In order to identify risk factors for the development of irritable bowel syndrome in children depending on the clinical variants of the disease, age, gender, были обследованы the basic group consisted of 56 children suffering from irritable bowel syndrome aged 7-14 years (middle age of 10.0±0,69 years), including 30 girls and 26 boys. The comparison group consisted of 100 patients with diseases of the upper gastrointestinal tract without IBS (the Syndrome of Irritated Bowel). According to the findings of a survey of 56 children aged 7-14 years, it was found that the stream of irritable bowel syndrome in children depends on age, sex and clinical options. The disease is frequently occurres in younger boys (57,4%) and girls (68,1%) of high school age. Pronounced clinical manifestations of the disease marked in children in the senior school age (57,8%) and in patients with clinical variant of irritable bowel syndrome with predominant diarrhea (30,6%).
The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.
The purpose of the study. Study of the clinical presentation of irritable bowel syndrome in children depending on the clinical variant of the disease, age, gender.
Materials and methods. 156 children and adolescents who passed the generally accepted set of studies for patients with gastropathology were examined.
Results. According to the data obtained from the study of 56 children aged 7-14 years, it was found that the course of irritable bowel syndrome in children depends on age, gender and clinical variant. The disease is more common in young boys (57.4%) and girls of high school age (68.1%). Clear clinical manifestations of the disease are observed in children of senior school age (57.8%) and in patients with a clinical variant of irritable bowel syndrome with a high prevalence of diarrhea (30.6%).
Irritable bowel syndrome (IBS) is a biopsychosocial disorder that consists of a set of functional disorders that cannot be explained by organic changes in the intestines. At present, it is very important to determine the indicators of quality of life (QOL) in patients with various diseases. QOL analysis allows us to determine how well a patient is coping with the disease, and is also important for addressing many of the issues that arise during treatment. The main complaints of patients were fecal incontinence (100%) and pain syndrome (100%). In patients with IBS with predominance of diarrhea and constipation, the leading symptom in the clinical picture of the disease is pain throughout the bowel, which decreases or disappears after defecation, accompanied by flatulence and a feeling of complete bowel emptying. ± 0.25 points (according to the results of the GSRS survey), which corresponds to severe and moderate intensity pain syndrome. At the end of the course of treatment, a statistically significant decrease in the intensity of abdominal pain was observed in patients.
Irritable bowel syndrome (IBS) is a biopsychosocial disease consisting of a set of functional disorders not explained by organic changes in the intestine. A total of 117 patients and healthy people were examined. Patients were divided into 2 groups: the first group were patients with IBS, which were divided into 2 subgroups: IBSd (diarrhea) - 51 patients (20 men and 31 women), IBSc (constipation) - 66 patients (33 men and 33 women). More abdominal pain syndrome was noted in patients with a clinical form of IBS with a predominance of diarrhea. The ordinal assessment of the severity of SRC symptoms allows to objectify the severity of clinical manifestation of intestinal dysfunction in patients, identify the clinical features of the course of this pathology.
In the monograph, in determining the role of antiphospholipid syndrome in the origin of cerebrovascular diseases in systemic diseases of connective tissue, an algorithm for the diagnosis of antiphospholipid syndrome was developed with the combined use of immunological and clinical-neuroimaging tests for the early diagnosis of antiphospholipid syndrome in patients with neurological manifestations of systemic diseases of connective tissue. It allows early diagnosis of patients, reduction of disease in their treatment and improvement of treatment efficiency. The monograph is intended for neuropathologists and general practitioners, rheumatologists, as well as graduate and clinical residency students.
Asthenia senile syndrome is coded R54 in the International Classification of Diseases (ICD-10). Today, the prevalence of this syndrome among elderly people worldwide is 13%, while the prevalence of "senile preadjustment syndrome" is 50%. With an unfavourable course, without early treatment and rehabilitation, senile prehospital syndrome develops into senile asthenia after 4-5 years. This syndrome is a key concept of modern gerontology.
Obesity has become an epidemic among children and adolescents around the world. To date, of
particular interest is the study of the mechanisms of development of metabolic syndrome, especially
associated with impaired iron metabolism. The simultaneous occurrence of diseases of two different
directions, namely obesity and anemia, cannot be considered a coincidence. Numerous studies have
shown that increased serum ferritin levels are associated with the development of metabolic
syndrome. This article provides an overview of current studies of neuropsychological and autonomic
changes in adolescents as a result of metabolic syndrome affecting the central nervous system, as
well as electroencephalographic and ultrasound Doppler changes, the relationship between
metabolic syndrome and serum ferritin levels. The psychoemotional and mnestic-intellectual
changes that develop as a result of metabolic syndrome in adolescents are widely covered.
The aim of the given work was study interactions of impairments sympa-thetic – adrenal systems functional condition and processes of peroxidal oxida-tion of lipids in woman with metabolic syndrome. 107women at the age of 25-49 were observation. They were randomized into 3 groups: I (control) – 15 healthy persons, II – 43 patients with arterial hypertension, III – 49 women with arterial hypertension in combination with metabolic syndrome. The results of carried investigations showed that activation of sympathetic adrenal system and processes of peroxidal oxidation of lipids took place in metabolic syn-drome. Marked lowering of sympathetic – adrenal system key ferment catechol-amins (MAO monoaminooxidaze) desamidization activity and considerable ac-tivation of peroxidal oxidation of lipid products which have great significance in revealing the mechanism of metabolic syndrome development were observed in metabolic syndrome. This results in the prolonged toxic influence of catechola-mins on myocardium.
Obesity has become an epidemic among children and adolescents around the world. To date, of
particular interest is the study of the mechanisms of development of metabolic syndrome, especially
associated with impaired iron metabolism. The simultaneous occurrence of diseases of two different
directions, namely obesity and anemia, cannot be considered a coincidence. Numerous studies have
shown that increased serum ferritin levels are associated with the development of metabolic
syndrome. This article provides an overview of current studies of neuropsychological and autonomic
changes in adolescents as a result of metabolic syndrome affecting the central nervous system, as
well as electroencephalographic and ultrasound Doppler changes, the relationship between
metabolic syndrome and serum ferritin levels. The psychoemotional and mnestic-intellectual
changes that develop as a result of metabolic syndrome in adolescents are widely covered.
Subjects of the inquiry: patients with acute intestinal obstruction.
The aim of the inquiry: improvement of treatment results of the patients with acute bowel obstruction by means of the perfection of the methods of intestinal decompression and enteral correction of metabolic disturbance of the organism with nutritive blend “Perative”.
Methods of inquiry: general clinical laboratory investigations, roentgenological studies, statistical technologies, clcctrocntcrography.
Novelty of inquiry: In complex treatment of the patients with acute bowel obstruction the improved intestinal tube has been used for intraoperative decompression of the gastrointestinal tract and it has been demonstrated of its effectiveness. The active intra- and postoperative decompression of the gastrointestinal tract, gut lavage, enteral [tube] feeding effectiveness in complex treatment of the patients with acute bowel obstruction has been proved. The necessity of addition of the complex treatment of the patients with acute bowel obstruction the enteral correction of metabolic disturbance of the organism has been proved and the balanced nutritive blend “Perative” efficacy has been defined.
Practical value: The application of the improved intestinal tube allowed accomplishing of the adequate evacuation of the toxic contents of the gastrointestinal tract and reducing of the enteric pressure. It has contributed to earlier recovery of the all gastrointestinal tract function and it has created the favourable conditions for enteral [tube] feeding. Carrying out of the enteral [tube] feeding with semi - substrate nutritive blend “Perative” has promoted to earlier replacement of the loss of power and plastic material needs. Clinical application of the developed patients management with acute bowel obstruction has promoted to the reduction of the complications rate (from 33,9% to 6,0%) and mortality (10,7% to 0%).
Degree of embed and economical effectivity: The main regulations of the dissertation have been applied in practical work of the urgent surgical department of the second clinic of the Second Tashkent State Medical Institute and it is used in process of 4-6 years students teaching in the Second Tashkent State Medical Institute.
Sphere of usage: urgent surgical help.