Topicality and demand of the subject of dissertation. Researches of human population genomic variety and scenarios of its genetic pool formation arc one of perspective directions of modem genetics. Prompt progress in this field has allowed defining the basic routes of continents settlement. However the information about Central Asian (CA) populations even on «classical» genetic markers has accidental, fragmentary character, and requires additional large-scale investigations. Besides, according to historical, archeological, paleontological and some anthropogenetic studies, given region was playing certain role in ancient moving of modem human ancestors throughout Eurasian continent. Therefore it is extremely important to summarize and perform complex assessment of new and collected data on Central Asian populations as practically there arc no multivariate analyses studies of given region as a complex population system.
In studies of human population genetic structure arc usually used various approaches allowing understanding concept of populations subdivision and character of genetic relationships between them. Among these techniques the prominent place belongs to approaches based on an assessment of genetic distances between populations with their subsequent analysis by multivariate statistics methods. For even more compelling picture of the relationships between the populations on tree diagram we composed «the genetic landscape» of area, where the description of population genetic structure is presented by equally spaced figures consistently consolidating populations according to their genetic distances from each other and thus creating a genetic landscape. This approach is not only a tool for elementary population boundary detection, but also can be effectively used for identification of borders and sizes of population as naturalistic unit.
Multigcnctic landscape is a collection of different genetic systems which arc specific to the region and ethnic groups, which have their geographical areas, their geographical, historical and cultural boundaries. Gene flows arc run through these conventional boundaries, but they arc less intense than in the limits of area. These limits arc ambiguous and fluid, but it is real. You can identify them by studying, for example, the structure of marriage migration. Therefore anthropogenesis of different populations will inevitably differ from each other. Ethnogenetic composition tends to change over time, from generation to generation, and hence there is a need to understand the structure of the genepool, not only at a given time, but also in the study of genetic processes that form and reform the gcncpooL In this regard, the studying of multigcnctic landscapes is in close contact with the demographics, medical and genetic ecology, anthropology, ethnology, archeology and history of the peoples, that is, with a range of areas, not only natural, but also the humanities knowleges.
Study of genomic diversity is important not only to address questions of origin and genetic history of different ethnic groups, but is also the basis for molecular epidemiology of hereditary and multifactor diseases. Each region is characterized by a specific set of common genetically determined diseases. To understand the causes of the prevalence of disease in different regions, and to develop approaches to their early DNA diagnosis and effective prevention, initially it is necessary to conduct population-based studies, which determine the development of the disease.
Purpose of research is to implement a comprehensive description of the structure of indigenous Central Asian populations genetic pool, examine demographic, phylogenetic and evolutionary features of Central Asian populations through the analysis of genetic variety of mtDNA, Y-chromosomal (NRY), autosomal, X-chromosomal microsatcllites and immunogcnetic variants of Helicobacter pylori (H.pylori) and hepatitis В virus (HB V).
To achieve this goal the following tasks of research is solved:
specification of immunogcnetic variants of H.pylori and HBV, allocated at the patients in Central Asian region, with the subsequent comparative phylogenetic analysis of H.pylori and HBV regional versions with those in other regions of the world;
examination of genetic variety and degree of genetic differentiation of Central Asian populations according to classical population-genetic objects -polymorphisms of mtDNA, Y-chromosomal, autosomal and X- chromosomal STRs;
assessment of the Western and East-Eurasian lines of population inheritance contribution to Central Asian populations’ genetic pool at regional, ethnic, sub-cthnic levels and in a level of elementary populations;
reviewing of character of regional populations relationships by genetic variety of mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers in view of ethnographic, social and linguistic data;
evaluation of sex-specific genetic structure and the social organization according to polymorphisms of mtDNA, autosomal, X-chromosomal, Y-chromosomal markers in the region;
determination of ancient ways of migrations and scripts of formation of Central Asian populations according to mtDNA, autosomal, X-chromosomal, Y-chromosomal STRs markers and immunogcnetic variants of H.pylori and HBV',
evaluation of ethnogenetic position of studied Central Asian populations in the system of genetic pools of Eurasia and the world in general through comparative analysis of all studied population-genetic parameters.
Scientific novelty of dissertational research consists in the following:
for the first time was performed a study of genetic pool structure of 26 Central Asian populations from 6 ethnic groups as complete population systems using a wide range of genetic objects;
for the first time was made an assessment of informativeness of each type of genetic subjects. For the first time was received detailed characteristic of genetic pool structure of indigenous Central Asian population on the basis of variability lines of the spectrum of genetical objects;
for the first time was defined the ratio of Westem-and the East-Eurasian lines in a genepool of Central Asian population and were made an assessments of genetic variety level and genetic differentiation degree of regional populations as a whole;
for the first time phylogenetic analysis of major haplogroups of investigated genetic subjects was conducted;
for the first time the position of Central Asian population in population genetic pool system of surrounding regions and Eurasia in the whole was studied;
for the first time the evolutionary-adaptable mechanisms, necessary in the forecast of formations of multigenic pathologies in region were studied at 6 ethnoses of Central Asian.
CONCLUSION
1. H.pylori from Central Asian territory is similar to Western Europe isolates, and shaped by two ancestral populations genotype Ancestral Europe 1 (dominant) and Ancestral Europe2 and for AE1-genotype Central Asian region probably is the source. H.pylori from the territory of Central Asia form a separate cluster group: close relationship of Tadjik, Uzbek strains and Iranian isolates from the north of Iran is established. Kirghiz isolates were found to be closer to populations from territory of Siberia.
2. High diversity of HBV genotypes in Central Asia was found -4 genotypes (A, C, D, and G). Phylogenetic analysis of Central Asian genotype HBV-with options for other regions of the world showed a close relationship between the dominant genotype D (0,78), the D1-subtype with variants of the virus in Europe, the Middle East and Africa.
3. The rates of genetic affinity for STR-NRY in Kazakhs, Turkmens, Karakalpaks Turtkul at the level of the same lineage were high: 0,58 (p<0,001); 0,34 (p<0,01) and 0,77 (p<0,001), respectively. The coefficients of relationship at the level of clan for Kazakhs, Turkmens, Uzbeks and Karakalpaks from Kungrad and Turtkul were lower: 0,30 (r<0,01); 0,21 (p<0,001) and 0,40 (r<0,001); 0,07 (p<0,05) and 0,09 (p<0,05), respectively. At the level of the tribe, the indicators were negative for all Turkic populations: -0,02 (r<0,05);-0,04 (r<0,001);-0,07 (p<0,01); -0,0011 (r<0,1) and -0,10 (r<0,01), respectively.
4. The analysis of mtDNA HVS-1 showed that total rate of differentiation level for all populations was low: FST=0,013; p<0,0001. Level of diversity between groups was 0,6% (p<0,001) of the total variability. Parameter of genetic differences between Turkic and Indo-Iranian populations made 0,55% (p<0,0283) of the total genetic variability. The rate of genetic differentiation on a sub-ethnic level was significantly expressed in Indo-Iranian group (FST=0,0197;r<0,001) than among the Turkic-speaking (0,3%; p=0,10). In all populations, in general, wasn‟t detected the correlation between genetic and geographic distances at the global level on mtDNA HVS-1: r=0,00682; p=0,502.
5. Analysis of STR-NRY showed that the level of the genetic differentiation between ethnic groups was 5,6% (p<0,02); general differentiation between populations made RST=0,186 (p<0,001). Combined analysis, taking into account the language and way of life of Turkic and Indo Iranian populations, showed the general differences between the two groups – 9,1% Value of genetic differentiation when comparing the ethnos-ethnos was slightly lower than the level within ethnos: 5,6% among ethnic groups, 18,6%, and 13,7%-between populations within the ethnic group.
6. Analysis of heterozygosity (H) and the average number of pairwise differences (p) of mtDNA, were high in nomadic populations (av.H=0,99; av.p=5,29) and farmer populations (av.H=0,99; av.p=5,32). Heterozygosity (H) on Y- chromosome was lower in nomadic groups than in the agrarian – 0,86 and 0,99,respectively (p<0,01). Nomadic populations exhibit a higher level of population differentiation (RST) in comparison with farmers - 0,19 and 0,06, respectively (p<0,01). Indicators of population growth (r) were lower in nomadic populations compared with farmers - 1,004 and 1,008, respectively (p=0,056).
7. The level of genetic differentiation in all ethnic groups was higher on the Y chromosome in comparison with mtDNA. The farming populations showed no significant difference in the genetic differentiation FST (Y)=0,069 and FST (mtDNA)=0,034, while among patrilineal nomadic population the level of genetic diversity was higher in the male line of inheritance - FST(Y)=0,177 and FST (mtDNA)=0,010. Genetic diversity of population structure in patrilineal nomads on autosomal and X-linked markers were: FST (A)=0,008 (0,006-0,010) and FST (X)=0,011 (0,001-0,004) (H0: FST(A)=FST(X); H1: FST(A)>FST(X); p=0,02). In bilinear farmer populations the differences of autosomal and X-chromosomal markers were insignificant: FST (A)=0,014 (0,012-0,016) and FST (X)=0,013 (0,008-0,018 at p=0,36).
8. Analysis of mtDNA indicated that the age of expansion on the territory of Eurasia (τw) declined significantly from East to West (r=0,72; p<0,001). The age of expansion had a pronounced tendency to decrease from 30 thousand years in China to 17 thousand years in Western Europe. Age of expansion in Central Asia amounted to 26 thousand years. Results of expansion analysis on NRY also show a decrease in genetic diversity from the East to the West of Eurasia (r=0,49; p<0,001). In Central Asia this age was 16 thousand yrs. According STRs-NRYBatwing analysis of the minimal age of Uzbek population origin was 1232,71 yrs old (Ne=14088 (6765-23942); α=0,0108 (0,0065-0,0155)).
9. The apportionment of multilocus genetic variations among ethnic and linguistic groups of Central Asian populations showed that more than 98% of all variations were within the population (p<0,0001). Evaluation of the ethnic and linguistic affiliations in the observed variations showed reliable conformity - FST=0,007; p<0,0001 and FST=0,011; p<0,0001, respectively. We didn‟t find evidence of geographical isolation within each of the Turkic and Indo Iranian groups of populations (p=0,363 and p=0,772, respectively).
10. Analysis of multilocus allelic diversity (AR) and heterozygosity (He) showed differences among the Central Asian and other populations in allelic variety (χ2 =105,29; d.f.=25; p<0,0001) and heterozygosity (χ2=67,98; d.f.=25; p<0,0001). Population differentiation at multilocus analysis at populations of Central Asia is more pronounced than in the other regions of Eurasia: in European and Middle Eastern groups pairwise estimation of FST ranged from 0,011 to 0,015 and -0,008-0,021, respectively; in East-Asian groups from -0,011 to 0,046; and finally, in Central Asia these rates ranged from -0,004 to 0,056. Heterozygosity was significantly higher in the group of the Indo-Iranian populations than among Turkic-speaking (He=0,818 and He=0,787, respectively; Z=-4, 55; p<0,0001). According to multilocus analysis all 26 Central Asian populations slightly but significantly differed (FST=0,015; CI99%=0,011-0,018; p<0,01).
The current examination expects to analyze the concern that pedant occurrence in commanding of illuminate investigation compute, to uncover the motivation of the concern and to create arrangement proposals. Contextual investigation plan of subjective examination techniques was utilized in this exploration and it incorporates 41 volunteer pedant. Organized meeting structure was utilized in information assortment and the information were examined with content examination. It was discovered that the majority of the concern pedant occurrence in commanding of educating investigation compute were identified with understudies. They likewise had concern with study hall/course the board. In commanding of illuminate investigation cycles of the pedant, concern were identified with understudies, actual foundation, instructive framework and society/climate. It very well may be stated that a large portion of the concern can be settled if their motivation are resolved and taken care of. Likewise it is proposed that approaching pedant who are new to scholastic life need to follow the guidelines that incorporates understudy discipline guidelines and the understudies should be educated about the negative practices and their results toward the start of the term.
With the collapse of the Soviet Union in the 1991s Central Asian nations and Japan established diplomatic relations and partnerships began to increase steadily as manifested by the level of official contacts. In 1997 the “Silk Road” Diplomacy concept was formulated for Japan’s policy toward Central Asia. At the beginning of the 21st century, we see the activation of new actors including India, Korea, and Japan in Central Asia, which were mainly welcomed in the region. Tokyo recognized the growing strategic importance of Central Asia in the context of international security and sought to play a more active role as an Asian nation in Eurasia. During two decades Central Asian nations and Japan began to increase steadily. Japan is one of the largest assistants to Central Asia in structural reforms and Japanese investments in the different aspects of the region's economy and transport communication add up to several billion. There are several areas of special interest to Japan in its relations with Central Asia, including cooperation in education, economic development of the region, political reforms, as well as energy resources. Japan’s effort in creating the “Central Asia plus Japan” dialog is part of its multilateral diplomacy. At the same time, there are some challenges and problems in Central Asia–Japan relations. However, there are potentialities for future bilateral and multilateral relations. Japan like Korea, India, and other countries has a strong positive image in Central Asia, which could be regarded as an additional factor for fostering partnerships between Central and East Asia as well as interregional relations with the vast Asian continent and beyond.
This article explores the interests of the Central Asian states as members of the SCO, and their compatibility with the SCO goals. This study shows that the SCO is compatible with the Central Asian states' security and economic interests, regional cooperation, and the need for balanced relations with the great powers— China, Russia, and the United States.
In the modern world, along with the processes of globalization, the increasing permeability of the integration and communication processes of the post-industrial society, the problem of studying such a universal as national identity is growing. Global changes are accompanied by the separation of cultures and peoples, an increase in the negative impact on national identity, which causes the desire for cultural self-affirmation, the desire to preserve national values and state interests. Due to the threat of disappearance of the identity of the people, it becomes necessary to search for an updated approach to the preservation and representation of national identity. In this regard, there is a growing need for philosophical and methodological research aimed at identifying the features of national identity. The scientific article examines the formation of the methodological base and philosophical categories within the cultural tradition of the Japanese and Uzbek peoples. The significance of the research topic is determined by the dynamics of the development of the modern global world, integration processes, the growth of interaction and cooperation between different countries and regions, in such conditions, a rapid transformation of national identity is taking place.
The scientific conception of the article is founded on the literary interpretation of the original essence of literature through national spirit and national literary-aesthetic thought as a core dimension in assessing a certain writer’s work. It is put on the agenda that it is necessary to analyze theoretically and scientifically the best selected samples of each nation’s literature in the world from the point of view of national spirit regardless of what language the work was created by. In Uzbek literature of the XX century the work “Bygone Days” by Abdulla Qodiri was analyzed as a novel to meet this dimension.
According to the author’s opinion the national spirit in the work “Bygone Days” displays itself on the bases of the following three principles: 1) interpretation of specific customs, traditions, values, nation’s dreams and expectations endowing the national spirit; 2) expression of the competence to assess critically the nation itself; 3) poetic embodiment of courageous faith peculiar to national personalities in the work. In its turn, out of these principles, the first one presents nation’s morality, the second - its will, the third – its faith, and these three angles make the national spirit as a whole unit. It was discovered that the expression of the national spirit and literary skill were harmonized uttermost.
At the end of the article the research results were theoretically generalized
The article discusses interdisciplinary Russian-Central Asian relations with a focus on its economic component. The specifics of the ongoing research, which is the basis for the article, is an attempt to systematically evaluate the key elements of interaction between Russia and Central Asian countries in the areas of politics, security, the economy (including in the energy sector), as well as in the social sphere. Through this lens, the most important factors and stages of relations in the period of 1991-2018 are also identified, and statistics not previously combined in one material are provided. Over the past years, since the declaration of independence of the Central Asian countries, economic relations between the Russian Federation and the regional countries have been characterized by a series of "ups" and "downs". A noticeable activation of Russian business and the overall economic policy of the Russian Federation in Central Asia began to be observed from the beginning of the 2000s. Russia's strategic interests have touched the oil and gas sector, where the vast majority of Russian investments have been represented. In recent years, in the face of continuing Western sanctions, the Central Asian region has become one of the most important, and non-alternative, economic regions for Russia. At present, new trends are beginning to intensify and deepen economic cooperation, including diversification of ties across sectors of the economy, expanding geography and improving the quality of cooperation. Investments from the Central Asian countries themselves in the Russian Federation have played and continue to play an important role in the development of economic relations. Moreover, relations between Russia and Central Asian countries in the labor migration segment have been developing dynamically and on a large scale for many years. In general, the importance of labor migration is high not only for the Russian Federation, but also for the Central Asian countries themselves. It is concluded that in recent years, Russian-Central Asian relations have been characterized by rather high dynamics. There is no doubt that the development of interaction is largely favored by traditionally close bilateral and multilateral ties: due to historical commonality, geographical proximity, socio-cultural and other proximity, the presence of institutional formats, and mutual desire for cooperation.
The scientific concept of the article is that the national literary-aesthetic thinking is of primary criterion in evaluating a writer’s work and the essence of literature is determined by the artistic interpretation of the national spirit. The best examples of folk literature in the world, regardless of the language in which it is written, is on the agenda as a question number one to be analyzed scientifically in terms of the expression of the national spirit. Abdulla Kadiri’s novel “Days Gone By” has been analyzed in twentiethcentury Uzbek literature as a work that can meet this criterion.
According to the author, the national spirit is reflected in the novel “Days Gone By” on the basis of the following three principles: 1) the interpretation of specific customs, traditions, values, dreams and aspirations of the nation, embodying the spirit of the nation; 2) an expression of the nation’s potential to look at itself in a critical spirit; 3) poetic depiction of fixed beliefs inherent in national personalities in the play. In turn, the first of these principles embodies the morals of the nation, the second - the will, and the third - the beliefs, and this trinity forms the national spirit as a whole.
At the end of the article, the research results are theoretically summarized.
Central Asia is a key region of the Korean administration's vision of building a global hub and building an overseas Korean community. Until now, the South Korean government has laid the foundation for northern diplomacy in Central Asia. It has developed strategies and visions for Central Asia through the Eurasian Initiative policy, Northeast Asia peace policy initiative, and the promotion of the New Northern Policy. As such, Central Asia, such as Uzbekistan, is a key country with high geopolitical and geographical strategic value, and has served as a cooperative base for previous governments to enter the Eurasian market. The fact that research on cooperation between Korea and Central Asia can look at institutional reforms being pursued by Central Asian countries after the transition to the socialist system has many implications. In other words, it is very meaningful in terms of the Korean government's construction of a global central country, the construction of an overseas Korean community, the establishment of a foundation for overseas unification, and the study of a unification model.
The objective of this review is to consider the best studied single nucleotide polymorphisms of matrix metalloproteinase genes, their influence on the development of aggressive atrophy of the jaw bone tissue, chronic and aggressive
periodontitis depending on ethnicity and other aspects.
Conceptual Field tests were attempted on sandy soils with three trimming frameworks at India for a very long time during 2011-2013. The trials were executed in split plot plan by relegating h2o dissolvable phosphorus composts in primary plot and suggest ed portion of phosphorus in sub-plot with three replications. The most extreme practical yield of rice, child corn and Chickpea were recorded with the utilization of . The most extreme efficient yield of progressive harvests - wheat, mustard and groundnut were recorded with the application of treatment. Practically comparable patterns were seen as far as side-reaction yield, supplement take-up and leftover soil richness status. Every one of the degrees of in compound manures were discovered to be similarly successful for grain yield, straw yield, supplement take-up, and leftover soil richness.
The ideological basis for the formation of the worldview of Mahatma Gandhi is based on the ideas put forward by his predecessors. If we consider this period from a theoretical and ideological point of view, then one of the most important aspects of the doctrine inherent in the Indian national liberation movement is its religious content. In the process of the Indian national liberation movement, the task of modernizing and adapting religious and philosophical teachings to the demands of the movement with the aim of adapting them to current political problems was especially urgent. Issues of social inequality, casteism and national unity were examined. The first national enlightened thinker of India was Ram Mohan Roy, who played an important role in the birth of the
national liberation movement in India. Dadabhai Naroji, one of the national thinkers of the second half of the nineteenth and early twentieth centuries, demanded the participation of Indians in the government and emphasized the need to create an Indian state as an Indian nation. Bonkimchondro Chottopaddhai believed that the main obstacle to the development of the country was the lack of common interests among the upper and lower layers of the population. The philosophical aspects of Hinduism were reflected in the views of Swama Vivekanda, who promoted the idea of a common religion. Bal Gangadhar Tilak condemned the vices of poverty. Rabindranath Tagore called rural society "the support and mother of the people." The ideas put forward by these thinkers prompted Mahatama Gandhi to come to the forefront of the national liberation movement, forming the basis of his socio-ideological views.
Every nation has national values that have lived on for centuriesin the world. The upbringing of the younger generation is based on undoubted, national and universal values.It is in a society where national and universal values are valued that the socio-political environment is sufficiently formed to develop civic institutions, in which public opinion on a particular issue is formed on the basis of these values. serves to strengthen solidarity. We all know that the attitude to the national spirituality, which reflects the worldview and way of life of the nation and the people, its development on the basis of modern requirements, changing the worldview and thinking of young people requires deep and thorough thinking. In order to do the right thing in this regard, it is necessary to clearly explain to young people what the national cadre is. Of course, the main criterion is that we value the ideas and concepts that have passed the test of history, our national interests, today's and tomorrow's dreams and aspirations, fully meet the requirements of development, and become more and more valuable over the years. National value is the fruit of national consciousness and thinking.
In the Middle Ages, Central Asian pilgrims traveled to Mecca in three directions: the North direction ‒ through the Russian Empire, the central direction‒ through the territory of Persia, and the south direction ‒ along roads through India and the Arabian Sea. Therefore, the question of the directions of the Hajj was reflected in the diplomatic correspondence of the Central Asian khanates with Persia, India, the Russian and Ottoman empires тоо. Depending on the political, economic and ideological interests of these states, sometimes pilgrims were given permits to be sent to Mecca through their territories, and sometimes not. The degree of intensity of pilgrimage movements, in most cases, depended on the activities of interstate ambassadors. On the issue of eliminating various prohibitions and obstacles in the movements of pilgrimage roads, the Central Asian ambassadors were active and historical documents reveal these data to us.
In the article explores the differences in the approaches of each Central Asian country to regional cooperation. The initiatives put forward by the leaders of the countries of the region were analyzed. The author describes the features of the foreign policy concepts of the countries of the region. The factors of foreign policy of the Central Asian countries are analyzed. The need for regional integration was explained by analyzing the evolutionary processes taking place in Uzbekistan's neighbors in Central Asia. Regional cooperation is based on an understanding of the evolution of geopolitical processes in the modern world, where the tendency to build international, political, economic, and other relations is growing. It is emphasized that such a view is extremely relevant for modern Central Asia, which is a link interconnected by relatively different ancient local ties. Some factors were considered, the development of a special legal document or a concept that reveals prospects aimed at enhancing the development of the countries of the region directly with neighbors. The speeches of the leaders of the countries of the region from the tribunes of influential international organizations and forums on the creation of a new system of international relations in the region have been studied. The main regional and international initiatives of the Central Asian states in the field of security and development were highlighted. Analyzed issues are the measures taken by the countries of the region to solve border problem
The history of all societies is associated with human activity, his economic and cultural needs, therefore, activity and needs as vital qualities of people are widely reflected in their interaction with nature and the environment. In the process of labor and production, nature is the main object of human activity, and certain economic and cultural types have developed in different geographic conditions. This law of historical and cultural development is confirmed by the example of the history of the Bronze Age in Central Asia.
In the Bronze Age, among the population living on the territory of the steppes, the socio-economic system was preserved, characteristic of the tribal communities of cattle-breeding tribes, which were at the stage of decomposition of primitive communal relations. In Central Asia at this time, the process of allocation of historical and cultural regions and ethnic territories was noted.
This article is dedicated to analysis of features of historical and cultural development of Central Asian population in different geographical conditions. The main attention is paid to the fact that the history of economic-cultural types and their development is connected with geographical atmosphere.
This article reveals the scientific and philosophical aspects of the stability of society in the positive aspects of the spiritual and moral factors of the National idea to social development. Spiritual and moral factors are based on the fact that at a new stage of the development of our society, a person is the skills necessary for a new life, accompanied by a change in the spiritual worldview. The awareness of the national identity in society, the formation of national feelings-a substantive feature of the National idea: the fact that it is from the conditions of stability is scientifically based.