In modern society, diseases of the oral cavity are of humanitarian, socio - economic significance. Today, tooth decay and periodontal disease remain the most common dental disease not only among adults, but also among younger populations around the world. According to recent epidemiological studies conducted on healthy children, the incidence of dental pathology is high, with the prevalence of caries among healthy age groups 12-15 years old is 63.3-83 years, 4% and 81.7-88.7%, intensity 3.02 -3.75 and 4.6-5.73, and the prevalence of periodontal tissue diseases in the group of healthy 12-year-old children ranged from 37.8% to 50%, in the 15-year-old group of children it ranged from 57.7% to 84, 7%. The prevalence of caries is also high in children with mental retardation of preschool and school age, while the intensity of caries is higher in children aged 13–18 years with mild mental retardation (MAD). These indicators increase with age and depend on the severity of the underlying disease.
We carried out a program for the prevention of dental diseases in children with disabilities, however, most of them were focused on children with mild and moderate mental retardation, where not only the degree of mental retardation was taken into account, but also teaching them oral care skills, the degree of socialization and the child's diet.
In modern society, diseases of the oral cavity are of humanitarian, socio - economic significance. Today, tooth decay and periodontal disease remain the most common dental disease not only among adults, but also among younger populations around the world. According to recent epidemiological studies conducted on healthy children, the incidence of dental pathology is high, with the prevalence of caries among healthy age groups 12-15 years old is 63.3-83 years, 4% and 81.7-88.7%, intensity 3.02 -3.75 and 4.6-5.73, and the prevalence of periodontal tissue diseases in the group of healthy 12- year-old children ranged from 37.8% to 50%, in the 15-year-old group of children it ranged from 57.7% to 84, 7%. The prevalence of caries is also high in children with mental retardation of preschool and school age, while the intensity of caries is higher in children aged 13–18 years with mild mental retardation (MAD). These indicators increase with age and depend on the severity of the underlying disease.
We carried out a program for the prevention of dental diseases in children with disabilities, however, most of them were focused on children with mild and moderate mental retardation, where not only the degree of mental retardation was taken into account, but also teaching them oral care skills, the degree of socialization and the child's diet.
The aim of the study is to development of an algorithm for managing pregnancy and childbirth by studying the functional state of the mother-placenta-fetus system in pregnant women who have undergone COVID-19 in different trimesters of pregnancy.
The object of the study was 105 pregnant women who, were treated at the Samarkand Regional Perinatal Center and a specialized maternity center for pregnant women with COVID-19
Тhe scientific novelty of the research consists of the followings: for the first time in pregnant women infected with COVID-19, a relationship was established between the course of pregnancy, childbirth, the postpartum period and the development of complications depending on the trimester and severity of the disease; a direct correlation has been established between the state of the vessels of the mother-placenta-fetus system (resistance and pulsation indices, Endothelin-1 indicators), disorders in the hemostasis system (D-dimer, platelet aggregation) and the clinical course of the disease in pregnant women who underwent COVID-19; it has been established for the first time that the developed scale for assessing risk factors for non-developing pregnancy in women infected with COVID-19 (age, BMI, obstetric history, gestation period, hemostasis system status, endothelial function and severity of the disease) can serve as a prognostic marker of the degree of risk of pregnancy complications; it was proved for the first time that the choice of effective therapy for restoring hemodynamics in the mother-placenta-fetus system, in women who underwent COVID-19 at different stages of pregnancy, leads to a decrease in the number of thrombophilic complications.
Implementation of the research results. The results of the scientific research were introduced into the practical activities of the Samarkand Regional Perinatal Center by Order No. 128/1 of 01.09.2022 and the Samarkand City Maternity Complex No. 1 by order No. 58/1 of 03.10.2022. In pregnant women who underwent COVID-19 at different periods of pregnancy, changes in the mother-placenta-fetus system were determined using simple and effective research methods, such as ultrasound and Dopplerography, and this saved 53,000 soums; obstetricians and gynecologists, as well as neonatologists and therapists, are needed to diagnose signs of complications in the echocartin, that is, it has been proven that there is no need for other highly qualified specialists for this, due to the lack of need to train new personnel, state budget funds have been saved. With early detection of disorders in the hemostasis system in pregnant women with COVID-19: the period of stay of patients in the hospital was reduced from 10.5 days to 7.5 days and the number of hospital bed days was reduced; due to the reduction of the period of stay in the hospital for several days, the number of necessary drugs was reduced (on average, drugs are used for 1 day in the amount of 130,000 soums). Examination of pregnant women infected with viral diseases using simple and effective research methods such as ultrasound and Dopplerography served to save 85,000 soums: in the early stages up to 16 (10-11 weeks. - fetometry), 19-21, 32-34, 38-40 weeks of pregnancy; due to the absence of the need to use other research methods, it was possible to reduce costs by 23.5%; early detection of changes in the hemostasis system and endothelial dysfunction using fast, budgetary and effective research methods, contributed to the prevention of possible pregnancy complications, as well as the absence of the need to use long-term and expensive research methods, and this saved 106 000 soums: the coagulogram was checked in 105 (100%) patients, time was saved and efficiency was increased; endothelin-1 was also determined in 105 (100%) patients, efficiency was increased by 78.6%.
Improving the functionality of blood circulation in the uteroplacental and fetal-placental systems, a comprehensive analysis of possible complications during pregnancy and childbirth in women who have had viral infections, improving diagnostic, preventive and prognostic measures for managing pregnancy and childbirth contributed to the birth of live, full-term and healthy newborns in women who experienced COVID-19 during pregnancy, as well as a decrease in maternal mortality and perinatal mortality, 43% of women underwent rehabilitation in the postpartum period, 23.8% of women who underwent severe COVID-19 improved their quality of life.
To introduce scientific novelty on the topic “The impact of COVID-19 on the state of hemodynamics in the mother-placenta-fetus system in pregnant women”, a letter was sent to the Ministry of Health from Samarkand State Medical University on November 9, 2022 under No. 4295 (Conclusion of the Ministry of Health No. 8 n-z / 679 of December 15, 2022).
The structure and volume of the dissertation. The content of the dissertation consists of an introduction, five chapters, conclusion, list of used references. The volume of the dissertation consists of 113 pages.
The novel severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2; also known as 2019-nCoV) has played havoc worldwide, beginning with Wuhan, China in December 2019. The disease caused by severe acute respiratory syndrome coronavirus-2 is highly contagious. COVID-19 is a global public health emergency, and could cause devastating health issues during pregnancy. Pregnant women have a high propensity to acquire this infection due to their altered physiological and immunological function.
Klinik amaliyotda stomatologlar ko'pincha endodont va parodont to’qimalarining birlashgan zararlanishiga duch kelishadi. Ushbu holatlar endodontoperodontal shikastlanishlar (EPSH) deb ataladi va endodont va parodontdagi yallig'lanish va destruktiv o'zgarishlar bilan kechadigan parodontal kasallikning kombinirlangan shikastlanishini anglatadi. Ushbu murakkab patologiya shifokor uchun diagnostika nuqtai nazaridan muhim muammolarni keltirib chiqaradi va ularning klinik ko'rinishlari, endodontiya va parodontologiyada diagnostika va davolash tamoyillari to'g'risida keng bilim va tushunishni talab qiladi. Parodontal to'qimalarda yallig'lanish jarayoni tishlarning pulpasiga sezilarli ta'sir ko'rsatadi: II darajali umumiy parodontit bilan pulpada qaytarilmas o'zgarishlar tishlarning 54-56 foizida aniqlangan. Parodont, pulpa va periodontdagi surunkali yallig'lanish odontogen o'chog’i sifatida qaraladi, bu esa o'z navbatida surunkali stomatogen o'choqning tarkibiy elementi hisoblanadi. Ushbu muammolarni hal qilish bu sohadagi tadqiqotchilar uchun dolzarb hisoblanadi.
in our country, the number of pregnant women with rhesus sensibility every year remains unchanged and does not have a downward trend. This is due to insufficient prophylaxis after the termination of pregnancy (spontaneous abortion, ectopic pregnancy, the birth of a rhesus-positive fetus) with the use of immunoglobulin against antiretroviruses. Previously effective methods of treatment, such as desensitization of antigens, plasmapheresis, hemosorption and intravenous administration of immunoglobulins, have only historical significance.
Objective: to study and analyze the literature data of foreign and local authors on the diagnosis of hemolytic disease of the fetus, the use of non-invasive methods of Prevention of Rh-immunization.
Search strategy: the search for information contained information such as regulatory documents, diagnostic protocols, and the conduct of RH-controversial pregnancy. Also in the databases Google Scholar, the Cochrane Library, PubMed, Library full-text scientific articles were used.
Inclusion criteria: randomized, cohort study data, systematic reviews, diagnostic protocols, and Rh-conflict pregnancy.
Exception criteria: practice, report, newspaper publications, articles describing theses.
Results: studies have shown that the prophylactic purpose and administration of anti-D-immunoglobulin, which is used during 28-30 weeks of pregnancy, significantly reduces the development of immunization after childbirth. Conclusion: due to the wide application of anti-D-immunoglobulin in pregnant women and family planning, it will be possible to reduce the frequency of immunization, but the goal will be achieved only if a clear сomplex prevention of Rh-immunization is developed, in which the appearance of hemolytic disease of the fetus occurs. Nevertheless, the diagnosis and treatment of hemolytic disease remains an urgent problem and requires the use of new possibilities of modern medicine in the field of genetics, ultrasound diagnostics, invasive and non-invasive methods.
Intrauterine infections are caused mainly by bacterial and viral pathogens that have penetrated to the fetus from the mother before or during childbirth. Intrauterine infection (IUI) has numerous manifestations, such as conjunctivitis, rhinitis, pyoderma, pneumonia, hepatitis, otitis, meningoencephalitis, up to the development of sepsis. However, intrauterine infection does not always lead to generalized IUI, in some cases infected children do not have any clinical symptoms of the disease. The aim of the study was to study the most common variants of IUI in newborns and to determine their relationship with infectious urogenital and extragenital diseases of the mother. The analysis of the birth histories and the development histories of newborns, including the somatic and obstetric-gynecological anamnesis of the pregnant woman, the course of pregnancy and childbirth, the results of clinical and laboratory studies, as well as the assessment of the child's condition after childbirth, was carried out.
the modern approach of antenatal care in pregnant women with rhesus-immunization means a timely diagnosis of the mutability of the rhesus (Rh) of the fetus through the blood of the mother, the detection of the anaemic syndrome and weight level of the fetus, the use of minimally invasive methods (diagnostic, therapeutic), as well as prevention of the development of immunization in pregnant women. The problem of rhesus-sensibilization in developed countries is rare, and only in immigrants.
Objective: to examine and analyze the literature data of foreign and local authors on the relevance, prevalence, use of non-invasive methods of Rh-sensibilization prevention of hemolytic disease of the fetus.
Search strategy: the search for information contained information such as regulatory documents, diagnostic protocols, and the conduct of RH-controversial pregnancy. Also in the databases Google Scholar, the Cochrane Library, PubMed, Library ru full-text scientific articles were used.
Inclusion criteria: randomized, cohort study data, systematic reviews, diagnostic protocols, and Rh-conflict pregnancy.
Exception criteria: practice, report, newspaper publications, articles describing theses.
Results: studies have shown that the prophylactic purpose and administration of anti-D-immunoglobulin, which is used during 28-30 weeks of pregnancy, significantly reduces the development of immunization after childbirth. Conclusion: due to the wide application of anti-D-immunoglobulin in pregnant women and family planning, it will be possible to reduce the frequency of immunization, but the goal will be achieved only if a clear Complex prevention of Rh-immunization is developed, in which the appearance of hemolytic disease of the fetus occurs. Nevertheless, the diagnosis and treatment of hemolytic disease remains an urgent problem and requires the use of new possibilities of modern medicine in the field of genetics, ultrasound diagnostics, invasive and non-invasive methods.
The main direction of the neonatology service is medical and diagnostic assistance. The training of highly qualified specialists, the effective organization of neonatal services and the availability of modern equipment make it possible to qualitatively help critically ill newborn children. The purpose of the study: to analyze the work of the department of intensive care and neonatal resuscitation of the Samarkand regional multidisciplinary Center for the period from 2017 to 2021. The research material was the annual reporting data of this department for 2017-2021. For the period from 2017 to 2021. 3666 newborns were admitted to the department, of which 589 (16%) and 3074 (84%) were admitted to the surgical department for somatic diseases, 3123 (85%) newborns were admitted from the districts of the Samarkand region, 537 (15%) from the city of Samarkand and 635 (17.3%) from other regions. High qualification of doctors, good diagnostics ensured timely resuscitation, respiratory support for newborns, correction of hemodynamic disorders, infusion therapy of newborns.
But despite the intensive therapy carried out, neonatal mortality averages 10%, which poses new challenges for improving neonatal care. Thus, intensive care in neonatal intensive care is one of the main links in the provision of medical care to newborns, which requires a high level of knowledge from our doctors, the use of modern diagnostic methods, treatment that comply with state protocols.
Every year on February 9, it has become a tradition in the Republic of Uzbekistan to widely celebrate the birthday of Hazrat Mir Alisher Navoi, a great man, writer, politician, linguist, mystic, painter, and sultan of poets. According to the Embassy of Uzbekistan in Seoul, this year marks the 580th anniversary of the birth of the poet-thinker who is widely celebrated not only in Uzbekistan, but also in many other parts of the world.
Laurocerasus officinalis (a synonym for the name Prúnus laurocérasus according to the old classification) - medicinal laurel has bactericidal properties, that is, it releases a wide variety of volatile substances, including phytoncides, which cleanse the environment from microbes and bacteria, and improve the microclimate. Due to these properties, this plant has high sanitary and hygienic properties. Based on this, cherry laurel is recommended for wide target cultivation. And for this it is necessary to develop the most effective methods for propagating this tree. The method of microclonal propagation of the apical meristem part of shoots in vitro is proposed for use
В статье рассматривается устойчивое развитие регионов, на основе эффективного использования местного туристического потенциала как уникального фактора экономического роста для стран мира. Также, уделяется особое внимание обеспечению экономического роста в регионах, повышению роли и значения туризма, в особенности внутреннего туризма, в решении важнейших социальных проблем (занятость, доходы, человеческий капитал и др.).
This article presents a comprehensive examination of derivational techniques in Uzbek language, aiming to unravel the intricacies that shape the lexical landscapes of this language. Through a meticulous exploration of affixation, compounding, conversion, and unique strategies such as reduplication, we delve into the shared patterns and distinctive features that define the derivational processes in linguistic system. The analysis extends beyond linguistic structures, offering insights into the cultural, historical, and cognitive dimensions that influence the evolution of words in Uzbek. As we navigate the labyrinth of derivational techniques, we unveil the features that transcend linguistic borders and the differences that weave unique narratives into language's tapestry.