Исследования последних лет, особенно эпидемиологического характера тех или иных заболеваний показывают, что факторы, влияющие на возникновение и развитие заболеваний, их частоту, структуру и распространённость, имеют комплексный характер. Нередко исследования сахарного диабета (СД) и его осложнений носят узколокальную клиническую направленность, не рассматривают комплексность воздействия изучаемых факторов и поэтому, меры профилактики его носят неполноценный характер.
This scientific article expounds analytical thoughts that in the first decades of the twenty-first century the level of global problems related to the security of mankind has increased many times over, the reasons for this phenomenon are also stated, including the inconsistency of the formation of a new world order, the difficulties of democratization. Conclusions are drawn about new false barriers to the formation of new international relations. The article focuses on the significance of the 75th anniversary session of the General Assembly of the United Nations and new conceptual ideas that were voiced in the speech of the President of the Republic of Uzbekistan Sh.Mirziyoyev. The author concludes that the constructive ideas and initiatives put forward in the speech of the President of our country will be of great importance in the formation of a fair international system, and at the same time, the institutional capacities and effectiveness of the UN will increase. The article concludes that as a result of the implementation of the new ideas put forward, the recommendations of the head of our state under the auspices of the UN, a very large number of problems facing humanity will find their positive solution, as a result, new conditions will appear for the formation of a modern, fair, democratic world order. The article emphasizes that the new ideas put forward by the President of our country, in their essence, are aimed at updating the world order. In this regard, our President calls for an increase in common responsibility, as well as strengthening the democratic approaches of the world community to address these challenges. Therefore, the author believes that the initiatives of our head of state have a very positive meaning for all peoples of the world. The scientific article emphasizes that the proposal of the head of the country to increase the role of national parliaments is also of historical importance. In this regard, as noted in the article, the initiative of the President of the Republic of Uzbekistan for the adoption by the UN of a special decision to enhance the role of parliaments is extremely important for the formation of modern foundations for the development of parliamentary diplomacy. Also, the article pays special attention to the historical role and significance of the new initiatives of the President of the Republic of Uzbekistan for the peaceful solution of the problem of Afghanistan. The article concludes that these fundamentally new, effective initiatives to solve the Afghan problem will contribute to a thorough solution to all the contradictions that exist in modern Afghanistan.
Промышленное и гражданское строительство входят в группу ключевых направлений развития государства. Данной утверждение основывается, во-первых, на значительных темпах обновления жилищного фонда (введение в действие новых жилых домов). Во вторых, на необходимости активизации промышленности, которой требуются новые высокотехнологичные здания и сооружения, отвечающие современным стандартам безопасности и требованиям заказчиков подобных строек. Такие приоритеты для государства весьма очевидны. Дело в том, что решая проблемы жилья, хотя бы в той мере, что его предложение на рынке неизменно растет, с соответствующими изменениями цен и изменением конкуренции, государство создает условия для решения и социальных проблем. В частности, новые микрорайоны в обязательном порядке должны быть снабжены детскими садами и школами, а о появлении новых магазинов общественного питания и сферы услуг вообще не вызывают сомнений. Выполняются социальные обязательства, формируются условия для развития малого предпринимательства, происходит стимулирование процессов обмена и распределения накоплений населения, т.е. стимулирование экономики и экономического роста. Темпы строительства новых жилых многоквартирных домов на сегодняшний день одни из самых высоких за новейшую историю государства, а качество строений напрямую зависит от эффективности и соблюдения технологий строительства, а также качества и состава материала, из которого оно ведется.
Relevance of the problem. The difficulties of diagnostics of orbital diseases are well known. Especially difficult is intraspecies differentiation among the multitude of tumour, pseudotumour, inflammatory, vascular, endocrine and other diseases occurring here, manifested by the symptom complex of unilateral exophthalmos [Beradze I.N., 1978; Brovkina A.F., 1993].
Malignant intraocular neoplasms are the main cause of death of patients with diseases of the organ of vision, with 45-48% of patients dying from metastases in the first 5 years after enucleation [Alekseeva I.B., 1990, Barkhash S.A.1978, Brovkina A.F..1991, 1997; Keizer R.W.. Viclvoyc G.L.,1986],
Retinoblastoma is the most frequent malignant neoplasm in children. According to different authors, the frequency of its occurrence is 1 case per 14000 - 35000 newborns. [Bobrova N.F. and Vit V.V., 1993; Brovkina A.F., 1997; Provenzale J.M., et al., 1995; Skulski M., et al., 1997; Weber A.L., Mafee M.F, 1992; Wilms G., et al., 1989]. The frequency of patients with the most malignant intraocular tumour in adults - uveal melanoma has recently reached 7-9 people per 1 million population [Brovkina A.F., 1997; Kotslyansky E.O., 1989; Yushko N.A., Peskova L.I., Kalenich L.A., 1989; Peyster R.G., Augsburger J..I., Shields J.A., 1988; Romani A.. Baldeschi L., ct al 1998; Scott I.U., 1998].
The fundamental difference in treatment tactics, depending on the stage of development, size and topography of the tumour, as well as the seriousness of the prognosis in retinoblastomas and melanomas sharply increase the requirements for the accuracy of their differential diagnosis. At the same time, the number of diagnostic errors in ocular tumours continues to be 10-30% even when complex clinical and instrumental examination is applied in specialised ophthalmological centres [Ternovoy S.K., Panfilova G.V., Rogozhin V.A., 1979; Friedman F.E., Malyuta G.D., Kodzov M.V., 1995; Song G.X., 1991].
Widely used in ophthalmological practice traditional diagnostic methods (ophthalmoscopy, gonioscopy, diaphanoscopy, fluorescence angiography, laboratory tests) are insufficient to obtain comprehensive information about the localisation, nature of growth and prevalence of volumetric pathological formations of the eye and orbit. This circumstance and not quite satisfactory results of surgical treatment are the causes of high mortality of patients [Muratova T.T., Nigmanova N.H., Kozlovskaya G.M.. 1989, Naches A.I., 1980; Cheremisin V.M., Trufanov G.E., Kholin A.V., 1991]. Untimely or erroneous recognition of pathological processes of the orbit leads to a sharp deterioration of visual functions, up to blindness, and in some cases to the death of the patient [Yuzhakov A.M., Travkin A.G., Kiseleva O.A., 1991]. All this determines the importance of timely and accurate diagnosis of diseases of the orbit, on the one hand, and the difficulty of such diagnosis - on the other [Gabunia R.I., Kolesnikova E.K., Tumanov L.B., 1982].
The fact that the orbit is closed from direct inspection and palpation by bone walls and the eyeball, indicates the advantage of radial diagnostics in comparison with other methods of examination. In the arsenal of clinicians there is a great variety of methods of clinical-radial diagnostics of orbital pathology, however, at present the information in the literature about their resolving capabilities and significance in comparative aspect is incomplete and not fully studied. The priority of using one or another instrumental investigation, their sequence and expedient combination have not been determined yet. This makes it difficult to choose the optimal standardised approach for diagnosis and adequate treatment [Cheremisin V.M., Trufanov G.E., 1993, Weber A.L., Sabates N.R., 1996; Wenig V.M., Mafee M.F., 1998].
Thus, the study of these and other questions, contributing to the improvement of diagnostics and treatment of patients with neoplasms of the eye and ocular cavity, should be recognised as urgent urgent.
Purpose of the study. Comparative evaluation of magnetic resonance tomography capabilities and development of algorithms for complex radial diagnostics of volumetric formations of the visual organ. To solve this goal we set the following tasks.
1. To study the normal picture of the magnetic resonance image of the visual organ in comparison with other methods of visualisation.
2. To find out the possibilities of magnetic resonance tomography, ultrasound and computed tomography in detection and evaluation of intraocular neoplasms.
3. To determine the role and place of magnetic resonance tomography in differential diagnostics of volumetric pathological formations of the eye cavity in comparison with other radial methods of research.
4. To determine the indications and to develop an algorithm for the complex application of radiography, ultrasound, computer and magnetic resonance tomography for diagnostics of volumetric formations of the eye organ.
Scientific novelty.
The present work is the first to give a detailed and detailed description of the complex clinical and radiation examination, with generalisation and standardisation of magnetic resonance, computer and ultrasound semiotics of volumetric pathological formations of the eye and eye cavity. The conducted clinical and instrumental investigations allowed to determine the diagnostic value and resolving capabilities of each of the applied methods. The ultrasound, CT and MRI signs of volumetric formations of the eye organ were studied, clarified and supplemented taking into account the use of low-field magnetic field and general-purpose ultrasound apparatus. The developed standardised diagnostic algorithm of examination of patients with this pathology is new, thanks to which the pre-oppositional diagnosis of tumour and other diseases of the visual organ is improved and the total radiation load on the patient is reduced.
Conclusions
1. MPT will provide an opportunity to study the weight of the soft tissue and anatomical components of the ocular cavity, up to the optic nerve sheath and perineural liquor space, the orbital apex and chiasmal-sellar region, as well as to assess the condition of adjacent structures of the brain and facial skull. The method is limited in the evaluation of changes in the bony walls of the orbital cavity.
2. MRI is inferior in detecting characteristic signs of retinoblastoma (presence of calcification). The sensitivity of MRI was 66.6%, while for ultrasound and CT these values were 96.1 and 100%, respectively. But when the tumour spreads rstrobulbarly outside the eyeball (at 3-4 stages) the informativeness of MRI increases significantly. In uveal melanoma the sensitivity and specificity of MRI reaches 100%.
3. Both MRI and CT have a high detection rate (98.1% and 95.8% respectively) of benign orbital tumours of both primary and secondary origin. However, MRI is the preferred method of investigation. MRI is especially informative when a cranioorbital tumour and pseudotumour are suspected. The sensitivity of the method is 90.9% and 91.6%, respectively
4. In some cases ultrasound can be used to differentiate between encapsulated and diffuse neoplasms, which facilitates the diagnosis. However, when the pathological process is localised near the orbital apex, the diagnostic value of ultrasound decreases. In such cases it is advisable to use MRI.
5. In detection of primary and secondary malignant tumours of the orbital cavity both MRI and CT are quite informative (sensitivity 97,2% and 95,4% respectively), but the most comprehensive information about the state of bone walls will be provided by CT. When the process spreads intracranially, the value of MRI increases significantly, especially with the use of contrast enhancement.
6. The developed algorithm of complex clinical and radiation examination of patients with the use of ultrasound, CT and MRI is the most effective in the diagnosis of volumetric pathological formations of the eye and eye cavity, allowing to reduce to an adequate minimum the total radiation load on the patient and diagnostic period, excluding duplication of research techniques and choosing the most informative in each case, which in turn allows to develop appropriate treatment tactics and reduce the level of disability of the patient.
The aim of the research consists in development of offers and recommendations about further improvement of criminal-legal and criminological measures of fight against crimes in the sphere of information technologies and safety.
The object of the research work is the system of the public relations regulating criminal-legal, criminological and organizational measures for counteraction to crimes in the sphere of information technologies and safety.
The scientific novelty of the research consists of the following:
the expediency of establishment of administrative responsibility for violation of personal privacy at compliance with the law about protection of private life, ensuring protection of the rights of citizens and also completion of legal gaps is proved;
need of establishment of responsibility for infringement of personal privacy in article 1411 Criminal Code of the Republic of Uzbekistan when ensuring criminal legal protection of personal privacy and inevitability of responsibility is proved;
for ensuring the principles of justice and humanity in the criminal legislation the expediency of awarding punishment in the form of restriction of freedom on the persons who have committed crimes in the sphere of information technologies is proved;
high degree of public danger of some crimes (illegal activities for attraction of money and (or) other property (article 1881 of CK), production, storage, distribution or demonstration of the materials containing threat of public safety and to public order (article 2441 of CK)) committed with use of networks of telecommunications and the Internet is explained;
establishment of responsibility for bringing to suicide and inducement to suicide with use of networks of telecommunications and the Internet is proved;
need of introduction of responsibility of the blogger for placement of public negative information of a certain look for the Internet is proved;
inadmissibility of use of personal data of the participants at implementation of electronic commerce for who aren't provided by the contract, need of nondisclosure of the specified data are proved;
establishment of the ban on distribution among children of the information justifying illegal behavior and promoting commission of offense, calling for promotion of the destructive ideas in society and also responsibility for the specified acts is offered;
expediency of application of a method of «confidential dialogue» concerning the persons who have committed information crimes, need of implementation of inquiry, the investigation and preventive measures proceeding from their psychological state are specified;
need of recognition of the actions exerting negative impact to life, health and morality of the personality, made with use of means of information technologies as socially dangerous act is offered.
Implementation of research results. The results of the study are used:
the proposal on establishment of administrative responsibility for violation of personal privacy has found the reflection in article 461 of the Code of the Republic of Uzbekistan about the administrative liability entered by the Law of the Republic of Uzbekistan of September 23, 2016 No. ZRU-411 (the act of Committee on the legislation and the judicial-legal matters of the Legislative Chamber of the Oliy Majlis of the Republic of Uzbekistan from September 28, 2016, No. 06/1-05/1148-vkh). This change provides compliance with the law about personal privacy, protection of the rights of citizens and also completion of a legal gap in the legislation;
the proposal on establishment of criminal liability for violation of personal privacy has found the reflection in article 1411 of the Criminal code of the Republic of Uzbekistan entered by the Law of the Republic of Uzbekistan of September 23, 2016 No. ZRU-411 (the act of Committee on the legislation and the judicial-legal matters of the Legislative Chamber of the Oliy Majlis of the Republic of Uzbekistan from September 28, 2016, No. 06/1-05/1148-vkh). Establishment of criminal liability for commission of the act breaking personal privacy provides criminal legal protection of private life of the person and inevitability of responsibility;
offers on expediency of awarding punishments in the form of restriction of freedom concerning the persons who have committed crimes in the sphere of information technologies, have found the reflection in articles 2781-2786 Criminal Code of the Republic of Uzbekistan according to the Law of the Republic of Uzbekistan from August 10, 2015 No. ZRU-389 (the act of Committee on the legislation and the judicial-legal matters of the Legislative Chamber of the Oliy Majlis of the Republic of Uzbekistan from July 2, 2018, No. 06/1-05). This offer serves purpose of alternative punishment for crimes in the sphere of information technologies;
high degree of public danger of commission of some types of crimes with use of networks of telecommunications and the Internet has found reflection in article 1881, the «g» point of third part of article 2441 Criminal Code of the Republic of Uzbekistan according to the Law of the Republic of Uzbekistan of April 25, 2016 No. ZRU-405 (the act of Committee on the legislation and the judicial-legal matters of the Legislative Chamber of the Oliy Majlis of the Republic of Uzbekistan from July 2, 2018, No. 06/1-05). According to this offer criminal liability for use of information technologies in criminal intents has been established;
responsibility for bringing to suicide, the inducement to suicide made with use of networks of telecommunications and the Internet have been established in article 103 and 1031 Criminal Code of the Republic of Uzbekistan according to the Law of the Republic of Uzbekistan of June 13, 2017 No. ZRU-436 (the act of Committee on the legislation and the judicial-legal matters of the Legislative Chamber of the Oliy Majlis of the Republic of Uzbekistan from July 2, 2018, No. 06/1-05). This offer has served establishment of criminal liability for the information attacks encroaching on human life;
regulations on responsibility of the blogger for dissemination of public negative information of some look on the Internet are introduced in articles 3 and 121 of the Law of the Republic of Uzbekistan from December 11, 2003 No. 560-II «About informatization» (the act of Committee on questions of innovative development, information policy and information technologies of the Legislative Chamber of the Oliy Majlis of the Republic of Uzbekistan from July 2, 2018, No. 05/2-01-71). This offer serves prevention of various crimes committed with use of the Internet;
offers on inadmissibility of use of personal data of the participants at implementation of electronic commerce for who aren't provided by the contract need of nondisclosure of the specified data have found the reflection in article 18 of the Law of the Republic of Uzbekistan of May 22, 2018 No. ZRU-385 «About electronic commerce» (the act of Committee on questions of innovative development, information policy and information technologies of the Legislative Chamber of the Oliy Majlis of the Republic of Uzbekistan from July 2, 2018, No. 05/2-01-71). This offer became a basis for the ban illegal use of personal data from participants of electronic commerce;
offers on establishment of the ban on distribution among children of the information justifying illegal behavior and promoting commission of offense, calling for promotion of the destructive ideas in society and also responsibility for the specified acts are introduced in article 16 of the Law of the Republic of Uzbekistan of September 8, 2017 No. ZRU-444 «About protection of children from information doing harm to their health» (the act of Committee on questions of innovative development, information policy and information technologies of the Legislative Chamber of the Oliy Majlis of the Republic of Uzbekistan from July 2, 2018, No. 05/2-01-71). This offer has served recognition of dissemination of information among children of information doing harm to their health as illegal behavior;
offers on improvement of criminal liability for crimes in the sphere of information technologies and safety have been used by preparation of analytical notes within the Concept of improvement of the criminal and criminal procedure legislation approved by the resolution of the President of the Republic of Uzbekistan of May 14, 2018 No. PP-3723 (the act of Committee on questions of innovative development, information policy and information technologies of the Legislative Chamber of the Oliy Majlis of the Republic of Uzbekistan from July 2, 2018, No. 05/2-01-71). This offer serves a proving of inevitability of responsibility for crimes in the sphere of information technologies and information security;
offers on expediency of application of a method of «confidential dialogue» concerning the persons who have committed information crimes, need of implementation of inquiry, the investigation and preventive measures proceeding from their psychological state have been introduced in activity of the relevant structural divisions of the Ministry of Internal Affairs of the Republic of Uzbekistan (the act of the Ministry of Internal Affairs of the Republic of Uzbekistan from July 2, 2018 No. 33/1985). This offer has served increase in efficiency of prevention of crimes in the sphere of information technologies and information security;
offers on need of definition of external influence, level of competence and practical skills of employees, motives of offense when studying the reasons of crimes in the sphere of information technologies and information security and also conducting monitoring of social networks have been introduced in activity of the relevant structural divisions of the Ministry of Internal Affairs of the Republic of Uzbekistan (the act of the Ministry of Internal Affairs of the Republic of Uzbekistan from July 2, 2018 No. 33/1985). This offer has served definition of the reasons and early warning of crimes in the sphere of information technologies and information security;
offers that the information security is object of criminal legal protection taking into account its direct connection with the state interests have found the reflection in the Law of the Republic of Uzbekistan «About modification and additions in the Law of the Republic of Uzbekistan «About the principles and guarantees of freedom of information» (the act of the Center of information security and assistance in ensuring public order at the Ministry of information technology development and communications of the Republic of Uzbekistan from November 13, 2017 No. 03-07-02/124). This offer has served protection of information security as object of criminal legal protection;
offers on need of implementation of complex measures from law enforcement agencies for ensuring information security at information security have found the reflection in the Law of the Republic of Uzbekistan «About modification and additions in the Law of the Republic of Uzbekistan «About the principles and guarantees of freedom of information» (the act of the Center of information security and assistance in ensuring public order at the Ministry of information technology development and communications of the Republic of Uzbekistan from November 13, 2017 No. 03-07-02/124). This offer has provided orientation of activity of law enforcement agencies on information security;
offer that threats of information security exert essential harm to the interests of the personality, society and state information have found the reflection in the Law of the Republic of Uzbekistan «About modification and additions in the Law of the Republic of Uzbekistan «About the principles and guarantees of freedom of information» (the act of the Center of information security and assistance in ensuring public order at the Ministry of information technology development and communications of the Republic of Uzbekistan from November 13, 2017 No. 03- 07-02/124). This offer has allowed to estimate high degree of public danger of information threats as a factor of commission of information crimes;
the rule about protection of the personality against illegal information influence taking into account that impact on consciousness of the personality with use of means of information technologies exerts negative impact on life, health and morality of the personality, has found the reflection in the Law of the Republic of Uzbekistan «About modification and additions in the Law of the Republic of Uzbekistan «About the principles and guarantees of freedom of information» (the act of the Center of information security and assistance in ensuring public order at the Ministry of information technology development and communications of the Republic of Uzbekistan from November 13, 2017 No. 03-07-02/124). This offer has served recognition of the specified actions as socially dangerous act.
Structure and volume of the dissertation. The thesis consists of an introduction, four chapters, a conclusion, a list of used literature and applications. The volume of the thesis is 260 pages.
Topicality and demand of the subject of dissertation. Various techniques of hybridization arc used in crop breeding, including cotton to produce a wide variability in agronomical valuable traits and develop new forms.
Regardless of its implementation hybridization process leads heredity decoding which allow the new plastic genotypes formation with an ability to change and adapt to the new conditions. Hybridization and selection arc considered as a main synthetic method of new varieties development and a success in this largely depends on the choice of crosses method and genotypes of initial forms. Therefore, there is given a special attention for studying the genetic basis and improving of hybridization methods. However, based on the most widely used of hybridization methods arc not always possible to develop varieties having high parameters of composite agronomical traits. Many developed varieties as a result of breeding methods arc genetically become homogeneous, which leads to a reduction of genetic variation and increasing of risk of cpiphytoty outbreaks and decreasing of total productivity (Boroycvich, 1981). Therefore, it is necessary to increase the genetic variability of crops’ agronomic traits by involving of original forms, as well as wild relatives of crops with genetic resistance to various stress factors, diseases and pests.
In increase cotton production through the creation of early maturing, high-yielding having good fiber yield and quality, resistant to various diseases, pests and stress factors, as well as with low level or toxic gossypol in cotton seeds still remain as critical problem in cotton production.
To overcome these problems there need to improving of genetic basis for assessment of existing donors and through the use of various hybridization methods to create new enriched genotypes, promoting positive recombination of polygene in hybrid’ organism for use in applied cotton breeding. Based on the above stated, the study of the genetic aspects of various methods of remote composite intraspecific and interspecific hybridization, based on the comparative evaluation of the effectiveness in order to isolate valuable recombinants and transgressive forms having new genetic variability of traits arc important both scientific and practical point of view.
The dissertation meets the objectives as set out in the Lows of Uzbekistan «On Seed Production» of December by 21, 2007 and «On Breeding achievements» by August 21, 2002 directed to developing and introduction of high-yielding cotton varieties, with a good yield and fiber quality, tolerance to various factors, as well as improving seed production.
Purpose of researches is comparative study of effectiveness of the various methods of intraspecific composite, convergent and inter-specific (3 to 5 species) hybridization revealing the nature of inheritance, form shaping and transgressive variation of traits, total and (+)-gossypol in creation of genetically enriched breeding material and for using in the applied cotton breeding.
Scientific novelty of the dissertation research is follows:
in the system of topcrosscs there used genetic evaluation for combining ability of main agronomic traits cotton varieties with different origins for further using in intraspecific composite and convergent hybridizations;
there established principally dominant inheritance and overdominance type of inheritance (with deviation toward the initial forms with the high agronomic traits) in F| at composite intra-and interspecific hybridization which genetically distinct accessions from the local and foreign selection and wide transgressive variability in F2-F3, facilitating to efficient selection of valuable recombinants;
first identified the inheritance nature and variability of total and (+)-gossypol in the cotton hybrids’ generative parts, developed by involving of American accessions with high (+)- gossypol and local varieties, as well as their correlation with some agronomical valuable traits;
first there held comparative study of economic traits at the different forms of amphidiploid G.thurheri x G.raimondii K-58 (hirsutum type) and K-59 (type harhadense) for free reproduction and after crossing the cultural forms of G.hirsutum L. species, it was established a wide range of variation of agronomic traits at mutant form of K-59 and composite hybrids, derived from it’s participation as compared to K-58 amphidiploid and it’s composite hybrids. It was found out those two types (type G.hirsutum K-58 and type G.harhadense K-59) of amphidiploid G.thurheri x G.raimondii at the free reproduction exhibits similarities with the both cultural tctraploid species; G.hirsutum L. and G.harhadense L., respectively. When they crossed with the cultivated G.hirsutum L. species these amphidiploid forms also behave as natural tctraploids;
it is revealed that, at the composite hybrids produced with the participation of the both forms of amphidiploid (K-58 and K-59) G.thurheri Tod. x G.raimondii Ulhr., as a result of transgressive variation, there is a disturbance of negative correlations between such traits as yield and fiber length, fineness and boll numbers conducive to positive recombinants emergence and increase donor opportunities of amphidiploids;
by comparative study of different methods of remote intra-and interspecific hybridization revealed the genetic nature of inheritance nature and variation degree of the main agronomic traits in composite hybrids, as well as their effectiveness in allocating recombinants having a new genetic variability of traits;
it is revealed that the possibility of breaking some negatively correlated traits by different methods of composite intra-and interspecific hybridization and selection of recombinants combining early maturity and high productivity, high fiber output with its quality and 1000 seed weight, etc.;
it is confirmed that the effectiveness of used methods such as a composite intraspecific and interspecific crosses, to increase positive transgressive variation and segregation genetically enriched recombinants having new combination of high levels of positive parameters of agronomic traits that were recommended and used to develop valuable initial material and new cotton varieties;
the obtained theoretical data on inheritance nature, hcritability and agronomic traits morphogenesis, levels of total and (+)-gossypol and their correlation with other agronomical valuable traits at developed hybrids could be successfully used in the field of fundamental research, and created unique hybrids, forms, progenies, lines and varieties could be used in applied cotton breeding.
Conclusion
1. There obtained and identified on comparative study base of intraspecific composed and converged hybrids with participation of six registered medium staple cotton cultivars in topcross system and high effects of GCA on the following traits:
«50%-cmcrgcncy-50 % flowering» Yulduz (-0.71); Tashkent-6 (-0.39) and in S-9070 (-0.38); “50% cmcrgcncy-50% maturing” S-9070 (-1.43), and in
Tashkent- 6 (-0.91); one boll weight S-6532 (+ 0.11); 1000 seeds weight S-9070 (+0.51); on productivity Tashkent-6 (+5,28), S-4911 (+4,04) and S-9070 (+2 24); fiber output S-6532 (+1,29); fiber length S-4911 (+0,70) and S-6532 (+0,48); fiber strength S-6532 (+1,57) and S-4911 (+0,91); micronairc S-6532 (+0,24) and Ak-Darya-6 (+0.24). These donors of high valuable traits were used by us for improving of the recurrent varieties by composite and convcrcgcnt hybridization. It was found that involvement of the varieties with a high GCA in convergent hybridization allows improving of the recurrent varieties and developing of a new initial material for cotton breeding:
inheritance nature and variability degree of agronomic traits at intraspecific composite and convergent cotton hybrids revealed the relative efficiency of the studied hybridization techniques during elaboration of new initial material with enriched genotypes of agronomic traits, and recommended to use in geneticselection process;
convergent hybrids F i dominated by early maturity, in terms of productivity and fiber output occurcd overall effect of overdominance, and F2-F3 appeared as positive transgressive forms;
significant effect of the genotype of the parental forms involved in hybridization on the inheritance nature of fiber quality (length, micronairc, strength) had convergent hybrids Fj, as well as their level of recombination in F2-F3 indicating the need for breeding of recombinants on these traits in early generations, taking into account genotype of initial forms;
the inheritance of the wilt tolcrancccs bccamcs not only depending on the pathogen load in soil fungus infections, but also depends on the used hybridization methods. Thus, most high resistance, i.c. negative superdominance on wilt tolerance observed in convergent hybrids F, and F2;
the direction and strength of correlation between the studied traits in intraspecific composite and convergent hybrids varied in depending on crosses type and from genotype of recurrent varieties. At present ease, the greatest number of recombinants with positive combination of high indicator traits which determining fiber quality, as well as its output, length, observed with with composite, particularly with convergent hybridization.
2. For the first time, on the basis of studies on determination the percentage of (+)- gossypol in seeds of genetically different cultivars of Uzbek cotton selection and analysis of variability, inheritance degree of total and (+)-gossypol in the environmentally and genetically remote hybrids and their correlations with economically valuable traits was proved:
the cultivars S-6524, S-6530 and S-6532 which were elaborated involving subspccic of G.ssp.punctatum had the highest level of (+)- gossypol and the «Turon» cultivar which was developed by composite hybridization has a low indicator of the current trait and relatively high level of total gossypol in seeds;
It was determined intermediate inheritance level of (+)- gossypol in the petals and seeds in F| hybrids and wide positive and negative transgressive variability in Ғ2-Ғ3. It was proved that the efficiency of plant selection with high (+)- gossypol in seeds since F2, that confirmed with segregation of constant progenies and lines on trait basis in F4 hybrids;
as a result of research the cross-correlation total and ( +)- gossypol and some agranomically valuable traits was found that between the ( +)- gossypol in the petals and seed exists a weak correlation. The data on correlations of studied traits showed an independent genetic control of (+)-gossypol in the generative organs and independent inheritance of them at cco- geographically and genetically remote hybridization.
3. For the first time, based on comparative study of agronomic traits of amphidiploid G.thurheri Tod. x G.raimondii Ulbr. two forms (hirsitum type -K-58 and harhadense type -K-59) and hybrids derived from G.hirsutum L. varieties revealed:
both studied forms of hirsutum type and harhadense type of amphidiploid G.thurheri Tod. x G.raimondii Ulbr., being functional diploids provided wide combinative variability in the progeny from the free reproduction and crossing with the cultivars of tetrapioid G.hirsutum L., and showed their similarity to G.hirsutum L. and G.harhadense L. tctraploid species, respectively;
as a result of the research a group of unique composite hybrids (F\G.thurherii Tod. x G.raimondii Ulbr.) x G.hirsutum L. confirmed unlimited transgressive variation as the basis of a new form revealing, new gene pool developing for use in applied cotton breeding. Herewith, at bud mutant K-59 observed emergence of phenotypes with higher variability for most agronomic traits compared to K-58;
it was found out that in composite hybrids which obtained by crossing of studied forms of G. thurberi Tod. x G. raimondii Ulbr. amphidiploids (2n=52) and with G.hirsutum L. cultivars were observed relatively rapid improvement on productivity and its components in comparison with freely propagated amphidiploids offspring. Herewith, composite hybrids involving K-58 on boll number in all generations was slower comparied to hybrids derived from K-59;
composite hybrids F, obtained involving two cultivars of cultivated forms on fiber output and length were observed deviation toward the parent with the best expression of the trait. It was revealed that the fiber output and length of the studied composite hybrids susceptible to less variability compared in terms productivity and its components. Relatively high variation was manifested on fiber output in F2, and on fiber length in F2-F3. In freely multiplying offspring of K-59 and its hybrids with varieties in F3 was observed the derivations of more long staple plants compared with hybrids, developed involving K- 58;
free propagating amphidiploids’ offsprings and composite hybrids selected by using of cultural forms showed the least wilt susceptibility compared with the control. Wilt resistance of barbadense type K-59 progenies from the free breeding was higher as compared than offspring of K-58, and higher in composite hybrids F2-F4, obtained involving K-59.
4. Under the general principle of correlation relationships among the studied hybrids were found that composite hybrids F2 amphidiploids’ G.thurberi Tod x G.raimondii Ulbr., both types (K-58 and K-59) with a G.hirsutum L. type Acala sj-5 cultivar showed mainly low positive and negative correlation coefficient values, which in most eases were none significant. In hybrid combination of K-58 x Andijan-60 fiber output and length correlated positively;
5. Based on comparative study of inheritance and variation of agronomic traits in developed 4 genomic [(G.thurberi Tod. X G.raimondii Ulbr.) X G.arhoreum L.] x G.hirsutum L., 5 - genome [(F|K-28 x S-6524 ) x G.harhadense L. hybrids and their backcross hybrids were proved:
the possibility of broad transgress variation and creation genetically enriched recombinants on unique traits;
efficiency of backcrosscs among the composite interspecific earlier generation hybrids for rapid improvement and stabilization of eultuvated forms of cotton;
wide transgress variability presence in 4 and 5 species composite hybrids and their backcross hybrids on productivity and its components starting with F|. In particular, it was confirmed the effectiveness of five species hybridization to increase the boll numbers per plant, boll weight and weight of 1000 seeds at 4 and 5 species and backcrosscs hybridization.
by obtaining recombinants having fiber output 43,1-45,0%, fiber length - 40 mm and above, micronairc of fiber 3.9-4.5 and wilt tolerance it was confirmed the effectiveness of introgressive and transgressive breeding at composite 4-5 species hybridization and their backcross hybrids.
6. As a result of studies of correlations in composite 4-5 species and backcrosscs hybridization of F2 hybrids it was revealed the effectiveness of used methods in interruption of such negatively correlated traits as «fiber output» and «fiber length» from medium positive (r=+0,39) up to high positive (r=+0,62), «fiber length» and «micronairc» -medium positive (r=+0,55), as well as «fiber length» and «fiber strength» -medium positive (r =+0,56 and r=+0.50).
7. Based on intraspecific composite and convergent, eco-geographically and genetically remote and 3-4-5 species and backcrosscs hybridizations were developed the following new breeding progenies, lines and varieties of upland cotton:
by composite and convergent hybridization way-L-7966, L-214/05; CC-896/05; CC-896/28; CC-991/05; CC-991/09; KC-1/05; КС-1/08; КС-1/18; KC-1/35; KC-1/51; KC-1/77, S-231-233/07, L-234-235/07, L-236-237/07, L-242-243/07, L-244-245/07, L-482-483/07, L-484-485/07, L-666-667/07, L-397-398/07, L-802-803/07, L-814-815/07, L-230/05;
cco- geographically and genetically distant hybridization - cultivar S-7300, S-7301, the progenies S-5344, S-5361. HPG-1;
composite 3 - specific hybridization -cultivar «Sulton», «Jarkurgan», S-7276, S-7277, as well as a number of lines;
8. Using the remote intra-and interspecific hybridization it was elaborated unique introgression hybrids, genetically enriched cotton recombinants, progenies, lines, and varieties «Sulton», «Jarkurgan», S-7276, S-7277, S-7300, S-7301 having positive combination of high agronomic traits. Cultivar «Sulton» was included in the State register from 2011 and for the period from 2008 up to 2014 it was sown on the area of over than 275,5 thousand hectares.
9. The following rcccomcndations were given for practize and future studies:
use of method convergent hybridization, allowing improving of agronomic valuable traits of recurrent parent and registered medium staple cotton cultivars and receiving a positive transgressive variability;
as an initial source in convergent crosses use cotton varieties with high General combination ability (GCA) on the following: on early maturity- Tashkent-6 and S-9070; boll weight - S-6532; weight of 1000 seeds S- 9070; on productivity -Tashkent-6, S-4911 and S-9070; fiber output -S-6532; fiber length - S-4911 and S-6532; fiber strength - S-6532 and S-4911; and for micronairc - S-6532 and Ak-Darya-6.
for use as an initial source in cotton genetics and breeding research such new cotton selection progenies as well as the lines: KS-1/05; K.S-1/08; K.S-1/18; KS-1/35; KS-1/51; and KS-1/77, L-7966, L-214/05, S-214/05, SS-896/05; SS-896/28; SS-991/05 and SS-991/09 with early maturity, productivity, wilt tolerance, fiber output and quality.
to use in cotton genetics and breeding researches both USA accessions BC3S,-47-8-l-17, BC3S|-l-3-6-15 with 95% of (+)-gossypol level in seeds and lines HPG-1 and others with 90% of (+)-gossypol level, as donors on this trait. Since 2012, developed and studied in the competitive variety testing of Institute the following lines: L-404-05 and L-6970 with high (+)- gossypol level were recommended for testing on ground control of the State Inspection Commission for Agriculture crops variety testing.
widespread use of various forms of synthetic tetrapioids G.thurheri Tod. x G.raimondii Ulbr., 4-5 species composite hybrids [(G. thurheri Tod. x G. raimondii Ulbr.) x G.arhoreum L.] x G.hirsutum L. and [(F t K- 28 x C-6524 ) x G.harhadense L., as well as their backcrosscs for achievement the broad transgress variation, elaboration genetically enriched recombinants on economically valuable traits and their use in practical cotton breeding;
to extend the areas in of early maturing commercialised cotton cultivar «Sulton» and perspective one «Jarkurgan» as well broad testing of such as new varieties S-7277, S-7300 and S-7301 in the republic.