The results of recent studies indicate that the informational significance of the criteria for systemic inflammatory response syndrome (SIR) is low. SVR-criteria (blood leukocytes, body temperature, heart rate and respiratory rate) to a certain extent reflect the development of inflammation, draw attention to the response of the macroorganism, but do not indicate its nature, life-threatening situation [Vincent J.L., 2012; Rudnov V. A., 2015]. According to the new definition, sepsis is a life-threatening acute organ dysfunction that occurs as a result of dysregulation of the macroorganism's response to infection, which is manifested by damage to its own tissues and organs.
Optimization of diagnostics and schemes of pathogenetic intensive therapy of surgical sepsis in children based on clinical and laboratory criteria and bacteriological monitoring.Materials and methods: The research period is 2018-2020. The object of the study (n=73) – children with surgical pathology (widespread peritonitis, bacterial destruction of the lungs, post-traumatic brain hematomas, abdominal trauma, etc.). Research methods: microbiological monitoring to determine the sensitivity of the micro-organism to antibiotics was carried out before and at the stages of treatment (sputum, urine, wound, bron-choalveolar lavage, tracheal aspirate, blood, contents from drainages, wound surface). Determination of the sensitivity of the isolated strains to antibiotics was carried out by the disk-diffusion method. To determine predictors of sepsis in surgical patients, clinical (mean arterial pressure (mAP), heart rate (HR), respiratory rate (RR), SpO 2 , etc. and laboratory parameters on days 1–2 (up to 48 hours) of sepsis identification, days 4 and 8 of intensive therapy. Procalcitonin was determined by immuno-fluorescence on a Triage® MeterPro analyzer (Biosite Diagnostics, USA). Blood gases and electrolytes were analyzed using a Stat Profile CCX analyzer (Nova Biomedical, USA). Results: studies have shown the effectiveness of complex intensive care in 86.3 % of cases. Mortality was found in 13.7 % of cases. Patients with severe surgical pathology died: widespread peritonitis, severe TBI + coma with irreversible neurological disorders, urosepsis against the background of chronic renal failure, after repeated surgical interventions, due to the development of refractory septic shock (SS).
Conclusions. Early diagnosis of sepsis, rational early ABT under the control of microbiological monitoring, non-aggressive infusion therapy with early prescription of vasopressors (SS) with constant monitoring of the child's main life support organs contribute to an improvement in sepsis outcomes and a decrease in mortality
It has now been established that the very process of interaction between an infect (microorganism) and a macroorganism is more complex than previously thought, and is characterized by the versatility of the latter's response to microbial invasion, the manifestations of which determine sex, age, race, genetic factors, and the nature of comorbidities [Kwan A. ,2013; Rudnov V. A., 2015]. The results of recent studies indicate that the informational significance of the criteria for systemic inflammatory response syndrome (SIR) is low. SVR-criteria (blood leukocytes, body temperature, heart rate and respiratory rate) to a certain extent reflect the development of inflammation, draw attention to the response of the macroorganism, but do not indicate its nature, life-threatening situation [Vincent J.L., 2012; Rudnov V. A., 2015]. According to the new definition, sepsis is a life-threatening acute organ dysfunction that occurs as a result of dysregulation of the macroorganism's response to infection, which is manifested by damage to its own tissues and organs.
The text provides a comprehensive analysis of the role and evolution of international commercial arbitration as a method of alternative dispute resolution. It emphasizes the growing preference for arbitration in international commerce due to its speed, confidentiality, and perceived fairness. The text also highlights the efforts made by the Republic of Uzbekistan to develop its arbitration infrastructure, including its adherence to international conventions and the establishment of the Tashkent International Arbitration Center. The article further delves into the legal intricacies of arbitration agreements, discussing their validity, enforceability, and the formal requirements they must meet. It concludes by noting the ongoing changes in international standards and laws governing arbitration, suggesting that these are in response to the changing needs of the global market.
Ushbu ilmiy izlanishda asosan xozirgi kundagi intellektual transport tizimlaridagi foydalanilayotgan tizimlar tahlili qolaversa ularda uchrayotgan muammolar qarab chiqilgan. So‘nggi o‘n yil ichida turli xil sharoitlarni (masalan, haydovchi monitoringi, shinalar bosimi, yog‘ bosimi, avtomobil tezligi, tezlashuv va joylashuvi) kuzatish uchun komponentlarni o‘z ichiga olgan ko‘plab transport vositalari paydo bo‘ldi. Narsalar interneti (IoT) ma’lum bir muhitdan har xil turdagi ma’lumotlarni to‘plash imkonini beradi. Ikkala tendentsiya natijalarining integratsiyasi transport vositalari interneti (IoV) kontseptsiyasining paydo bo‘lishiga olib keldi. IoVni amalga oshirish turli texnologiyalardan foydalangan holda boshqa qurilmalar va infratuzilma bilan aloqa o‘rnatish uchun qurilmalarni (datchiklar, shaxsiy qurilmalar, aktuatorlar va boshqalar) talab qiladi. Bunday qurilmalarning o‘zaro ta’siri qurilmalar o‘rtasidagi nomuvofiqlik, internetga ulanish uchun turli sifatlar va javob vaqtlari, cheklangan ishlov berish va saqlash imkoniyatlari kabi bir qancha muammolariga olib keldi. Ushbu muammolarning qisqacha tahlili ushbu maqolada qarab chiqilgan.
Гипертоническая болезнь и ежедневный приём гипотензивных препаратов могут инициировать изменение количества и качества ротовой жидкости секретируемой слюнными железами . Физические показатели слюны зависит от концентрации белка и/или неорганических минерализирующих компонентов. Изменения физико-химических показателей ротовой жидкости указывают на нарушения в её состава, что неизбежно сказывается на здоровье полости рта и целостности зубов
Maqolada kontakt elementi uyurmali oqim xosil qiluvchi ho‘l usulda chang ushlovchi va gaz tozalovchi qurilmaning gidrodinamik qarshiliklari aniqlash rejimlari tavsiya etilgan.
У детей, находящихся в предпубертатном и пубертатном периоде, метаболизм костной ткани протекает гораздо интенсивнее, чем у взрослых. В этот период требуется достаточное поступление в организм витаминов и микроэлементов. Вместе с тем, на сегодняшний день отмечается несбалансированность пищевого рациона подростков, которая способствует дефициту витаминов и микроэлементов, формированию дисбиоза полости рта. Поэтому, в комплексной профилактике стоматологических заболеваний важное значение имеют эндогенные средства, включающие витамины и минералы.
To evaluate the effectiveness of the use of a domestic production of Vinifer in the prevention of alveolitis after the removal of impacted and dystopic teeth. Material and methods: 72 patients aged 17 to 30 years and older, who applied from district polyclinics in Tashkent and other regions of Uzbekistan in 2019-2021, were under observation. Results: When using Vinifer to prevent alveolitis, the frequency of complications after tooth extraction decreased markedly. Treatment of alveolitis with the use of powder from the Vinifer preparation has reduced the number of visits to the dental surgeon. Conclusions: In terms of therapeutic and prophylactic properties, the drug showed positive results, while not inferior to imported counterparts.
Оценить альбуминурию и альбумин-креатининовый индекс (АКИ), с последующей оценкой степени прогрессирования ХБП и риска по шкале KDIGO у пациентов с ХБП.
In this work, cotton gin waste – CGW-phosphorus composts based on the waste of CGW and deposit Guliob phosphorite (GPh) were prepared, with wide mass ratios of CGW : GPh = 80 : 20; 75:25; 70 : 30; 65:35; 60 : 40; 55:45; 50 : 50; 45:55 and 40:60. The kinetics of the conversion of indigestible forms of phosphorus and calcium into a form assimilable for plants in poor GPh has been studied. It has been shown that an increase in the mass fraction of phosphate raw materials in relation to CGW leads to an increase in the content of the total form of phosphorus pentoxide in composts, but to a decrease in the relative content of the assimilable form of P2O5 and CaO. The longer the exposure time of CGW-phosphorite composts, the more forms of phosphorus and calcium digestible for plants.
To evaluate the effectiveness of the use of a domestic production of Vinifer in the prevention of alveolitis after the removal of impacted and dystopic teeth. Material and methods: 72 patients aged 17 to 30 years and older, who applied from district polyclinics in Tashkent and other regions of Uzbekistan in 2019-2021, were under observation. Results: When using Vinifer to prevent alveolitis, the frequency of complications after tooth extraction decreased markedly. Treatment of alveolitis with the use of powder from the Vinifer preparation has reduced the number of visits to the dental surgeon. Conclusions: In terms of therapeutic and prophylactic properties, the drug showed positive results, while not inferior to imported counterparts.
Плановым кесаревым сечением является операция, показания для проведения которой определены до разрешения беременности. В эту же категорию входит кесарево сечение по желанию.