In conditions of age-related decrease in sex hormones and a number of pathological conditions and diseases in postmenopausal women, there is a deficiency of D hormone. In our country, the geographic location of which is below northern latitude and sufficient ultraviolet radiation, an insufficient content of vitamin D is seen in postmenopausal women. There are a lot of risk factors leading to vitamin D deficiency - the presence of smog and dust in cities, insufficient consumption of vitamin-fortified foods, the presence of problems with the gastrointestinal tract and excretory system and a number of others. One of the important factors that reduce vitamin storage is overweight and obesity, especially in combination with old age, when all absorption processes are reduced. The aim of our research was to study risk factors in women with vitamin D deficiency with subsequent correction of the deficiency state. We examined the level of total 25 (OH) D in the blood serum in 46 postmenopausal women, and identified risk factors. Vitamin D deficiency was detected in 86.96% of women, and its deficiency was registered in 10.87%. At the same time, a pronounced vitamin deficiency was not registered in any patient. Overweight was registered in 32.6%, obesity of varying degrees in 26.1%. Given the indicators, recommendations were given for correcting vitamin D deficiency. All postmenopausal women, especially those with risk factors for deficiency, are recommended to determine the basic level of vitamin D. In case of deficiency, drug correction is recommended to reduce the risk of cardiovascular and oncological diseases.
The study of vitamin D - dependent risk factors for the formation of essential arterial hypertension
(EAH) based on the assessment of serum levels of calcidiol (25 (OH) D), calcium and vasoconstrictor factor endothelin-1-21 in 132 students aged 13 to 16 years (average age 14.64 ± 0.19 years) with normal, high normal blood pressure and essential arterial hypertension (EAH) established the priority effect of vitamin D supply on the level of diastolic blood pressure in the group of children with labile arterial hypertension and in the group of children with stable on the parameters of systolic blood pressure. In the mechanism of EAH formation in children, an interdependence between vitamin D deficiency and the severity of endothelial dysfunction by the level of endothelin -1-21 was revealed. The following vitamin D were determined by diagnostic efficiency - dependent risk factors for the formation of EAH in children in decreasing importance: endothein-1-21> 0.41fmol / ml; vitamin D <20ng / ml; Ca <2.22 mmol / L.
52 patients with rickets and 10 healthy children were examined. Among patients with rickets, 35 children were born in women with a complicated course of pregnancy (threat of termination, toxicosis of the first and second half). In 12 children, mothers had chronic liver and kidney diseases before giving birth.
The level of 25(OH) vitamin D (25-oxycalciferol) and 24.25 (OH)2 vitamin D (24.25-dioxycalciferol) was determined. The content of calcium-regulating hormones in the blood serum was determined by radioimmunological analysis. To assess the severity of the rickets process, the activity of alkaline phosphatase in the blood serum was determined using a standard kit.
The aim of our study was to determine the effect of specific prevention on the metabolism and course of the clinical form of rickets in young children.
Sugar metabolism is the biochemical processes that imply formation, breakdown, and conversion of sugar in human body. Several biological processes are involved during Sugar metabolism. This report discusses comprehensively both sugar metabolism phases and digestion pathways. The biological activities related to sugar metabolism in every relevant human body organs, chemical reactions, hormones and enzymes effects, transport routes and absorption mechanisms have been highlighted.
Subject of the inquiry: rabbits, visceral-ischemic shock, metabolism, mitochondria, suktsinasol, suktsivil.
Aim of the inquiry: to study effect of new hemocorrectors such as suktsinasol and suktsivil on the basic pathogenetic mechanisms of visceral-ischemic shock.
Methods of inquiry: physiological, biochemical, biophysical, statistical.
The results achieved and their novelty: A complete evaluation of indices in hemodynamics is given in VIS including AAB and toxemia, functional changes in liver, indices of carbohydrate-phosphoric metabolism. A number of research methods have been studied which gave the opportunity to have a distinct understanding about metabolic status of the organism. Efficiency of a new polyfunctional hemocorrection - suktsinasol on hemodynamic and metabolic indices of VIS have been studied for the first time. The effect of a new polyfunctional hemocorrector Suktsivil on the hemodynamical and metabolic indices of VIS have been studied. A comparative analysis of effective blood substitutes during infusion for VIS in experiment has been carried out.
Practical value: We have determined hypothesis about disorder of energetic metabolism in liver cells in VIS. We have proved efficiency of using new complex blood substitutes sulktsinasol and suktsivil as supply of rich energetic compounds (sulktsinasol) and corrector of electronic and transport function of mitochondria in liver in emergency complicated by hypoxia and toxemia.
Degree of embed and economical efficiency: Obtained results concerning effective new substitutes suktsinasol and sukrsivil for VIS can be recommended for combined treatment of VIS in medicine new blood substitutes can restore hemodynamics, acid-alkaline balance, metabolism, reduce toxemia.
Sphere of usage: medicine.
An increased tendency towards high morbidity of liver diseases requires a detailed study of the pathogenesis of the liver and the search for effective hepatoprotectors that can eliminate pathobiochemical changes in hepatocytes: increased lipid peroxidation against the background of a decrease in the activity of antioxidant defense enzymes and a violation of the lipid composition of membranes.
Liver pathology leads to a violation of lipid metabolism, because it plays a leading role in this metabolism. The synthesis of bile is disrupted, hydrolytic enzymes are activated, the synthesis of phospholipids decreases, the digestion of lipids in the gastrointestinal tract and the absorption of fat breakdown products, as well as fat-soluble vitamins, including the antioxidant vitamin E are disrupted.
Percentage of human population that suffer from chronic inflammatory parodontal diseases amounts to 70-98% [1]. This group of diseases is considered to be one of the most common reasons of teeth loss among people over 40 years of age. There are more than 50 somatic pathologies known to date, that get compounded by damage of parodontal tissues with 100% probability [2]. There is a tendency for «rejuvenation» of parodontal inflammatory diseases, that results in increasing prevalence among the age group of 18-24 [3]. Another tendency is that aggressiveness and severity of diagnosed pathologies increases considerably [4]. Statistically significant prevalence of vitamin D (21-29 ng/ml or 52,5-72,5 nmol/l) and deficiency (11-20 ng/ml or 27,5-50 nmol/l) [5], laboratory data in an array of research enable us to claim a substantial reverse dependence of parodontal inflammatory diseases’ intensity on vitamin D levels.
To evaluate changes in the oral cavity caused by osteoporosis in conditions of estrogen deficiency and the effect of hormone replacement therapy with calcium and vitamin D preparations
The article presents the results of our own research on the study of the period of postnatal adaptation in newborns with a vitamin D deficiency. It was revealed that early postnatal adaptation in most newborns with vitamin D deficiency occurs with disorders manifested by the pathological course of neonatal jaundice, maladjustment of the cardiovascular system, significant loss of the initial body weight and its long recovery