The aim is to study the review of the literature review on autoimmune thyroiditis and violations of the reproductive function in women of fertile age
Methods. In total, 100 cases of Ait in women of fertile age with various disorders of the menstrual function (MF) and the reproductive system (PC) were studied. The average age of women was ranging from 18 to 45 years (31.5 ± 0.4).
All 100 patients were performed by a study spectrum, including the study of endocrine status (anthropometric - height, weight, waist volume, thighs, body weight index), general crystal, biochemical, hormonal (TSH, LG, FSH, prolactin, estradiol, progesterone, free thyroxine, antibodies to TPO and other - in the laboratory of radioimmune hormonal studies of the RSNPMC Endocrinology of the Ministry of Health of Ruz. In addition, they performed an ultrasound study of the brief and genital organs, an ECG, as well as a study of the quality of life on the questionnaire of The World Health Organization Quality Of Life (WHOQOL -Qol).
Research results. Depending on the body mass index (BMI), the patients were distributed into 2 groups: 1 group - patients with ait with soblinic hypothyroidism -48 (48.0%) patients, 2 groups - patients with AIT with manifestic hypothyroidism - 52 (52.0%) patients.
In the structure of violations of MC in women, the 1st groups were allowed -24.6%, secondary amenorrhea -12.5%. These patients had a history of miscarriage (12.5%), stillbirth (14.6%). Violations of reproductive function were not observed.
In the structure of violations of the MC in women, 2 groups were an olnognosorya -59.6%, the metrrahny frequency is 21.2%, secondary amenorrhea -19.2%. For this category of patients, a high frequency of violations of the reproductive system (53.9%) is characterized, of which: primary infertility was observed in 40.4% of cases, secondary infertility - 13.5% of cases. These patients had a history of miscarriage (32.8%), stillbirth (39.8%), butorous prevention of the fetus (22.7%).
Conclusions. 1) The first stage in the treatment of menstrual disorders and infertility in women with ait should be the correction of excess body weight. 2) Most often, the violation of the MC and the reproductive function was observed in patients with ait and 1 degree of obesity than with ait and normal body weight.
As is known to science, the reproductive system is a collection of interrelated structural elements, such as the hypothalamus, pituitary gland, ovaries, target organs and other endocrine glands, which ensures reproductive function. Hormonal changes are key during pregnancy. One of the most important parts of the neuroendocrine system is the thyroid gland (thyroid gland), which hasa significant effect on reproductive function. Since thyronines are involved in all types of metabolism and affect sexual development, menstrual function and ovulation, a normal level of thyroid hormones is a prerequisite for the harmonious functioning of a woman's body. This article examines analyzes of pregnant women with autoimmune thyroiditis.
This study assesses the activity of autoimmune reactions in adolescent children with HIV encephalopathy of varying severity. According to the results of the study, it was found that in children with HIV encephalopathy, symptomatic neurocognitive impairments are associated with the activation of cellular and humoral immunity - mainly natural killers, apoptosis markers, antibody-producing and reactive lymphocytes. In this regard, a hypothesis was put forward about the role of autoimmune reactions in the formation of HIV encephalopathy. Possible ways of damage to the CNS can be both vasculitis and autoimmune damage to the nervous tissue itself. Based on this hypothesis, during the study, a study was made of the concentration of autoantibodies - Abs to myelin, APA (vasculitis induction), Abs to cell nuclei (ANA) and their components - 1- and 2-stranded DNA.
Монография посвящена аутоиммунным полиглаидулярным синдромам (АПС), которые в настоящее время являются одной из актуальных проблем эндокринологии. АПС - редкая полиэндокринопатия, которая характеризуется поражением нескольких эндокринных желез и неэндокринных тканей в результате иммунных нарушений. Обычно это приводит к снижению активности участников. Скрининг, диагностика, иммуногенетическое, эпидемиологическое и клиническое изучение АПС является одним из актуальных направлений современной эндокринологии.
Монография расчитана для врачей- эндокринологов, клинических ординаторов, резидентов и студентов медицинских вузов
The article considers a clinical case of a young patient with autoimmune polyglandular
syndrome type 2, represented by type 1 diabetes mellitus, thyroid dysfunction and
primary adrenal cortex insufficiency.
The article considers a clinical case of a young patient with autoimmune polyglandular
syndrome type 2, represented by type 1 diabetes mellitus, thyroid dysfunction and
primary adrenal cortex insufficiency.
Purpose of the study. Determination of the clinical and pathogenetic characteristics of COVID-19 in the early rehabilitation period according to retrospective analysis
Material and research methods. A retrospective analysis of the case histories of 128 patients who underwent COVID-19 and persistent symptoms of the disease was carried out. The number and frequency of underlying diseases and clinical manifestations of various pathological syndromes were determined.
The results of the analysis of case histories of patients showed that 44 patients suffered moderate severity of COVID 19, 45 patients - severe, 39 - extremely severe. 40 patients were diagnosed with a lesion of 25% of the lungs or less (CT 1), in 43 patients - more than 25 to 50% of the lung volume (CT-2), in 32 patients - more than 50 to 75% (CT-3) and in 13 patients - more than 75% (CT-4). On average, the number of background pathologies was 4.53 ± 2.20. The average number of background diseases was significantly higher in patients of the older age group (p <0.001). In patients with severe and extremely severe infections diabetes and obesity were more common (p <0.05 for both comparisons). In the group of patients with moderate severity of infection, chronic viral hepatitis was more common (p <0.05). Clinical syndromes pathogenetically associated with an autoimmune inflammatory reaction were observed in 99 patients (77.34%), cell dystrophy - in 123 patients (96.09%), coagulopathy - in 73 patients (57.03%), fibrosis - in 44 patients (34.38%). Conclusion. According to the data of retrospective analysis, the average number of background diseases was significantly higher in patients of the older age group. Diabetes and obesity were more common in patients with severe and extremely severe COVID-19. In patients with moderate severity of infection, chronic viral hepatitis was more common. The pathogenetic syndrome of an autoimmune inflammatory reaction was observed in 77.34% of patients, cell dystrophy syndromes in 96.09%, coagulopathic in 57.03% and fibrosis in 34.38% of patients.
Coeliac disease is a common autoimmune disorder characterized by an abnormal immune response to gluten. While the classic presentation of coeliac disease involves gastrointestinal symptoms such as diarrhea, abdominal pain, and malabsorption, atypical or non-classic presentations can pose diagnostic challenges. This paper presents a case study approach to explore the unusual manifestations of coeliac disease and their clinical implications. The selected case studies highlight patients who presented with atypical symptoms or extraintestinal manifestations of coeliac disease, including dermatological, neurological, and psychiatric manifestations. Through an in-depth analysis of these cases, this research aims to increase awareness among healthcare professionals regarding the diverse presentations of coeliac disease, improve diagnostic accuracy, and enhance patient outcomes.
The problem of free radical pathology, the most important characteristic of which is the accumulation of toxic products of lipid peroxidation, is of exceptional scientific and practical importance. Radical oxidative processes are a significant pathogenetic factor in many diseases and pathological conditions (1,2,4,7,11). One of the important aspects of studying the pathogenesis of various diseases is the study of the state of lipid peroxidation and the antioxidant system. Violation of the stationary state of free-radical oxidation is considered one of the universal, non-specific indicators of the presence of damage and is characteristic of a wide variety of diseases: atherosclerosis, stress, neuroses, diabetes mellitus, inflammatory processes, autoimmune diseases, etc. (3,5,6,8,9 ,10).
Guillain-Barre syndrome (GBS) is a very rare autoimmune disease that is associated with demyelination of the peripheral nervous system and progressive muscle weakness that occurs mainly in previously healthy people. The incidence of GBS is 1.1-1.8 cases per 100,000 per year, and the incidence increases with age. The clinical spectrum of GBS is heterogeneous and includes acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor and sensory axonal neuropathy (AMSAN), and Miller Fisher Syndrome (MFS). The disease is usually characterized by a rapid onset of symmetrical limb weakness, which progresses within a few days to 4 weeks and occurs in patients of any age. In developed countries, GBS has become the most common cause of acute flaccid paralysis. Despite improved recognition and treatment, GBS continues to be a serious disease.