Biriktiruvchi to'qima differentsiyalanmagan displaziyasi (BTDD) - turli xil klinik ko'rinishlar bilan ajralib turadigan har xil sindromlar va fenotiplarni o'z ichiga oladi. Ushbu ishning maqsadi 2.9 – turdagi matriksli metalloproteinazalarning (MMP-2,-9) ekspressiyasi, matriksli metalloproteinazalarning to'qima ingibitorlari (TIMP) va ularning magniy ionlari (Mg + 2) bilan o'zaro bog'liqligini, BTDD bemorlarning qondagi glikozaminoglikan va glyukuronidaza faolligini aniqlash uchun taqqoslama tekshiruvni o’tkazish. 15 yoshdan 25 yoshgacha (19,9 ± 1,42) bo’lgan 208 ta bemor tekshiruvdan o'tkazildi. Klinik belgilar va rivojlangan asoratlarga qarab, bemorlar 2 guruhga bo'lingan, 1-guruh - 97 BTDD ning tashqi fenotiplar (fenlari) belgilari bo'lgan bemorlar, 2- guruhi - ayrim asoratlari bilan tashqi va ichki fenlarning belgilariga ega bo'lgan 111 ta bemor. Tadqiqotlar shuni ko'rsatdiki, BTDD bilan kasallangan bemorlarning qonida MMP-2 va MMP-9 ning ko'payishi va TIMP-1ning pasayishi qayd etilgan. Kasallikning avj olib borishi bilan MMP-2 va MMP-9 ekspressiyasi kuchayadi va TIMP-1 nazorat ma'lumotlariga nisbatan kamayadi. Shu bilan birga, bemorlarda Mg + 2 ionlarining qonida pasayish kuzatiladi. Shunday qilib, BTDD bilan og'rigan bemorlarda MMP-2 va MMP-9, shuningdek TIMP-1 ekspressiyasidagi o'zgarishlarning dinamikasi patologik jarayonning rivojlanishini va kasallikning prognozini baholash uchun xizmat qilishi mumkin.
As it is clear that wounds of the maxillofacial area are much more different from other parts of the body. Due to the importance of its function and cosmetic value combined soft tissue lesions occupy a special position in human bones and tissues. In this article certain valuable information is shown about ozone’s physical, chemical compositions and its positive effect on the recovery of the combined soft tissue wounds located in the facial region. To evaluate the effectiveness of ozone for the treatment of soft tissue wounds of maxillofacial injuries overall 60 patients investigated [1,2]. As a result of this, ozone tends to be much more effective than traditional ways of treatments.
Бириктирувчи тўқима дисплазияси – бу организмнинг ривожланишидаги ноёб онтогенетик аномалия бўлиб, юрак фаолиятидаги функционал ўзгаришларининг морфологик асосидир. У мураккаб, замонавий тиббиётнинг тўлиқ ўрганилмаган масалаларидан бири хисобланади. 115 нафар мактабгача ва мактаб ёшидаги бириктирувчи тўқима дисплазияси ва юрак ривожланишида кичик аномалиялари бўлган болалар ўрганилди. Бириктирувчи тўқима дисплазияси синдроми ва эмбриогенез стигмаларининг ташқи фенотипик белгиларининг юқори учраш частотаси аниқланди. Юрак қон томир патологияси ва юрагида кичик аномалиялари бўлган болаларнинг қон зардобида гидроксипролиннинг ўртача кўрсаткичининг ортиши ва минераллар дисбаланси билан касалликнинг клиник белгиларининг узаро муносабати аниқланди. Дислементозли болаларда патологик жараён ривожланишининг баъзи патогенетик йўналишлари аниқланди. Минераллар ҳолати асосий касалликнинг оғирлигини баҳолаш учун муҳим информатцион мезон эканлиги исботланган.
Стоматология соҳасида, жумладан жарроҳлик стоматология йўналиши бўйича ўтказилган кўп сонли тадқиқотларга қарамасдан, тиш олингандан кейинги яллиғланиш асоратларининг этиология ва патогенези охиригача аниқланмаган. Бу эса тиш катакчасининг битиш жараёнини ва суяк тўқимасининг меъёрий шаклланишини секинлаштиради. Шу билан бирга ёндош касаллиги бор беморларда тиш катакчасининг битиши ҳам турли ҳил асоратларни келиб чиқишига сабаб бўлади. ЖССТнинг янги ҳисоботларига кўра, “...бутун дунё бўйлаб В ва C сурункали гепатит билан 354 миллион киши касалланган. Европа минтақасида жигар циррози ва саратонининг асосий сабабчиси бўлган В ва C турдаги гепатит билан мос равишда 14 ва 12 миллион киши яшайди...” . Ҳозирги вақтда нафақат тиббий, балки ижтимоий жиҳатдан ҳам глобал муаммолардан бирини жигарнинг вирусли касалликлари ҳисобланади. Аввало, бу ўтказилаётган профилактик тадбирларга қарамасдан, вирусли гепатитнинг сезиларли даражада тарқалганлиги билан боғлиқ. Замонавий жарроҳлик стоматологиясининг долзарб муаммоси бўлиб, сурункали гепатит билан касалланган беморларда тиш олингандан кейин профилактика ва даволаш усулларини такомиллаштириш ҳисобланади.
Удаление зубов является самой распространенной операцией, после которого часто возникают геморрагические осложнения, особенно у больных хронической вирусной заболеванием печени. Данное состояние обусловлено повреждением эндотелиальной выстилки сосудов. Исходя из этого целью настоящего исследования явилось изучение особенностей эндотелиальной дисфункции перед удалением зуба у больных вирусным гепатитом. Обследованы 58 больных гепатитом В и С с различной сроком давности заболевания. У больных вирусной гепатитом перед удалением зуба отмечено повышение агрегационной активности тромбоцитов на воздействие индуктора АДФ (Тма) на 45%. Наблюдаемой нами удлинение активированного время рекальцификации (АВР) на 37% у больных с вирусной гепатитом отражает дефицит плазменных факторов ( XII,XI,XIII) системы свертывания крови и указывает на состояние гипокоагуляции. На этом фоне отмечено высокие значения альфа-2 макроглобулина в крови ( в 4 раза) и фактора Виллебранда (15%) и достоверное снижение (на 35%) содержания протеина С в крови у обследуемых больных. Полученные результаты исследование указывают, что эти пациенты имеют узкую полосу поддержания гемостатического баланса, и существующие равновесие легко может трансформироваться в гипо- или гиперкоагуляцию, которое требует проведение профилактических мероприятий для предупреждения осложнений после удаления зуба.
It is known that in chronic liver diseases, secondary immunodeficiency is formed, which is of great importance for the dental system and the entire body as a whole. Therefore, it becomes clear the importance of studying the state of the protective system of oral tissues in chronic viral liver pathology, which requires timely and constant correction. The aim of this study was to evaluate the activity of proinflammatory cytokines and cytolytic enzymes in patients with chronic viral hepatitis before tooth extraction. The level of cytokine IL-1 in patients with CVI before tooth extraction was on average 43.97±3.56 pg / ml, whereas in healthy people the studied indicator was on average 5.41 ± 0.42 pg / ml. The patients showed an increase in the level of IFN in the blood serum by an average of 6.2 times, the level of interleukin-18, belonging to the IL-1 family, was statistically significantly increased by 2.4 times in patients with CVI, compared with the control group. The features of CVH are dissociations between the levels of proinflammatory cytokines IL-1, IL-6, IL-18 and interferon. This indicates the disintegration of the inflammatory process occurring in the periodontal tissues and with the transition to a chronic course of the disease. Changes in the level of IL-1, IL-6, IL-18 and interferon in the blood serum of patients with CVI from normal parameters before tooth extraction is an indicator of the severity of the inflammatory process in the liver, as evidenced by changes in the dynamics of cytolytic enzymes.
It is known that in chronic liver diseases, secondary immunodeficiency is formed, which is of great importance for the dental system and the entire body as a whole. Therefore, it becomes clear the importance of studying the state of the protective system of oral tissues in chronic viral liver pathology, which requires timely and constant correction. The aim of this study was to evaluate the activity of proinflammatory cytokines and cytolytic enzymes in patients with chronic viral hepatitis before tooth extraction. The level of cytokine IL-1 in patients with CVI before tooth extraction was on average 43.97±3.56 pg / ml, whereas in healthy people the studied indicator was on average 5.41 ± 0.42 pg / ml. The patients showed an increase in the level of IFN in the blood serum by an average of 6.2 times, the level of interleukin-18, belonging to the IL-1 family, was statistically significantly increased by 2.4 times in patients with CVI, compared with the control group. The features of CVH are dissociations between the levels of proinflammatory cytokines IL-1, IL-6, IL-18 and interferon. This indicates the disintegration of the inflammatory process occurring in the periodontal tissues and with the transition to a chronic course of the disease. Changes in the level of IL-1, IL-6, IL-18 and interferon in the blood serum of patients with CVI from normal parameters before tooth extraction is an indicator of the severity of the inflammatory process in the liver, as evidenced by changes in the dynamics of cytolytic enzymes.
Implant placement in maxillary anterior region has most aesthetic challenges in implant dentistry because tooth loss lead to bone resorption and collapse of gingival architecture, which lead to aesthetic compromise and inadequate bone for implant placement. Immediate implant placement into fresh extraction socket reduces the treatment time, cost, preserved the gingival aesthetic and increases the comfort of the patient. This article describes the procedure for immediate implant placement in fresh extraction socket and early loading of implant with zirconia crown. Clinical and radiographic examination revealed width and length of the tooth for selecting implant size and design. Cement retained zirconia crown was used for early loading. Implant was successfully loaded and was functional during 36 months follow up period. Immediate placement and early loading of dental implant provides advantages like fewer surgical procedures, shorter treatment time, and improved aesthetic and psychological confidence. Loss of tooth in the aesthetic zone is a traumatic experience with or without compromise in phonetics. Hence, in the aesthetic zone implant supported single tooth replacement is one of the most challenging situations confronting the clinician. According to the traditional protocols 3-4 months of healing period is required for the consolidation of extraction socket. Taking into account the prosthetic treatment, patients frequently are required to wait up to 1 year for replacement of a lost tooth.