For parents, a child of any age seems vulnerable, so adults take care of him, they want protection from all difficulties. Unfortunately, a person is not strong and some diseases are very dangerous for the life of children. Some pathologies pass quickly and affect the future life, otherwise others will significantly affect the future life of the child. In order to reduce the impact of pathologies on the child's body, it is possible to diagnose the disease in the early stages, it is necessary to identify and immediately begin treatment. Among these diseases are ophthalmic we can not do without the introduction of diseases. If a child has vision problems from an early age, it can lead to a delay in the development of the child in the future. Ophthalmic diseases the main part: eye injuries, glaucoma, cataracts, glaucoma, retinopathy, myopia, cataract diseases, etc. More than 20% of diseases in ophthalmological practice, depending on the injury, damage the orbit and the eyeball. From an eye injury, then in 13% of cases, subatrophy of the eye develops, in 25% anophthalmos may occur. As for the characteristics of injuries, 10% of children suffer from damage to the organ of vision. This leads to various pathologies of the eye, in 30-60% of cases it can lead to one- or two-sided blindness. The most important traumatic factors in children are: knives, bullets, stones and clubs, hockey sticks, spears, nails, wire, etc. Glaucoma is one of these diseases. The disease also requires special attention. Reason: Prevalence of glaucoma in children Occurs in 1:10,000-1:12,000 cases. Its share in eye pathology is 0.1%. enough. More than 75% of glaucoma cases are bilateral. In parallel, there was glaucoma in 5 to 15% among children, blind and non-blind schoolchildren. Blindness in children, the proportion of this pathology ranges from 2 to 15%. in the Russian Federation Congenital glaucoma accounts for 10.1% of childhood blindness.
The aim of the study. To improve the quality of perioperative analgesia by combined multimodal use of paracetamol and ketorolac tromethamine in children after abdominal surgery.
Materials and methods. 48 children (6–17 years old) with choledochal, pancreatic cysts, hepatic echinococcosis, and abdominal trauma. The study period was from January 2021 to January 2022. Group 1 (main group, n=28): baseline analgesia - 15 min before surgery, intravenous paracetamol administration at 25–30 mg/kg. In order to prevent postoperative pain syndrome 15 minutes before the end of the surgery, we administered ketorolac and tromethamine in a dose of 0.5 mg/kg. Pain relief was repeated 6-8 h later with ketorolac at a dose of 0.5 mg/kg. Group 2 (comparison, n=20), who received 0.2 – 0.3 mg/kg promedol (trimeperidin) in the postoperative period. Both groups received standard endotracheal anaesthesia (propofol + fentanyl + arduan against the background of Low-flow anaesthesia with sevoflurane MAK=1). Systemic haemodynamics, C-reactive protein, and glucose were investigated, and a visual analogue scale was applied at the main stages of the study.
Results: Analysis of the parameters of central hemodynamics, parameters of the operational stress response and clinical data showed that in the postoperative period, sufficient analgesic effect was established only in children in group 1 with the preventive combined administration of paracetamol and ketorolac on the operating table, which allows recommending them in the practice of perioperative analgesia during abdominal surgical interventions.
Conclusions. Optimised method of preventive (preoperative) use of paracetamol in children at a dose of 25–30 mg/kg during abdominal surgery followed by administration of ketorolac tromethamine (15 minutes before the end of the surgery) increases the degree of nociceptive protection. It ensures high efficiency of postoperative pain relief, which allows to recommend it in the practice of perioperative analgesia for the above abdominal surgical interventions in children
Purpose — to determine the values of central corneal thickness (CCT) in children depending on the level of intraocular pressure
(IOP) and the stage of congenital glaucoma (CG).
Material and methods. Clinical studies were carried out in the eye department of the clinic at the Tashkent Pediatric Medical In-
stitute. The study involved 18 patients (36 eyes) aged 9 to 11 years (mean age 9.3±1.6 years) with confirmed diagnosis of CG.
All patients underwent basic ophthalmologic examination prior to surgical and conservative treatment. In addition to basic meth-
ods, axial eye length and CCT were determined using an automatic non-contact tonometer/pachymeter manufactured by NIDEK
(USA).
Results. Analysis of the obtained data showed that in initial, moderate and advanced stages of glaucoma, the CCT values were sig-
nificantly lower than the age norm values. This indicates stretching of the fibrous capsule and thinning of the cornea in glaucoma.
In terminal stage CG, the CCT values practically did not differ from the age norm, but were higher than in initial, moderate and ad-
vanced stages of the disease. The noted thickening of the corneal membrane in terminal stage may be explained by edema of the cor-
neal tissue as a result of elevated IOP.
Conclusion. The age norm values of CCT should be taken into account when characterizing the severity of glaucomatous process
in children. Compared to the age norm, the cornea is significantly thinner in children aged 9 to 11 years with initial, moderate
and advanced stages of CG, and becomes significantly thicker in terminal stage, which is associated with edema caused by ele-
vated IOP.
The present article seeks to explain the impact of the processes globalization on national cultures and the response of ethnic cultures to such processes from the viewpoint of alternate progress theories. The immanent connection between globalization and ethno-cultural diversity, proximity and national-cultural models of alternative development are the object of our research.In the current period, the communicative function of culture has expanded dramatically, transformation processes are taking place in it in accordance with global changes. In particular, forms of indirect communication (mobile phone, Internet) are making radical changes in this function. Now there is rapid rapprochement of cultures, exchange of experience and mutual enrichment. At the same time, it is necessary that the communicative function does not harm the diversity of ethno-cultures, does not interfere with intercultural communication in accordance with national interests, and especially does not focus on the decision-making of Western popular culture. No matter how much international dialogue and integration help to establish universal values and norms, they should not serve to make a culture in a mood of expansion become a dominant force.During the period of democratic reforms, scientific and practical research was started on the restoration of Uzbek ethnic culture, the use of its historical, educational and artistic-aesthetic possibilities. The state is leading the development of many types of folk creativity and art. However, comprehensive research of Uzbek ethnic culture, its genesis, sociological and axeological foundations, integration relations with the culture of sister nations, and comparison with other ethnic cultures in the system of these relations is one of the tasks before us. Philosophical studies conducted today are mainly empirical in nature, philosophical generalizations are rare in them. Therefore, there is a scientific-theoretical need to study cooperation, communication and integration between ethnic cultures under the influence of globalization from a philosophical point of view, without forgetting the allogenesis and ideogenesis of ethnic culture. It should focus not only on making philosophical generalizations, but also on finding ways to effectively use artistic-aesthetic possibilities, tools, and artifacts.
The purpose of the study. To compare the effects of the traditional inhalation method and VIMA (Volatile Induction and Maintenance Anesthesia) anesthesia and the new VIMA technique in two-bolus induction with sevoflurane on the frequency of development of agitation, bradycardia and agitation in children. Materials and styles. Studies were conducted at the clinic of the Tashkent Pediatric Medical Institute. The studies are retrospective and prospective. A clinical analysis of 245 anesthesiological practices with sevoflurane (traditional VIMA technique) in children with neurological symptoms of various urological, surgical and ophthalmosurgical pathologies was conducted. Results. The VIMA technique of double-bolus sevoflurane induction of anesthesia provides a preconditioned result and minimizes the frequency of bradycardia development, as well as excitability and agitation in children. In our opinion, this inhalation anesthesia application of the method is promising, it is necessary to continue its research.
The aim of the study was to evaluate the effectiveness of using dexmedetomidine for the treatment of delirium in the early postoperative period of cardiac surgery in children. Materials and methods. The study was conducted in 28 children (3*7 years old) who underwent surgery for an atrial (ASD), interventricular (VSD) septal defect under general combined anesthesia (OCA), and 9 children (3-7 years old) with clinical manifestations of delirium in the early postoperative period (POP). Upon admission of children to the ICU, after cardiac surgery, intravenous infusion (50 μg/kg/h) of dexmedetomidine was performed, and analgesic therapy was also carried out: ketoprofen. trimeperidine. The level of sedation was assessed by Ramsay. RASS-scale AJdrete score VAS-scale. In the absence of consciousness, a visual assessment of motor excitation, lacrimation, sweating, negative facial expressions, vocal signs of pain (groans) was carried out. In patients with delirium, the type of delirium, the day of occurrence, the doses of administered drugs, the duration of therapy and the duration of the episode of psychomotor agitation, the incidence of side effects, and the number of days in the ICU were assessed. Results. The use of dexmedetomidine provides a dose-dependent level of sedation and retrograde amnesia with intact verbal contact with the patient, does not cause respiratory depression, reduces the duration of mechanical ventilation, and facilitates care. The need for narcotic analgesics is reduced, since the drug has an independent analgesic effect. The high efficacy of Dexdor in the treatment of delirium continues after the cessation of the infusion of the drug.
Atherosclerosis is a chronic lesion of the arteries caused by the growth of multiple dense nodular thickenings of the walls of the artery (plaques), narrowing its lumen and contributing to the formation of a blood clot - a thrombus, which can clog the vessel. Atherosclerosis develops as a result of complex structural changes that occur in the intima (inner layer) and in the media (muscle layer) of the arteries, and it is associated with the accumulation of lipids and mucopolysaccharides in the blood vessels, the growth of connective tissue and the deposition of calcium. Cardiovascular pathology, and this is ischemic heart and brain disease, occlusive diseases of peripheral arteries, is the most common cause of morbidity, mortality and disability in the population of industrialized countries. According to the statistics of the World Health Organization, in the structure of total mortality in Russia, cardiovascular diseases account for 57%. Most of these cases are associated with diseases caused by atherosclerosis [3]. The development of atherosclerotic lesions of the vascular wall is a complex multi-stage process. It has now been established that even before endothelial damage, blood components begin to interact with the endothelial surface. In particular, low-density lipoprotein cholesterol (LDL-C) and their active component apolipoproteins are able to penetrate into the subendothelial space and, being oxidized, affect endothelial cells. In this regard, the initial stage of atherosclerosis is characterized as a response to the retention of atherogenic particles [2]. The main risk factors that play a significant role in endothelial damage are smoking, arterial hypertension and hypercholesterolemia. It has been shown that with an increase in cholesterol levels of more than 8.5 mmol/l, the risk of fatal cardiovascular complications increases by 4 times, when combined with arterial hypertension by 9 times, with smoking, the presence of hypercholesterolemia and arterial hypertension by 16 times [1]. The problem of primary and secondary prevention of ischemic stroke is not only medical, but also of great social importance, since patients who have had it become disabled in more than 80% of cases and often need outside help. Statins are considered highly effective drugs with the greatest evidence in reducing the risk of cardiovascular events in patients with coronary artery disease.
A clinical case of EYE MANIFESTATIONS of complications is presented in a teenager who has had COVID-19. The studies were carried out in the intensive care unit and intensive care unit (ICU) of the clinic of the Tashkent Pediatric Medical institute. The patient underwent standard laboratory and instrumental studies, as well as an ophthalmological examination, including visometry, biomicroscopy, ophthalmoscopy. This clinical case showed that COVID-19 infection was complicated polymorphic ophthalmic symptoms indicating involvement in the process lacrimal gland, mucous membranes of the eyeball and eyelids, cornea of the lacrimal sac, retrobulbar tissue, while from the side of the eyes these complications are expressed in dry keratoconjunctivitis (Sjögren's syndrome).
BACKGROUND: Sepsis is one of the leading causes of hospital mortality in children. a decisive role in improving the results of treatment of this group of patients belongs to early diagnosis and pathogenetic therapy. AIM: this study optimizes the diagnosis and intensive care of surgical sepsis in children based on clinical and laboratory criteria and bacteriological monitoring.
MATERIALS AND METHODS: the study period is 2018–2020. the study subjects were children (n = 73) with surgical pathology (diffuse purulent peritonitis, bacterial destruction of the lungs, post-traumatic brain hematomas, injuries of the abdominal organs, and others). clinical and laboratory parameters were analyzed, and microbiological monitoring was performed to determine antibiotic sensitivity.
RESULTS: Patients who developed sepsis had a pronounced hypermetabolic syndrome, which was manifested by tachycardia and tachypnea, hyperthermia, low levels of albumin, and total protein in the blood. Protein catabolism in patients was accompanied by a decrease in globulins (IgG) synthesis and the development of a secondary immunodeficiency state. Both gram-positive and gram-negative microorganisms were involved in developing surgical sepsis in children, increasing the proportion of the latter. Given the high proportion of multi-resistant flora, empirical combined de-escalation antibiotic therapy (aBt) with broad-spectrum antibiotics was prescribed. this was followed by its revision based on microbiological monitoring and clinical and laboratory data of the patient with sepsis. Studies have shown the effectiveness of complex intensive care in 86.3% of cases. Mortality occurred in 13.7% of cases. Patients with severe surgical pathology died: fecal, generalized peritonitis, severe traumatic brain injury + coma with irreversible neurological disorders, and urosepsis against the background of chronic renal failure after repeated surgical interventions.
CONCLUSIONS: early diagnosis of sepsis, rational aBt under the control of microbiological monitoring, non-aggressive infusion therapy, and active sanitation of the surgical infection focus contributed to a decrease in mortality in this category of patients.
One of the vital minerals in the human body is calcium. This mineral takes part in more than 300 biologically active reactions. Medicinal products (PM), including calcium salts, have been used in medicine for many decades. In total, the body of an adult contains about 1000-1500 mg of Ca. In the body, calcium is in two forms - it is ionized (free) and associated with Ca proteins (mainly albumin). A decrease in the concentration of ionized calcium causes signs of hypocalcemia. The main way calcium enters the body is the alimentary route. By consuming milk, dairy products, fish, meat, fruits, vegetables, greens, we take the daily intake of calcium. Sources of calcium for children at different stages are different. The intake of calcium to the fetus depends on the saturation of the mother's body with calcium, vitamin D. In the last trimester of pregnancy, the rate of calcium incorporation into the fetal body increases, which means that the state of bone mineralization will also depend on gestational age. After birth, the source of calcium is breast milk, and for formula-fed babies, an adapted milk formula. With breast milk, a child receives up to 300 mg of calcium, and in mixtures, an average of 400 mg of calcium.
Chast naseleniya, zanyatye rabotoy, a takje te lyudi, kotorye khotyat rabotat, ischut botu, no po raznym prichina poka ee ne imeyut, predstavlyayut soboy trudovye resursy. Ix izuchenie imeet bolshoe znachenie pri otsenke rynka truda iprovedenii gosudarstvom sootvetstvuyushche demographiceskoy politiki s tselyu vozdeistviya na processy vosproizvodstva naseleniya i ego zanyatosti. Gosudarstvennaya politika zanyatosti naseleniya – eto chast social-economic policy of the gosudarstva, napravlennaya na rreshenie problem zanyatosti naseleniya vy ekonomiki na osno povysheniya effektivnosti program obespecheniya zanyatosti, razvitiya sistemy sotsialnogo partnership, stimulating the mobility of the economic active population i sileniya gibikosti rynka truda. [1, p.188] Nastoyashchee issledovanie napravleno na reshenie sleduyushchikh zadach: obzor sovremennoy literatury po tematice trudovye resursy i obespechenie regionalnoy zanyatosti; statisticheskiy analyz zanyatosti i rovnya bezrabotitsy v Respublike Uzbekistan; Izuchenie i otsenka vliyaniya faktorov, vliyayushchikh na zanyatost trudovykh resursov Republic of Uzbekistan, s tselyu vyavleniya naibolee znachimyx iz nix. Ob'ektom issledovaniya yavlyayutsya trudovye resursy Respubliki Uzbekistan, objektom — faktori, povyshayushchie ee zanyatost. Issledovanie osnovano na ispolzovanii kak kachestvennyx, tak i kolichestvennyx metodov analiza. Qualitative analysis is based on modern research factors that define labor resources in the whole world. The quantitative analysis is based on the data of the State Committee of the Republic of Uzbekistan for Statistics, the Ministry of Industry and Labor Relations of the Republic of Uzbekistan, the Scientific Center for Industry and Labor Relations of the Republic of Uzbekistan, and some other organizations. The theoretical significance of the study is presented in detailed quantitative and qualitative analysis and detailed comparison of factors of regional labor resources of the Republic of Uzbekistan.
There are many factors which have impact whether positive or negative on the development of tourism. One clear illustration of the factors is seasonality. This factor can be recognized as the primary reason for the uneven distribution of tourists in a certain period (a year, half a year). From an economic point of view, it represents recurring fluctuations in demand with alternating peaks and valleys. Lower seasonal demand unevenness is also characteristic of medical and business tourism; different tourist regions have specific forms of seasonal demand unevenness. Therefore, we can talk about the specifics of tourist demand in a particular locality, region, country, on a global scale. The seasonality of demand is also influenced by psychological factors (traditions, imitation, fashion). Peaks and declines in tourist activity can be largely explained by the conservatism of most tourists such as the ingrained opinion that summer is the most favorable time for holidays. Seasonal fluctuations in tourist demand can lead to forced downtime of the material and technical base, give rise to social problems. Furthermore, this factor heavily influences when it comes to major tourist centers. The main aim of this paper is to research the possibilities of alleviating the negative impact of the seasonality factor in the development of tourism in Samarkand.
The purpose of the study. Traditional inhalation method and VIMA (Volatile Induction and Maintenance Anesthesia) method of applying anesthesia and using the new VIMA technique in double-bolus induction with sevoflurane to compare the effect on the frequency of development of agitation, bradycardia and agitation in children. Materials and styles. Studies were conducted at the clinic of the Tashkent Pediatric Medical Institute. The studies are retrospective and prospective. A clinical analysis of 245 anesthesiological practices with sevoflurane (traditional VIMA technique) in children with neurological symptoms of various urological, surgical and ophthalmosurgical pathologies was conducted. Results. The VIMA method is a technique of double-bolus sevoflurane induction of anesthesia provides a preconditioned result and minimizes the frequency of development of bradycardia, as well as excitability and agitation in children. In our opinion, the use of this method of inhalation anesthesia is promising, it is necessary to continue its research.
Time of planting is a normal part of any agricultural operation. It has a particularly importance in water-challenged areas where soil moisture is an issue. During the winter months in these areas, there is usually sufficient precipitation to maintain adequate water content levels in freshly planted trees. However, during the summer and early autumn, there is very little precipitation. This can adversely affect young trees. In this study, measurements were taken to determine root growth and variations in the upper parts of apple trees that were planted in the winter, compared to those planted in the spring when planting usually takes place. To do so, one-year-old 'Miyabi Fuji', grafted onto Marubakaido (Ma) (Malus prunifolia 'Ringo') and M.9 rootstocks, were examined from January through May. The results showed dramatic changes in root growth from March (average root length less than two cm before March) to May (average root length longer than 10 cm)for both rootstocks. Furthermore, trunk moisture content increased over time (51.8% in January and 56.1% in May on M.9). Although root growth in the young apple trees occurred, it is unknown if root water absorption began before or at the same time of the root growth. Root growth developed favorably because of the soil moisture generated by the winter precipitation. We found satisfactory root growth and tree moisture content changes in the trees used in the study, leading us to recommend winter planting in areas where water resources are limited in the non-winter months.
Small business is one of the most important areas of self-reliance and raising the standard of living
of the population. It is necessary to study the various experiences of the advanced countries of the world at the aim of developing small business widely and broadly. The greatest experience of China deserves to learn it in this direction.
The issues of support and financing of small business and private entrepreneurship are covered in the works of many scientists in scientific and economic literature. The place and role of small business in the economic development of China is the object of study of many scientific works of our time. Nowadays, there is no clear methodology for assessing the system of economic relations, taking into account the social component in the process of its transformation. The state in every possible way supports small business realizing that the increase in employment of the population has a beneficial effect on the standard of living and relieves social tensions in society. The article carefully examines the economic category of Huaqiao as a social phenomenon between relatives, but gives a powerful impetus to business development in the end. An important feature of East Asian entrepreneurship, and Chinese methods in
particular way are the most nepotism of business, as well as, the transfer of control by inheritance, as a rule, from father to son, and at all levels, from small business to major corporations. Economic efficiency of business contacts of the Chinese is very high. In many ways, production of many types of products was established, market management methods were mastered, and lifestyles changed in China. Close mutually beneficial cooperation, played a huge role in
the entry of the PRC into the global and regional market.
Taking into account the primary role of thyroid hormones in the formation and growth of the nervous system in children, the special significance of transient hypothyroidism among other endocrinopathies of newborns and children becomes obvious, which makes it necessary to further study it. Methods: indications for treatment: disorders in the development of psychomotor and perceptual functions, assessment of neuropsychic development below 21 points. 60 children were examined, the patients were divided into 2 groups: group 1 - 30 children treated with Piracitam by Gedeon Reichter. Patients of the 2nd group (30 children) received l-thyroxine as monotherapy. The results of treatment were monitored by changes in clinical and psychological parameters according to the MDI scale. The examination was carried out at the beginning of treatment and 3 months after it. Results: there was a decrease in hyperexcitability syndrome by 1.5 times in the first group and 1.8 times in the second group, vegetative-visceral dysfunction (9 times). and 2 times respectively). An acceleration in the pace of mental development was noted by almost 3 times in the first group and 1.3 times in the second group, as well as a significant increase in CPR (21.2±1.3 and 25.6±1.4; p<0.05) , and in the second group there was a noticeable increase in this indicator (20.1±0.9 and 22.8±1.1; p>0.05). This indicates the effectiveness of the use of complex therapy with the appointment of Piracetam. Conclusion: complex therapy with the use of the drug Piracetam in children with congenital transient hypothyroidism contributes to the timely correction of identified mental disorders and can be recommended for the prevention of mental consequences of CH
Young apple trees that are planted in areas with limited water resources face challenges in their early growth stages. Insufficient intake of moisture often stunts the growth of the young tree and impacts its subsequent growth. In this study, we observed the interaction of semi-vigorous Marubakaido (Ma) (Malus prunifolia
„Ringo‟) and dwarfing Jm7 („Marubakaido‟ × M.9) rootstocks, water treatments (50% and 70% soil water content) and soil treatments (water retention substances) on young „Miyabi Fuji‟ apple trees and how this interaction impacts their growth under dry climactic conditions. The development of shoots, stems and roots was analyzed. The results showed that the interaction of rootstock and water and soil treatments had
a significant impact on total shoot length (p < 0.01), as did the interaction of rootstock and soil treatment on the length of the top three shoots (p< 0.05) and trunk fresh weight (p < 0.05). In addition, it was found that the interaction of water and soil treatments impacted shoot fresh weight (p < 0.05). This study revealed that the growth of young apple trees in areas with limited water resources can be aided by providing a 70% and 50% saturation of water and soil retention treatments for young trees that have been grafted onto semi-vigorous Ma and dwarfing Jm7 rootstocks. Growers in these areas should think about which rootstock to use, what soil water retention treatments that can be introduced into the soil as well the amount of water that should be applied.
Conceptual Field tests were attempted on sandy soils with three trimming frameworks at India for a very long time during 2011-2013. The trials were executed in split plot plan by relegating h2o dissolvable phosphorus composts in primary plot and suggest ed portion of phosphorus in sub-plot with three replications. The most extreme practical yield of rice, child corn and Chickpea were recorded with the utilization of . The most extreme efficient yield of progressive harvests - wheat, mustard and groundnut were recorded with the application of treatment. Practically comparable patterns were seen as far as side-reaction yield, supplement take-up and leftover soil richness status. Every one of the degrees of in compound manures were discovered to be similarly successful for grain yield, straw yield, supplement take-up, and leftover soil richness.
The purpose of the study was to evaluate the effectiveness of the selective α2-adrenoreceptor agonist dexmedetomidine for short-term controlled sedation and treatment of delirium in the early postoperative period in children after cardiac surgery. Material and Methods: Dexmedetomidine infusions were performed for sedative purposes against the background of anesthesia with Kktoprofen and trimeperidine in 28 children who underwent surgery for atrial and ventricular septal defects under general combined anesthesia and in 9 children with clinical manifestations of delirium in the early postoperative period. Results and discussion: against the background of infusions of dexmedetomidine in medium therapeutic doses, a moderate and mild level of sedation was registered, which lasted up to 8 hours. Pain syndrome did not exceed 1 point on the V\S scale in 96% of patients. Additional administration was required only in 23% of patients. Of the side effects, bradycardia (39%) and arterial hypotension (36%) were most often detected. Dexmedetomidine therapy provided the most optimal level of sedation compared with other drug combinations in children with delirium, as measured by the sedation-arousal and wakefulness scales.
Nowadays, many people suffer from iodine deficiency. Globally, a very large number of 1.5 billion people suffer from iodine deficiency. According to statistics, more than 800 million people are experiencing endemic goiter and other diseases of the thyroid gland. Unfortunately, these indicators are increasing instead of decreasing over the years. Especially in the countries of Central Asia, these diseases and iodine deficiency are common, one of the reasons for this is explained by the lack of seas in the territory of Central Asia. Iodine deficiency has several negative effects on growth and development and is the most common cause of preventable mental retardation in the world. Dysfunction of the thyroid gland, in turn, leads to iodine deficiency. Even when we eat iodine, our iodine needs are not met. As a result, the thyroid gland increases its activity, and the gland becomes 20-30-50 times larger. Iodine deficiency can lead to negative consequences such as retardation of physical and mental development, reproductive health disorders. For the treatment of this disease, iodine-retaining substances such as iodamarin and iodofol are used.
Purpose of the study. Study of the activity and topography of enteral enzymes in rats of mixed, non-aggressive and aggressive groups under conditions of immobilization stress.
Material and methods. The experiments were carried out on adult outbred rats weighing 180-200 g. Animals were tested for aggressiveness. Immobilization stress was induced by forced immobilization for 24 hours. The activity of digestive enzymes was determined. Statistical data processing was carried out according to the Student-Fisher method. Results. Depending on the behavioral characteristics of animals, there are variations in the activity and topography of enzymes throughout the small intestine. These parameters are close to each other in rats from the mixed and non-aggressive groups, while in aggressive individuals there is a different picture, sharply different from the two groups described above: the activity of enteral enzymes, except for lactase, is higher and the topography of enzymes is different.
This article is devoted to the application of new teaching methods in medical universities in the context of distance learning. The events of 2019 - 2020 related to the COVID-19 pandemic turned out to be not only a test for the economy of our country and its healthcare system, but also a kind of stress test for the education system. The system of higher medical education is no exception, which, in comparison with universities in other areas, faced additional difficulties. The quarantine conditions necessary to preserve the health and life of the population touched and could not but affect the medical education system. Spring semester of 2020 from March 18, in connection with measures to prevent the import and spread of a new coronavirus infection (COVID-19), training at universities in Uzbekistan was transferred to a distance format. During this period, a voluntary anonymous survey of 170 students was conducted. The distance form of the educational process is based on the principle of independent learning, in which students are distant from the teacher both in space and in time. At the same time, students have a constant opportunity to maintain constant information contact with teachers using modern Internet technologies. New forms of education are in demand at this time, as they form an extraordinary and effective approach to teaching in the subject of pharmacology. From the results of the survey it follows that the attitude to the possible use of elements of the distance learning system increases the independent training of students in pharmacology by 60 -70%. Distance learning in medical universities can be used as an alternative to traditional education in a pandemic.
The monograph offered to the attention of readers is devoted to presenting the results of the analysis of modern literature on the problems of postoperative pain relief and summarizing the results of our own clinical experience in the use of various drug methods of analgesia, regional blockades and reflexotherapy methods. The relevance of this monograph is determined by the continuing high frequency of inadequacy of postoperative pain relief (up to 50%, Verlaecki M., 1997). In the specialized literature, both domestic and foreign, the problem of pain in children is still extremely poorly covered. Pain and pain management in children are only briefly mentioned in the leading guidelines for the management of pediatric emergencies. An unresolved problem in pediatric anesthesiology and resuscitation remains an objective assessment of the severity of pain and methods of postoperative pain relief. The monograph provides a brief excursion into the neurophysiology of pain, presents modern theories and concepts on the formation of pain sensations and the characteristics of the reflection of nociceptive stimuli in the CNS. The anatomical and physiological features of the child's organism, the clinical pharmacology of various analgesics are presented, as well as the issues of infusion therapy and parenteral nutrition in the early postoperative period. Getting acquainted with the material of the monograph, the reader will note the fundamental nature of the author's approach to solving the tasks set, and the high level of provision of clinical fragments of the work, in which modern methods of registration, analysis and processing of the information received were used, are the basis for them to formulate detailed conclusions. Comparing various drug methods of analgesia with methods of reflex therapy, regional blockades based on clinical characteristics, influence on the main vital functions of the body, the author gives indications and contraindications for their use depending on the patient's age, trauma and duration of surgery, the severity of postoperative pain syndrome. The author gives clinical cases emphasizing the importance of the problem and focusing on the key points given in the chapters. The monograph, from our point of view, will find a wide range of interested readers.
The article is devoted to the analysis of the views of the great Uzbek poet and thinker
Alisher Navoi on the literature of the reign of Mirzo Ulughbek, encyclopedic scholar, the Temurids’ ruler. The author studied the ideas and interpretations on this theme in the works of Navoi on the basis of the following classification: 1) the praising of Mirzo Ulughbek in the works of the great poet; 2) The literary environment that emerged during the period of Mirzo Ulughbek and the attitude to its representatives’ work; 3) the development of literary and aesthetic thinking during the time of this ruler.
In the concluding section of Alisher Navoi's epic poem "Farhod and Shirin" and in "Majolis un-nafois" (“Tender meetings”) Mirzo Ulughbek is described and praised as a unique hafiz who memorized and learned the Holy Qur'an with seven recitations, a great astronomer who wrote "Ziji jadidi Koragoniy", as well as he was referred to as a poet with a great taste. In the example of Abdullatif Mirzo it was illustrated that Mirzo Ulughbek's natural inclination towards poetry was passed on to his children too.
In addition, the author of the article used information from Abdurazzoq Samarkandi's "Matla'i sadayn va majmai bahrain" and Davlatshah Samarkandi's "Tazkirat ush-shuaro" to prove his views. It has been scientifically proven that the information in these sources is valuable in terms of supplementing the views of Alisher Navoi provided in the "Majolis un-nafois" and enriching it with new facts and evidences. In turn, the views in the monographs of V.V Bartold "Ulughbek and his time", Ergash Rustamov’s "Uzbek poetry of the first half of the XV century" were analyzed too.