Subject of the inquiry: 298 patients with finn deformations of the larynx and trachea
Aim of the inquiry: early rehabilitation of patients with firm deformations of the larynx and trachea path optimization and creating clinical and pathogenic methods of complex treatment.
Methods of the inquiry: clinical examination, special examination: LOR-examination, endoscopy of air ways, X-ray, CT, MRI of larynx, trachea and bronchus, bacterial examination of larynx and trachea wounds; morphological examination, biochemical methods of examination: lipid peroxidation, antioxidant enzymes, activity of hepatic monooxygenase system (MOS); biophysical methods of examination: исследование electric damage of erythrocytes’ membrane (EDEM), blood viscosity (BV) and blood shift velocity (BSV); cytological examination.
The results achieved and their novelty: In patients with firm deformations of the larynx and trachea, firstly basing on complex investigation clinical and structural-functional parameters revealed pathomorphological changes in neck tissues as chronic inflammation with productive component. Despite, revealed disrupt balance of process lipid peroxidation and antioxidant system, hydroxylic function of liver, decrease of electoral penetrability of erythrocytes’ membrane and aggravate of hemorheology. With this, level of expression of changes depends on clinic form and load disease, correlate with stage of wound healing and after restore of functions of the larynx and trachea gradually becoming normal. Presented classification of the firm deformations of the larynx and trachea, permitting complexly counting etiologic factor and morphological variant of the damage of laryngotracheal tract. In scheme of the pathogenic complex conservative therapy before and after reconstructive operations included medicine, influencing on Hemodynamic, with ability membranotrope action, systemic enzymotherapy, immunostimulators, and correction of the tissue metabolism by laser. Created private and modified methods of reconstructive laryngotracheoplasty in case of cicatricle stenosis of glottic and subglottic parts, bilateral paralyses of the larynx, cicatricle deformations of pharyngolarynx, combination deformations and defects of the larynx and trachea, permitting single stage restore laryngotracheal ways.
Practical value: The investigation of pathogenic mechanism of developing of the firm deformations of the larynx and trachea on data of changes of main functional and metabolic processes will permit not only activating and improving of pathogenic therapy, and forecasting variant of development and course of postoperative period after reconstructive operations.
Use of proposed methods of complex conservative and surgical treatment of the firm deformations of the larynx and trachea allowed to provide whole volume of restoring means in more short time and with less quantity of stage operations, preoperative preparing till 3 days, hospital stay till 14-20 days, surgical operations in 1.9 time.
Degree of embed and economical effectivity: The results of investigation intruded in treatment practice of the First and Second Tashkent Medical Institutes, LOR-clinics of Samarqand territorial children hospital, territorial hospital of Karshi. Materials of the investigation using in study process of LOR - cathedra First Tashkent Medical Institutes during lectures and practice tutorials with students, magistracies, and clinic ordinators. Determined main economic effect in use of proposed complex therapy in connection with reduce of term of treatment and hospital stay (on an average 10 days) and taking off or decreased disability on 67% patients.
Sphere of usage: otorhinolaryngology, surgery, reanimation
In the textual studies of the peoples of the world, attention to the study of national literary heritage based on primary sources is growing stronger than ever. The study of manuscript sources makes it possible to restore the texts of the works of a poet or writer in accordance with the original (at least close to it), regardless of the period in which they lived. Without restoring a reliable text, the poet's work cannot be analyzed in terms of theoretical problems of literary studies. In world textology, research is being conducted on such scientific problems as comparative analysis of manuscript sources, creating a scientific biography of the creator, and studying the history of the text of an artistic work. Among them, a great deal of experience, knowledge and material has been collected within the framework of studying the sources of Eastern manuscripts spread throughout the world's libraries, including the works of Alisher Navoi and Babur, great figures of Turkish literature. Extensive research is the basis for the creation of the theoretical foundations of textual studies. Uzbek textology has progressed on the basis of existing scientific experiences and has achieved certain results in the study of classic literary sources. Researching the literary heritage of authors who have left a bright mark in the history of national literature, studying manuscript and lithographic sources based on the latest scientific achievements is one of the primary tasks of source studies and textual studies. After all, "...studying and promoting Uzbek classic and modern literature at the international level, analyzing this multifaceted topic in integral connection with the most important processes taking place in the world's literary space today, creating the necessary scientific - drawing practical conclusions is of great importance..." 1 . Accordingly, it becomes clear that it is urgent to carry out a scientific monographic study of the sources of the lyric divan of Khorezm literary environment representative Mutrib Khonakharob (1853-1923), study the textual history of the poet's works, and develop the principles of preparing a scientific and critical text. The study of Mutrib's work began during the poet's lifetime. Tabibiy recognizes the achievements of the poet in poetry and music in the collections "Majmuat ush-shuaroyi payravi Feruzshahi" and "Majmuat mukhammasot ush-shuaroyi Feruzshahi". "Biographies of poets and writers of Khiva" by Hasanmurad Laffasi, "Poets and singers of Khorezm" by Bobojon Tarroh, "Tazkirayi Qayyumiy" by Polatjon Qayyumiy also provide valuable information about the poet's work. O. Sharafiddinov, M. Yunusov, N.M. Mallayev, Yu. Yusupov, M. Pirnazarov, A. Abdugafurov published articles. These articles cover the biography of the poet, the ideological scope and artistry of his works, thematic and genre features of his literary heritage. But in most of them, the poet's works were interpreted under the influence of communist ideology. M. Pirnazarov studied manuscript and lithographic sources of Mutrib's lyrical heritage, subject scope, genre features, and artistic skills. Although this research provided valuable information for its time, problems such as creating a scientific biography of the poet, researching the author's works in the field of theoretical problems of textual studies, and creating a scientific-critical text are still waiting to be solved. In studying the poet's literary heritage, the book "Mutrib Khonaharobi (Ref. Collection)" is noteworthy. However, besides the fact that the text of these poems is not complete, there are also errors in the reading of words. In this tutorial, the manuscripts numbered 906/VII, 903/IV, 2679/II of the Department of Muhammad Hasan Mutrib kept in the main and H. Sulayman funds of the Academy of Sciences of the Republic of Uzbekistan, as well as Turkish manuscripts in bayoz, complex and tazkira poems, information about the poems in manuscript bayoz kept in Khiva Ichonqala Muhammad Rahimkhan Feruz II Museum.
The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
This scientific article endeavors to delve into and draw comparisons between the linguistic and cultural elements of advertising texts in both Uzbek and English languages. This study thoroughly examines and analyzes diverse linguistic and cultural characteristics embedded within advertisements, with a particular emphasis on their influence on target audiences within distinct cultural contexts. Through meticulous examination and interpretation, this research sheds light on the intricate interplay between language, culture, and advertising strategies, ultimately offering valuable insights for enhancing cross-cultural advertising communication. By employing a systematic research approach, the study explores the multifaceted dimensions of advertising language in both Uzbek and English. It investigates how language choices, rhetorical devices, and persuasive techniques are adapted and employed differently across these two languages to effectively convey messages to their respective audiences. Additionally, the research delves into the cultural aspects manifested within these advertisements, such as values, symbols, and societal norms, which greatly impact the effectiveness and reception of the advertisements within their target cultures.
This scientific article endeavors to delve into and draw comparisons between the linguistic and cultural elements of advertising texts in both Uzbek and English languages. This study thoroughly examines and analyzes diverse linguistic and cultural characteristics embedded within advertisements, with a particular emphasis on their influence on target audiences within distinct cultural contexts. Through meticulous examination and interpretation, this research sheds light on the intricate interplay between language, culture, and advertising strategies, ultimately offering valuable insights for enhancing cross-cultural advertising communication. By employing a systematic research approach, the study explores the multifaceted dimensions of advertising language in both Uzbek and English. It investigates how language choices, rhetorical devices, and persuasive techniques are adapted and employed differently across these two languages to effectively convey messages to their respective audiences. Additionally, the research delves into the cultural aspects manifested within these advertisements, such as values, symbols, and societal norms, which greatly impact the effectiveness and reception of the advertisements within their target cultures.
The article presents the results of an experiment to study the effect of surfactant concentration and type on foam formation in clay suspensions. As a result of the study, it was found that the addition of surfactants to the system leads to an increase in the volume of foam, and the most significant effect is observed when using surfactants of the type OP-10. With an increase in the concentration of surfactants to a specific value (0.3%), a sharp increase in the height of the foam is observed; however, a further increase in the concentration does not have a significant effect on the
amount of the formed foam. The study also showed that the height of the foam in the system with surfactant type OP-10 is higher than in the system with surfactant type GKJ-11, which indicates greater foam adsorption at the liquid-air interface. The study of the surface tension of surfactant solutions showed that the surfactant type OP-10 has more significant properties of the surfactant than the surfactant type GKJ-11. These results may be useful to improve the foaming in slurry drilling fluids using various types and concentrations of surfactants.
The aim of the study is to improving the quality of treatment of ventral hernias in patients with morbid obesity by improving the tactical and technical aspects and optimizing the choice of hernioplasty method.
The object of the study were 121 patients with ventral hernias and morbid obesity who were hospitalized in the surgical department of the 1st clinic of the Samarkand State Medical University in the period from 2012 to 2021.
The scientific novelty of the study is as follows: a method was developed for preoperative preparation of patients with ventral hernia and morbid obesity using a modified pneumatic belt-bandage to adapt the cardiovascular and respiratory systems to intra-abdominal hypertension after hernioplasty; improved technical aspects of the reconstruction of the anterior abdominal wall in patients with morbid obesity; the surgical instrument "retractor" has been improved for technical optimization of the stage of suturing the anterior abdominal wall for fixing the prosthesis in patients with concomitant obesity and abdominal ptosis; clarified clinical and instrumental criteria for the specific unification of the scale for assessing the quality of life of patients after hernioplasty and abdominoplasty for ventral hernias and morbid obesity with differentiation of the value of physical, mental and social daily activity. The practical results of the study are as follows: According to the results of a scientific study to improve the diagnosis and surgical treatment of patients with ventral hernias and morbid obesity: improved "retractor". The use of the proposed tool made it possible to level the technical difficulties in fixing the prosthesis against the background of severe overweight with a reduction in the operation time; developed guidelines "Technical aspects of hernioplasty for ventral hernias in patients with morbid obesity" (certificate of the Ministry of Health 8n-r / 905 dated October 12, 2021), "Criteria for the choice of surgical treatment of patients with ventral hernias and obesity" (certificate of the Ministry of Health 8n-r /906 dated October 12, 2021). The proposed recommendations made it possible to optimize the choice of tactics for surgical treatment of patients with ventral hernias and morbid obesity; the obtained scientific results on improving the quality of diagnosis and surgical treatment of patients with ventral hernias and morbid obesity have been introduced into the practice of health care, in particular, in the departments of surgery of the 1st clinic of the Samarkand State Medical Institute, the Jizzakh Regional Multidisciplinary Medical Center and the Sh. Rashidov District Medical Association of the Jizzakh region (certificate of the Ministry of Health 8n-z / 368 dated October 22, 2021). The implementation of research results by improving the tactical and technical aspects of the surgical treatment of patients with ventral hernias and morbid obesity made it possible to reduce the overall incidence of postoperative complications from 14.8% to 8.9%, including wound complications from 11.1% to 4.5% and extra-abdominal from 7.4% to 4.5%, as well as significantly reduce the duration of surgical treatment and rehabilitation periods after various types of hernioplasty and abdominoplasty. The structure and scope of the dissertation. The dissertation consists of an introduction, five chapters, a conclusion, conclusions, practical recommendations and a list of cited literature. The volume of the text material is 107 pages.
In Uzbek poetry of the independence period, which is a legitimate part of world literature, special attention is paid to the generalization of scientific theoretical views on the creative worldview and creative philosophy of the socio historical period, the artistic perception of reality in poetry and the study of artistic realization. The intensification of the desire for the deep artistic development of the human spiritual world in the poetry of the independence period is associated with the renewal of the period, the historical environment and the artistic thinking of the creators themselves. The harmony of poetry and literary-aesthetic views is a direct result of the synthesis of the principles of creative phenomenon, personality, perception of the world, which is reflected in the author's "I". Image poetics plays an important role in revealing the creative concept and uniting it into a common denominator. The perfection of the product of artistic thinking as a synthesized system is determined by the level of creative thinking and talent. The work of Amir Khudoiberdi is one of such events in the history of national artistic thought, and in the works of the poet created in different genres, he expresses the life, dreams and will of the people in different socio-historical periods. The poet's tendency to create a holistic artistic history of the Uzbek people in the twentieth century is explained by the vast opportunities provided by independence, the end of ideological monopoly, the restoration of national values, the renewal of literary and aesthetic views, the translation of world literature into Uzbek. The transition from the depiction of things to the depiction of ideas has changed the content of artistic creation, while enriching the formal, semantic scale of artistic research.
Close acquaintance with world poetry has long served as one of the important factors in the renewal of our national literature, separated from its spiritual sources- religious and mystical literature, classical and modern literature. The content of the themes of emotional literature is characterized by a focus on the person, not directly on reality. The synthesis of world literary traditions can be seen in the works of Fakhriyor, Ulugbek Hamdam, Bahrom Ruzimuhammad, Farida Afroz, Nodira Afokova, Zebo Mirzaeva, Khosiyat Rustamova, Gozal Begim. Amir Khudoiberdi is also one of the poets of this literary generation who has his own creative credo and works in various genres. Any national literature manifests itself as a systematic, evolving stable phenomenon only in the harmony of different ideologies, styles, views, approaches, ideas, and even contradictions. Only then can it be a true metaphorical representation of being. Amir Khudoiberdi is one of the new generation of artists who lived in a complex and controversial period and saw and understood the subjective approaches to the literature of the Soviet era. A comprehensive scientific study of the creative style, individuality and mastery in the poetry of the independence period on the example of the work of a poet, the generalization of scientific and theoretical views on the poetry of this period gives important conclusions, this scientific research is the product of such a necessary need. In Uzbek literature, the works of Amir Khudoiberdi have not yet been comprehensively studied. The study of the poet’s work is also important in determining the influence, position, and place of local artists in literature. Also, the issue of art and literature, which is one of the means of spiritual and educational environment, education and their formation in our country, has always been in the forefront. Therefore, as the President of Uzbekistan Sh.M.Mirziyoev said: “...attention to literature and art, culture is first of all attention to our people, attention to our future, as our great poet Cholpon said, we have no right to forget that literature, culture and nation can live ”. This fact also determines the relevance of the topic.
Accordingly, this study is based on the Decree of the President of the Republic of Uzbekistan dated February 7, 2017 No. PF-4947 "On the Strategy for further development of the Republic of Uzbekistan", dated September 13, 2017 No. PQ- 3271 "Development of the system of publishing and distribution of books. to a certain extent in the implementation of the tasks set out in the Resolution "On a comprehensive program of measures to improve and promote the culture of reading and reading" and other regulations related to this activity.
Target. То study the structure of nosology, demonstrated by the syndrome of recurrent vomiting, for timely assistance in primary health care. Materials and methods. The study included 176 sick children with recurrent vomiting symptoms. Verification of clinical diagnoses were carried out based on clinical, laboratory and instrumental research methods, including: clinical anamnestic methods,biochemical blood analysis, ultrasound examination, EGDS, X-ray contrast method for the study of the gastrointestinal tract.
Result. The symptom of recurrent vomiting in preschool children, regardless of the sex of patients, occurs most often in functional and organic diseases of the gastrointestinal tract (83.5%), in metabolic disorders - in 14.2% and in pathology of the central system - in 2.27 % of cases.
Conclusion. The most common causes of vomiting in children are diseases of the gastrointestinal tract (GIT), both functional and organic. Vomiting can also be caused by both congenital metabolic defects and endocrine disorders.
The study examined the effectiveness of complex methods of ultrasound diagnostics using elastography in assessing the prevalence of cervical cancer (CC). This article presents the results of a complex ultrasound examination using elastography of 42 women aged 32-73 years. (average age is 52.1 years). Examination of the pelvic organs included a transabdominal examination (B-mode) followed by a transvaginal approach using the compression elastography technique.