All articles - Research and experimental medicine
Number of articles: 291
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COMPARATIVE ANALYSIS OF MALIGNANT NEOPLASMS INCIDENCE INDICATORS OF ANDIJAN REGION POPULATION OF OVER THE LAST 10-YEAR OBSERVATION PERIOD (2007-2018)This article is aimed at analyzing the results when the government of the Republic of Uzbekistan adopted a strategy for the development of health care until 2021. which clearly defines the tasks of the oncological service, which can improve the situation for the early detection of malignant neoplasms, change the proportion of accumulation contingents to the early stages of cancer, which increase medical knowledge of the population can significantly help in the prevention and detection of malignant neoplastic disease in the early stages, can lead to a complete cure for malignant ailment
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COMPARATIVE ANALYSIS OF MICROELEMENT STATUS INDICATORS IN THE ELDERLY AGE IN THE ASPECT OF GENDERThe modem demographic situation is everywhere characterized by a general aging of the population and an increase in the proportion of people in the general age structure of the population over 80, which objectively contributes to an increase in the number of elderly and senile patients. In the general structure of diseases in elderly and senile people, anemia occupies one of the leading places, putting this group of people at risk of developing iron deficiency, as well as deficiencies of other important hematopoietic trace elements, for example, zinc and copper.
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TO STUDY THE EFFECTIVENESS OF DIRECT-ACTING ANTIVIRAL DRUGS IN THE TREATMENT OF CHRONIC VIRAL HEPATITIS CEpidemiological features of patients with HCV infection who were under dispensary observation in polyclinics of the Bukhara region were studied, the number of patients was 125, of which 87 (69.6%) were women and 38 (30.4%) were men. Epidemiological diagnosis of HCV was performed by detecting the RNA and genotype of HCV virus infection in blood scrum by polymerase chain reaction (PCR) in real time. The first genotype of the virus was detected in 87.2% (n=109) patients, 0.8% (n=l) the second, and 12% (n l 5) the third. Complete elimination of viruses in 98.4% of cases was achieved using a combination of sofosbuvir and Daclatasvir, directly from antiviral drugs.
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The article points to the opinion on the relationship between the successful use of calcium alginate, as one of the calcium-containing compounds in changing the main biochemical parameters of blood, by compacting bone beams, as the main indicator of the intensity of strengthening the growth of bone tissue in experimental osteoporosis. -
Study of systemic inflammation markers in the aspect of hiv - encephalopathy Development in childrenIn this article, the authors presented the results of clinical-neurological and immunological examination of 260 children with HIV - encephalopathy of various severity. All children included in the study studied the activity of HIV replication in mononuclears and other indicators that are candidates for the role of a predictive marker of the course of VCE. The analysis of the relationship between these indicators and the severity of VCE was also studied. The study evaluated the activity of 11-6, IL-10, TNF-alpha, C-reactive protein, СЗ, C4 complement components and the predictor significance of various parameters of systemic inflammation in the aspect of the development of symptomatic HIVE.
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Research of surface sensitivity in patients with chronic pain syndrome at Radiculopathies of different genesisIn patients with radiculopathies ol various origins, along with chronic pain syndrome (CHD), there is a violation of tactile sensitivity [1]. In groups of patients with radiculopathies, surface sensitivity was studied using a monofilament. which revealed a statistically significant increase in the sensitivity threshold (2]. The performed electroneu-romyography confirmed the defeat of superficial sensitivity in patients with CHD with radiculopathies of various origins.
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The basis for the study consisted of 217 patients with postoperative ventral hernias of comparable age who were under observation and admitted to the department of the surgical departments of the 1st and 2nd clinics of Samarkand state medical institute in the periods from 2009 to 2017. After the application of the proposed development and innovative approaches, the quality of life of patients with postoperative ventral hernias undergoing hernioplasty in the main group improved in contrast to the patients in the comparison group.
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Children chronic pyelonephritis in the background of disturbed uric acid Exchange: features of anamnesis and clinical and laboratory characteristicsA comparative clinical, laboratory and instrumental evaluation of 62 children with chronic pyelonephritis has been carried out. Il has been revealed that the clinical picture of pyelonephritis occurring against the background of uric nephropathy is characterized by a pronounced clinical symptoms characteristic of increased uric acid metabolism.
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Currently, in the treatment of urolithiasis (UL) preference is given to herbal preparations. Despite the wide range of herbal medicines (HM) for the treatment of UL, none of those currently used are ideal for the treatment of patients with calcium urolithiasis and preurolithiasis. In this regard, the further research on the study of the properties of drugs from medicinal plants of the Hora of Uzbekistan is important. The goal is to examine the relationship between the anti-lithogenic efficacy and the diuretic power of plant diuretics. Material and methods. In 212 patients with the calcium type of urolithiasis, the diuretic and saluretic abilities of the infusions from seven medicinal plants of the flora of Uzbekistan were investigated. The selected HM are widely known among doctors and patients. Results. Their diuretic ability of HM is different. The strong diuretics: Alhagi pseudoalhagi (+ 65.2%) and Herba Aervea Lanata a (+ 50.19%). The moderate diuretics: Stigmata Maydis (+ 42.12%), Achillea fllipendulina (41.34%) and Hypericum perforatum (+ 29.06%). The weak diuretics: Folia Menthae piperitae (+ 23.53%) and Friictus Rosae (+ 12.59%). The calculation of the ion activity index revealed differences in the severity of the anti-litogenic effect. Infusions were distributed in the following sequence: Alhagi pseudoalhagi (-71.65%) - Achillea fllipendulina (-63.14%) -Herba Aervea Lanata (-49.86%) - Folia Menthae piperitae (-41.36%) - Stigmata Maydis (-33.08%) - Hypericum perforatum (-33.02%) - Fructus Rosae (-15.43%). Conclusion. The strength of the diuretic effect should not be considered the primary factor in the change in the activity of stone formation. Therefore, when prescribing HM, this factor (diuretic effect) is not the main criterion for prevention and metaphy lax is. -
Comparative characteristics of the neurological symptoms in children de- Pending on type of delivery85 newborns bom with the help of different types of delivery were examined, it was revealed that in case of emergency caesarean section, the highest frequency of neonatal ma (adaptation to extrautcrinc life was observed, w'hich was accompanied by a large number of cases of perinatal Central nervous system damage.
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Changes in activity of non-specific cell immunity in experimental bacterial-immune periodontite and correction with their flavonolThe aim of the investidation was to evaluate activity of a non-specific link of the body protection for experimental bacterial-immune periodontitis and to find out the effects of flavonol quercetin on its parameters. The article presents the results of indices phagocytic activity of blood granulocytes by phagocyte index and phagocyte number on the 14 th day, in the period the most expressed manifestation of the experimental bacteri- al-immune periodontitis and after correction with quercetin (on the 14 th day). In this case, the character of changes in phagocytic activity in the process of inflammatory site formation in the periodontal complex was determined. The use of quercetin, which acting immune processes, limited the inflammatory response in the periodontal tissues and led to a decrease in the activity of the non-specific immune cell relative to the rates of animals that did not take the medicine. These indices were near to the control group, but did not reach their
Journal problems of biology and medicine -
Evaluating the effectiveness of treatment of purulent-inflammatory diseases in the experiment by using laser (co2 laser and photodynamic therapy) treatment methodsObjective: Improve the treatment of purulent destructive wounds by topical application of CO2 laser and photodynamic therapy in the experiment. Materials and methods: purulent wound model reproduced in 80 male rats by MP Thick (2002) with some modification. Animals from the third day were divided into 4 groups: 1) 20 rats with physiological regeneration, 2) 20 rats with standard therapy, and 3) 20 rats PDT 4) rats 20 inclusion complex treatment with conventional methods, the CO2 laser (JZ- 3A) 3 times daily until the wound cleansing from necrotic raids and PDT. Studied plane geometry, healing time, peripheral blood counts and morphology of biopsies from the wound bed and the wall on the 1st, 3rd, 7th and 10th day of the experiment. Results. Photodynamic therapy in a CO2 laser complex was not sufficiently effective invasive treatment of purulent wounds and allows to recommend its use in clinical practice for the treatment of local purulent-destructive diseases of soft tissues. Complex application of PDT and CO2 laser leads to an earlier cleansing from the pus, the active formation of granulation tissue and shortening deadlines complete epithelialization of the wound surface. Conclusions: Complex treatment with CO2 laser and photodynamic therapy is the most effective, as compared to other methods studied separately
Journal problems of biology and medicine -
The effect of intraportal introduction of tripsine on the change of utilization of cholecystokinin-8 of liverThe effect of intraportal administration of trypsin on the degree of utilization of cholecystokinin (CCK-8) shortchain peptide by the liver by the liver was studied in rats according to the degree of its influence on the secretory function of the pancreas. Studies were conducted on 56 rats in 8 series, 7 acute experiments in each series. Conclusions were made: in rats, the liver utilizes short-chain peptide CCK-8. Trypsin, when со-administered with CCK-8 in the peripheral vein, slightly increases the secretory activity of the pancreas and significantly when administered into the portal vein, which indicates that trypsin can reduce the ability of the liver to utilize the CCK-8 short chain peptide. This fact confirms the involvement of the liver in the change in utilization of short-chain peptides, which is one of the mechanisms regulating pancreatic secretory activity. Trypsin is also involved in these mechanisms of regulation of the activity of the digestive glands, which is new evidence of the existence of a physiological mechanism of the relationship between the gastrointestinal tract and the liver.
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Effect of tripsin on immune characteristics and proteolytic activity of sperm in men with fertility disorderIn men with unpaired tenuity, proteolytic and anti-proteolytic activity was studied in the ejaculate, as well as the rates of pro- and anti-inflammatory interleukins after their treatment with trypsin. In men with impaired fertility, there is a decrease in total proteolytic activity and an increase in the antiproteolytic activity of sperm. The increase in antiproteolytic activity is more associated with the local and systemic reaction to the inflammatory process, but to a lesser extent with the inhibition of sperm proteases. After treatment with trypsin in men with impaired fertility, there was a decrease in antiproteolytic and an increase in the proteolytic activity of sperm. The use of trypsin as an immunocorrective factor of male sperm helps to improve its immune characteristics.
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The study of cellular immune response on the hyaluronidase in the experiment in miceIn article are presented the data on experimental studying immunostimulating properties of polyions SD and PO at mice hybrids. It was established, that antigene Hyal. possessed low immunogenicity. Studying immunoadjuvan-ticity SD. ON to Hyal. at research of their influence on cellular reactions DTH has shown, that only SD induced the given type of the response at mice. On the immunostimulating to properties concerning cellular reactions DTH on Hyal. SD conceded CFA (mycobacterial adjuvants).
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Innovative technologies and tactical approaches in the treatment of abdominal injuriesThe authors proposed active surgical tactics as "damage control" in traumatic liver injuries. The method of "damage control" in SFRICAN used since 2006 as the only method of saving the life of patients with traumatic injuries of the liver in the IV and V degree (for E. Moore, 1986). In the departments of emergency surgery STRNCMP 2008 - 2018 127 operated patients with liver trauma. Of these, 19 (14,96%) patients with severe liver injuries of IV and V degree of damage by E. Moore. The effectiveness of multi-stage tactics was evaluated by the level of mortality and the number of purulent-septic complications. The results of surgical treatment of 19 patients with massive liver injuries, aged 17 to 50 years, were analyzed. The median age was 26 years. There were 11 men and 8 women. The average assessment of the severity of damage on the ISS scale was 34 points (17-76), E. Moore IV and V degree of damage. The average blood loss was 2850 ml (1750 -3850 ml). ЛИ patients underwent multi-stage laparotomy with gauze (film) tamponade, the average number of operations per 1 person 2,7 (2-5), suturing of the liver wound with tamponade (13), extensive hepatotomy and vascular ligation (3), atypical resection (2), stitching of large major vessels with taponade (1). The average bed/day in the intensive care unit is 13 (3-16), and the average bed/day in the clinic is 25 (3-28). Mortality was 26,3% (5 out of 19), mainly purulent-septic complications and multiple organ failure. Multi-stage surgical tactics "damage control" in isolated and combined severe liver damage is an effective method in unstable patients with the risk of developing coagulopathy and multiple organ failure. The use of the "damage control" technique helped to reduce the mortality rate from acute abdominal pathology by 26,3%.
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Investigation of physical and mechanical properties of thrombusThe study of the physico-mechanical properties of blood clots has recently become of increasing interest in practical medicine. The study of such physical parameters of a thrombus as adhesion force, density, porosity, elasticity, as well as changes in these properties of a thrombus over time, thrombus dynamics opens up new opportunities in hematology, surgery and other branches of medicine.
Journal problems of biology and medicine -
Characteristic of morphological changes in the liver into nitric and nitrate intoxication in experimentAs a result of an intoxication of an organism of experimental animals salts of nitrites and nitrates in a liver of rats find out a number morphological the changes, characterized by infringement braced structures, by changes of quantity of two and multinuclear hepatocyte, expressiveness of vascular changes. Noted morpholog-ical changes, undoubtedly, are connected with formation trengthening oxides nitrogen from nitrites and ni-trates
Journal problems of biology and medicine -
Based on our experience, it was found that Seller is a class III drug with a 20% toxicity. The drug has an irritating effect on the skin and eye mucosa. The daily dose 0.72 mg/kg/day. Has no carcinogenic, mutagenic, embryotoxicaction. As a result of the research, the insecticide is determined by the amount of atmospheric air and jobs allowed, maximum permissible levels in food, and possible levels in food, and possible soil contamination. -
Experimental substantiation of effective therapeutic dose of albendazole for prevention of recovery of echinococcosisTo study the effect of albendazole in various dosages on the formation of the echinococcal cyst (bladder), experiments were conducted on sheep (8 sheep) artificially infected with echinococcosis. To determine the ef-fect of albendazole, liver tissues of sheep subjected to and not subjected to chemotherapy were studied. A com-parative study of the emerging embryonic blisters of sheep treated and not treated with albendazole showed a significant difference in the dynamics of the formation of embryonic blisters. Albendazole in a dose of 5 mg / kg of weight affects the fatal effect on the embryonic form of echinococcus and is an effective therapeutic dose without toxic effect in the prevention of relapse of echinococcosis
Journal problems of biology and medicine -
Hygienic justification of the permissible safety standards for the insecticide “zaragen” in some environmental objectsScientifically substantiated the maximum permissible concentration (MAC) of the drug Zeragen k.s. in the water of reservoirs (taking into account the organoleptic properties of water and the sanitary regime of the water of reservoirs), in atmospheric air and air of the working area. Taking into account the generally accepted approaches in hygienic practice, the maximum allowable level (MRL) of a drug in food products has been established for rationing pesticidal preparations. Based on the data on the toxicity of the drug, the maximum permissible concentration (MPC) in the atmospheric air of the working area, as well as the estimated permissible concentration (MPC) in the soil, the maximum permissible levels in food products, were developed by calculation.
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Estimation of efficiency of application of minimally invasive technologies in diagnostics and treatment of tuberculosis obstructive forms of the urinary waysPercutaneous nephrostomy and stenting for tuberculosis of the kidneys with supravesical obstruction creates the conditions for normalizing the passage of urine. The accumulated experience allows us to positively assess the role of PKNS as a method of choice for the release and assessment of the reserves of renal function against the background of tuberculous changes in the upper urinary tract, and stenting for tuberculosis of the kidneys with supravesical obstruction creates the conditions for normalizing the passage of urine.
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The article gives an example from practice with the analysis of materials of commission forensic medical examination. It was revealed that the main pathology was not recognized, and the treatment, which was due to subjective reasons, was appropriately treated incorrectly -
The role of functional studies of cardiorespiratory system with funnel chest deformityThe article presents its own material 66 observations of patients with funnel-like deformation of the chest. It is shown that multispiral computed tomography is the most informative method in determining the shape, severity of curvature and the degree of cardiorespiratory disorders, and also determining the choice of therapeutic tactics. Starting in 2013, patients with this congenital pathology were operated using the method of minimally invasive thoracoplasty according to D. Nuss. It is noted that the application of this method of correc-tion of funnel-shaped deformation of the chest is a method of choice and gives good functional and cosmetic results.
Journal problems of biology and medicine -
Lifestyle preschool children are brought up in educational institutions of general and health types of tashkent cityThe method of questionnaire in 1175 households studied social and hygienic factors that are typical for parents and children - pupils of pre-school educational institutions and the general type of tuberculosis sanato-rium profile. Statistically reliably established that the increase in the risk of developing chronic diseases tub-contacts child consistently influenced by factors such as consumption of tobacco and alcohol by parents, the duration of feeding children breast milk (up to 9 months), consanguineous marriages between parents living child in a single-parent family, the duration of television viewing (2 or more hours a day) and play on the com-puter (more than 30 minutes a day), the social position of the father (temporarily or permanently unemployed), long walks in the fresh air (up to 1 hour per day) and the education of the child in beshik (over 2 years), the presence of professional production hazards parents (the temperature factor and contact with animals), living in a large (4 or more children) and large (7 or more people) family
Journal problems of biology and medicine
