Viral hepatitis C (HCV) is one of the most important problems of modern medicine. According to WHO statistics, there are between 500 and 700 million HCV carriers worldwide. The aim of the study was to study the clinical and immunological features of the course of chronic viral hepatitis C, depending on the genotype of the virus, and to assess the diagnostic and prognostic value of immunological disorders. The clinical and laboratory features of the course of chronic viral hepatitis C depending on the genotype of the virus, the immunological features of the course of chronic viral hepatitis C depending on the genotype of the virus were studied, the diagnostic and prognostic value of immunological indicators as objective criteria for assessing the severity of the disease and the prognosis of the disease was determined. We examined 83 patients with chronic viral hepatitis, 35-50 years old with chronic viral hepatitis C, and 20 practically healthy individuals of the same age and gender.
The aim of the study is to development of an algorithm for managing pregnancy and childbirth by studying the functional state of the mother-placenta-fetus system in pregnant women who have undergone COVID-19 in different trimesters of pregnancy.
The object of the study was 105 pregnant women who, were treated at the Samarkand Regional Perinatal Center and a specialized maternity center for pregnant women with COVID-19
Тhe scientific novelty of the research consists of the followings: for the first time in pregnant women infected with COVID-19, a relationship was established between the course of pregnancy, childbirth, the postpartum period and the development of complications depending on the trimester and severity of the disease; a direct correlation has been established between the state of the vessels of the mother-placenta-fetus system (resistance and pulsation indices, Endothelin-1 indicators), disorders in the hemostasis system (D-dimer, platelet aggregation) and the clinical course of the disease in pregnant women who underwent COVID-19; it has been established for the first time that the developed scale for assessing risk factors for non-developing pregnancy in women infected with COVID-19 (age, BMI, obstetric history, gestation period, hemostasis system status, endothelial function and severity of the disease) can serve as a prognostic marker of the degree of risk of pregnancy complications; it was proved for the first time that the choice of effective therapy for restoring hemodynamics in the mother-placenta-fetus system, in women who underwent COVID-19 at different stages of pregnancy, leads to a decrease in the number of thrombophilic complications.
Implementation of the research results. The results of the scientific research were introduced into the practical activities of the Samarkand Regional Perinatal Center by Order No. 128/1 of 01.09.2022 and the Samarkand City Maternity Complex No. 1 by order No. 58/1 of 03.10.2022. In pregnant women who underwent COVID-19 at different periods of pregnancy, changes in the mother-placenta-fetus system were determined using simple and effective research methods, such as ultrasound and Dopplerography, and this saved 53,000 soums; obstetricians and gynecologists, as well as neonatologists and therapists, are needed to diagnose signs of complications in the echocartin, that is, it has been proven that there is no need for other highly qualified specialists for this, due to the lack of need to train new personnel, state budget funds have been saved. With early detection of disorders in the hemostasis system in pregnant women with COVID-19: the period of stay of patients in the hospital was reduced from 10.5 days to 7.5 days and the number of hospital bed days was reduced; due to the reduction of the period of stay in the hospital for several days, the number of necessary drugs was reduced (on average, drugs are used for 1 day in the amount of 130,000 soums). Examination of pregnant women infected with viral diseases using simple and effective research methods such as ultrasound and Dopplerography served to save 85,000 soums: in the early stages up to 16 (10-11 weeks. - fetometry), 19-21, 32-34, 38-40 weeks of pregnancy; due to the absence of the need to use other research methods, it was possible to reduce costs by 23.5%; early detection of changes in the hemostasis system and endothelial dysfunction using fast, budgetary and effective research methods, contributed to the prevention of possible pregnancy complications, as well as the absence of the need to use long-term and expensive research methods, and this saved 106 000 soums: the coagulogram was checked in 105 (100%) patients, time was saved and efficiency was increased; endothelin-1 was also determined in 105 (100%) patients, efficiency was increased by 78.6%.
Improving the functionality of blood circulation in the uteroplacental and fetal-placental systems, a comprehensive analysis of possible complications during pregnancy and childbirth in women who have had viral infections, improving diagnostic, preventive and prognostic measures for managing pregnancy and childbirth contributed to the birth of live, full-term and healthy newborns in women who experienced COVID-19 during pregnancy, as well as a decrease in maternal mortality and perinatal mortality, 43% of women underwent rehabilitation in the postpartum period, 23.8% of women who underwent severe COVID-19 improved their quality of life.
To introduce scientific novelty on the topic “The impact of COVID-19 on the state of hemodynamics in the mother-placenta-fetus system in pregnant women”, a letter was sent to the Ministry of Health from Samarkand State Medical University on November 9, 2022 under No. 4295 (Conclusion of the Ministry of Health No. 8 n-z / 679 of December 15, 2022).
The structure and volume of the dissertation. The content of the dissertation consists of an introduction, five chapters, conclusion, list of used references. The volume of the dissertation consists of 113 pages.
Chronic hepatitis B virus (HBV) infection is a global public health problem of the same magnitude as tuberculosis, HIV and malaria. The International Coalition to Eliminate HBV (ICE- HBV) is a coalition of experts to accelerate the discovery of a cure for chronic hepatitis B. After extensive consultations with more than 50 scientists from around the world, as well as with key stakeholders, including people affected by it. We believe that research should focus on discovering interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in these cells. There is also an urgent need to create repositories of standardized HBV reagents and protocols that can be accessed by all HBV researchers around the world. The HBV cure research agenda set out in this position paper will make a significant contribution to the goal of eliminating HBV infection worldwide.
The study aimed to investigate the protective mechanisms of substance Darmonal and phytin compounds in the experimental model of acute toxic drug-induced hepatitis caused by paracetamol in rats.
The material and methods The research was carried out on white outbred rats of both sexes weighing 140-200 g. Drug-in¬duced liver damage was reproduced by introduction of paracetamol into the stomach in dose 500 mg/kg for 2 days. The test compounds Darmonal, Fitin-C and reference drug Liv.52 were administered for 7 days after hepatitis reproduction in doses 100 mg/kg. The effectiveness and mechanism of action for selected supramolecular complexes in the model of toxic drug-induced hepatitis was made by paracetamol. It was researched that liver protein-synthesizing function was due to the content of total protein and albumin in the blood serum, the excretory and toxic function of the liver by the content of total and direct bilirubin as well as the endogenous intoxication were according to the content of urea in the blood serum, but cytolytic syndrome occurred because of the activity of indicator enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in blood serum).
Research results. The study of specific activity of Darmonal in combination with Fitin-C and the reference drug Liv.52 on the model of paracetamol and carbon tetrachloride hepatitis showed that the drugs, being administered in dose 100 mg/kg, had a pronounced hepatoprotective effect.
При длительной химиотерапии резистентного туберкулеза легких наиболее часто наблюдается побочные реакции со стороны печени, что удлиняют сроки стационарного лечения и ухудшают прогноз.
Количественно исследовать регуляторные механизмы (регуляторику) взаимосвязанной деятельности молекулярно- генетических систем гепатоцита и вируса гепатита B (ВГВ) при различных значениях параметра вирусной нагрузки.
Вирусные гепатиты относятся к числу повсеместно распространенных инфекционных заболеваний и часто становятся причиной хронического вирусного гепатита, цирроза печени, первичного рака печени. Актуальность проблемы обостряется тем, что заболевание развивается чаще в молодом трудоспособном возрасте, что приносит огромный экономический ущерб государству.
In this article plant lectins and their spesifications as biologically active substances of nonimmune origin, possessing a common property of specifically binding to the surface of bacterial cells and viral protein are examined. The main attention is paid to the possibility of using plant lectins in medicine and biomedical practice.
Одной из наиболее глобальных проблем современной инфектологии остается выбор эффективного лечения хронического вирусного гепатита Д. Исходы хронического гепатита В с дельта агентом весьма обширны - от минимальных гистологических изменений до формирования цирроза и гепатоцеллюлярной карциномы. За последние годы подходы к лечению хронических вирусных гепатитов С быстро меняются. Это связано с более углубленным изучением знаний о данном заболевании, совершенствовании методов диагностики и лечения.
As a result of numerous clinical and experimental studies, a relationship has been established between changes in the oral cavity and pathology of internal organs. In modem dentistry, interest in research on concomitant pathologies is explained by the accumulation of new arguments, the emergence of new information in the system of the whole organism [3,5]. This analysis focuses on the prevalence of hepatitis infection and its various oral manifestations,consequences and clinical course. In this regard, the monitoring of outpatient records of patients with concomitant pathology, such as hepatitis А, В, C with inflammatory processes of the oral cavity and maxillofacial area after tooth extraction for emergency indications in the clinic of surgical dentistry of the clinic of the Tashkent State Dental Institute over the past 5 years was carried out.
Проводили моделирование токсического гепатита у белых крыс самцов линии Вистар массой 200 г путем внутрибрюшинного введения 50%-го раствора CCl 4 (четыреххлористый углерод, тетрахлорметан) на оливковом масле из расчета 1 мл на кг массы тела два раза в неделю на протяжении всего эксперимента. Для потенцирования развития цирроза печени вместо питьевой воды крысы получали 10%-ный раствор этилового спирта с 3-х суток эксперимента.