamination have been established, which makes it possible to reveal the patients with high risk of development of complications.
2. It is proven that the application of the infra-R emitters in combination with the traditional treatment in patients peritonitis contributes to more favorable flow of the disease and to reduction of postoperative complications and lethality.
3. Two programs have been created with the methods of mathematical modeling which allow: 1) To estimate severity of the patients condition on the basis of clinical-anamnestic, laboratorial- instrumental, metabolic and microbiological data;
2) To predict the complications of the disease; 3) To predict the healing of the postoperative wound; 4) To identify the indications for NIDE (UIDI) applications.
Level of induction: method of application of narrow-spectrum infrared distant emitters in peritonitis is used in surgical department of the Clinical Hospital of Emergencies and Casualties, Г' Municipal Clinic Hospital and in Central Military Clinical Hospital named after P.F. Borovskiy.
Region application: Surgery.
Relevance of the topic: the use of antibiotics after surgery in the treatment of periodontal disease is aimed at eliminating the pathogenic microflora of the periodontium, oral cavity and restoring the normal microbiota, which is inherent in healthy periodontal tissues. We know that periodontal diseases are caused by periodontal pathogens: Porphyromonas gingivalis. Actinobacillus actinomycetemcommitans ,Bacteroides forsithus, Threponema denticola , Prevotella intermedia, Actinomices viscosus. Numerous studies suggest that the role of polymicrobial synergy in the development of dental diseases. When prescribing antibacterial drugs, the doctor should remember that most microorganisms of the oral cavity are combined into a microbial biofilm. Microorganisms of the oral cavity form a microbial biofilm on the surface of the teeth – a special form of organization of microorganisms, which is surrounded by a protective matrix – a complex of glycosaminoglycans and proteins. It is this protective matrix that does not allow antibacterial drugs from saliva or gingival fluid to penetrate inside the biofilm. Therefore, microorganisms in the biofilm are more resistant to antibiotics, antimicrobials and other active agents. The most effective choice for the treatment of infectious and inflammatory processes of the oral cavity should be based on the results of modern scientific research, proving the clinical and microbiological efficacy and safety of any drugs.
Нормальная микрофлора влагалища – это природный барьер для развития патогенных бактерий. Нарушение равновесия в микрофлоре влагалища ведет к уменьшению лактобацилл и увеличению условно-патогенной флоры, которая является причиной воспалительного процесса. Урогенитальные микоплазмы, являются представителями комменсальной (нормальной) микрофлоры женщин, выделяются у 12 –60% здоровых женщин.
То study the effect of local immunocorrective therapy on pathogenic microflora in patients with post-traumatic osteomyelitis.